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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | RNA interference (RNAi)-induced suppression of nicotine demethylase activity reduces levels of a key carcinogen in cured tobacco leaves显示文摘 | Lewis RS Jack AM Morris JW | | 0，，4： | 1 |
| 3 | RNA interference (RNAi) -induced suppression of nicotine demethylase activity reduces levels of a key carcinogen in cured tobacco leaves 显示文摘 | Lewis RS Jack AM Morris JW | 2008 | Plant Biotechnology Journal2008，6，4： | 1 |
| 4 | Accuracy of unenhanced MR imaging in the detection of axillary lymph node metastasis: study of reproducibility and reliability 显示文摘 | Scaranelo AM Eiada R Jacks LM | 2012 | Radiology2012，262，2： | 1 |
| 5 | Effects of the protein kinase C beta inhibitor LY333531 on neural and vascular function in ras with streptozotocin-induced diabetes 显示文摘 | Cotter MA Jack AM Camoron NE | 2002 | Clin Sci2002，103，： | 1 |
| 6 | Effects of aldose reductase inhibition on responses of the corpus cavernosum and mesenteric vascular bed of diabetic rats 显示文摘 | Keegan A Jack AM Cotter MA | 2000 | J Cardio-vase Pharmacol2000，35，： | 1 |
| 7 | Effects of the diacylglycerol complexing agent,cremophor,on nerve-conduction velocity and perfusion in diabetic rats 显示文摘 | Jack AM Cameron NE Cotter MA | 1999 | J Diabetes Compl1999，13，： | 1 |
| 8 | Neovascularisation in a patent chorioretinal anastomosis显示文摘 | Mehta JS Jacks AS Maurino V Hamilton AM | 2000 | Eye2000，14，6： | 1 |
| 9 | Effects of the protein kinase C 13 inhibitor LY333531 on neural and vascular function in rats with streptozotocin-induced diabetes 显示文摘 | Cotter MA Jack AM Cameron NE | 2002 | Clin Sci2002，103，3： | 1 |
| 10 | Resilience to care:A systematic review and meta-synthesis of the qualitative literature concerning the experiences of student nurses in adult hospital settings in the UK显示文摘 | Thomas J Jack BA Jinks AM | | 0，，32： | 1 |
| 11 | Protein kinase C effets on nerve function,perfusion,Na^+ , K^+ - ATPase activity and glutathione content in diabetic rats 显示文摘 | Cameron NE Cotter MA Jack AM | 1999 | Diabetologia1999，42，： | 1 |
| 12 | Accuracy of unenhanced MR imaging in the detection of axillary lymph node metastasis: study of reproducibility and reliability显示文摘 | Scaranelo AM Eiada R Jacks LM | 2012 | Radiology2012，262，2： | 1 |
| 13 | A novel dendritic ceU-based cancer vaccine produces promising results in a syngenic CC-36 murine colon adenocarcinoma model 显示文摘 | Jack AM Aydin N Montenegro G | 2007 | Jsurgres2007，139，2： | 1 |
| 14 | Accuracy of unenhanced MR imaging in the detection of axillary lymph node metastasis: study of reproducibility and reliability显示文摘 | Scaranelo AM Eiada R Jacks LM | 2012 | Radiology2012，262，2： | 1 |
| 15 | Improved classification of recent HIV-1 infection by employing a two-stage sensitive/ less-sensitive test strategy 显示文摘 | Constantine NT Sill AM Jack N | 2003 | J Acquit Immune Defic Syndr2003，32，1： | 1 |
| 16 | Effects of the protein kinaseC beta inhibitor LY333531 on neural and vascular function in ratswith streptozococin-induced diabetes 显示文摘 | Cotter MA Jack AM Cameron NE | 2002 | Clin Sci ( Lond)2002，103，3： | 1 |
| 17 | Effects of the protein kinase C beta inhibitor LY333531 on neural and vascular function in rats with streptozotocin-induced diabetes显示文摘 | Cotter MA Jack AM Cameron NE | 2002 | Clin Sci2002，103，3： | 1 |
| 18 | RNA interference(RNAi)induced suppression of uicoti ne demethylase activity reduces levels of a key carcinogen in cured tobacco leaves显示文摘 | Lewis RS Jack AM Morris JW | 2008 | Plant Bio technology Joumal2008，6，4： | 1 |
| 19 | Resilience to care: a systematic review and meta-synthesis of the qualitative literature concerning the experiences of student nurses in adult hospital settings in the UK 显示文摘 | Thomas J Jack BA Jinks AM | 2012 | Nurse Educ Today2012，32，6： | 1 |
| 20 | Accuracy of unenhanced MR imaging in the detection of axillary lymph node metastasis:study of reproducibility and reliability显示文摘 | Scaranelo AM Eiada R Jacks LM | 2012 | Radiology2012，262，2： | 1 |
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