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| 1 | Through-needle all-optical ultrasound imaging in vivo: a preclinical swine study显示文摘High-frequency ultrasound imaging can provide exquisite visualizations of tissue to guide minimally invasive procedures.Here,we demonstrate that an all-optical ultrasound transducer,through which light guided by optical fibers is used to generate and receive ultrasound,is suitable for real-time invasive medical imaging in vivo.Broad-bandwidth ultrasound generation was achieved through the photoacoustic excitation of a multiwalled carbon nanotube-polydimethylsiloxane composite coating on the distal end of a 300-μm multi-mode optical fiber by a pulsed laser.The interrogation of a high-finesse Fabry–Pérot cavity on a single-mode optical fiber by a wavelength-tunable continuous-wave laser was applied for ultrasound reception.This transducer was integrated within a custom inner transseptal needle(diameter 1.08 mm;length 78 cm)that included a metallic septum to acoustically isolate the two optical fibers.The use of this needle within the beating heart of a pig provided unprecedented realtime views(50 Hz scan rate)of cardiac tissue(depth:2.5 cm;axial resolution:64μm)and revealed the critical anatomical structures required to safely perform a transseptal crossing:the right and left atrial walls,the right atrial appendage,and the limbus fossae ovalis.This new paradigm will allow ultrasound imaging to be integrated into a broad range of minimally invasive devices in different clinical contexts. | Malcolm C Finlay Charles A Mosse Richard J Colchester Sacha Noimark Edward Z Zhang Sebastien Ourselin Paul C Beard Richard J Schilling Ivan P Parkin Ioannis Papakonstantinou Adrien E Desjardins | 2017 | Light(Science & Applications)2017，6，1： | 6 |
| 2 | The Chloroplast Kinase Network: New Insights from Large-Scale Phosphoproteome Profiling显示文摘蛋白质 phosphorylation 是在真核细胞的房间的最重要的 posttranslational 修正之一并且影响几乎所有基本细胞的过程。有重要新陈代谢的函数的植物特定的房间细胞器集成于细胞的发信号和 phosphorylation 网络的叶绿体。在 Arabidopsis 的最近的大规模叶绿体 phosphoproteome 分析关于 phosphorylation 目标提供了新信息并且扩展了新陈代谢的叶绿体和被蛋白质 phosphorylation 潜在地控制的规章的功能的表。从叶绿体蛋白质识别的 Phosphorylated 肽提供新卓见进 phosphorylation 主题,蛋白质 kinase 活动,和底层利用。在蛋白质 kinases 的 Phosphorylation 地点能揭示可以由集成发信号的链联网不同功能的叶绿体 phosphorylation 串联。我们的评论提供当前可得到的叶绿体 phosphoproteome 信息的元分析并且从象 kinase 网络分析的工艺的限制一样介绍的大规模叶绿体邻蛋白质讨论生物卓见。 | Sacha Baginsky Wilhelm Gruissem | 2009 | Molecular Plant2009，2，6： | 5 |
| 3 | Dynamic full-field optical coherence tomography:3D live-imaging of retinal organoids显示文摘Optical coherence tomography offers astounding opportunities to image the complex structure of living tissue but lacks functional information.We present dynamic full-field optical coherence tomography as a technique to noninvasively image living human induced pluripotent stem cell-derived retinal organoids.Coloured images with an endogenous contrast linked to organelle motility are generated,with submicrometre spatial resolution and millisecond temporal resolution,creating a way to identify specific cell types in living tissue via their function. | Jules Scholler Kassandra Groux Olivier Goureau Jose-Alain Sahel Mathias Fink Sacha Reichman Claude Boccara Kate Grieve | 2020 | Light(Science & Applications)2020，9，1： | 2 |
| 4 | Postnatal roles of glial cell line-derived neurotrophic factor family members in nociceptors plasticity显示文摘The neurotrophin and glial cell line-derived neurotrophic factor(GDNF) family of growth factors have been extensively studied because of their proven ability to regulate development of the peripheral nervous system.The neurotrophin family,which includes nerve growth factor(NGF),NT-3,NT4/5 and BDNF,is also known for its ability to regulate the function of adult sensory neurons.Until recently,little was known concerning the role of the GNDF-family(that includes GDNF,artemin,neurturin and persephin) in adult sensory neuron function.Here we describe recent data that indicates that the GDNF family can regulate sensory neuron function,that some of its members are elevated in inflammatory pain models and that application of these growth factors produces pain in vivo.Finally we discuss how these two families of growth factors may converge on a single membrane receptor,TRPV1,to produce long-lasting hyperalgesia. | Sacha A. Malin Brian M. Davis | 2008 | 生理学报2008，60，5： | 2 |
