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| 1 | Tumor-expressed B7-H3 mediates the inhibition of antitumor T-cell functions in ovarian cancer insensitive to PD-1 blockade therapy显示文摘Although PD-L1/PD-1 blockade therapy has been approved to treat many types of cancers,the majority of patients with solid tumors do not respond well,but the underlying reason remains unclear.Here,we studied ovarian cancer(OvCa),a tumor type generally resistant to current immunotherapies,to investigate PD-1-independent immunosuppression.We found that PD-L1 was not highly expressed in the tumor microenvironment(TME)of human OvCa.Instead,B7-H3,another checkpoint molecule,was highly expressed by both tumor cells and tumor-infiltrating antigen-presenting cells(APCs),which correlated with T-cell exhaustion in patients.Using ID8 OvCa mouse models,we found that B7-H3 expressed on tumor cells,but not host cells,had a dominant role in suppressing antitumor immunity.Therapeutically,B7-H3 blockade,but not PD-1 blockade,prolonged the survival of ID8 tumorbearing mice.Collectively,our results demonstrate that tumor-expressed B7-H3 inhibits the function of CD8^(+)T cells and suggest that B7-H3 may be a target in patients who are not responsive to PD-L1/PD-1 inhibition,particularly OvCa patients. | Dongli Cai Jiaming Li Dingfeng Liu Shanjuan Hong Qin Qiao Qinli Sun Pingping Li Nanan Lyu Tiantian Sun Shan Xie Li Guo Ling Ni Liping Jin Chen Dong | 2020 | Cellular & Molecular Immunology2020，17，3： | 8 |
| 2 | Precise temporal regulation of Dux is important for embryo development显示文摘Dear Editor,Zygotic genome activation(ZGA)following fertilization is accomplished through a process termed the maternal-to-zygotic transition,during which the maternal RNAs and proteins are degraded and zygotic genome is transcriptionally activated.In mice,minor ZGA occurs from S phase of the zygote to G1 phase of the two-cell(2C)embryo,while major ZGA takes place during the middle-to-late 2C stage with a burst of transcription of totipotent cleavage stage-specific genes and retrotransposons. | Mingyue Guo Yanping Zhang Jianfeng Zhou Yan Bi Junqin Xu Ce Xu Xiaochen Kou Yanhong Zhao Yanhe Li Zhifen Tu Kuisheng Liu Jiaming Lin Peng Yang Shaorong Gao Yixuan Wang | 2019 | Cell Research2019，29，11： | 5 |
| 3 | Rearrangement on surface structures by boride to enhanced cycle stability for LiNi0.80Co0.15Al0.05O2 cathode in lithium ion batteries显示文摘The side reaction between the active material and liquid-electrolyte cause structural damage and particle pulverization is one of the important factors leading to the capacity decay of LiNi0.80Co0.15Al0.05O2(NCA)materials in Li ion batteries(LIBs).Surface modification is an effective strategy for NCA cathodes,which could alleviate the degradation associated with surface processes.Herein,a surface structure rearrangement of NCA cathode secondary particles was reported by in-situ forming a solid electrolyte LiBO2.The LiBO2 is beneficial for alleviating the stress during charge/discharge process,thereby slowing down the rate of cracks formation in the secondary particles,which facilitates the Li+de-intercalation as well as prevents penetration of the liquid-electrolyte into the interior of the particles.As a result,the surface structure rearrangement NCA(RS-NCA)delivers a high discharge capacity of 202.5 m Ah g^-1 at 0.1 C,and exhibits excellent cycle stability with discharge capacity retaining 148 m Ah g^-1 after 200 cycles at 2 C.This surface structure rearrangement approach provides a new viewpoint in designing high-performance high-voltage LIBs. | Shubiao Xia Wenjin Huang Xiang Shen Jiaming Liu Feixiang Cheng Jian-Jun Liu Xiaofei Yang Hong Guo | 2020 | Journal of Energy Chemistry2020，29，6： | 3 |
