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| 1 | Colonic manifestations of PTEN hamartoma tumor syndrome: Case series and systematic review显示文摘AIM:To investigate our clinical experience with the colonic manifestations of phosphatase and tensin homolog on chromosome ten(PTEN)hamartoma tumor syndrome(PHTS)and to perform a systematic literature review regarding the same.METHODS:This study was approved by the appropriate institutional review board prior to initiation.A clinical genetics database was searched for patients with PHTS or a component syndrome that received gastrointestinal endoscopy or pathology interpretation at our center.These patient’s records were retrospectively reviewed for clinical characteristics(including family history and genetic testing),endoscopy results and pathology findings.We also performed a systematic review of the literature for case series of PHTS or component syndromes that reported gastrointestinal manifestations and investigations published after consensus diagnostic criteria were established in 1996.These results were compiled and reported.RESULTS:Eight patients from our institution met initial inclusion criteria.Of these,5 patients underwent4.2 colonoscopies at mean age 45.8±10.8 years.All were found to have colon polyps during their clinical course and polyp histology included adenoma,hyperplastic,ganglioneuroma and juvenile.No malignant lesions were identified.Two had multiple histologic types.One patient underwent colectomy due to innumerable polyps and concern for future malignant potential.Systematic literature review of PHTS patients undergoing endoscopy revealed 107 patients receiving colonoscopy at mean age 37.4 years.Colon polyps were noted in92.5%and multiple colon polyp histologies were reported in 53.6%.Common polyp histologies included hyperplastic(43.6%),adenoma(40.4%),hamartoma(38.3%),ganglioneuroma(33%)and inflammatory(24.5%)polyps.Twelve(11.2%)patients had colorectal cancer at mean age 46.7 years(range 35-62).Clinical outcomes secondary to colon polyposis and malignancy were not commonly reported.CONCLUSION:PHTS has a high prevalence of colon polyposis with multiple histologic types.It should be considered a mixed polyposis syndrome.Systematic review found an increased prevalence of colorectal cancer and we recommend initiating colonoscopy for colorectal cancer surveillance at age 35 years. | Peter P Stanich Robert Pilarski Jonathan Rock Wendy L Frankel Samer El-Dika Marty M Meyer | 2014 | World Journal of Gastroenterology2014,20,7: | 5 |
| 2 | Trace metal enrichment in core sediments in muthupet mangroves, SE coast of India: Application of acid leachable technique 显示文摘 | Janaki-Raman D Jonathan M P Srinivasalu S | 2007 | Environmental Pollution2007,145,26: | 1 |
| 3 | Hashash,Nonlinear Ground-Response Analysis of Turkey Flat Shallow Stiff-soil Site to Strong Ground Motion显示文摘 | Annie 0 L Kwok Jonathan P Stewart Youssef M A | 2008 | Bulletin ot' the Seis- mological Society of America February2008,98,: | 1 |
| 4 | Biogenic synthesis and reduction of Fe(Ⅲ)-hydroxysulfates显示文摘 | Jonathan P Gramp Wang Hongmei Jerry M Bigham | 2009 | Geomicrobiology Journal2009,26,: | 1 |
| 5 | Psychometric properties of a Chinese version of the Buss-Warren Aggression Questionnacre显示文摘 | JONATHAN P M | 2008 | Personal Indiv Differ2008,44,: | 1 |
| 6 | Ecohydrology and hydroecology:A ' new paradigm显示文摘 | David M Hannah Paul J Wood Jonathan P Sadler | | 0,,: | 1 |
| 7 | Acute endophthalmitis following intravitreal triamcinolone acetonide injection显示文摘 | Darius M Moshfeghi Peter K Kaiser Ingrid U Scott Jonathan E Sears Matthew Benz Juan P Sinesterra Richard S Kaiser Sophie J Bakri Raj K Maturi Jonathan Belmont Paul M Beer Timothy G Murray Hugo Quiroz-Mercado William F Mieler | 2003 | American Journal of Ophthalmology2003,,5: | 1 |
| 8 | Co- rporate-NGO Collaboration:Co-creating New Business Models for Developing Markets 显示文摘 | NICOLAS M D JONATHAN P D JENNIFER O | 2010 | Long Range Planning2010,43,23: | 1 |
| 9 | Trace metal enrichments in core sediments in Muthupet mangroves, SE coast of India: Application of acid leachable technique 显示文摘 | JANAKI-RAMAN D JONATHAN M P SRINIVASALU S | 2007 | Environmental Pollution2007,145,1: | 1 |
| 10 | Exercise capacity and mortality among men referred for exercise testing显示文摘 | Manish P Victor F | 2002 | N Engl J Med2002,346,: | 1 |
| 11 | Reservoir quality variation on an Eocene carbonate ramp, EI Garia Formation, offshore Tunisia: Structural eontrol of burial corrosion and dolomitisation显示文摘 | Nadin P Clarke E Jonathan M | 2008 | Sedimentary Geology2008,209,: | 1 |
| 12 | Keeping time with the human genome显示文摘 | Jonathan D C Charalambos P K Repert S M | 2001 | Nature2001,409,6822: | 1 |
| 13 | Relative Dynamics and Control of Spacecraft Formation in Eccentric Orbits 显示文摘 | Inalhan G Tillerson M Jonathan P H | 2002 | Journal of Guidance Control and Dynamics2002,25,1: | 1 |
| 14 | Flow of Wormlike Micelle Solu- tions Through a Periodic Array of Cylinders显示文摘 | Geoffrey R M Jonathan P R | 2010 | Journal of Non - Newtonian Fluid Mechanics2010,,165: | 1 |
| 15 | Outlook for ellulase improvement: Screening and selection strategies 显示文摘 | Zhang Y H P Michael E H Jonathan R M | 2006 | Biotechnology Advances2006,24,: | 1 |
| 16 | Speak- ing the Buick Language: Capturing, Understanding, and Exploring Brand Identity with Shape Grammars 显示文摘 | JAY P MeCormaek JONATHAN Cagan CRAIG M Vogel | 2004 | Design Studies2004,25,: | 1 |
| 17 | Relative dynamics and control of spacecraft formations in eccentric orbits 显示文摘 | Inalhan G Tillerson M Jonathan P How | 2002 | Journal of Guidance Control and Dynamics2002,25,1: | 1 |
| 18 | Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial显示文摘 | Stephen M Davis Geoffrey A Donnan Mark W Parsons Christopher Levi Kenneth S Butcher Andre Peeters P Alan Barber Christopher Bladin Deidre A De Silva Graham Byrnes Jonathan B Chalk John N Fink Thomas E Kimber David Schultz Peter J Hand Judith Frayne Graeme | 2008 | Lancet Neurology2008,,4: | 1 |
| 19 | Reservoir quality variation on an Eocene carbonate ramp, EI Garia Formation, offshore Tunisia: Structural controlof burial corrosion and dolomitisation显示文摘 | Nadin P Clarke E Jonathan M | 2008 | Sedimenta- ry Geology2008,209,: | 1 |
| 20 | Trace metal enrichments in core sediments in Muthupet mangroves, SE coast of India: application of acid leachable technique 显示文摘 | JANAKI-RAMAN D J JONATHAN M P SRINIVASALU S | 2007 | E nviron Pollut2007,145,: | 1 |