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| 1 | Validation of the Rockall scoring system for outcomes from non-variceal upper gastrointestinal bleeding in a Canadian setting显示文摘AIM: To validate the Rockall scoring system for predicting outcomes of rebleeding, and the need for a surgical procedure and death. METHODS: We used data extracted from the Registry of Upper Gastrointestinal Bleeding and Endoscopy including information of 1869 patients with non-variceal upper gastrointestinal bleeding treated in Canadian hospitals. Risk scores were calculated and used to classify patients based on outcomes. For each outcome, we used χ2 goodness-of-fit tests to assess the degree of calibration, and built receiver operating characteristic curves and calculated the area under the curve (AUC) to evaluate the discriminative ability of the scoring system. RESULTS: For rebleeding, the χ2 goodness-of-fit test indicated an acceptable fit for the model [χ2 (8) = 12.83, P = 0.12]. For surgical procedures [χ2 (8) = 5.3, P = 0.73] and death [χ2 (8) = 3.78, P = 0.88], the tests showed solid correspondence between observed proportions and predicted probabilities. The AUC was 0.59 (95% CI: 0.55-0.62) for the outcome of rebleeding and 0.60 (95% CI: 0.54-0.67) for surgical procedures, representing apoor discriminative ability of the scoring system. For the outcome of death, the AUC was 0.73 (95% CI: 0.69-0.78), indicating an acceptable discriminative ability. CONCLUSION: The Rockall scoring system provides an acceptable tool to predict death, but performs poorly for endpoints of rebleeding and surgical procedures. | Robert A Enns Yves M Gagnon Alan N Barkun David Armstrong Jamie C Gregor Richard N Fedorak RUGBE Investigators Group | 2006 | World Journal of Gastroenterology2006，12，48： | 14 |
| 2 | AngioJet流体溶血栓吸引术对急性心肌梗死血栓性病变的疗效显示文摘目的 AngioJet流体溶血栓吸引术是通过流体击碎并吸引冠状动脉内血栓而将其移出体外的一种新的冠状动脉介入治疗技术。本研究以TIMI心肌灌注级别作为疗效指标评价该技术对急性心肌梗死血栓性病变的疗效。方法 选择澳大利亚皇家珀斯医院 2 0 0 0年 1月至 2 0 0 1年 1月所有冠状动脉造影明确显示血栓性病变的急性心肌梗死患者共 2 8例作为研究对象。其中 1 3例患者于支架置入术前进行了AngioJet流体溶血栓吸引术 (AngioJet组 ) ,而另 1 5例患者只行直接支架置入术(支架组 )。重点比较两组患者之间治疗前后心表面冠状动脉TIMI血流及TIMI心肌灌注级别 (后者与预后有强烈的相关性 )的变化。结果 支架组术后心表面冠状动脉TIMI血流及TIMI心肌灌注级别均明显优于AngioJet组 (分别为 2 60± 0 0 9vs 2 2 3± 0 1 6 ,P =0 0 4 2及 2 50± 0 1 1vs 1 92± 0 2 3 ,P=0 0 2 4 )。AngioJet组冠状动脉穿孔的例数显著多于支架组 (分别为 3例及 0例 ,P =0 0 4 9)。结论对于急性心肌梗死血栓性病变 ,支架置入术治疗可获得良好疗效 ;支架置入前采用AngioJet流体溶血栓吸引术并不增加疗效 。 | 刘海波 高润霖 Richard A Clugston Jamie M Rankin Geoffrey Mews Geoffrey DCope | 2002 | 中华心血管病杂志2002，30，12： | 6 |
| 3 | Mycophenolate mofetil for maintenance of remission in steroid-dependent autoimmune pancreatitis显示文摘Systemic corticosteroids represent the standard treatment for autoimmune pancreatitis with IgG4-associated cholangitis.For steroid-dependent disease,azathioprine has been used for maintenance of remission.Mycophenolate mofetil has been used for transplant immunosuppression and more recently for autoimmune hepatitis;however,there are no case reports to date on the use of mycophenolate mofetil in adult patients with autoimmune pancreatitis.A patient with IgG4-mediated autoimmune pancreatitis and IgG4-associated cholangitis refractory to steroids and intolerant of azathioprine was treated with mycophenolate mofetil,which inhibits de novo guanosine synthesis and blockade of both B and T lymphocyte production.Introduction of mycophenolate mofetil and uptitration to 1000 mg by mouth twice daily over a treatment period of 4 mo was associated with improvement in the patient's energy level and blood glucose control and was not associated with any adverse events.The patient was managed without a biliary stent.However,there was a return of symptoms,jaundice,increase in transaminases,and hyperbilirubinemia when the prednisone dose reached 11 mg per day.In