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| 1 | Gastrointestinal stromal tumors:a multidisciplinary challenge显示文摘Gastrointestinal stromal tumors(GISTs) are the most common mesenchymal tumors located in the alimentary tract. Its usual manifestation is gastrointestinal bleeding. However, small asymptomatic lesions are frequently detected as incidental finding. Characteristically, most GISTs(> 95%) are positive for the KIT protein(CD117) by IHC staining and approximately 80%-90% of GISTs carry a mutation in the c-KIT or PDGFRA genes. Mutational analysis should be performed when planning adjuvant and neoadjuvant therapy, due to its possible resistance to conventional treatment. The arise of tyrosine kinase inhibitor has supposed a revolution in GISTs treatment being useful as adjuvant, neoadjuvant or recurrence disease treatment. That is why a multidisciplinary approach to this disease is required. The correct characterization of the tumor at diagnosis(the diagnosis of recurrences and the evaluation of the response to treatment with tyrosine kinase inhibitors) is fundamental for facing these tumors and requires specialized Endoscopist, Radiologists and Nuclear Medicine Physician. Surgery is the only potentially curative treatment for suspected resectable GIST. In the case of high risk GISTs, surgery plus adjuvantImatinib-Mesylate for 3 years is the standard treatment. Neoadjuvant imatinib-mesylate should be considered to shrink the tumor in case of locally advanced primary or recurrence disease, unresectable or potentially resectable metastasic tumors, and potentially resectable disease in complex anatomic locations to decrease the related morbidity. In the case of Metastatic GIST under Neoadjuvant treatment, when there are complete response, stable disease or limited disease progression, complete cytoreductive surgery could be a therapeutic option if feasible. | Juan Manuel Sanchez-Hidalgo Manuel Duran-Martinez Rafael Molero-Payan Sebastian Rufian-Pena Alvaro Arjona-Sanchez Angela Casado-Adam Antonio Cosano-Alvarez Javier Briceno-Delgado | 2018 | World Journal of Gastroenterology2018，24，18： | 10 |
| 2 | 策略将在肝移植以后减少丙肝病毒复发显示文摘 Hepatitis C virus (HCV) is a major health problem that leads to chronic hepatitis, cirrhosis and hepatocellular carcinoma, being the most frequent indication for liver transplantation in several countries. Unfortunately, HCV re-infects the liver graft almost invariably following reperfusion, with an accelerated history of recurrence, leading to 10%-30% of patients progressing to cirrhosis within 5 years of transplantation. In this sense, some groups have even advocated for not retransplanting this patients, as lower patient and graftoutcomes have been reported. However, the management of HCV recurrence is being optimized and several strategies to reduce post-transplant recurrence could improve outcomes, decrease the rate of re-transplantation and optimize the use of available grafts. Three moments may be the focus of potential actions in order to decrease the impact of viral recurrence: the pretransplant moment, the transplant environment and the post-transplant management. In the pre-transplant setting, it is not well established if reducing the pre transplant viral load affects the risk for HCV progression after transplant. Obviously, antiviral treatment can render the patient HCV RNA negative post transplant but the long-term benefit has not yet been fully established to justify the cost and clinical risk. In the transplant moment, factors as donor age, cold ischemia time, graft steatosis and ischemia/reperfusion injury may lead to a higher and more aggressive viral recurrence. After the transplant, discussion about immunosuppression and the moment to start the treatment (prophylactic, pre-emptive or once-confirmed) together with new antiviral drugs are of interest. This review aims to help clinicians have a global overview of posttransplant HCV recurrence and strategies to reduce its impact on our patients. | Ruben Ciria María Pleguezuelo Shirin Elizabeth Khorsandi Diego Davila Abid Suddle Hector Vilca-Melendez Sebastian Rufian Manuel de la Mata Javier Briceo Pedro López Cillero Nigel Heaton | 2013 | World Journal of Hepatology2013，5，5： | 2 |
| 3 | Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: a pooled analysis of individual patient data显示文摘 | Monique Maas Patty J Nelemans Vincenzo Valentini Prajnan Das Claus R?del Li-Jen Kuo Felipe A Calvo Julio García-Aguilar Rob Glynne-Jones Karin Haustermans Mohammed Mohiuddin Salvatore Pucciarelli William Small Javier Suárez George Theodoropoulos Sebastian | 2010 | Lancet Oncology2010，，9： | 1 |
| 4 | The discontinuous conduction mode sepic and cuk power factor pre - regulators: analysis and design显示文摘 | Domingos Savio Lyrio Simonetii Javier Sebastian Javier Uceda | 1997 | IEEE Trans on Industrial Electronics1997，44，5： | 1 |
