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| 1 | Tumor-expressed B7-H3 mediates the inhibition of antitumor T-cell functions in ovarian cancer insensitive to PD-1 blockade therapy显示文摘Although PD-L1/PD-1 blockade therapy has been approved to treat many types of cancers,the majority of patients with solid tumors do not respond well,but the underlying reason remains unclear.Here,we studied ovarian cancer(OvCa),a tumor type generally resistant to current immunotherapies,to investigate PD-1-independent immunosuppression.We found that PD-L1 was not highly expressed in the tumor microenvironment(TME)of human OvCa.Instead,B7-H3,another checkpoint molecule,was highly expressed by both tumor cells and tumor-infiltrating antigen-presenting cells(APCs),which correlated with T-cell exhaustion in patients.Using ID8 OvCa mouse models,we found that B7-H3 expressed on tumor cells,but not host cells,had a dominant role in suppressing antitumor immunity.Therapeutically,B7-H3 blockade,but not PD-1 blockade,prolonged the survival of ID8 tumorbearing mice.Collectively,our results demonstrate that tumor-expressed B7-H3 inhibits the function of CD8^(+)T cells and suggest that B7-H3 may be a target in patients who are not responsive to PD-L1/PD-1 inhibition,particularly OvCa patients. | Dongli Cai Jiaming Li Dingfeng Liu Shanjuan Hong Qin Qiao Qinli Sun Pingping Li Nanan Lyu Tiantian Sun Shan Xie Li Guo Ling Ni Liping Jin Chen Dong | 2020 | Cellular & Molecular Immunology2020，17，3： | 8 |
| 2 | Human INO80/YY1 chromatin remodeling complex transcriptionally regulates the BRCA2-and CDKNIA-interacting protein (BCCIP) in cells显示文摘 | Jiaming Su Yi Sui Jian Ding Fuqiang Li Shuang Shen Yang Yang Zeming Lu Fei Wang Lingling Cao Xiaoxia Liu Jingji Jin Yong Cai | 2016 | Protein & Cell2016，7，10： | 3 |
| 3 | Passivity breakdown on 436 ferritic stainless steel in solutions containing chloride显示文摘Passivity breakdown on 436 ferritic stainless steel(FSS) has been investigated in solutions containing different concentrations of chloride at 25?C and interpreted in terms of the point defect model(PDM). The measured near-normal distributions of passivity breakdown potentials for 436 FSS under experimental conditions are in good agreement with the calculated results according to the PDM. The linear dependence of breakdown potential on the square root of potential scanning rate, which was described by the PDM,provides the estimation of the critical concentration of condensed vacancies at the metal/film interface,which leads to the passivity breakdown. This value is in good agreement with that calculated from the microstructure properties of the alloy substrate and the barrier layer of the passive film. This study demonstrates the validity of the PDM in describing the passivity breakdown on 436 FSS in NaCl solutions. | Jiaming Wang Shengsheng Qian Yanhui Li Digby D.Macdonald Yiming Jiang Jin Li | 2019 | Journal of Materials Science & Technology2019，35，4： | 2 |
| 4 | Smart heightened-containment biological laboratory:Technologies,modules,and aims显示文摘With the rapid development of intelligent technology,the smart heightened-containment biological laboratory(sHCBL)has moved from concept to reality.Experimental activities and laboratory construction,operation,and management will undoubtedly lead to disruptive changes.Conventional laboratories are increasingly being replaced by smart laboratories;however,the key technologies involved in this transition remain at an exploratory stage.It is necessary for HCBLs to absorb the advanced ideas of smart laboratories to guarantee the establishment of biosafety and biosecurity in a more automated way.This study examines in detail sHCBL module structures,the functions of each module,laboratory operation processes,and the advanced nature of smart laboratories.It may provide a theoretical foundation for the future transformation and smart construction of sHCBLs. | Jiaming Li Zhongyi Wang Gang Tao Yingying Fu Yifei Jin Hongliang Cheng Jingjing Li Xinrong Shu Jianjian Yang Jiuxiang Yang Bing Lu | 2022 | Journal of Biosafety and Biosecurity2022，4，2： | 1 |
| 5 | Detection and Localization of Active Gastrointestinal Bleeding With Multidetector Row Computed Tomography Angiography: A Five-year Prospective Study in One Medical Center显示文摘 | Hao Sun Zhengyu Jin Xiaoguang Li Jiaming Qian Jianchun Yu Feng Zhu Huadong Zhu | 2012 | Journal of Clinical Gastroenterology2012，，1： | 1 |
