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| 1 | Efficacy and safety of metformin and sitagliptin based triple antihyperglycemic therapy(STRATEGY):a multicenter,randomized,controlled,non-inferiority clinical trial显示文摘Despite the current guideline's recommendation of a timely stepwise intensification therapy,the 'clinical inertia',termed as the delayed treatment intensification,commonly exists in the real world,which may be partly due to the relatively little substantial evidence and no clear consensus regarding the efficacy and safety of triple oral agents in patients inadequately controlled with dual therapy.In this clinical trial performed in 237 centers in China,5,535 type 2 diabetic patients inadequately controlled by previous therapies were treated with a stable metformin/sitagliptin dual therapy for 20 weeks.The patients who did not reach the glycated hemoglobin A1c(HbA1c) goal were then further randomized into glimepiride,gliclazide,repaglinide,or acarbose group for an additional 24-week triple therapy.A mean HbAlc reduction of 0.85%was observed when sitagliptin was added to the patients inadequately controlled with metformin in 16 weeks.Further HbAlc reductions in the 24-week triple therapy stage were 0.65%in glimepiride group,0.70%in gliclazide group,0.61%in repaglinide group,and 0.45%in acarbose group.The non-inferiority criterion for primary hypotheses was met for gliclazide and repaglinide,but not for acarbose,compared with glimepiride,when added to metformin/sitagliptin dual therapy.The incidences of adverse events(AEs) were 29.2%in the dual therapy stage and30.3%in the triple therapy stage.Metformin/sitagliptin as baseline therapy,with the addition of a third oral antihyperglycemic agent,including glimepiride,gliclazide,repaglinide,or acarbose,was effective,safe and well-tolerated for achieving an HbAlc<7.0%goal in type 2 diabetic patients inadequately controlled with previous therapies.The timely augmentation of up to three oral antihyperglycemic agents is valid and of important clinical benefit to prevent patients from exposure to unnecessarily prolonged hyperglycemia. | Wen Xu Yiming Mu Jiajun Zhao Dalong Zhu Qiuhe Ji Zhiguang Zhou Bin Yao Anhua Mao Samuel S.Engel Bin Zhao Yan Bi Longyi Zeng Xingwu Ran Juming Lu Linong Ji Wenying Yang Weiping Jia Jianping Weng | 2017 | Science China(Life Sciences)2017，60，3： | 19 |
| 2 | Therapeutic angiogenesis induced by human hepatocyte growth factor gene in hindlimb ischemia of dogs显示文摘A preclinical study of treating peripheral ar-tery occlusive disease (PAD) was performed by using ahepatocyte growth factor (HGF) gene-expressing vector,plasmid pUDKH, in a dog model with complete ischemia of one hindlimb. After ligation of femoral artery of onehindlimb, pUDKH was transferred directly into the ischemic limb muscles. The angiogenic activity of the plasmid pUDKH was evaluated. On D 30 after injecting once of pUDKH at different doses into local muscles immediately after opera-tion, the degree of augmentation of collateral vessel forma-tion was significantly greater than that treated by blankvector. In addition, the blood flow rate of femoral artery in dogs treated with pUDKH was recovered on D 90, while the flow rate was only 1/5 to 1/3 in control dogs. The pulse am-plitude of pUDKH-treated dogs was recovered on D 90, but it was hardly detectable in most of the control dogs. The sideeffects of intramuscular transfection of pUDKH were alsoinvestigated, and no significant positive change was found. It is suggested that angiogenesis induced by HGF gene has the potential for clinical use in the treatment of peripheral arte-rial diseases. | HA Xiaoqin, REN Jianping, BI Jianjin, ZHANG Jinhui & WU Zuze (Wu Chu-tse) Beijing Institute of Radiation Medicine, Beijing 100850, China | 2003 | Chinese Science Bulletin2003，48，7： | 13 |
| 3 | A Dormant Multi-Controller Model for Software Defined Networking显示文摘In order to improve the scalability and reliability of Software Defined Networking(SDN),many studies use multiple controllers to constitute logically centralized control plane to provide load balancing and fail over.In this paper,we develop a flexible dormant multi-controller model based on the centralized multi-controller architecture.The dormant multi-controller model allows part of controllers to enter the dormant state under light traffic condition for saving system cost.Meanwhile,through queueing analysis,various performance measures of the system can be obtained.Moreover,we analyze the real traffic of China Education Network and use the results as the parameters of computer simulation and verify the effects of parameters on the system characteristics.Finally,a total expected cost function is established,and genetic algorithm is employed to find the optimal values of various parameters to minimize system cost for the deployment decision making. | FU Yonghong BI Jun WU Jianping CHEN Ze WANG Ke LUO Min | 2014 | China Communications2014，11，3： | 11 |