| 5 | Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: a pooled analysis of individual patient data显示文摘 | Monique Maas Patty J Nelemans Vincenzo Valentini Prajnan Das Claus R?del Li-Jen Kuo Felipe A Calvo Julio García-Aguilar Rob Glynne-Jones Karin Haustermans Mohammed Mohiuddin Salvatore Pucciarelli William Small Javier Suárez George Theodoropoulos Sebastian | 2010 | Lancet Oncology2010，，9： | 1 |
| 6 | Stock market cycles, financial liberalization and volatility显示文摘 | Sebastian Edwards Javier Gómez Biscarri Fernando Pérez de Gracia | 2003 | Journal of International Money and Finance2003，，7： | 1 |
| 7 | Practical implementation of the spatial images technique for the analysis of shielded multilayered printed circuits显示文摘 | Juan Sebastian Gemez-Diaz Monica Martinez-Mendoza Francisco Javier Perez-Soler | 2008 | IEEE Trans on Microwave Theory Tech2008，56，1： | 1 |
| 8 | Inorganic carbon limitations on nitrification: Experimental assessment and modelling显示文摘 | Albert Guisasola Sebastian Petzet Juan A. Baeza Julián Carrera Javier Lafuente | 2006 | Water Research2006，，2： | 1 |
| 9 | European Asymmetries显示文摘 | Fernando Ballabriga Miguel Sebastian Javier Valles | | 0，，02： | 1 |
| 10 | Distinct DNA methylomes of newborns and centenarians显示文摘 | Holger Heyn Ning Li Humberto J. Ferreira Sebastian Moran David G. Pisano Antonio Gomez Javier Diez Jose V. Sanchez-Mut Fernando Setien F. Javier Carmona Annibale A. Puca Sergi Sayols Miguel A. Pujana Jordi Serra-Musach Isabel Iglesias-Platas Francesc Form | 2012 | Proceedings of the National Academy of Sciences2012，，26： | 1 |
| 11 | The discontinuous conduction mode Sepic and Cuk power factor preregulators : analysis and design 显示文摘 | DOMINGOS Savio Lyrio Simonetti JAVIER Sebastian JAVIER Uceda | 1997 | IEEE transaction on industrial electronics1997，44，5： | 1 |
| 12 | A new oxidative pathway of nitric oxide production from oximes in plants显示文摘Nitric oxide(NO)is an essential reactive oxygen species and a signal molecule in plants.Although several studies have proposed the occurrence of oxidative NO production,only reductive routes for NO production,such as the nitrate(NO_(3)^(-))-upper-reductase pathway,have been evidenced to date in land plants.However,plants grown axenically with ammonium as the sole source of nitrogen exhibit contents of nitrite and NO3−,evidencing the existence of a metabolic pathway for oxidative production of NO.We hypothesized that oximes,such as indole-3-acetaldoxime(IAOx),a precursor to indole-3-acetic acid,are intermediate oxidation products in NO synthesis.We detected the production of NO from IAOx and other oximes catalyzed by peroxidase(POD)enzyme using both 4-amino-5-methylamino-2′,7′-difluorescein fluorescence and chemiluminescence.Flavins stimulated the reaction,while superoxide dismutase inhibited it.Interestingly,mouse NO synthase can also use IAOx to produce NO at a lower rate than POD.We provided a full mechanism for POD-dependent NO production from IAOx consistent with the experimental data and supported by density functional theory calculations.We showed that the addition of IAOx to extracts from Medicago truncatula increased the in vitro production of NO,while in vivo supplementation of IAOx and other oximes increased the number of lateral roots,as shown for NO donors,and a more than 10-fold increase in IAOx dehydratase expression.Furthermore,we found that in vivo supplementation of IAOx increased NO production in Arabidopsis thaliana wild-type plants,while prx33-34 mutant plants,defective in POD33-34,had reduced production.Our data show that the release of NO by IAOx,as well as its auxinic effect,explain the superroot phenotype.Collectively,our study reveals that plants produce NO utilizing diverse molecules such as oximes,POD,and flavins,which are widely distributed in the plant kingdom,thus introducing a long-awaited oxidative pathway to NO production in plants.This knowledge has essential implications for understanding signaling in biological systems. | Pedro Lopez-Gomez Javier Buezo Marina Urra Alfonso Cornejo Raquel Esteban Jorge Fernandez de los Reyes Estibaliz Urarte Estefania Rodriguez-Dobreva Alejandro Chamizo-Ampudia Alejandro Eguaras Sebastian Wolf Daniel Marino Victor Martinez-Merino Jose F.Moran | 2024 | Molecular Plant2024，17，1： | 0 |
| 13 | β-淀粉样蛋白损害星形胶质细胞在阿尔茨海默病中对营养不良突触的吞噬作用显示文摘摘要在阿尔茨海默病(AD)中,在β-淀粉样蛋白斑块周围发现了反应性星形胶质细胞和营养不良的神经突(异常的突触前元件)。笔者的前期研究已经表明,反应性星形胶质细胞会包裹、吞噬和降解APP小鼠以及AD患者海马中营养不良的突触,但仅波及不到7%的营养不良神经突,这表明星形胶质细胞在AD中的吞噬能力降低。本研究旨在通过分析原代星形胶质细胞培养物对分离突触(突触神经小体,SNs)吞噬和降解的能力来深入了解其潜在机制。SNs分别来自APP(包含营养不良性突触和β淀粉样肽)小鼠、Tau(包含AT8-和AT100-阳性磷酸化Tau)小鼠以及WT(对照)小鼠。我们发现与SNs-WT相比,星形胶质细胞的吞噬和降解能力在SNs-APP大大降低,但在AT8/AT100阳性的SNs-Tau却没有。在12月大的APP小鼠的海马中证实了星形胶质细胞吞噬能力的降低,因为只有(1.60±3.81)%的斑块状星形胶质细胞具有吞噬结构。 | Maria V Sanchez-Mico Sebastian Jimenez Angela Gomez-Arboledas Clara Muñoz-Castro Carmen Romero-Molina Victoria Navarro Elisabeth Sanchez-Mejias Cristina Nuñez-Diaz Raquel Sanchez-Varo Elena Galea JoséC Davila Marisa Vizuete Antonia Gutierrez Javier Vitorica 杜一星(编译) | 2021 | 神经损伤与功能重建2021，16，5： | 0 |
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