| 4 | Low‐intensity pulsed ultrasound ameliorates angiotensin II-induced cardiac fibrosis by alleviating inflammation via a caveolin-1-dependent pathway显示文摘Objective:Cardiac hypertrophy and fibrosis are major pathological manifestations observed in left ventricular remodeling induced by angiotensin II(AngII).Low-intensity pulsed ultrasound(LIPUS)has been reported to ameliorate cardiac dysfunction and myocardial fibrosis in myocardial infarction(MI)through mechano-transduction and its downstream pathways.In this study,we aimed to investigate whether LIPUS could exert a protective effect by ameliorating AngII-induced cardiac hypertrophy and fibrosis and if so,to further elucidate the underlying molecular mechanisms.Methods:We used AngII to mimic animal and cell culture models of cardiac hypertrophy and fibrosis.LIPUS irradiation was applied in vivo for 20 min every 2 d from one week before mini-pump implantation to four weeks after mini-pump implantation,and in vitro for 20 min on each of two occasions 6 h apart.Cardiac hypertrophy and fibrosis levels were then evaluated by echocardiographic,histopathological,and molecular biological methods.Results:Our results showed that LIPUS could ameliorate left ventricular remodeling in vivo and cardiac fibrosis in vitro by reducing AngII-induced release of inflammatory cytokines,but the protective effects on cardiac hypertrophy were limited in vitro.Given that LIPUS increased the expression of caveolin-1 in response to mechanical stimulation,we inhibited caveolin-1 activity with pyrazolopyrimidine 2(pp2)in vivo and in vitro.LIPUS-induced downregulation of inflammation was reversed and the anti-fibrotic effects of LIPUS were absent.Conclusions:These results indicated that LIPUS could ameliorate AngII-induced cardiac fibrosis by alleviating inflammation via a caveolin-1-dependent pathway,providing new insights for the development of novel therapeutic apparatus in clinical practice. | Kun ZHAO Jing ZHANG Tianhua XU Chuanxi YANG LiqingWENG TingtingWU XiaoguangWU Jiaming MIAO Xiasheng GUO Juan TU Dong ZHANG Bin ZHOU Wei SUN Xiangqing KONG | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，10： | 2 |
| 5 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 6 | Isolation and Characteristics of the CN Gene, a Tobacco Mosaic Virus Resistance N Gene Homolog, from Tobacco 显示文摘 | Zhang Gaiyun Chen Ming Guo Jiaming | 2009 | Biochem Genet2009，47，： | 1 |
| 7 | Synergistic effect of EMS1-shRNA and sorafenib on proliferation, migration, invasion and endocytosis of SMMC-7721显示文摘 | Jiaming Zhou Li Chen Yixin Zhang Yuanyuan Wu Guilan Wang Song He Zhongying Guo Yingze Wei | 2014 | Journal of Molecular Histology2014，，： | 1 |
| 8 | Multi-technique integration separation frameworks after steam reforming for coal-based hydrogen generation显示文摘Coal-based H2 generation has abruptly increased in recent years.The PSA-VPSA-SC process is the matured and standard framework for H2 purification and CO_(2) capture in many existing plants,including normal and vacuum pressure swing adsorption units in series(PSA-VPSA),and shallow condensation unit(SC).However,this standard process is frequently subjected to low H2 recovery ratio and high purification cost.In this work,H2-selective and C02-selective membrane units,i.e.,HM and CO_(2) M,are attempted to support the standard process and ameliorate constraints.In the beginning,HM unit is arranged after VPSA to enhance H2 recovery from the decarbonized stream,i.e.,the PSA-VPSA-SC/HM process.As a result,H2 recovery ratio can be enhanced significantly from 83%to 98%.In the following,VPSA is replaced with CO_(2) M unit to reduce investment and operation cost,i.e.,the PSA-CO_(2) M-SC/HM process.Accordingly,the specific purification cost is diminished from 33.46 to 32.02 USD·(103 m^(3) H_(2))-1,saved by 4.3%,meanwhile the construction cost is falling back and just a little higher than that for the standard process.In the end,another CO_(2) M unit is launched before PSA,i.e.,the CO_(2) M-PSA-CO_(2) M-SC/HM process,which could unbundle CO_(2) enrichment partially from H2 purification,and then save more investment and operation cost.In comparison with the standard process,this ultimate retrofitted process can be superior in all the three crucial indices,i.e.,recovery ratio,investment,and specific purification cost.On the whole,coal-based H2 generation can be ameliorated significantly through high efficient H2-selective and CO_(2)-selective membrane units. | Xuehua Ruan Wenbo Huo Jiaming Wang Minggang Guo Wenji Zheng Yun Zou Aibin Huang Jianxiang Shou Gaohong He | 2021 | Chinese Journal of Chemical Engineering2021，34，7： | 1 |
