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| 1 | Ferroptosis as a novel form of regulated cell death:Implications in the pathogenesis,oncometabolism and treatment of human cancer显示文摘The treatment of cancer mainly involves surgical excision supplemented by radiotherapy and chemotherapy.Chemotherapy drugs act by interfering with tumor growth and inducing the death of cancer cells.Anti-tumor drugs were developed to induce apoptosis,but some patient’s show apoptosis escape and chemotherapy resistance.Therefore,other forms of cell death that can overcome the resistance of tumor cells are important in the context of cancer treatment.Ferroptosis is a newly discovered iron-dependent,non-apoptotic type of cell death that is highly negatively correlated with cancer development.Ferroptosis is mainly caused by the abnormal increase in iron-dependent lipid reactive oxygen species and the imbalance of redox homeostasis.This review summarizes the progression and regulatory mechanism of ferroptosis in cancer and discusses its possible clinical applications in cancer diagnosis and treatment. | Feifei Pu Fengxia Chen Zhicai Zhang Deyao Shi Binlong Zhong Xiao Lv Andrew Blake Tucker Jiaming Fan Alexander J.Li Kevin Qin Daniel Hu Connie Chen Hao Wang Fang He Na Ni Linjuan Huang Qing Liu William Wagstaff Hue H.Luu Rex C.Haydon Le Shen Tong-Chuan He Jianxiang Liu Zengwu Shao | 2022 | Genes & Diseases2022，9，2： | 6 |
| 2 | Ground-based Observations of Ultraviolet and Total Solar Radiation in Shenyang,Northeast China显示文摘Objective This work explores the diurnal variation of Solar ultraviolet radiation (UVR) and total solar radiation (TSR) in northeast China,using daily observations of UVR and TSR in Shenyang.Methods UVR and TSR measurements were carried out from March 1st,2006 to December 31st,2009 in Shenyang,Liaoning province,China (41°51' N,123°27' E).Results Both TSR and UVR showed seasonal variation,reaching the highest levels in summer and the lowest in winter.They showed the greatest fluctuation in summer and autumn.The irradiance of TSR and UVR on clear days around the equinoxes and solstices increased substantially compared with the mean seasonal irradiance,especially in autumn.The whole day accumulated dose of UVR in winter was far less than that during the middle part of a summer day (i.e.between 10:00 and 14:00).It was also less than the accumulated summer dose of morning and afternoon (i.e.between 8:00 and 10:00 and 14:00 and 16:00).Conclusion The instant irradiance and daily accumulated amount of UVR are low in Shenyang,especially in autumn and winter.Thus concern about the health effects arising because shortage of UVR in northeast China is warranted. | GAO Qian HU LiWen GONG HuiZhi GAO Na YU JiaMing WANG Yang CHU Chun YANG Hui LIU Yang | 2011 | Biomedical and Environmental Sciences2011，24，5： | 2 |
| 3 | Enhanced biodegradation of chlorobenzene via combined Fe^(3+) and Zn^(2+) based on rhamnolipid solubilisation显示文摘Biotrickling filters(BTFs) for hydrophobic chlorobenzene(CB) purification are limited by mass transfer and biodegradation. The CB mass transfer rate could be improved by 150 mg/L rhamnolipids. This study evaluated the combined use of Fe^(3+) and Zn^(2+) to enhance biodegradation in a BTF over 35 day. The effects of these trace elements were analysed under different inlet concentrations(250, 600, 900, and 1200 mg/L) and empty bed residence times(EBRTs;60, 45, and 32 sec). Batch experiments showed that the promoting effects of Fe^(3+)/Zn^(2+) on microbial growth and metabolism were highest for 3 mg/L Fe^(3+) and 2 mg/L Zn^(2+), followed by 2 mg/L Zn^(2+), and lowest at 3 mg/L Fe^(3+). Compared to BTF in the absence of Fe^(3+) and Zn^(2+), the average CB elimination capacity and removal efficiency in the presence of Fe^(3+) and Zn^(2+) increased from 61.54 to 65.79 g/(m 3 hr) and from 80.93% to 89.37%, respectively, at an EBRT of 60 sec. The average removal efficiency at EBRTs of 60, 45, and 32 sec increased by 2.89%, 5.63%, and 11.61%, respectively. The chemical composition(proteins(PN), polysaccharides(PS)) and functional groups of the biofilm were analysed at 60, 81, and 95 day. Fe^(3+) and Zn^(2+) significantly enhanced PN and PS secretion, which may have promoted CB adsorption and biodegradation. High-throughput sequencing revealed the promoting effect of Fe^(3+) and Zn^(2+) on bacterial populations. The combination of Fe^(3+) and Zn^(2+) with rhamnolipids was an efficient method for improving CB biodegradation in BTFs. | Na Liu Dan Li Kang Li Liping Wang Ruiwei Xu Jiaming Zhang Bairen Yang | 2021 | Journal of Environmental Sciences2021，33，5： | 2 |
