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| 1 | Overview of immunosuppression in liver transplantation显示文摘Continued advances in surgical techniques and immunosuppressive therapy have allowed liver transplantation to become an extremely successful treatment option for patients with end-stage liver disease.Beginning with the revolutionary discovery of cyclosporine in the 1970s,immunosuppressive regimens have evolved greatly and current statistics confirm one-year graft survival rates in excess of 80%. Immunosuppressive regimens include calcineurin inhibitors,anti-metabolites,mTOR inhibitors,steroids and antibody-based therapies.These agents target different sites in the T cell activation cascade,usually by inhibiting T cell activation or via T cell depletion.They are used as induction therapy in the immediate periand post-operative period,as long-term maintenance medications to preserve graft function and as salvage therapy for acute rejection in liver transplant recipients. This review will focus on existing immunosuppressive agents for liver transplantation and consider newer medications on the horizon. | Anjana A Pillai Josh Levitsky | 2009 | World Journal of Gastroenterology2009，15，34： | 21 |
| 2 | 应用数字图象处理技术对颜面审美观的研究显示文摘目的 本研究使用可调式数字图象模型比较美国正畸医师与中国普通人对颜面的审美观是否一致。对标准比较法和配对比较法这两种容貌美学评判方法的有效性也进行了比较。方法 由一张正常中国成人的头颅侧位片经处理产生四幅不同的数字图象构成一个系列。这些图象的骨骼或牙齿与正常值相差 2倍标准差 ,软组织侧貌图象则经相应软件处理产生。结果 一系列非参数检验证实数字变形模型的有效性 ,且配对比较法优于普通的标准比较法。专业和非专业人士都认为和谐或“正常”型最具吸引力 ,其次是“直面”或双颌后缩的男性中国人、“前部发育不足”或上颌后缩的女性中国人。研究发现牙齿后缩而骨骼型协调的男性与上颌后缩而余无异常的女性同“双牙弓前突”的正常型具有同样的吸引力。结论 本研究有利于中外正畸医师在治疗中国患者时有所依据 ,以达到医患均满意的治疗效果。 | Anthony L.Maganzini 曾应魁 Josh Z.Epstein Luis J.Alvarez 邹冰爽 曾祥龙 | 2000 | 口腔正畸学2000，7，3： | 16 |
| 3 | Single Nucleotide Polymorphism Identification in Polyploids: A Review, Example, and Recommendations显示文摘 | Josh Clevenger Carolina Chavarro Stephanie A. Pearl Peggy Ozias-Akins Scott A. Jackson | 2015 | Molecular Plant2015，8，6： | 16 |
| 4 | 北美神经内分泌肿瘤学会和核医学与分子影像学会有关177Lu-DOTATATE肽受体放射性核素治疗患者选择和合理应用共识显示文摘随着177Lu-1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸-D-苯丙氨酸1-酪氨酸3-苏氨酸8-奥曲肽(DOTATATE)肽受体放射性核素治疗(PRRT)的日益普及,有关患者合理选择的问题日益增多。该文回顾了有关177Lu-DOTATATE在不同原发性神经内分泌肿瘤(NETs)中的应用文献,讨论了一些有争议的问题,并回顾了治疗的潜在禁忌证。此共识是由北美神经内分泌肿瘤学会(NANETS)和核医学与分子影像学会(SNMMI)共同制定的。NANETS是成立于2005年的北美多学科神经内分泌专家专业学会,目的在于通过增加研究和教育机会改善对NETs的管理。NANETS致力于多学科研究,由NETs涉及的不同专业的医师和科学家组成。SNMMI成立于1954年,旨在促进核医学科学、技术和实践应用的国际性科学专业组织,除了出版期刊、时事通讯和书籍外,还主办提高核医学从业人员能力和促进核医学科学新发展的国际会议及讲习班。 | 邓艳(译) 张伟(审校) Thomas A.Hope Lisa Bodei Jennifer A.Chan Ghassan El-Haddad Nicholas Fidelman Pamela L.Kunz Josh Mailman Yusuf Menda David C.Metz Erik S.Mittra Daniel A.Pryma Diane L.Reidy-Lagunes Simron Singh Jonathan R.Strosberg | 2020 | 中华核医学与分子影像杂志2020，40，11： | 11 |
