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| 1 | Screening for main components associated with the idiosyncratic hepatotoxicity of a tonic herb, Polygonum multiflorum显示文摘典型药用的植物的主要成分,蓼 multiflorum (用汉语的 Heshouwu ) ,那导致特质的肝损害仍然保持不清楚。我们的以前的工作证明了有 lipopolysaccharide (LPS ) 的无毒的剂量和 Heshouwu 的治疗学的剂量的 cotreatment 能在老鼠导致肝损害,而独唱治疗不能导致看得见的损害。在现在的工作,用成分大美人和敲门在里面策略,我们发现 Heshouwu 的乙醇醋酸盐(EA ) 摘录在对待 LPS 的老鼠显示了可比较的特质的 hepatotoxicity 到整个摘录。结果显示血浆丙氨酸 aminotransferase, aspartate aminotransferase,和肝 histologic 的重要举起变化,而另外的分开的部分没能导致肝损害。有另外的分开的部分的 EA 摘录的混合在对待 LPS 的老鼠导致了可比较的特质的 hepatotoxicity 到整个摘录。化学分析进一步揭示了那 2,3,5,4-tetrahydroxy trans-stilbene-2-O -- 配糖物(trans-SG ) 和它的 cis 异构体是在 EA 的二主要混合物摘录。而且,孤立的 cis- ,并且不它的 trans 异构体,显示的可比较的特质的 hepatotoxicity 到在对待 LPS 的老鼠的 EA 摘录。cis-SG 的更高的内容从与收集的将军相比与 Heshouwu 联系的实际的肝沉醉病人在 Heshouwu 白酒或准备被检测样品。另外,血浆 metabolomics 分析证明 cis-SG-disturbing 充实显著地不同于的小径在对待 LPS 的老鼠的 trans-SG。所有这些结果建议 cis-SG 仔细与 Heshouwu 的特质的 hepatotoxicity 被联系。认为 trans-SG 的 cis-trans 异构化被紫外光或日光调停,我们的调查结果为在药发现控制 photoisomerization 并且为 Heshouwu 和芪相关的药的临床的使用用作参考。 | Chunyu Li Ming Niu Zhaofang Bai Congen Zhang Yanling Zhao Ruiyu Li Can Tu Huifang Li Jing Jing Yakun Meng Zhijie Ma Wuwen Feng Jinfa Tang Yun Zhu Jinjie Li Xiaoya Shang Zhengsheng Zou Xiaohe Xiao Jiabo Wang | 2017 | Frontiers of Medicine2017，11，2： | 41 |
| 2 | New incompatible pair of TCM:Epimedii Folium combined with Psoraleae Fructus induces idiosyncratic hepatotoxicity under immunological stress conditions显示文摘Epimedii Folium(EF)combined with Psoraleae Fructus(PF)is a common modern preparation,but liver injury caused by Chinese patent medicine preparations containing EF and PF has been frequently reported in recent years.Zhuangguguanjiewan pills(ZGW),which contain EF and PF,could induce immune idiosyncratic liver injury according to clinical case reports and a nonhepatotoxic dose of lipopolysaccharide(LPS)model.This present study evaluated the liver injury induced by EF or PF alone or in combination and investigated the related mechanism by using the LPS model.Liver function indexes and pathological results showed that either EF or PF alone or in combination led to liver injury in normal rats;however,EF or PF alone could lead to liver injury in LPS-treated rats.Moreover,EF combined with PF could induce a greater degree of injury than that caused by EF or PF alone in LPS-treated rats.Furthermore,EF or PF alone or in combination enhanced the LPS-stimulated inflammatory cytokine production,implying that IL-1β,which is processed and released by activating the NLRP3 inflammasome,is a specific indicator of EF-induced immune idiosyncratic hepatotoxicity.Thus,EF may induce liver injury through enhancing the LPS-mediated proinflammatory cytokine production and activating the NLRP3 inflammasome.In addition,the metabolomics analysis results showed that PF affected more metabolites in glycerophospholipid and sphingolipid metabolic pathways compared with EF in LPS model,suggesting that PF increased the responsiveness of the liver to LPS or other inflammatory mediators via modulation of multiple metabolic pathways.Therefore,EF and PF combination indicates traditional Chinese medicine incompatibility,considering that it induces idiosyncratic hepatotoxicity under immunological stress conditions. | Yuan Gao Zhilei Wang Jinfa Tang Xiaoyi Liu Wei Shi Nan Qin Xiaoyan Wang Yu Pang Ruisheng Li Yaming Zhang Jiabo Wang Ming Niu Zhaofang Bai Xiaohe Xiao | 2020 | Frontiers of Medicine2020，14，1： | 32 |