| 9 | T-Splines Based Isogeometric Topology Optimization with Arbitrarily Shaped Design Domains显示文摘In this paper,a new isogeometric topology optimization(ITO)method is proposed by using T-splines based isogeometric analysis(IGA).The arbitrarily shaped design domains,directly obtained from CAD,are represented by a single T-spline surface which overcomes the topological limitations of Non-Uniform Rational B-Spline(NURBS).The coefficients correlated with control points are directly used as design variables.Therefore,the T-spline basis functions applied for geometry description and calculation of structural response are simultaneously introduced to represent the density distribution.Several numerical examples show that the proposed approach leads to a coherent workflow to handle design problems of complicated structures.The optimized results are free of checkerboard patterns without additional stabilization and filtering techniques due to the properties of T-splines,which also simplified the post-processing.In addition,through performing local refinement,we can easily achieve multiresolution optimization and infill optimization within the T-splines based framework.In general,the proposed method provides a possibility to design,analyze,and optimize engineering structures in a uniform model,which has the potential to improve design efficiency and reduce the cost of product development. | Gang Zhao Jiaming Yang Wei Wang Yang Zhang Xiaoxiao Du Mayi Guo | 2020 | Computer Modeling in Engineering & Sciences2020，，6： | 1 |
| 10 | In situ biaxial stretching for the platelet formation of an ethylene-vinyl alcohol copolymer through multistage stretching and its effect on the gas-barrier properties of polyethylene显示文摘 | Zhu Jiaming Shen Jiabin Guo Shaoyun | 2014 | Journal of Applied Polymer Science2014，131，40： | 1 |
| 11 | T-Splines for Isogeometric Analysis of Two-Dimensional Nonlinear Problems显示文摘Nonlinear behaviors are commonplace in many complex engineering applications,e.g.,metal forming,vehicle crash test and so on.This paper focuses on the T-spline based isogeometric analysis of two-dimensional nonlinear problems including general large deformation hyperelastic problems and small deformation elastoplastic problems,to reveal the advantages of local refinement property of T-splines in describing nonlinear behavior of materials.By applying the adaptive refinement capability of T-splines during the iteration process of analysis,the numerical simulation accuracy of the nonlinear model could be increased dramatically.The Bézier extraction of the T-splines provides an element structure for isogeometric analysis that can be easily incorporated into existing nonlinear finite element codes.In addition,T-splines show great superiority of modeling complex geometries especially when the model is irregular and with hole features.Several numerical examples have been tested to validate the accuracy and convergence of the proposed method.The obtained results are compared with those from NURBS-based isogeometric analysis and commercial software ABAQUS. | Mayi Guo Gang Zhao Wei Wang Xiaoxiao Du Ran Zhang Jiaming Yang | 2020 | Computer Modeling in Engineering & Sciences2020，，5： | 1 |
| 12 | Micromotor-derived composites for biomedicine delivery and other related purposes显示文摘Biocompatible designed micromotor has attracted more and more concerns in the field of biomedicine due to their self-propulsion and delivery abilities.Such micromotors,mostly consisting of alkali earth metals,hydrogels,or other motile biomaterials,can effectively transform chemical energy into mechanical or kinetic energy to achieve the expected delivery of cargos to the sites of action.Except for conveying power,the modifiable surface and inner cavity of micromotors guarantee that their potential as versatile delivery systems for therapeutic agents.Here,this review generalizes the propelling mechanisms,composites,and shapes of micromotors.Besides,the application of micromotor-derived composites for biomedicine delivery and other versatile purposes are also discussed. | Xiang Xu Zhiyi Huo Jiaming Guo Hao Liu Xiaole Qi Zhenghong Wu | 2020 | Bio-Design and Manufacturing2020，3，2： | 1 |
