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266篇 您的检索式:作者名="Jakoby"
    题名 作者 年代 出处 被引量
1Pro?ling and Validation of the Circular RNA Repertoire in Adult Murine Hearts显示文摘For several decades, cardiovascular disease has been the leading cause of death throughout all countries. There is a strong genetic component to many disease subtypes(e.g., cardiomyopathy) and we are just beginning to understand the relevant genetic factors. Several studies have related RNA splicing to cardiovascular disease and circular RNAs(circ RNAs) are an emerging player. circ RNAs, which originate through back-splicing events from primary transcripts, are resistant to exonucleases and typically not polyadenylated. Initial functional studies show clear phenotypic outcomes for selected circ RNAs. We provide, for the ?rst time, a comprehensive catalogue of RNase R-resistant circ RNA species for the adult murine heart. This work combines state-of-the-art circle sequencing with our novel DCC software to explore the circ RNA landscape of heart tissue.Overall, we identi?ed 575 circ RNA species that pass a beta-binomial test for enrichment(false discovery rate of 1%) in the exonuclease-treated sequencing sample. Several circ RNAs can be directly attributed to host genes that have been previously described as associated with cardiovascular disease. Further studies of these candidate circ RNAs may reveal disease-relevant properties or functions of speci?c circ RNAs.Tobias Jakobi Lisa F. Czaja-Hasse Richard Reinhardt Christoph Dieterich 2016Genomics, Proteomics & Bioinformatics2016,14,4:13
2QSPR study about sampling rates of semipermeable membrane devices for monitoring of organochlorine pesticides in Alps air显示文摘Organochlorine pesticides (OCP) were monitored at the Weissfluhjoch site (Switzerland) and the top of Mt. Sonnblick (Austria) with a low volume active air sampler and semipermeable membrane devices (SPMD). The air sampling rates (Rair) of the SPMD for OCP were calculated. Statistical tests showed that there was no significant difference between Rair at the two different sampling sites. Quantitative structure-property relationship (QSPR) models of the Rair of the SPMD were developed for OCP using partial least square (PLS) regression. Quantum chemical descriptors computed by the semi-empirical PM6 method were used as predictor variables. The cumulative variance of the dependent variable explained by the PLS components and determined by cross-validation (Q2cum) was >0.818 for each optimal model. This indicates that the model has good predictive ability and robustness. The Rair of the SPMD for OCP is related to the total energy, the van der Waals area and the total dipole moment of the OCP molecules. The main factors governing Rair values of OCP are intermolecular interactions and the energy required for cavity-formation in dissolution of OCP into triolein of the SPMD. The linear correlation coefficient between predicted and experimental values were all >0.921.ZHU XiuHua DING GuangHui LEVY Walkiria JAKOBI Gert OFFENTHALER Ivo MOCHE Wolfang WEISS Peter SCHRAMM Karl-Werner 2011Chinese Science Bulletin2011,56,18:5
3bZIP transcription factors in Arabidopsis显示文摘Marc Jakoby Bernd Weisshaar Wolfgang Dr?ge-Laser Jesus Vicente-Carbajosa Jens Tiedemann Thomas Kroj Fran?ois Parcy 2002Trends in Plant Science2002,,3:2
4Renal Cell Carcinoma With Tumor Thrombus Extension Into the Vena Cava: Prospective Long-Term Followup显示文摘Axel Haferkamp Patrick J. Bastian Hildegard Jakobi Maria Pritsch Jesco Pfitzenmaier Peter Albers Peter Hallscheidt Stefan C. Müller Markus Hohenfellner 2007The Journal of Urology2007,,5:2
5Surgery for recurrent goi- tre: its complications and their risk factors 显示文摘Muller PE Jakoby R Heinert G 2001Eur J Surg2001,167,11:1
6Glutathione S-transferase AA from rat liver显示文摘HABIG W H PABST M J JAKOBY W B 1976Arch Biochem Biophys1976,175,2:1
7Glutathione S-transferase AA from rat liver显示文摘Habig W H Pabst M J Jakoby W B 1976Archives of Biochemistry and Biophysics1976,175,:1
8Mechanism for the several activities of the glutathione S-mmsfermea显示文摘Keen JH Habig WH Jakoby WB 1976J Bid Chem1976,251,20:1
9Variations of the climatological growing season (1951-2000) in Germany compared with other countries显示文摘Menzel A Jakobi G Ahas R 2003Intemational Journal of Climatology2003,23,7:1
10bZIP transcription factors in Arabidopsis 显示文摘Jakoby M Weisshaar B DrOge-Laser W 2002Trends Plant Sci2002,7,3:1
11Host immume response to Cryptosporidium parvum infection显示文摘FRANZ PETRY VERA JAKOBI TESFAYE S 2010Experimental Parasitology2010,126,:1
12High Temperature Corrosion of Cracking Tubes 显示文摘Grabke H J Jakobi D 2002Materials and Corrosion2002,53,:1
13Glutathione - S - transferases AA form rat liver显示文摘HabigW H Pabst M J Jakoby W B 1976Arch biochem Biophys1976,175,2:1
14Physical performance andclinical work_flow of a new LSO HI - REZ PET/CT scanner显示文摘Jakoby BW Bercier Y Watson CC 2006IEEE Nucl Sci Symp Conf Record2006,5,:1
15bZIP tran?scription factors in Arabidopsis显示文摘Jakoby M Weisshaar B Droge-Laser W 2002Trends in Plant Science2002,7,3:1
16Variations of the climatological growing season (1951-2000) in Germany compared with other countries显示文摘Menzel A Jakobi G Ahas R 0,,:1
17Assays for differentiation of glutathi-one S-transferases 显示文摘Habig W H? Jakoby W B 1981Methods in Enzymology1981,77,:1
18The effects ofwhole-body vibration on upper- and lower-body EMG duringstatic and dynamic contractions显示文摘HAZELL T J JAKOBI J M KENNO K A 2007Appl Physiol Nutr Metab2007,32,6:1
19A Concept of an Infrared Sensor System for Oil Condition Mo- nitoring显示文摘Agoston A Jakoby B Schneidhofer C 2008e & i Elektrotechnik und Informationstechnik2008,125,3:1
20Glutathione S- transferases:The first enzymaticstep in mercaptufic acid forma- tion 显示文摘HABIG W H PABST M J JAKOBY W B 1974The Journal of Biological Chemistry1974,249,:1
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