| 3 | High-density Linkage Map of Cultivated Allotetraploid Cotton Based on SSR, TRAP, SRAP and AFLP Markers显示文摘一张高密度的连锁图为从在 Gossypium hirsutum L 之间的 cultivatedallotetraploid 种类的一个种间的十字导出的一张 F_2 人口被构造。并且 G.barbadense L。从种间的十字的 186 个 F_2 个人的一个总数“ CRI36 x 哈尔 7124' 是在包括一个新奇标记系统的 1 252 多态的 loci 的 genotyped,目标区域扩大多型性(陷井) 。地图由 1 097 个标记组成,包括 697 简单顺序重复(SSR ) , 171 个陷井, 129 顺序相关的放大多型性, 98 放大 fragmentlengthpolymorphisms,和二个词法标记,并且跨越了 4 有 4.1cM 的平均遗传距离的 536.7 厘米每标记。用在染色体之中的 45 复制 SSR loci, 13 同源染色体中的 11 个在四倍体棉花被识别。这张地图将为量的特点 loci 并且在棉花的分子的繁殖印射的高分辨率提供一个必要资源。 | Jiwen Yu Shuxun Yu Cairui Lu Wu Wang Shuli Fan Meizhen Song Zhongxu Lin Xianlong Zhang Jinfa Zhang | 2007 | Journal of Integrative Plant Biology2007，49，5： | 29 |
| 4 | Immunological synergistic mechanisms of trans-/cis-stilbene glycosides in Heshouwu-related idiosyncratic liver injury显示文摘Heshouwu is a traditional non-toxic Chinese medicine commonly used in the clinical setting;however,clinical cases of Heshouwu-induced hepatotoxicity have been frequently reported^([1]).Pharmacoepidemiological studies have found that Heshouwu-induced liver injury occurs only in a small fraction of individuals taking the drug;these patients presented with the typ- | Lanzhi He Ping Yin Yakun Meng Jinfa Tang Tingting He Ming Niu Yuming Guo Yun Zhu Jing Jing Chunyu Li Zhijie Ma Jiabo Wang Zhaofang Bai Xiaohe Xiao | 2017 | Science Bulletin2017，62，11： | 29 |
| 5 | Progress in green and efficient enrichment of rare earth from leaching liquor of ion adsorption type rare earth ores显示文摘Ion adsorption type rare earth ores(IATREOs)are a valuable strategic mineral resource in China,which feature a complete composition of fifteen rare earth elements and are rich in medium and heavy rare earth(RE)elements.In the leaching process for recovering rare earth elements from IATREOs,many impurities will be leached together with rare earth elements and enter the leaching liquor.An impurity removal-precipitation enrichment technique is currently applied to selectively recovery rare earth elements from the leaching liquor with the high content of impurities and low concentration of rare earth elements by using ammonium bicarbonate in the industry.However,a high loss of rare earth elements and severe ammonia nitrogen pollution are caused by this process.Therefore,more beneficial impurities removal technologies,mainly for aluminum,and green enrichment technologies with lower pollution are now urgently needed.For this purpose,this paper analyzed two aspects of research progress in recent decades:the green separation of rare earth elements and aluminum from leaching liquor and the green and efficient enrichment of rare earth elements.Finally,an approach for the high-efficiency and green enrichment of rare earth elements from leaching liquor of the IATREOs is proposed in several aspects,including impurity inhibition leaching,neutralization and impurity removal,alkaline calcium and magnesium salt precipitation enrichment,and centrifugal extraction enrichment. | Qiang He Jiang Qiu Jinfa Chen Miaomiao Zan Yanfei Xiao | 2022 | Journal of Rare Earths2022，40，3： | 5 |