| 4 | Unique and complementary suppression of cGAS-STING and RNA sensing- triggered innate immune responses by SARS-CoV-2 proteins显示文摘The emergence of SARS-CoV-2 has resulted in the COVID-19 pandemic,leading to millions of infections and hundreds of thousands of human deaths.The efficient replication and population spread of SARS-CoV-2 indicates an effective evasion of human innate immune responses,although the viral proteins responsible for this immune evasion are not clear.In this study,we identified SARS-CoV-2 structural proteins,accessory proteins,and the main viral protease as potent inhibitors of host innate immune responses of distinct pathways.In particular,the main viral protease was a potent inhibitor of both the RLR and cGAS-STING pathways.Viral accessory protein 0RF3a had the unique ability to inhibit STING,but not the RLR response.On the other hand,structural protein N was a unique RLR inhibitor.0RF3a bound STING in a unique fashion and blocked the nuclear accumulation of p65 to inhibit nuclear factor-KB signaling.3CL of SARS-CoV-2 inhibited K63-ubiquitin modification of STING to disrupt the assembly of the STING functional complex and downstream signaling.Diverse vertebrate STINGs,including those from humans,mice,and chickens,could be inhibited by 0RF3a and 3CL of SARS-CoV-2.The existence of more effective innate immune suppressors in pathogenic coronaviruses may allow them to replicate more efficiently in vivo.Since evasion of host innate immune responses is essential for the survival of all viruses,our study provides insights into the design of therapeutic agents against SARS-CoV-2. | Yajuan Rui Jiaming Su Si Shen Ying Hu Dingbo Huang Wenwen Zheng Meng Lou Yifei Shi Meng Wang Shiqi Chen Na Zhao Qi Dong Yong Cai Rongzhen Xu Shu Zheng Xiao-Fang Yu | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 1 |
| 5 | Bank gully extraction from DEMs utilizing the geomorphologic features of a loess hilly area in China显示文摘As one of most active gully types in the Chinese Loess Plateau,bank gullies generally indicate soil loss and land degradation.This study addressed the lack of detailed,large scale monitoring of bank gullies and proposed a semi-automatic method for extracting bank gullies,given typical topographic features based on 5 m resolution DEMs.First,channel networks,including bank gullies,are extracted through an iterative channel bum-in algorithm.Second,gully heads are correctly positioned based on the spatial relationship between gully heads and their corresponding gully shoulder lines.Third,bank gullies are distinguished from other gullies using the newly proposed topographic measurement of 'relative gully depth (RGD).'The experimental results from the loess hilly area of the Linjiajian watershed in the Chinese Loess Plateau show that the producer accuracy reaches 87.5%. The accuracy is affected by the DEM resolution and RGD parameters,as well as the accuracy of the gully shoulder line.The application in the Madigou watershed with a high DEM resolution validated the duplicability of this method in other areas.The overall performance shows that bank gullies can be extracted with acceptable accuracy over a large area,which provides essential information for research on soil erosion,geomorphology,and environmental ecology. | Xin YANG Jiaming NA Guoan TANG Tingting WANG Axing ZHU | 2019 | Frontiers of Earth Science2019，13，1： | 1 |