| 5 | The role of phosphorus in the metabolism of arsenate by a freshwater green alga, Chlorella vulgaris显示文摘A freshwater microalga, Chlorella vulgaris, was grown in the presence of varying phosphate concentrations(< 10–500 μg/L P) and environmentally realistic concentrations of arsenate(As(Ⅴ))(5–50 μg/L As). Arsenic speciation in the culture medium and total cellular arsenic were measured using AEC-ICP-MS and ICP-DRC-MS, respectively, to determine arsenic biotransformation and uptake in the various phosphorus scenarios. At high phosphate concentration in the culture medium, > 100 μg/L P, the uptake and biotransformation of As(Ⅴ) was minimal and dimethylarsonate(DMAs(Ⅴ)) was the dominant metabolite excreted by C. vulgaris, albeit at relatively low concentrations. At common environmental P concentrations, 0–50 μg/L P, the uptake and biotransformation of As(Ⅴ) increased. At these higher As-uptake levels, arsenite(As(Ⅲ)) was the predominant metabolite excreted from the cell. The concentrations of As(Ⅲ) in these low P conditions were much higher than the concentrations of methylated arsenicals observed at the various P concentrations studied. The switchover threshold between the(small) methylation and(large) reduction of As(Ⅴ) occurred around a cellular As concentration of 1 fg/cell. The observed nearly quantitative conversion of As(Ⅴ) to As(Ⅲ) under low phosphate conditions indicates the importance of As(Ⅴ) bio-reduction at common freshwater P concentrations. These findings on the influence of phosphorus on arsenic uptake, accumulation and excretion are discussed in relation to previously published research. The impact that the two scenarios of As(Ⅴ) metabolism, As(Ⅲ) excretion at high As(Ⅴ)-uptake and methylarsenical excretion at low As(Ⅴ)-uptake, have on freshwater arsenic speciation is discussed. | Josh Baker Dirk Wallschlager | 2016 | Journal of Environmental Sciences2016，28，11： | 7 |
| 6 | Depression following a traumatic brain injury:uncovering cytokine dysregulation as a pathogenic mechanism显示文摘A substantial number of individuals have long-lasting adverse effects from a traumatic brain injury(TBI). Depression is one of these long-term complications that influences many aspects of life. Depression can limit the ability to return to work, and even worsen cognitive function and contribute to dementia. The mechanistic cause for the increased depression risk associated with a TBI remains to be defined. As TBI results in chronic neuroinflammation, and priming of glia to a secondary challenge, the inflammatory theory of depression provides a promising framework for investigating the cause of depression following a TBI. Increases in cytokines similar to those seen in depression in the general population