|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Multiparametric analysis of colorectal cancer immune responses显示文摘Colorectal cancer(CRC) is a heterogeneous disease, with a diverse and plastic immune cell infiltrate. These immune cells play an important role in regulating tumour growth-progression or elimination. Some populations of cells have a strong correlation with disease-free survival, making them useful prognostic markers. In particular, the infiltrate of CD3^+ and CD8^+ T cells into CRC tumours has been validated worldwide as a valuable indicator of patient prognosis. However, the heterogeneity of the immune response, both between patients with tumours of different molecular subtypes, and within the tumour itself, necessitates the use of multiparametric analysis in the investigation of tumour-specific immune responses. This review will outline the multiparametric analysis techniques that have been developed and applied to studying the role of immune cells in the tumour, with a focus on colorectal cancer. Because much of the data in this disease relates to T cell subsets and heterogeneity, we have used T cell populations as examples throughout. Flow and mass cytometry give a detailed representation of the cells within the tumour in a single-cell suspension on a per-cell basis. Imaging technologies, such as imaging mass cytometry, are used to investigate increasing numbers of markers whilst retaining the spatial and structural information of the tumour section and the infiltrating immune cells. Together, the analyses of multiple immune parameters can provide valuable information to guide clinical decision-making in CRC. | Julia KH Leman Sarah K Sandford Janet L Rhodes Roslyn A Kemp | 2018 | World Journal of Gastroenterology2018，24，27： | 12 |
| 2 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 3 | 抗茵药物敏感性试验折点的解读与应用显示文摘抗菌药物敏感性试验是指导临床医生正确使用抗菌药物的重要工具。正确理解和运用药敏试验结果要求临床医生和临床微生物工作者具备药敏试验和药敏折点的相关知识,并能使用药代动力学/药效学原理优化抗菌药物治疗。(中华检验医学杂志,2013,36:289-291) | 杨启文 Janet A Hindler 徐英春 | 2013 | 中华检验医学杂志2013，36，4： | 4 |
| 4 | 急性附睾睾丸炎显示文摘急性附睾睾丸炎是原发于附睾的感染,有时继发累及睾丸。在35岁以下的病人中,通常由性传播的细菌引起,如沙眼衣原体或淋病奈瑟菌。尽管不是常见病原菌,生殖器支原体和解脲脲原体也曾被提及。 | Rachel A Lee Janet D Wilson 许可见(译) 刘跃华(校) | 2006 | 国际内科双语杂志(中英文)2006，6，4： | 2 |
| 5 | 14 Years of Eosinophilic Esophagitis: Clinical Features and Prognosis显示文摘 | Jonathan M Spergel Terri F Brown-Whitehorn Janet L Beausoleil James Franciosi Michele Shuker Ritu Verma Chris A Liacouras | 2009 | Journal of Pediatric Gastroenterology and Nutrition2009，，1： | 2 |
| 6 | Loss of PTEN expression as a prognostic marker for tongue cancer显示文摘 | Janet IL Jean-Charles S Khaled A H | 2001 | Arch Otolaryngol2001，127，14： | 1 |
| 7 | Mechanisms of resistance to the cytotoxic effects of oxysterols in human leukemic cells显示文摘 | Claudia C Gregorio-King Tamara Gough Gavin J Van Der Meer Jane B Hosking Caryll M Waugh Janet L McLeod Fiona Mc Collier Mark A Kirkland | 2004 | Journal of Steroid Biochemistry and Molecular Biology2004，，3： | 1 |
| 8 | Comparison of PCR- based molecular marker analyses of Musa breeding populations 显示文摘 | Crouch JH Crouch HK Constandt H Van Gysel A Breyne P Van Montagu M Janet RL Ortiz R | 1999 | Mol Breed1999，5，： | 1 |
| 9 | New activities and changing roles of health sciences librarians: a systematic review, 1990-2012 显示文摘 | Cooper I D Janet C A | 2013 | The Journal of the Medical Library Association2013，101，4： | 1 |
| 10 | A comparison of methods for monitoring multitemporal vegetation change using Thematic Mapper imagery显示文摘 | John Rogan Janet Franklin Dar A Roberts | 2002 | Remote Sensing of Environment2002，，1： | 1 |
| 11 | Fetal state concordance predicts infant state regulation 显示文摘 | Janet A Dipietro Kathleen | 2002 | Early Hum Dev2002，68，1： | 1 |
| 12 | A specific antibody to the carbohydrate recognition domain of the asialoglycoprotein receptor RHL1 subunit Does not react with RHL2/3 but blocks ligand binding显示文摘 | Zeng Fuyue Janet A Oka Paul H Weigel | 1998 | Biochemical and Biophysical Research Communications1998，249，： | 1 |
| 13 | Interspecies variation of Kitasatospora recifensis endophytic from yam bean produ-cing thermostable amylases in alternative media显示文摘 | Yong H P Jin W B Janete M A | 2007 | World Journal of Microbiology and Biotechnology2007，23，12： | 1 |
| 14 | Extraction of organic pollutants from solid samplesusing microwave energy显示文摘 | VIORIA L A RICHARD Y JANET B | 1995 | Analytical Chemistry1995，67，13： | 1 |
| 15 | Participation of Bone Marrow Derived Cells in Cutaneous Wound Healing 显示文摘 | Evangelos VB Mehrdad A Janet B | 2003 | J cell physiol2003，196，： | 1 |
| 16 | Contracts, markets, and prices: organizing the production and use of agricultural commodities显示文摘 | James M Janet P Mary A | 2004 | US Department of Agriculture Economic Research Service2004，1，81： | 1 |
| 17 | Molybdenum Intake Influences Molybdenum Kinetics in Men显示文摘 | Janet A N Judith R T | 2007 | The American Society forNutrition J Nutr2007，137，： | 1 |
| 18 | Driver distraction: The effects of concurrent in-vehicle tasks, road environment complexity and age on driving performance显示文摘 | Horberry Tim Anderson Janet Regan Michael A | 2006 | Accident Analysis and Prevention2006，38，： | 1 |
| 19 | A comparison of in situ hybridisation, reverse transcriptase-polymerase chain reaction (RT-PCR) and in situ-RT-PCR for the detection of canine distemper virus RNA in Paget’s disease显示文摘 | Judith A Hoyland Janet A Dixon Jacqueline L Berry Michael Davies Peter L Selby Andrew P Mee | 2003 | Journal of Virological Methods2003，，2： | 1 |
| 20 | The toxicity of microcystin-LR in mice following 7 days of inhalation exposure显示文摘 | JANET M B JULIE A H KATHLEEN R | 2005 | Toxicon2005，45，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员