| 6 | Sub-nanometer ultrathin epitaxy of AlGaN and its application in efficient doping显示文摘Solving the doping asymmetry issue in wide gap semiconductors is a key dificulty and long-standing challenge for device applications.Here,a desorption-tailoring strategy is proposed to juggle the carrier concentration and transport.Specific to the p-doping issue in Al-rich AlGaN,self-assembled p-AlGaN superlattices with an average Al composition of over 50%are prepared by adopting this approach.The hole concentration as high as 8.1×10^(18)cm^(-3)is thus realized at room temperature,which is attributed to the signifcant reduction of effective Mg activation energy to 17.5 meV through modulating the activating path,as well as the highlighted Mg surface-incorporation by an intentional interruption for desorption.More importantly,benefting from the constant ultrathin barrier thickness of only three monolayers via this approach,vertical miniband transport of holes is verifed in the p-AlGaN superlattices,greatly satisfying the demand of hole injection in device application.280 nm deep-ultraviolet light emitting diodes are then fabricated as a demo with the desorption-tailored Al-rich p-AlGaN superlattices,which exhibit a great improvement of the carrier injection efficiency and light extraction efficiency,thus leading to a 55.7%increase of the light output power.This study provides a solution for p-type doping of Al-rich AlGaN,and also sheds light on solving the doping asymmetry issue in general for wide-gap semiconductors. | Jiaming Wang Mingxing Wang Fujun Xu Baiyin Liu Jing Lang Na Zhang Xiangning Kang Zhixin Qin Xuelin Yang Xinqiang Wang Weikun Ge Bo Shen | 2022 | Light(Science & Applications)2022，11，4： | 1 |
| 7 | Effect of composite pore-former on the fabrication and performance of anode-supported membranes for SOFCs显示文摘 | Jinyan Hu Zhe Lü Kongfa Chen Xiqiang Huang Na Ai Xiaobo Du Chengwei Fu Jiaming Wang Wenhui Su | 2008 | Journal of Membrane Science2008，，1： | 1 |
| 8 | Argonaute(AGO)proteins play an essential role in mediating BMP9-induced osteogenic signaling in mesenchymal stem cells(MSCs)显示文摘As multipotent progenitor cells,mesenchymal stem cells(MSCs)can renew themselves and give rise to multiple lineages including osteoblastic,chondrogenic and adipogenic lineages.It’s previously shown that BMP9 is the most potent BMP and induces osteogenic and adipogenic differentiation of MSCs.However,the molecular mechanism through which BMP9 regulates MSC differentiation remains poorly understood.Emerging evidence indicates that noncoding RNAs,especially microRNAs,may play important roles in regulating MSC differentiation and bone formation.As highly conserved RNA binding proteins,Argonaute(AGO)proteins are essential components of the multi-protein RNA-induced silencing complexes(RISCs),which are critical for small RNA biogenesis.Here,we investigate possible roles of AGO proteins in BMP9-induced lineage-specific differentiation of MSCs.We first found that BMP9 upregulated the expression of Ago1,Ago2 and Ago3 in MSCs.By engineering multiplex siRNA vectors that express multiple siRNAs targeting individual Ago genes or all four Ago genes,we found that silencing individual Ago expression led to a decrease in BMP9-induced early osteogenic marker alkaline phosphatase(ALP)activity in MSCs.Furthermore,we demonstrated that simultaneously silencing all four Ago genes significantly diminished BMP9-induced osteogenic and adipogenic differentiation of MSCs and matrix mineralization,and ectopic bone formation.Collectively,our findings strongly indicate that AGO proteins and associated small RNA biogenesis pathway play an essential role in mediating BMP9-induced osteogenic differentiation of MSCs. | Yukun Mao Na Ni Linjuan Huang Jiaming Fan Hao Wang Fang He Qing Liu Deyao Shi Kai Fu Mikhail Pakvasa William Wagstaff Andrew Blake Tucker Connie Chen Russell R.Reid Rex C.Haydon Sherwin H.Ho Michael J.Lee Tong-Chuan He Jian Yang Le Shen Lin Cai Hue H.Luu | 2021 | Genes & Diseases2021，8，6： | 1 |