| 6 | 棉花重组自交系群体重要农艺性状的遗传分析显示文摘通过产量、纤维品质、株型三类农艺性状来探究棉花重组自交系(recombinant inbred line, RIL)群体的综合表现,并进行纤维品质优异株系的筛选,是提高棉花育种效率的有效途径。本研究以鲁棉研28为母本,海岛棉渐渗材料爱字棉73003为父本,进行杂交并多代自交获得的126个RILs材料为研究对象,在四个环境下对5个产量、5个品质、4个株型相关性状进行变异系数、方差、遗传力和相关性分析。方差分析表明,该RIL群体的各性状受环境效应影响显著;变异分析和超亲分析表明群体内部存在丰富的遗传变异;相关性分析表明衣分与上半部平均长度、断裂比强度、整齐度指数呈极显著负相关,株高和果枝数与单位面积产量呈显著正相关,第一果枝高度与整齐度呈极显著正相关,果枝数与伸长率呈极显著正相关。通过综合分析,在该RIL群体中筛选出9个纤维品质性状表现优异的材料,为棉花新品种选育提供参考。 | 李丹 裴文锋 宋吉坤 吴嫚 刘国元 臧新山 Zhang Jinfa 于霁雯 | 2019 | 中国棉花2019，46，5： | 4 |
| 7 | Sources and Accumulation Risk of Heavy Metal in Major Animal Manure显示文摘Feed and corresponding manure samples were collected from 27 scale pig farms and 7 scale chicken farms in Jiaxing City,Zhejiang Province,and their heavy metal contents were analyzed. The weighted average values of Cr,Cu,Zn,Pb and As in pig feed were 4. 6,123. 4,370. 7,0. 69 and 6. 9 mg/kg,respectively. However,referred to Safe Use Specification of Feed Additives and MOA Announcement No. 1224,the exceeding standards rates of Cr,Cu,Zn,Pb and As in pig feed were 5. 36%,62. 5%,19. 64%,3. 57% and 37. 5%,respectively. The sequences of heavy metal content in pig feed successively were piglet > growing pig > big pig > sow,but the exceeding standard rates of heavy metal in feed were big pig > sow > growing pig > piglet,and the exceeding standard rate of big pig feed was more than 95%. The exceeding standard rates of Cu,Zn and As in chicken feed were 46. 7%,11. 1% and 33. 3% respectively. Based on Organic Fertilizer( NY525-2012) and Sludge Agricultural Pollution Control Standard( GB4284-84),Cu,Zn and As in pig manure and chicken manure exceeded the standard; the exceeding standard rates of pig manure were 71. 9%,78. 9% and 42. 1%,while that of chicken manure were 12. 5%,25. 0% and 44. 4%,respectively. The exceeding standard rates of Cu and Zn in piglet manure reached 100%. There were very significant positive correlations in Cu,Zn and As between pig feed and corresponding manure,or Hg,Cu and As between chicken feed and corresponding manure,and the correlation coefficients r^2 were greater than 0. 8. Besides,the correlation coefficient r^2 of Pb between pig feed and corresponding manure was above 0. 6. Continuous and high intensity of livestock manure application significantly promoted the accumulation of heavy metal in farmland soil,but the effects on heavy metal accumulation in rice was not significant. | Shi Yanping Huang Jinfa Ni Xiongwei Xie Jianping Ren Jiajia | 2016 | Animal Husbandry and Feed Science2016，8，6： | 4 |