are also increased following a TBI. Biomarker levels of cytokines peak within hours-to-days after the injury, yet pro-inflammatory cytokines may still be elevated above physiological levels months-to-years following TBI, which is the time frame in which post-TBI depression can persist. As tumor necrosis factor α and interleukin 1 can signal directly at the neuronal synapse, pathophysiological levels of these cytokines can detrimentally alter neuronal synaptic physiology. The purpose of this review is to outline the current evidence for the inflammatory hypothesis of depression specifically as it relates to depression following a TBI. Moreover, we will illustrate the potential synaptic mechanisms by which tumor necrosis factor α and interleukin 1 could contribute to depression. The association of inflammation with the development of depression is compelling; however, in the context of post-TBI depression, the role of inflammation is understudied. This review attempts to highlight the need to understand and treat the psychological complications of a TBI, potentially by neuroimmune modulation, as the neuropsychiatric disabilities can have a great impact on the rehabilitation from the injury, and overall quality of life. | Colleen N.Bodnar Josh M.Morganti Adam D.Bachstetter | 2018 | Neural Regeneration Research2018，13，10： | 6 |
| 7 | 国际标准文件 孔板流量计-案例研究(英文)显示文摘对孔板流量计在湿气计量上的工业应用进行了详细的回顾。分析表明,孔板流量计与湿气的响应与湿气的流动状态紧密相关。为使孔板流量计能够准确计量湿气流体,必须加强预防措施以确保压差传感器不被湿气饱和。文章深入探讨了如何校正孔板流量计在计量湿气时的弱读和超读现象。认为监控孔板流量计的压力损失率对于得到准确读数的益处有限。所有的情况均表明,对于ISO来说,发表有关湿气流量计量的技术报告是当务之急。 | Richard Steven Josh Kinney | 2011 | 石油与天然气化工2011，40，6： | 5 |
| 8 | Dispersal behavior correlates with personality of a North American fish显示文摘 | Josh E. RASMUSSEN Mark C. BELK | 2012 | Current Zoology2012，58，2： | 4 |
| 9 | Genome-wide SNP Genotyping Resolves Signatures of Selection and Tetrasomic Recombination in Peanut显示文摘花生(Arachis hypogaea;2n = 4x = 40 ) 是滋养的食物和维生素,矿物质,和健康脂肪的好来源。扩大基因并且为栽培花生的基因改进的 genomic 资源从栽培花生的双祖先的定序的染色体获得了动量。便于 Arachis 种类的高产量的 genotyping, 20 遗传型被重新定序,染色体宽的单个核苷酸多型性(SNP ) 被选择开发一个大规模 SNP genotyping 数组。为在 genotyping 应用程序的灵活性,在 tetraploid 和双种类之间多态的 SNP 为使用被包括在栽培并且种间的人口。一套 384 就职被用来测试导致生产了在双种类之间的高质量的多态的簇的 54 564 个标记的数组, 47 116 个多态的标记在之间栽培并且种间的混血儿,和在 A 以内的 15 897 个多态的标记。hypogaea germplasm。一另外 1193 个标记被识别那照亮的 genomic 区域展出 tetrasomic 再结合。而且,完成美国跑步者 germplasm 的家谱的一套精英栽培变种是 genotyped 并且过去常识别经历了积极选择的 genomic 区域。这些观察在栽培花生在新基因差异的包括上提供关键卓见并且将通知发展高分辨率的印射的人口。由于它的效率,范围,和灵活性,最新发达的 SNP 数组将为在 Arachis 的进一步基因、引起的应用程序是很有用的。 | Josh Clevenger Ye Chu Carolina Chavarro Gaurav Agarwal David J. Bertioli Soraya C.M. LeaI-Bertioli Manish K. Pandey Justin Vaughn Brian Abernathy Noelle A. Barkley Ran Hovav Mark Burow Spurthi N. Nayak Annapurna Chitikineni Thomas G. Isleib C. Corley Holbrook Scott A. Jackson Rajeev K. Varshney Peggy Ozias-Akins | 2017 | Molecular Plant2017，10，2： | 4 |