| 9 | Reversibly immortalized keratinocytes(iKera)facilitate re-epithelization and skin wound healing:Potential applications in cell-based skin tissue engineering显示文摘Skin injury is repaired through a multi-phase wound healing process of tissue granulation and re-epithelialization.Any failure in the healing process may lead to chronic non-healing wounds or abnormal scar formation.Although significant progress has been made in developing novel scaffolds and/or cell-based therapeutic strategies to promote wound healing,effective management of large chronic skin wounds remains a clinical challenge.Keratinocytes are critical to re-epithelialization and wound healing.Here,we investigated whether exogenous keratinocytes,in combination with a citrate-based scaffold,enhanced skin wound healing.We first established reversibly immortalized mouse keratinocytes(iKera),and confirmed that the iKera cells expressed keratinocyte markers,and were responsive to UVB treatment,and were non-tumorigenic.In a proof-of-principle experiment,we demonstrated that iKera cells embedded in citrate-based scaffold PPCN provided more effective re-epithelialization and cutaneous wound healing than that of either PPCN or iKera cells alone,in a mouse skin wound model.Thus,these results demonstrate that iKera cells may serve as a valuable skin epithelial source when,combining with appropriate biocompatible scaffolds,to investigate cutaneous wound healing and skin regeneration. | Jiamin Zhong Hao Wang Ke Yang Huifeng Wang Chongwen Duan Na Ni Liqin An Yetao Luo Piao Zhao Yannian Gou Shiyan Sheng Deyao Shi Connie Chen William Wagstaff b Bryce Hendren-Santiago b Rex C.Haydon b Hue H.Luu b Russell R.Reid Sherwin HHo Guillermo A.Ameer Le Shen Tong-Chuan He Jiaming Fan | 2022 | Bioactive Materials2022，7，3： | 0 |
| 10 | NEURO PROTECTIVE EFFECT OF SCHISANDRA B ON AD-RELATED CELLULAR MODEL INVOLVES THE ATTENUATION OF APOPTOSIS显示文摘Schisandrin B(Sch B),the major lignans isolated from Schisandra chinensis,exerts high arntioxidant activities.However,it is unknown whether SchB protects neural cell against Aβinduced cellular apoptosis.This study aims to investigate the neuroprotective action of SchB on cellular model of AD,and revealed the underlying mechanisms. | Na Li Zhe Lin Hui Li Jiaming Sun Kai Zhu Guangfu LV Qing Yang Xiaobo Qu | 2015 | World Journal of Traditional Chinese Medicine2015，1，4： | 0 |
| 11 | Height estimation from single aerial imagery using contrastive learning based multi-scale refinement network显示文摘Height map estimation from a single aerial image plays a crucial role in localization,mapping,and 3D object detection.Deep convolutional neural networks have been used to predict height information from single-view remote sensing images,but these methods rely on large volumes of training data and often overlook geometric features present in orthographic images.To address these issues,this study proposes a gradient-based self-supervised learning network with momentum contrastive loss to extract geometric information from non-labeled images in the pretraining stage.Additionally,novel local implicit constraint layers are used at multiple decoding stages in the proposed supervised network to refine high-resolution features in height estimation.The structural-aware loss is also applied to improve the robustness of the network to positional shift and minor structural changes along the boundary area.Experimental evaluation on the ISPRS benchmark datasets shows that the proposed method outperforms other baseline networks,with minimum MAE and RMSE of 0.116 and 0.289 for the Vaihingen dataset and 0.077 and 0.481 for the Potsdam dataset,respectively.The proposed method also shows around threefold data efficiency improvements on the Potsdam dataset and domain generalization on the Enschede datasets.These results demonstrate the effectiveness of the proposed method in height map estimation from single-view remote sensing images. | Wufan Zhao Hu Ding Jiaming Na Mengmeng Li Dirk Tiede | 2023 | International Journal of Digital Earth2023，16，1： | 0 |
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