| 8 | Nanocluster PtNiP supported on graphene as an efficient electrocatalyst for methanol oxidation reaction显示文摘In this study,phosphorus doped graphene supported PtNiP nanocluster electrocatalyst(PtNiP/P-graphene)was successfully prepared via a simple hypophosphite-assisted co-reduction method.The improved anchoring force and increased anchoring sites of graphene support result from phosphorus doping as well as size-confined growth effect of NaH_(2)PO_(2) leads to uniform dispersion of ultrafine PtNiP nanoclusters.Doped P also promotes the removal of CO-like intermediate by adjusting Pt electronic structure combining with alloyed Ni via electronic effects.As a result,the as-prepared PtNiP/P-graphene catalyst with more exposed active sites and optimized electronic structure of Pt alloy shows excellent electrocatalytic performances for methanol oxidation reaction(MOR)both in activity and durability in an acidic medium. | Long Yang Guoqiang Li Rongpeng Ma Shuai Hou Jinfa Chang Mingbo Ruan Wenbin Cai Zhao Jin Weilin Xu Guiling Wang Junjie Ge Changpeng Liu Wei Xing | 2021 | Nano Research2021，14，8： | 4 |
| 9 | 利用马克隆值差异显著的BILs鉴定棉纤维品质相关基因显示文摘【目的】马克隆值是衡量棉纤维品质的重要指标之一。利用马克隆值存在显著差异的2个陆海回交近交系材料进行高通量基因芯片分析,旨在筛选和鉴定棉纤维发育相关的关键基因。【方法】从SG747(Gossypium hirsutum L.)和Giza75(Gossypium Barbadense L.)高世代回交近交系(Backcross Inbred Lines,BILs)群体中选取NMGA-140(马克隆值6.2)和NMGA-051(马克隆值4.0)为材料,利用Affymetrix公司的棉花寡聚核苷酸基因芯片对其开花后10 DPA(Days after anthesis)的棉纤维进行了表达谱分析。【结果】获得了2655个差异表达基因,包括功能预测基因(15.57%),翻译、核糖体结构与生物合成相关基因(13.54%)和翻译后修饰、蛋白质转换、分子伴侣相关基因(9.31%)等。推测β-tub10正向调控棉纤维发育过程,β-tub1负向调控棉纤维发育过程,Ghi.3578.1.S1_s_at在棉纤维发育早期起到了作用。【结论】为棉花纤维品质的遗传改良提供了丰富的基因资源,为分子标记辅助育种开发更多新的分子标记。 | 吴嫚 李龙云 裴文锋 Zhang Jinfa 于霁雯 | 2020 | 棉花学报2020，32，1： | 4 |
| 10 | Trail armed oncolytic poxvirus suppresses lung cancer cell by inducing apoptosis显示文摘 | Jinqing Hu Huaiyuan Wang Jinfa Gu Xinyuan Liu Xiumei Zhou | 2018 | Acta Biochimica et Biophysica Sinica2018，50，10： | 3 |
| 11 | DNA methylation-based subclassification of psoriasis in the Chinese Han population显示文摘Psoriasis (Ps)is an inflammatory skin disease caused by genetic and environmental factors.Previous studies on DNA methylation (DNAm)found genetic markers that are closely associated with Ps,and evidence has shown that DNAm mediates genetic risk in Ps.In this study,Consensus Clustering was used to analyze DNAm data,and 114Ps patients were divided into three subclassifications.Investigation of the clinical characteristics and copy number variations (CNVs)of DEFB4,IL22,and LCE3C in the three subclassifications revealed no significant differences in gender ratio and in Ps area and severity index (PASI)score.The proportion of late-onset (≥40 years)Ps patients was significantly higher in type I than in types H and III (P =0.035).Type III contained the smallest proportion of smokers and the largest proportion of non-smoking Ps patients (P =0.086).The CNVs of DEFB4and LCE3C showed no significant differences but the CNV oflL22significantly differed among the three subelassifications (P =0.044).This study is the first to profile Ps subclassifications based on DNAm data in the Chinese Han population.These results are useful in the treatment and management of Ps from the molecular and genetic perspectives. | Fusheng Zhou Changbing Shen Yi-Hsiang Hsu Jing Gao Jinfa Dou Randy KO Xiaodong Zheng Liangdan Sun Yong Cui Xuejun Zhang | 2018 | Frontiers of Medicine2018，12，6： | 3 |