| 6 | Preparation of mesoporous carbons from amphiphilic carbonaceous material for high-performance electric double-layer capacitors显示文摘 | Jin Wang Mingming Chen Chengyang Wang Jiuzhou Wang Jiaming Zheng | 2010 | Journal of Power Sources2010，，1： | 1 |
| 7 | Hepatic steatosis is associated with dysregulated cholesterol metabolism and altered protein acetylation dynamics in chickens显示文摘Background Hepatic steatosis is a prevalent manifestation of fatty liver, that has detrimental effect on the health and productivity of laying hens, resulting in economic losses to the poultry industry. Here, we aimed to systematically investigate the genetic regulatory mechanisms of hepatic steatosis in laying hens.Methods Ninety individuals with the most prominent characteristics were selected from 686 laying hens according to the accumulation of lipid droplets in the liver, and were graded into three groups, including the control, mild hepatic steatosis and severe hepatic steatosis groups. A combination of transcriptome, proteome, acetylome and lipidome analyses, along with bioinformatics analysis were used to screen the key biological processes, modifications and lipids associated with hepatic steatosis.Results The rationality of the hepatic steatosis grouping was verified through liver biochemical assays and RNA-seq. Hepatic steatosis was characterized by increased lipid deposition and multiple metabolic abnormalities. Integration of proteome and acetylome revealed that differentially expressed proteins(DEPs) interacted with differentially acetylated proteins(DAPs) and were involved in maintaining the metabolic balance in the liver. Acetylation alterations mainly occurred in the progression from mild to severe hepatic steatosis, i.e., the enzymes in the fatty acid oxidation and bile acid synthesis pathways were significantly less acetylated in severe hepatic steatosis group than that in mild group(P < 0.05). Lipidomics detected a variety of sphingolipids(SPs) and glycerophospholipids(GPs) were negatively correlated with hepatic steatosis(r ≤-0.5, P < 0.05). Furthermore, the severity of hepatic steatosis was associated with a decrease in cholesterol and bile acid synthesis and an increase in exogenous cholesterol transport.Conclusions In addition to acquiring a global and thorough picture of hepatic steatosis in laying hens, we were able to reveal the role of acetylation in hepatic steatosis and depict the changes in hepatic cholesterol metabolism. The findings provides a wealth of information to facilitate a deeper understanding of the pathophysiology of fatty liver and contributes to the development of therapeutic strategies. | Xiaoli Guo Qianqian Zhou Jiaming Jin Fangren Lan Chaoliang Wen Junying Li Ning Yang Congjiao Sun | 2024 | Journal of Animal Science and Biotechnology2024，15，1： | 0 |
| 8 | Traffic signal coordination control for arterials with dedicated CAV lanes显示文摘Purpose–This study aims to make full use of the advantages of connected and autonomous vehicles(CAVs)and dedicated CAV lanes to ensure all CAVs can pass intersections without stopping.Design/methodology/approach–The authors developed a signal coordination model for arteries with dedicated CAV lanes by using mixed integer linear programming.CAV non-stop constraints are proposed to adapt to the characteristics of CAVs.As it is a continuous problem,various situations that CAVs arrive at intersections are analyzed.The rules are discovered to simplify the problem by discretization method.Findings–A case study is conducted via SUMO traffic simulation program.The results show that the efficiency of CAVs can be improved significantly both in high-volume scenario and medium-volume scenario with the plan optimized by the model proposed in this paper.At the same time,the progression efficiency of regular vehicles is not affected significantly.It is indicated that full-scale benefits of dedicated CAV lanes can only be achieved with signal coordination plans considering CAV characteristics.Originality/value–To the best of the authors’knowledge,this is the first research that develops a signal coordination model for arteries with dedicated CAV lanes. | Liang Xu Sheng Jin Bolin Li Jiaming Wu | 2022 | Journal of Intelligent and Connected Vehicles2022，5，2： | 0 |