| 13 | Antioxidant biocompatible composite collagen dressing for diabetic wound healing in rat model显示文摘Associated with persistent oxidative stress,altered inflammatory responses,poor angiogenesis and epithelization,wound healing in diabetic patients is impaired.N-acetylcysteine(NAC)is reported to resist excess reactive oxygen species(ROS)production,prompt angiogenesis and maturation of the epidermis.Studies have revealed that graphene oxide(GO)can regulate cellular behavior and form cross-links with naturally biodegradable polymers such as collagen(COL)to construct composite scaffolds.Here,we reported a COL-based implantable scaffold containing a mixture of GO capable of the sustained delivery of NAC to evaluate the wound healing in diabetic rats.The morphological,physical characteristics,biocompatibility and NAC release profile of the GO-COL-NAC(GCN)scaffold were evaluated in vitro.Wound healing studies were performed on a 20mm dorsal full-skin defect of streptozotocin(STZ)-induced diabetic rats.The injured skin tissue was removed at the 18th day post-surgery for histological analysis and determination of glutathione peroxidase(GPx),catalase(CAT)and superoxide dismutase(SOD)activity.In diabetic rats,we confirmed that the GCN scaffold presented a beneficial effect in enhancing the wound healing process.Additionally,due to the sustained release of NAC,the scaffold may potentially induce the antioxidant defense system,upregulating the expression levels of the antioxidant enzymes in the wound tissue.The findings revealed that the antioxidant biocompatible composite collagen dressing could not only deliver NAC in situ for ROS inhibition but also promote the wound healing process.This scaffold with valuable therapy potential might enrich the approaches for surgeon in diabetic wound treatment in the future. | Bei Qian Jialun Li Ke Guo Nengqiang Guo Aimei Zhong Jie Yang Jiecong Wang Peng Xiao Jiaming Sun Lingyun Xiong | 2021 | Regenerative Biomaterials2021，8，2： | 1 |
| 14 | Fabrication of wear-resistant PA6 composites with superior thermal conductivity and mechanical properties via constructing highly oriented hybrid network of SiC-packed BN platelets显示文摘Herein,a strong extensional and shearing field was introduced to construct highly oriented hybrid networks of silicon carbide(SiC)-packed boron nitride(BN)platelets to fabricate high-performance wearresistant PA6 composites.Results show that in-plane and through-plane thermal conductivity(TC)of the prepared PA6 composites with a total filler loading of 20 wt.%reached 1.31 and 0.35 W/(m K),352%and 25%higher than those of pure PA6,respectively.It is attributed to the highly oriented hybrid network that facilitates the formation of efficient thermal conductivity pathways.Temperature monitoring results during friction confirm that high TC favors the friction heat dissipation performance.Meanwhile,the yield strength of PA6 composites increased by 39.1%and they still have excellent ductility with an elongation at break of 207.1%.Finally,the wear rate of PA6 composites decreased sharply by 92.5%.This method can be used to manufacture advanced linear bearing and guideway parts,etc。 | Jing Chen Jiaming Zhu Yang Pan Hong Wu Shaoyun Guo Jianhui Qiu | 2023 | Journal of Materials Science & Technology2023，，15： | 0 |
| 15 | Hepatic steatosis is associated with dysregulated cholesterol metabolism and altered protein acetylation dynamics in chickens显示文摘Background Hepatic steatosis is a prevalent manifestation of fatty liver, that has detrimental effect on the health and productivity of laying hens, resulting in economic losses to the poultry industry. Here, we aimed to systematically investigate the genetic regulatory mechanisms of hepatic steatosis in laying hens.Methods Ninety individuals with the most prominent characteristics were selected from 686 laying hens according to the accumulation of lipid droplets in the liver, and were graded into three groups, including the control, mild hepatic steatosis and severe hepatic steatosis groups. A combination of transcriptome, proteome, acetylome and lipidome analyses, along