| 12 | Evidence of multistage late Quaternary strong earthquakes on typical segments of Longmenshan Active Fault Zone in Sichuan, China显示文摘Investigation of offset landforms and trench excavation are important means to acquire the evidence of multistage activities of active faults. Here we present the result of fault trough investigation in Beichuan County and the Pingtong Town of Pingwu County along the Longmenshan Central Fault Belt, as well as the result from trench excavation at the platform foreslope in Hanwang Town of Mianzhu County on the Longmenshan Front Range Fault Belt. These results show that at least three fault activity events, including the Wenchuan earthquake, occurred in the Beichuan fault trough, at least two, including the Wenchuan earthquake, at Pingtong fault trough, and 2-3 paleoearthquakes in the Hanwang trench. Among these three localities, the times of the last strong earthquake prior to Wenchuan earthquake at Beichuan fault trough and Hanwang trench are close, approximately 6000 years ago, i.e., greater than 5.8 ka and smaller than 6.63 ka ago. This provides the evidence of synchronous activity of the Central Fault Belt and the Front Range Fault Belt of the Longmenshan Active Fault Zone during the previous strong earthquake activities prior to Wenchuan earthquake. | JIANG WaLi XIE XinSheng ZHANG JinFa SUN ChangBin HUANG Wei SHENG Qiang FENG XiYing | 2009 | Science China Earth Sciences2009，52，9： | 3 |
| 13 | Formulation of Organic Fertilizer Standard in Jiaxing City Based on NY525-2012显示文摘On the basis of research, analysis and argumentation, we conduct analysis and research on the current situation of quality of commercial organic fertilizer in Jiaxing City, and carry out the inspection and testing of organic matter indicators using the laboratory. Based on the standard of NY525-2012 Organic Fertilizer by the Ministry of Agriculture, this paper formulates the quality level indicators of local commercial organic fertilizer and adding specifications of raw materials. | Jinfa HUANG Xiongwei NI Jianping XIE Yanping SHI | 2013 | Asian Agricultural Research2013，5，4： | 2 |
| 14 | BIK1 cooperates with BAK1 to regulate constitutive immunity and cell death in Arabidopsiss显示文摘In Arabidopsis,both the membrane-anchored receptor-like kinase(RLK) BAK1 and the receptor-like cytoplasmic kinase(RLCK) BIK1 are important mediators of transmembrane signal transduction that regulate plant development and immunity.However,little attention has been paid to their genetic association.This study found the bak1 bik1 double mutant of Arabidopsis displayed a severe dwarfism phenotype due to constitutive immunity and cell death in developing plants.These data suggest that BIK1 cooperates with BAK1 to regulate constitutive immunity and cell death. | Jun Liu Sufen Chen Lijuan Chen Qi Zhou Menglong Wang Dongru Feng Jian-Feng Li Jinfa Wang Hong-Bin Wang Bing Liu | 2017 | Journal of Integrative Plant Biology2017，59，4： | 2 |
| 15 | Biosorption of Cr(VI) by carbonized Eupatorium adenophorum and Buckwheat straw: thermodynamics and mechanism显示文摘高质量、低的费用碳能从 Eupatorium adenophorum 被准备(E。adenophorum ) 并且荞麦稻草。biosorbent 被用于 Cr (VI ) 移动。试验性的参数的效果吸着剂剂量和温度例如 pH,被检验,最佳的试验性的条件是坚定的。答案 pH 被发现影响吸附。Cr (VI ) 移动效率被发现在 pH = 是最大值(98%) 1。兰米尔和 Freundlich 吸附等温线对吸附过程适用,他们的常数被评估。获得的吸附数据与兰米尔吸着等温线模型一起同意了很好。为 Cr (VI ) 的最大的吸附能力从 46.23 ~ 55.19 mg 吗?? | Jinfa CHEN Ping YANG Dagang SONG Sha YANG Li ZHOU Lei HAN Bo LAI | 2014 | Frontiers of Environmental Science & Engineering2014，8，6： | 2 |
