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| 1 | Defining response to radiotherapy in rectal cancer using magnetic resonance imaging and histopathological scales显示文摘AIM To define good and poor regression using pathology and magnetic resonance imaging(MRI) regression scales after neo-adjuvant chemotherapy for rectal cancer.METHODS A systematic review was performed on all studies up to December 2015, without language restriction, t h a t w e r e i d e n t i f i e d f r o m M E D L I N E, C o c h r a n e Controlled Trials Register(1960-2015), and EMBASE(1991-2015). Searches were performed of article bibliographies and conference abstracts. MeS H and text words used included 'tumour regression', 'mr TRG', 'poor response' and 'colorectal cancers'. Clinical studies using either MRI or histopathological tumour regression grade(TRG) scales to define good and poor responders were included in relation to outcomes [local recurrence(LR), distant recurrence(DR), disease-free survival(DFS), and overall survival(OS)]. There was no age restriction or stage of cancer restriction for patient inclusion. Data were extracted by two authors working independently and using pre-defined outcome measures.RESULTS Quantitative data(prevalence) were extracted and analysed according to meta-analytical techniques using comprehensive meta-analysis. Qualitative data(LR, DR, DFS and OS) were presented as ranges. The overall proportion of poor responders after neo-adjuvant chemoradiotherapy(CRT) was 37.7%(95%CI: 30.1-45.8). There were 19 different reported histopathological scales and one MRI regression scale(mrT RG). Clinical studies used nine and six histopathological scales for poor and good responders, respectively. All studies using MRI to define good and poor response used one scale. The most common histopathological definition for good response was the Mandard grades 1 and 2 or Dworak grades 3 and 4; Mandard 3, 4 and 5 and Dworak 0, 1 and 2 were used for poor response. For histopathological grades, the 5-year outcomes for poor responders were LR 3.4%-4.3%, DR 14.3%-20.3%, DFS 61.7%-68.1% and OS 60.7-69.1. Good pathological response 5-year outcomes were LR 0%-1.8%, DR 0%-11.6%, DFS 78.4%-86.7%, and OS 77.4%-88.2%. A poor response on MRI(mr TRG 4,5) resulted in 5-year LR 4%-29%, DR 9%, DFS 31%-59% and OS 27%-68%. The 5-year outcomes with a good response on MRI(mrT RG 1,2 and 3) were LR 1%-14%, DR 3%, DFS 64%-83% and OS 72%-90%.CONCLUSION For histopathology regression assessment, Mandard 1, 2/Dworak 3, 4 should be used for good response and Mandard 3, 4, 5/Dworak 0, 1, 2 for poor response. MRI indicates good and poor response by mr TRG1-3 and mrT RG4-5, respectively. | Muhammed RS Siddiqui Jemma Bhoday Nicholas J Battersby Manish Chand Nicholas P West Al-Mutaz Abulafi Paris P Tekkis Gina Brown | 2016 | World Journal of Gastroenterology2016，22，37： | 6 |
| 2 | Para-aortic lymph node involvement should not be a contraindication to resection of pancreatic ductal adenocarcinoma显示文摘BACKGROUND Para-aortic lymph nodes(PALN)are found in the aortocaval groove and they are staged as metastatic disease if involved by pancreatic ductal adenocarcinoma(PDAC).The data in the literature is conflicting with some studies having associated PALN involvement with poor prognosis,while others not sharing the same results.PALN resection is not included in the standard lymphadenectomy during pancreatic resections as per the International Study Group for Pancreatic Surgery and there is no consensus on the management of these cases.AIM To investigate the prognostic significance of PALN metastases on the oncological outcomes after resection for PDAC.METHODS This is a retrospective cohort study of data retrieved from a prospectively maintained database on consecutive patients undergoing pancreatectomies for PDAC where PALN was sampled between 2011 and 2020.Statistical comparison of the data between PALN+and PALN-subgroups,survival analysis with the Kaplan-Meier method and risk analysis with univariable and multivariable time to event Cox regression analysis were performed,specifically assessing oncological outcomes such as median overall survival(OS)and disease-free survival(DFS).RESULTS 81 cases had PALN sampling and 17(21%)were positive.Pathological N stage was significantly different between PALN+and PALN-patients(P=0.005),while no difference was observed in any of the other characteristics.Preoperative imaging diagnosed PALN positivity in one case.OS and DFS were comparable between PALN+and PALN-patients with lymph node positive disease(OS:13.2 mo vs 18.8 mo,P=0.161;DFS:13 mo vs 16.4 mo,P=0.179).No difference in OS or DFS was identified between PALN positive and negative patients when they received chemotherapy either in the neoadjuvant or in the adjuvant setting(OS:23.4 mo vs 20.6 mo,P=0.192;DFS:23.9 mo vs 20.5 mo,P=0.718).On the contrary,when patients did not receive chemotherapy,PALN disease had substantially shorter OS(5.5 mo vs 14.2 mo;P=0.015)and DFS(4.4 mo vs 9.8 mo;P<0.001).PALN involvement was not identified as an independent predictor for OS after multivariable analysis,while it was for DFS doubling the risk of recurrence.CONCLUSION PALN involvement does not affect OS when patients complete the indicated treatment pathway for PDAC,surgery and chemotherapy,and should not be considered as a contraindication to resection. | Rupaly Pande Shafiq Chughtai Manish Ahuja Rachel Brown David C Bartlett Bobby V Dasari Ravi Marudanayagam Darius Mirza Keith Roberts John Isaac Robert P Sutcliffe Nikolaos A Chatzizacharias | 2022 | World Journal of Gastrointestinal Surgery2022，14，5： | 2 |