| 5 | Recent development in multizonal scaffolds for osteochondral regeneration显示文摘Osteochondral(OC)repair is an extremely challenging topic due to the complex biphasic structure and poor intrinsic regenerative capability of natural osteochondral tissue.In contrast to the current surgical approaches which yield only short-term relief of symptoms,tissue engineering strategy has been shown more promising outcomes in treating OC defects since its emergence in the 1990s.In particular,the use of multizonal scaffolds(MZSs)that mimic the gradient transitions,from cartilage surface to the subchondral bone with either continuous or discontinuous compositions,structures,and properties of natural OC tissue,has been gaining momentum in recent years.Scrutinizing the latest developments in the field,this review offers a comprehensive summary of recent advances,current hurdles,and future perspectives of OC repair,particularly the use of MZSs including bilayered,trilayered,multilayered,and gradient scaffolds,by bringing together onerous demands of architecture designs,material selections,manufacturing techniques as well as the choices of growth factors and cells,each of which possesses its unique challenges and opportunities. | Le Yu Sacha Cavelier Brett Hannon Mei Wei | 2023 | Bioactive Materials2023，，7： | 2 |
| 6 | The relationship of pain provocation to lumbar disc deterioration as seen by CT/discography显示文摘 | Vanharanta H Sachas BL Spivey MA | 1987 | Spine1987，12，： | 1 |
| 7 | Crizotinib in the Treatment of Non–Small-Cell Lung Cancer显示文摘 | Sacha I. Rothschild Oliver Gautschi | 2013 | Clinical Lung Cancer2013，，： | 1 |
| 8 | Properties and mechanisms of self-organizing MANET and P2P systems 显示文摘 | BISKUPSKI B DOWLING J SACHA J | 2007 | ACM Transactions on Autonomous and Adaptive Systems ( TAAS )2007，2，1： | 1 |
| 9 | Molecular structure of water at interfaces:Wetting at the nanometer scale显示文摘 | Verdaguer A Sacha G M Bl uhm H | | 0，，： | 1 |
| 10 | The TRIM5 alpha genotype of rhesus macaques affects acquisition of simian immunodeficiency virus SWsmE660 infection after repeated limiting- dose intrarectalchallenge显示文摘 | Reynolds M R Sacha J B Weiler A M | 2011 | Journal of Virology2011，85，18： | 1 |
| 11 | Trends in regional inequality in China显示文摘 | Jian T Sacha J D Warner A M | 1996 | China Economics Review1996，7，1： | 1 |
| 12 | Measuring the real-time operating system performance and determinism显示文摘 | SACHA M | 1996 | Control Engineering Practice1996，4，10： | 1 |
| 13 | Muhidrug resistant Acinetobaeter banmannii - - the role of AdeABC ( RND tamily) efflux pump in resistance to antibiotics显示文摘 | Wieczorek P Sacha P Hauschild T | 2008 | Folia Histochem Cyto- biol2008，46，3： | 1 |
| 14 | Bayesian learning for cardiac SPECT image interpretation 显示文摘 | Sacha J P Goodenday L | 2002 | Artificial Intelligence in Medicine2002，26，： | 1 |
| 15 | Differential expression of stress proteins in human adult astrocytes in response to cytokines 显示文摘 | Jeffreg JB Malika Bsibsi Sacha BG etal | 2002 | Jaurnal of Neuroimmunology2002，106，12： | 1 |
| 16 | Keyloggers-your security nightmare? 显示文摘 | Sacha Chahrvin SmartLine | 2007 | Computer Fraud & Security2007，，7： | 1 |
| 17 | Morbidity, mortality, and long-term survival after sleeve lobectomy for non-small cell lung cancer显示文摘 | Bedrettin Y Elie F Sacha M | 2007 | European Journal of2007，31，： | 1 |
| 18 | Bayesian learning for cardiac SPECT image interpretation显示文摘 | Sacha JP Goodenday LS Cios KJ | | 0，，1： | 1 |
| 19 | Short-term deceleration capacity re- vealshigher reproducibility reveals higher reproducibility than spectral- heart rate variability indices during self-monitoring at home 显示文摘 | Sacha J Sobon J Sacha K | 2011 | Int J Cardiol2011，152，2： | 1 |
| 20 | Hazard and risk of herbicides for marine microaIgae显示文摘 | Sacha B S Gema M G Harm G G | 2014 | EnvironmentaI PoIIution2014，187，： | 1 |
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