with bioinformatics analysis were used to screen the key biological processes, modifications and lipids associated with hepatic steatosis.Results The rationality of the hepatic steatosis grouping was verified through liver biochemical assays and RNA-seq. Hepatic steatosis was characterized by increased lipid deposition and multiple metabolic abnormalities. Integration of proteome and acetylome revealed that differentially expressed proteins(DEPs) interacted with differentially acetylated proteins(DAPs) and were involved in maintaining the metabolic balance in the liver. Acetylation alterations mainly occurred in the progression from mild to severe hepatic steatosis, i.e., the enzymes in the fatty acid oxidation and bile acid synthesis pathways were significantly less acetylated in severe hepatic steatosis group than that in mild group(P < 0.05). Lipidomics detected a variety of sphingolipids(SPs) and glycerophospholipids(GPs) were negatively correlated with hepatic steatosis(r ≤-0.5, P < 0.05). Furthermore, the severity of hepatic steatosis was associated with a decrease in cholesterol and bile acid synthesis and an increase in exogenous cholesterol transport.Conclusions In addition to acquiring a global and thorough picture of hepatic steatosis in laying hens, we were able to reveal the role of acetylation in hepatic steatosis and depict the changes in hepatic cholesterol metabolism. The findings provides a wealth of information to facilitate a deeper understanding of the pathophysiology of fatty liver and contributes to the development of therapeutic strategies. | Xiaoli Guo Qianqian Zhou Jiaming Jin Fangren Lan Chaoliang Wen Junying Li Ning Yang Congjiao Sun | 2024 | Journal of Animal Science and Biotechnology2024，15，1： | 0 |
| 16 | Gastric cancer with soft tissue metastasis of the abdominal wall:a case report显示文摘Abdominal wall metastasis of gastric cancer(GC)is a very rare occurrence in the clinic setting.We recently diagnosed and treated a patient with abdominal wall metastasis of GC and we hope to provide some helpful guidance on the clinical diagnosis and treatment of this disease.A 49-year-old male patient with GC was admitted to our hospital(Dalian Municipal Central Hospital,Dalian,China)complaining of left upper abdominal wall mass.Physical examination and regular laboratory blood tests showed no obvious abnormalities.Ultrasound and CT of the abdomen showed a subcutaneous solid mass in the abdominal wall.Radical gastrectomy was performed on February 27,2019,six months after it was first noticed by the patient.Pathological examination and immunohistochemistry showed GC with abdominal metastasis.Postoperative radiotherapy or chemotherapy was not pursued after the second operation and no recurrence or metastasis has been noted so far.GC with abdominal metastasis is very rare and can be easily missed or misdiagnosed.For metastasis to a single site in the abdominal wall,surgical resection,which is recommended,may improve patient outcomes. | Tenglong Guo Huiliang Yang Jiaming Xue Wenbin Li Taotao Zhang Xiangwen Zhang Guo Zu | 2020 | Oncology and Translational Medicine2020，6，4： | 0 |
| 17 | Pressure-induced instability and its coupled aeroelasticity of inflated pillow显示文摘A floating air weapon system(such as airborne floating mines)plays an important role in modern air defense operations.This paper focuses on aeroelastic characteristics of airborne floating mine named inflated pillow.Firstly,the dynamic deployable process of the pillow and characteristics of the local instability of the edge are studied,and the evolution mechanism of wrinkles and kinks is analyzed.Secondly,in the cruising stage,the fluid-structural-thermal coupling analysis is performed on the pillow,and the aeroelastic characteristics are studied.Thirdly,the shapepreserving effect of the inflated pillow during the“negative pressure”slow landing stage is evaluated.It is found that when the wind velocity is higher,the pillow has a collapsed instability(surface extrusion and contact),and when the wind velocity is lower,snap-through instability occurs.Finally,for the collapsed instability,a carbon fiber skeleton is added to discrete the large global collapsed fold into small local folds,thus achieving shape-preserving effect of pillow.For snapthrough instability,the critical internal pressure and different shape evolution under different wind velocity are evaluated.Through the analysis of the mechanical mechanism and control of the structural morphological evolution,it provides theoretical guidance for the application of the curved shell structure in floating air weapon system. | Ji ZHANG Changguo WANG Jiaming GUO Jiawei ZHANG | 2022 | Chinese Journal of Aeronautics2022，35，2： | 0 |