| 16 | SOME PROBLEMS OF FRACTIONAL PARTIAL DIFFERENCE DIFFUSION EQUATIONS显示文摘This paper mainly discusses the problems of fractional variational problems and fractional diffusion problems using fractional difference and summation.Through the Euler finite difference method we get a variational formulation of the variation problem and the discrete solution to the time-fractional and space-fractional difference equation using separating variables method and two-side Z-transform method. | Jinfa Cheng | 2014 | Annals of Differential Equations2014，30，1： | 2 |
| 17 | Ferredoxin:Thioredoxin Reductase Is Required for Proper Chloroplast Development and Is Involved in the Regulation of Plastid Gene Expression in Arabidopsis thaliana显示文摘 | Peng Wang Jun Liu Bing Liu, Qingen Da, Dongru Feng, Jianbin Su, Yang Zhang, Jinfa Wang Hong-Bin Wang | 2014 | Molecular Plant2014，7，10： | 2 |
| 18 | RESPONSE OF SEDIMENT YIELD TO BASIN CHARACTERISTICS IN THE MIDDLE YELLOW RIVER BASIN显示文摘 | Jinfa LU Xiuhua HUANG | 2003 | International Journal of Sediment Research2003，，02： | 1 |
| 19 | A multi-step induced strategy to fabricate core-shell Pt-Ni alloy as symmetric electrocatalysts for overall water splitting显示文摘Devising an electrocatalyst with brilliant efficiency and satisfactory durability for hydrogen production is of considerable demand,especially for large-scale application.Herein,we adopt a multi-step consequential induced strategy to construct a bifunctional electrocatalyst for the overall water splitting.Graphene oxide(GO)was used as a carbon matrix and in situ oxygen source,which was supported by the octahedral PtNi alloy to form the PtxNiy-GO precursor.When calcinating in Ar atmosphere,the oxygen in GO induced the surface segregation of Ni from the PtNi octahedron to form a core-shell structure of Ptx@Niy.Then,the surface-enriched Ni continuously induced the reformation of C in reduced graphene oxide(rGO)to enhance the degree of graphitization.This multi-step induction formed a nanocatalyst Pt_(x)@Ni_(y)-rGO which has very high catalytic efficiency and stability.By optimizing the feeding ratio of PtNi(Pt:Ni=1:2),the electrolytic overall water splitting at 10 mA·cm^(-2) can be driven by an electrolytic voltage of as low as 1.485 V,and hydrogen evolution reaction(HER)only needs an overpotential of 37 mV in 1.0 M KOH aqueous solution.Additionally,the catalyst exhibited consistent existence form in both HER and oxygen evolution reaction(OER),which was verified by switching the anode and cathode of the cell in the electrolysis of water.This work provides a new idea for the synthesis and evaluation of the bifunctional catalysts for water splitting. | Wenjuan Xu Jinfa Chang Yinggang Cheng Hongqi Liu Jifan Li Yongjian Ai Zenan Hu Xinyue Zhang Yiming Wang Qionglin Liang Yang Yang Hongbin Sun | 2022 | Nano Research2022，15，2： | 1 |
| 20 | An analysis of arithmetic problem posing by middle school students显示文摘 | SILVER E A JINFA CAI | 1997 | Journal for Research in Mathematics Education1997，27，5： | 1 |
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