the first report of mycophenolate mofetil use in an adult patient with IgG4-associated autoimmune pancreatitis and IgG4-associated cholangitis,the introduction of mycophenolate mofetil was safe and well-tolerated without adverse events,but it did not enable discontinuation of the steroids.Mycophenolate mofetil and other immunomodulatory therapies should continue to be studied for maintenance of remission in the large subset of patients with refractory or recurrent autoimmune pancreatitis. | Jamie B Sodikoff Steven A Keilin Sheila J Bharmal Melinda M Lewis Gottumukkala S Raju Field F Willingham | 2012 | World Journal of Gastroenterology2012，18，18： | 6 |
| 4 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 5 | Origin of dynamical properties in PMMA - C60 nano - composites 显示文摘 | Jamie M Kropka Karl W Putz Victor Pryamitsyn | 2007 | Macromolecules2007，40，： | 1 |
| 6 | Antimicrobial activity and partial characterization of bacteriocins produced by laetobacilli isolated from Sturgeon fish显示文摘 | Ghanbari M Jami M Kneifel W | 2013 | Food Control2013，32，37： | 1 |
| 7 | Getting New- comers Engaged: the Role of Socialization Tactics显示文摘 | Saks Alan M Gruman Jamie A | 2011 | Jour- nal of Managerial Psychology2011，26，5： | 1 |
| 8 | Characterization of a unique ethanologenic yeast capableof fermenting galactose显示文摘 | Jamie R Rodney J Bothast John N S Shawn D M | 2004 | Enzyme and Microbial Technology2004，35，： | 1 |
| 9 | The performance of Brevicoryne brassicae on ornamental cabbages grown in CO2 - enriched atmospheres 显示文摘 | Amiri - Jami AR Sadeghi H Shoor M | 2012 | Journal of Asia -Pacific Entomology2012，15，2： | 1 |
| 10 | Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels显示文摘 | Masato Kato Tina W. Han Shanhai Xie Kevin Shi Xinlin Du Leeju C. Wu Hamid Mirzaei Elizabeth J. Goldsmith Jamie Longgood Jimin Pei Nick V. Grishin Douglas E. Frantz Jay W. Schneider She Chen Lin Li Michael R. Sawaya David Eisenberg Robert Tycko Steven L. M | 2012 | Cell2012，，： | 1 |
| 11 | Regulated firms in pollution permit markets with banking 显示文摘 | Cronshaw M B Brown-Kruse Jamie | | Journal of Regulatory Economies0，9，9： | 1 |
| 12 | Fourier Transform Infrared Spectrometry in Atmospheric and Trace Gas Analysis显示文摘 | Griffith D W Jamie I M | 2006 | Encyclopedia ofAnalytical Chemistry2006，9，15： | 1 |
| 13 | Mechanism of an antifungal action of selected cyclic peptides 显示文摘 | Graz M Jamie H Versluis C | 2001 | Pharmazie2001，56，： | 1 |
| 14 | Pattern and regulation of cell proliferation during routine urcteric bud development显示文摘 | Lydia M Jamie AD | 2004 | J Anat2004，204，4： | 1 |
| 15 | Biweekly intensified ambulatory chronomodulated chemotherapy with oxaliplatin,fluorouracil and leucovorin in patients with metastatic colorectal cancer显示文摘 | Bertheault-Cvitkovic F Jami A Ithzak M | 1996 | J Clin Oncol1996，14，11： | 1 |
| 16 | Postharvest changes in broccoli and lettuce during storage in mgon,helium,and nitrogen atmospheres containing 2% oxygen显示文摘 | JAMIE P SALTVEIT M E | 2002 | Postharvest Biology and Technology2002，26，1： | 1 |
| 17 | Methane emission from free-ranging sheep:a comparison of two measurement methods显示文摘 | Leuning R Baker S K Jamie I M | 1999 | Atmospheric Environment1999，33，9： | 1 |
| 18 | A longitudinal study of relational and physical aggression in preschool 显示文摘 | Crick N R Jamie M Ostrov Jean E | 2006 | Applied Developmental Psychology2006，27，： | 1 |
| 19 | The neglec- ted role of proaetive behavior and outcomes in newcomer socialization显示文摘 | Alan M S Jamie A G Helena C T | 2011 | Journal of Vocational Behavior2011，79，1： | 1 |
| 20 | Unconventional gas: a review of regional and global resource estimates显示文摘 | Christophe M Jamie S Steve S | 2013 | Energy2013，55，： | 1 |
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