| 9 | Multiple Non-Axially Solutions to a Mean Field Equation on S^2显示文摘We study the following mean field equation■,whereρis a real parameter.We obtain the existence of multiple non-axially symmetric solutions bifurcating from u=0 at the valuesρ=4 n(n+1)πfor any odd integer n≥3. | Zhuoran Du Changfeng Gui Jiaming Jin Yuan Li | 2020 | Analysis in Theory and Applications2020，36，1： | 0 |
| 10 | Genome transfer for the prevention of female infertility caused by maternal gene mutation显示文摘Poor oocyte quality is associated with early embryo developmental arrest and infertility.Maternal gene plays crucial roles in the regulation of oocyte maturation,and its mutation is a common cause of female infertility.However,how to improve oocyte quality and develop effective therapy for maternal gene mutation remains elusive.Here,we use Zar1 as an example to assess the feasibility of genome transfer to cure maternal gene mutationecaused female infertility.We first discover that cytoplasmic deficiency primarily leads to Zar1-null embryo developmental arrest by disturbing maternal transcript degradation and minor zygotic genome activation(ZGA)during the maternal-zygotic transition.We next perform genome transfer at the oocyte(spindle transfer or polar body transfer)and zygote(early pronuclear transfer or late pronuclear transfer)stages to validate the feasibility of preventing Zar1 mutationecaused infertility.We finally demonstrate that genome transfer either at the oocyte or at the early pronuclear stage can support normal preimplantation embryo development and produce live offspring.Moreover,those pups grow to adulthood and show normal fertility.Therefore,our findings provide an effective basis of therapies for the treatment of female infertility caused by maternal gene mutation. | Dandan Bai Jin Sun Yanping Jia Jiqing Yin Yalin Zhang Yanhe Li Rui Gao Xiling Du Kunming Li Jiaming Lin Zhifen Tu Yu Wang Jiaping Pan Shanshan Liang Yi Guo Jingling Ruan Xiaochen Kou Yanhong Zhao Hong Wang Cizhong Jiang Fengchao Wang Xiaoming Teng Wenqiang Liu Shaorong Gao | 2020 | Journal of Genetics and Genomics2020，47，6： | 0 |
| 11 | Observation of Refractive Index Line Shape in Ultrafast XUV Transient Absorption Spectroscopy显示文摘Ultrafast extreme ultraviolet (XUV) transient absorption spectroscopy measures the time- and frequencydependent light losses after light–matter interactions. In the linear region, the matter response to an XUV light field is usually determined by the complex refractive index ̃n. The absorption signal is directly related to the imaginary part of ̃n, namely, the absorption index. The real part of ̃n refers to the real refractive index, which describes the chromatic dispersion of an optical material. However, the real refractive index information is usually not available in conventional absorption experiments. Here, we investigate the refractive index line shape in ultrafast XUV transient absorption spectroscopy by using a scheme that the XUV pulse traverses the target gas jet off-center. The jet has a density gradient in the direction perpendicular to the gas injection direction, which induces deflection on the XUV radiation. Our experimental and theoretical results show that the shape of the frequency-dependent XUV deflection spectra reproduces the refractive index line profile. A typical dispersive refractive index line shape is measured for a single-peak absorption;an additional shoulder structure appears for a doublet absorption.Moreover, the refractive index line shape is controlled by introducing a later-arrived near-infrared pulse to modify the phase of the XUV free induction decay, resulting in different XUV deflection spectra. The results promote our understanding of matter-induced absorption and deflection in ultrafast XUV spectroscopy. | Mingze Sun Zixiang Jiang Yong Fu Yanrong Jiang Hongtao Hu Chunyuan Bai Zhongyao Yue Jiaming Jiang Hongqiang Xie Cheng Jin Ruxin Li P.B.Corkum D.M.Vileneuvere Ppeng Peng | 2023 | Ultrafast Science2023，3，4： | 0 |
| 12 | Literature Review on the Impact of Blockchain Technology on Resource Allocation Efficiency显示文摘With the rapid development of Internet technology,the importance of blockchain technology has become increasingly prominent.Faced with this situation,extensive research has been carried out at home and abroad.Through the analysis of relevant literature on blockchain in recent years,it is found that there are many research results of blockchain technology in medical care,finance,education,etc.,but its application in the field of resource allocation efficiency is rare.From the existing studies on the influencing factors of resource allocation efficiency in China,it is found that there are significant differences in resource allocation efficiency between China and some developed countries or between various provinces and cities of China. | Nuoya LIN Li'nan JIN Jiaming LI Xiaofei LI Yihan XU | 2022 | Asian Agricultural Research2022，14，6： | 0 |