| 3 | Novel biomarkers for patient stratification in colorectal cancer:A review of definitions,emerging concepts,and data显示文摘Colorectal cancer(CRC) treatment has become more personalised,incorporating a combination of the individual patient risk assessment,gene testing,and chemotherapy with surgery for optimal care.The improvement of staging with high-resolution imaging has allowed more selective treatments,optimising survival outcomes.The next step is to identify biomarkers that can inform clinicians of expected prognosis and offer the most beneficial treatment,while reducing unnecessary morbidity for the patient.The search for biomarkers in CRC has been of significant interest,with questions remaining on their impact and applicability.The study of biomarkers can be broadly divided into metabolic,molecular,micro RNA,epithelial-to-mesenchymal-transition(EMT),and imaging classes.Although numerous molecules have claimed to impact prognosis and treatment,their clinical application has been limited.Furthermore,routine testing of prognostic markers with no demonstrable influence on response to treatment is a questionable practice,as it increases cost and can adversely affect expectations of treatment.In this review we focus on recent developments and emerging biomarkers with potential utility for clinical translation in CRC.We examine and critically appraise novel imaging and molecular-based approaches; evaluate the promising array of micro RNAs,analyze metabolic profiles,and highlight key findings for biomarker potential in the EMT pathway. | Manish Chand Deborah S Keller Reza Mirnezami Marc Bullock Aneel Bhangu Brendan Moran Paris P Tekkis Gina Brown Alex Mirnezami Mariana Berho | 2018 | World Journal of Gastrointestinal Oncology2018，10，7： | 2 |
| 4 | Market Reforms in India and the Quality of Economic Growth显示文摘 | Manish G P | 2013 | Independent Review2013，18，2： | 1 |
| 5 | Studies of Novel Water-Soluble Colored Polyesters Containing Azo Moiety 显示文摘 | Manish P Patel Bhavin J Modi Ranjan G Patel | 1998 | Journal Applied Polymer Science1998，69，12： | 1 |
| 6 | Microcystic lymphatic malformation (lymphangioma circumseriptum) treated using a minimally invasive technique of radiofrequency ablation and sclerother- apy显示文摘 | Niti K Manish P | 2010 | Dermatol Surg2010，36，11： | 1 |
| 7 | Exercise capacity and mortality among men referred for exercise testing显示文摘 | Manish P Victor F | 2002 | N Engl J Med2002，346，： | 1 |
| 8 | High temperature C/C-SiC composite by liquid silicon infiltration显示文摘 | MANISH P KUMAR S | 2012 | Bulletin of Materials Science2012，35，1： | 1 |
| 9 | Melt sonocrystallization of ibuprofen:Effect on crystal properties显示文摘 | MANISH M HARSHAL J ANANT P | 2005 | Eur J Pharm Sci2005，25，1： | 1 |
| 10 | Intr-aoperative pulse and blood pressure recordings of neurosurgeons : Apilot study of cardiovascular performance 显示文摘 | Manish Singh Sharma Amit Thapa Sharat P Chandra | 2010 | Neurosurgery2010，66，： | 1 |
| 11 | Surface chemical modification of silica aerogels using various alkyl-alkoxy/chlorosilanes显示文摘 | VENKATESWARA A KULKARNI Manish M AMALNERKAR D P | 2003 | Appl Surf Sci2003，206，： | 1 |
| 12 | Microcystic lymphatic malformation ( lym- phangioma circumscriptum) treated using a minimally inva- sive technique of radiofrequency ablation and sclerotherapy 显示文摘 | Niti K Manish P | 2010 | Dermatol Surg2010，36，11： | 1 |
| 13 | A method for judicious fusion of inconsistent multiple sensor data显示文摘 | Manish Kumar Devendra P Garg Randy A Zachery | 2007 | IEEE Sensors Journal2007，，5： | 1 |
| 14 | Superhydrophobic Silica Aerogels Based on Methyltrimethoxysilane Precursor显示文摘 | Venkateswara A Rao Manish M Kulkarni Amalnerkar D P | 2003 | Journal of Non-Crystalline Solids2003，330，： | 1 |
| 15 | Inducing toxicity by introducing a leucine-zipper-like motif in frog antimicrobial peptide, magainin 2 显示文摘 | Brijesh K P Saurabh S Manish S | 2011 | Biochemical journal2011，436，3： | 1 |
| 16 | Rotavirus vaccines:Successes and challenges显示文摘 | ROGER I GLASS U P MANISH P | 2014 | J Infect2014，，68： | 1 |
| 17 | Optimization techniques applied to multiple manipulators for path planning and torque minimization显示文摘 | DEVENDRA P G MANISH K | 2002 | Engineering Applications of Artificial Intelligence2002，15，： | 1 |
| 18 | A pulsedUWB receiver SoC for insect motion control 显示文摘 | DENIS C D PATRICK P M MANISH B | 2010 | IEEE Jof Solid-State Circuits2010，45，1： | 1 |
| 19 | Discriminant analysis of edible oils and fats by FTIR, FT-NIR and FT-Raman spectroscopy显示文摘 | HONG Y JOSEPH I MANISH M P | 2005 | Food Chemistry2005，93，1： | 1 |
| 20 | 3,6-Di- subtituted fluorans containing 4 ( 3 H)-quinazolinon-3-yl, die- hyl amino groups and their application in reversible thermo- chromic materials显示文摘 | Ritesh G Patel Manish P Patel Ranjan G Patel | 2005 | Dyes and Pigments2005，66，： | 1 |
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