| 4 | Trusted Next Generation Internetand Its Development显示文摘The ongoing research on secure and trustworthy issues in next generation Internet technology is still insufficient. China has achieved some progress in the field of the trusted next generation Internet. Under the support of the National High Technology Research and Development Program of China (863 Program), Tsinghua University and other units have completed the program named 'Research on Critical Technologies and Demonstration Applications of the Trusted Next Generation Internet', which targets the secure and trustworthy problems existing in the current Internet. With focus on tackling the technical problem of authentic address access in the Internet, a prototype system for trusted Internet infrastructure, security service and typical applications are designed and implemented. It is expected that the trusted next generation Internet will support the trusted computer network, trusted telecom network and trusted broadcast & TV network applications. | Wu Jianping, Bi Jun (Network Research Center of Tsinghua University, Beijing 100084, China) | 2008 | ZTE Communications2008，6，1： | 2 |
| 5 | Isolation and genetic analysis revealed no predominant new strains of avian infectious bronchitis virus circulating in South China during 2004–2008显示文摘 | Linlin Li Chunyi Xue Feng Chen Jianping Qin Qingmei Xie Yingzuo Bi Yongchang Cao | 2009 | Veterinary Microbiology2009，，2： | 2 |
| 6 | Determination of the speciation of aluminum(Ⅲ) in natural waters by adsorption stripping voltammetry and complexation with AlⅢ-solochrome violet RS显示文摘 | WANG Xianlong LEI Jianping Bi Shuping | 2001 | Anal Chim Acta2001，449，： | 1 |
| 7 | Rapid optimization of electroporation conditions for plant cells, protoplasts, and pollen显示文摘 | James A. Saunders Chin Ho Lin Bi Huei Hou Jianping Cheng Nombasa Tsengwa Jhy Jhu Lin Camelia R. Smith Maria S. McIntosh Sally Wert1 | 1995 | Molecular Biotechnology1995，，3： | 1 |
| 8 | Dust aerosol vertical structure measurements using three MPL lidars during 2008 China-U.S. joint dust field experiment显示文摘 | Huang Zhongwei Huang Jianping Bi Jianrong Wang Guoyin Wang Wencai Fu Qiang Li Zhanqing Tsay Si-Chee Shi Jinsen | 2010 | Atmospheres2010，，： | 1 |
| 9 | Clinical observation of sodium hyaluronate in the treatment of osteoarthritis显示文摘 | Huangshao Bi Xiao Zhengyu Liu Jianping | 2007 | Journal of Internal Medicine2007，36，04： | 1 |
| 10 | Prevalence of hypoglycemia identified by intensive bedside glucose monitoring among hospitalized patients with diabetes mellitus (住院的糖尿病患者强化床边血糖监测检出的低血糖患病率)显示文摘 | Yan Bi Jinhua Yan Weili Tang Jing Yang Jianping Weng | 2013 | Journal of Diabetes2013，，3： | 1 |
| 11 | An IPv6 source ad- dress validation testbed and prototype implementation 显示文摘 | Bi Jun Yao Guang Wu Jianping | 2009 | J Networks2009，4，2： | 1 |
| 12 | Observation analysis of land-atmosphere interactions over the Loess Plateau of northwest China显示文摘 | Wang Guoyin Huang Jianping Guo Weidong Zuo Jinqing Wang Jiemin Bi Jianrong Huang Zhongwei Shi Jinsen | 2010 | Atmospheres2010，，： | 1 |
| 13 | An overview of the Semi-arid Climate and Environment Research Observatory over the Loess Plateau显示文摘 | Jianping Huang Wu Zhang Jinqing Zuo Jianrong Bi Jinsen Shi Xin Wang Zhoulin Chang Zhongwei Huang Su Yang Beidou Zhang Guoyin Wang Guanghong Feng Jiuyi Yuan Lei Zhang Hongchao Zuo Shigong Wang Congbin Fu Chou Jifan | | 0，2008，： | 1 |
| 14 | lnvestiga ring the aerosol optical and radiative characteristics of heavy haze episodes in Beiiing during January of 2013显示文摘 | BI Jianrong HUANG Jianping HU Zhiyuan et ai | 2014 | Journal of Geophysical Research2014，119，16： | 1 |
| 15 | Connecting IPvX Networks Over IPvY with a P2P Method显示文摘 | Xiaoxiang Leng Jun Bi Miao Zhang Jianping Wu | 2007 | Journal of Network and Systems Management2007，，3： | 1 |
| 16 | Comparison of CERES surface radiation fluxes with surface observations over Loess Plateau显示文摘 | Hongru Yan Jianping Huang Patrick Minnis Tianhe Wang Jianrong Bi | 2011 | Remote Sensing of Environment2011，，6： | 1 |
| 17 | 二维能量平衡模式中高纬度植被绿化的全球温度响应显示文摘在全球变暖的背景下,包含中纬度荒漠的干旱地区对气候的变化最为敏感,但高纬度植被绿化对中纬度荒漠地区域的气候影响仍然未知。本研究采用二维能量平衡模式研究高纬度地区植被绿化对中纬度荒漠的影响。研究结果表明,高纬度地区绿化会导致中纬度荒漠南边界后退,极地冰带和低纬度植被带扩大。同时,也会引发高纬度负温度异常和低纬度正温度异常。在CO2浓度增加试验中,中纬度荒漠的南北边界一直在扩展,直到CO2浓度达到600ppm(饱和状态)为止。 | BI Lu HE Yongli HUANG Jianping LI Yaokun GUAN Xiaodan LIU Xiaoyue | 2020 | Atmospheric and Oceanic Science Letters2020，13，1： | 0 |