| 18 | Modulating the tumor microenvironment via oncolytic virus and PI3K inhibition synergistically restores immune checkpoint therapy response in PTEN-deficient glioblastoma显示文摘Dear Editor,Glioblastoma(GBM)is a lethal primary brain cancer,with a median survival of less than 2 years.1 Immune checkpoint blockades(ICBs)have revolutionized cancer therapy in the last decade,but they have little clinical benefit in GBM.1 Genomic and transcriptomic analysis revealed a significant enrichment of PTEN mutations in GBM patients resistant to ICBs.2 PTEN deficiency activates the phosphatidylinositol 3-kinase(PI3K)-AKT pathway to shape an immunosuppressive microenvironment. | Fan Xing Jingshu Xiao Junyu Wu Jiaming Liang Xiaoyu Lu Liping Guo Ping Li Panpan Hou Chunmei Li Deyin Guo | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 0 |
| 19 | A topological polymer network with Cu(Ⅱ)-coordinated reversible imidazole-urea locked unit constructs an ultra-strong self-healing elastomer显示文摘It is exceedingly desired, but difficult to construct self-healing materials with both excellent mechanical properties and healing efficiency, which are usually realized by using mutually exclusive methods. Here, we reconcile this contradiction by utilizing copper-bis-(imidazole-2-yl)-methane-urea(Cu-BIMU) locked units based on novel designed dynamic imidazole-urea bonds with coupled multiple noncovalent bonds(coordination bonds, π-π stacking bonds, and hydrogen bonds). The coordination of Cu(II) greatly reduces the electron-cloud density of imidazole, which lowers the free energy barrier of imidazole-urea bonds and promotes their reversible dissociation, as demonstrated by the density functional theory and small-molecule model reaction. The topological design of Cu-BIMU polyurethane(Cu-BIMU-PU), which concentrates multiple crosslinking-in-one locked unit to avoid the formation of excessive crosslinking sites to ensure high chain mobility, facilitates self-healing. Accumulative extensive intermolecular interactions endowed excellent mechanical properties to the resulting Cu-BIMU-PU elastomer with a tensile strength of 65.3 MPa, among the highest ever-reported value. This work provides a novel molecular design principle for fabricating high-performance dynamic polymers. | Lei Yang Zenghe Liu Rasoul Esmaeely Neisiany Jiaming Lou Yifan Guo Luzhi Zhang Huijie Liu Shuo Chen Shijia Gu Zhengwei You | 2023 | Science China Chemistry2023，66，3： | 0 |
| 20 | C_(60) as a metal-free catalyst for lithium-oxygen batteries显示文摘Carbon materials have shown significant potential as catalysts for lithium-oxygen batteries(LOBs).However,the intrinsic carbon sites are typically inert,necessitating extensive modifications and resulting in a limited density of active sites.Here we present C_(60) as a metal-free cathode catalyst for LOBs,using density functional theory calculations and experimental verifications.The lithiation reactions on the pristine carbon sites of C_(60) are energetically favorable due to its curvedπ-conjugation over the pentagon-hexagon networks.The kinetic analysis specifically reveals low energy barriers for Li_(2)O_(2) decomposition and Li diffusion on C_(60).Consequently,C_(60) exhibits significantly higher catalytic activity than typical carbon materials such as graphene and carbon nanotubes.Our electrochemical measurements validate the predictions,notably demonstrating that the intrinsic activity of C_(60) is comparable to that of noble metals. | Xinxin Zhang Jiaming Tian Yu Wang Shaohua Guo Yafei Li | 2024 | Nano Research2024，17，5： | 0 |
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