| 13 | Volterra series based predistortion for broadband RF power amplifiers with memory effects显示文摘RF power amplifiers (PAs) are usually considered as memoryless devices in most existing predistortion techniques.However,in broadband communication systems,such as WCDMA,the PA memory effects are significant,and memoryless predistortion cannot linearize the PAs effectively.After analyzing the PA memory effects,a novel predistortion method based on the simplified Volterra series is proposed to linearize broadband RF PAs with memory effects.The indirect learning architecture is adopted to design the predistortion scheme and the recursive least squares algorithm with forgetting factor is applied to identify the parameters of the predistorter.Simulation results show that the proposed predistortion method can compensate the nonlinear distortion and memory effects of broadband RF PAs effectively. | Jin Zhe Song Zhihuan He Jiaming | 2008 | Journal of Systems Engineering and Electronics2008，19，4： | 0 |
| 14 | Similar aerosol emission rates and viral loads in upper respiratory tracts for COVID-19 patients with Delta and Omicron variant infection显示文摘Dear Editor,In 2021,the Delta variant of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)caused the coronavirus disease 2019(COVID-19)pandemic to spread in the UK,Nepal,southeast Asia and elsewhere,which seems to be approximately 60%more transmissible than the already highly infectious Alpha variant in late 2020(Callaway,2021).In addition to the high efficiency of the invading infection and the acquired immune escape ability,changes in the aerodynamic characteristics of SARS-CoV-2 aerosols may be another important reason for the Delta variant spread.Previously,it was identified that SARS-CoV-2 can spread through close contact and airborne routes(Guo et al.,2020;Morawska and Milton,2020). | Jiaming Li Yidun Zhang Lina Jiang Hongliang Cheng Jingjing Li Li Li Zehui Chen Fei Tang Yingying Fu Yifei Jin Bing Lu Jing Zheng Zhongyi Wang | 2022 | Virologica Sinica2022，37，5： | 0 |
| 15 | A high-precision borehole gravimeter显示文摘The paper describes the working principle and structure of a newly designed high-precision (micro-gal) gravimeter, which is basically a vertically suspending spring-weight system, using a highly sensitive capacitance sensor of movement in a controlled temperature environment in a borehole and a multi-frequency output for both earth-tide and earthquake monitoring. The preliminary test indicated that, while in a stabilization process, it had met all the technical requirements for a relative gravimeter used for earth tide and earthquake monitoring. | Li Jiaming Yao Zhigui Wen Xingwei Gong Ping Wei Jin | 2011 | Geodesy and Geodynamics2011，2，3： | 0 |
| 16 | Application of Blockchain Technology in Optimizing Resource Allocation Efficiency显示文摘Based on the existing literature,this paper analyzed and explored the factors that affect the efficiency of resource allocation,and evaluated the current situation of resource allocation in various fields.It is found that with the emergence of the new pattern of China’s economic development,the economic growth rate has slowed down,and the method of large-scale production driving economic growth is no longer applicable to the current economic situation.Nowadays,when structural transformation and upgrading have entered a new stage,to achieve the optimization of resource allocation efficiency,it is necessary to start from three aspects:improving information transparency,upgrading industrial structure,and planning government intervention.Through the adaptation analysis of blockchain technology and the existing problems in optimizing resource allocation efficiency,it explored the feasibility of blockchain technology to optimize resource allocation efficiency,and promote economical,efficient and high-quality development. | Jiaming LI Yihan XU Li'nan JIN Nuoya LIN Xiaofei LI | 2022 | Asian Agricultural Research2022，14，7： | 0 |
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