| 18 | Multiple Equilibria in a Land–Atmosphere Coupled System显示文摘Many low-order modeling studies indicate that there may be multiple equilibria in the atmosphere induced by thermal and topographic forcings.However,most work uses uncoupled atmospheric model and just focuses on the multiple equilibria with distinct wave amplitude,i.e.,the high-and low-index equilibria.Here,a low-order coupled land–atmosphere model is used to study the multiple equilibria with both distinct wave phase and wave amplitude.The model combines a two-layer quasi-geostrophic channel model and an energy balance model.Highly truncated spectral expansions are used and the results show that there may be two stable equilibria with distinct wave phase relative to the topography:one(the other)has a lower layer streamfunction that is nearly in(out of)phase with the topography,i.e.,the lower layer ridges(troughs)are over the mountains,called ridge-type(trough-type)equilibria.The wave phase of equilibrium state depends on the direction of lower layer zonal wind and horizontal scale of the topography.The multiple wave phase equilibria associated with ridge-and trough-types originate from the orographic instability of the Hadley circulation,which is a pitch-fork bifurcation.Compared with the uncoupled model,the land–atmosphere coupled system produces more stable atmospheric flow and more ridge-type equilibrium states,particularly,these effects are primarily attributed to the longwave radiation fluxes.The upper layer streamfunctions of both ridge-and trough-type equilibria are also characterized by either a high-or low-index flow pattern.However,the multiple wave phase equilibria associated with ridge-and trough-types are more prominent than multiple wave amplitude equilibria associated with high-and low-index types in this study. | Dongdong LI Yongli HE Jianping HUANG Lu BI Lei DING | 2018 | Journal of Meteorological Research2018，32，6： | 0 |
| 19 | Research on unified recognition model and algorithm for multi-modal gestures显示文摘In gesture recognition,static gestures,dynamic gestures and trajectory gestures are collectively known as multi-modal gestures.To solve the existing problem in different recognition methods for different modal gestures,a unified recognition algorithm is proposed.The angle change data of the finger joints and the movement of the centroid of the hand were acquired respectively by data glove and Kinect.Through the preprocessing of the multi-source heterogeneous data,all hand gestures were considered as curves while solving hand shaking,and a uniform hand gesture recognition algorithm was established to calculate the Pearson correlation coefficient between hand gestures for gesture recognition.In this way,complex gesture recognition was transformed into the problem of a simple comparison of curves similarities.The main innovations:1) Aiming at solving the problem of multi-modal gesture recognition,an unified recognition model and a new algorithm is proposed;2) The Pearson correlation coefficient for the first time to construct the gesture similarity operator is improved.By testing 50 kinds of gestures,the experimental results showed that the method presented could cope with intricate gesture interaction with the 97.7% recognition rate. | Guo Xiaopei Feng Zhiquan Sun Kaiyun Liu Hong Xie Wei Bi Jianping | 2019 | The Journal of China Universities of Posts and Telecommunications2019，26，2： | 0 |
| 20 | Mongolia Contributed More than 42%of the Dust Concentrations in Northern China in March and April 2023显示文摘Dust storms are one of the most frequent meteorological disasters in China,endangering agricultural production,transportation,air quality,and the safety of people’s lives and property.Against the backdrop of climate change,Mongolia’s contribution to China’s dust cannot be ignored in recent years.In this study,we used the Weather Research and Forecasting model coupled with Chemistry(WRF-Chem),along with dynamic dust sources and the HYSPLIT model,to analyze the contributions of different dust sources to dust concentrations in northern China in March and April 2023.The results show that the frequency of dust storms in 2023 was the highest observed in the past decade.Mongolia and the Taklimakan Desert were identified as two main dust sources contributing to northern China.Specifically,Mongolia contributed more than 42%of dust,while the Taklimakan Desert accounted for 26%.A cold high-pressure center,a cold front,and a Mongolian cyclone resulted in the transport of dust aerosols from Mongolia and the Taklimakan Desert to northern China,where they affected most parts of the region.Moreover,two machine learning methods[the XGBoost algorithm and the Synthetic Minority Oversampling Technique(SMOTE)]were used to forecast the dust storms in March 2023,based on ground observations and WRF-Chem simulations over East Asia.XGBoost-SMOTE performed well in predicting hourly PM10 concentrations in China in March 2023,with a mean absolute error of 33.8μg m−3 and RMSE of 54.2μg m−3. | Siyu CHEN Dan ZHAO Jianping HUANG Jiaqi HE Yu CHEN Junyan CHEN Hongru BI Gaotong LOU Shikang DU Yue ZHANG Fan YANG | 2023 | Advances in Atmospheric Sciences2023，40，9： | 0 |
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