| 10 | 智慧城市–环境噪声控制的全球趋势(英文)显示文摘众所周知,过量的环境噪声会令人失眠、焦虑、或引发心脏病等。根据世界卫生组织报告,全球各国都有一定数量的人已达至这水平,很多人是受环境噪声的影响。当大家在追求提高经济效益及生活质素的同时,各国为了建立智慧城市,有着不同的思维和构思去改善环境噪声,其中利用轨道交通工具作集体运输被各国视为一石二鸟的聪明出行方法。文章旨在分享全球在这方面的现状和趋势。 | 梁浩贤 黃国中 Josh Fothergill 钟伟樑 | 2016 | 声学技术2016，35，6： | 3 |
| 11 | Completion and stimulation trends in North American unconventional plays and resulting impact on well productivity显示文摘过去十年,非常规油气勘探开发在全球范围内大幅扩张。水平钻井和多级水力压裂技术也在不断地发展和创新,使得超长水平井成为可能。同时,因为压裂强度不断增加,作业者可以最大限度地提高储层接触面积和对储层的改造体积(SRV)。然而,完井优化方面的挑战仍然存在,作业者持续不断地尝试和试验各种完井与增产参数组合,以确保非常规油气藏开发的经济可行性。优选最佳的完井与增产参数组合是一项非常关键的任务,应结合油气田的具体储层特征进行优化。本文总结了2014—2020年间北美9个主要非常规油气藏的压裂增产趋势,包括Marcellus,Haynesville,Barnett,Utica,Bone Spring,Bakken,Wolfcamp Midland,Eagle Ford,Scoop/Stack。分析了各油气田几个关键的完井和增产参数的整体趋势,同时还评估了单个参数(如水平段压裂长度、支撑剂强度、段间距等)对井产能的影响。然后对比分析相应的初始井产量(90天平均初始产量),评估各个参数对产能的影响,从而确定每个完井参数的最佳范围,以实现产能最优化。 | Roman Galchenko Qing Liu Yan Gao Yu Liu David He Josh Zhang Huailiang Liu Xiaohua Ke | 2021 | 钻探工程2021，48，10： | 3 |
| 12 | 重塑能源-中国:能效在中国面向2050年路线图中的作用显示文摘作为《巴黎协定》承诺的一部分,中国计划在2030年左右达到二氧化碳(CO_2)排放峰值并争取尽早达峰。在研究如何实现上述减排承诺的前提下,中美研究人员组成的团队构建了一个自下而上的中国能源供需综合模型。基于该模型对比分析了两种情景的差异,即沿着当前趋势发展的参考路径情景以及'重塑能源'替代路径情景。'重塑能源'替代路径是指为满足国家需求,在2050年前最大程度地应用当前成本有效的能源效率策略和可再生能源。结果表明,如果中国走更积极的重塑能源路径,那么其二氧化碳排放量可比参考路径提前11年达峰。本文重点分析了在更积极的路径下能源效率策略对于二氧化碳减排的作用。除能源效率外,本研究还分析了燃料替换(从碳密集型燃料转向其他燃料)的减排作用。结果表明,对于重塑能源情景,能源效率提高及相关策略贡献了中国2050年二氧化碳总减排潜力的75%,而燃料替换仅占25%。为在中国实现上述具有显著成本效益的能效潜力。 | Lynn Price Nina Khanna Nan Zhou David Fridley Ali Hasanbeigi Hongyou Lu Feng Wei 戴彦德 田智宇 杨宏伟 白泉 朱跃中 熊华文 张建国 Jon Creyts Kate Chrisman Ellen Franconi Josh Agenbroad Michael Bendewald Yi Ke Robert McIntosh David Mullaney Clay Stranger Daniel Wetzel Cvrd Yee | 2018 | 科学与管理2018，38，3： | 3 |
| 13 | Optical force-induced nonlinearity and self-guiding of light in human red blood cell suspensions显示文摘Osmotic conditions play an important role in the cell properties of human red blood cells(RBCs),which are crucial for the pathological analysis of some blood diseases such as malaria.Over the past decades,numerous efforts have mainly focused on the study of the RBC biomechanical properties that arise from the unique deformability of erythrocytes.Here,we demonstrate nonlinear optical effects from human RBCs suspended in different osmotic solutions.Specifically,we observe self-trapping and scattering-resistant nonlinear propagation of a laser beam through RBC suspensions under all three osmotic conditions,where the strength of the optical nonlinearity increases with osmotic pressure on the cells.This tunable nonlinearity is attributed to optical forces,particularly the forward-scattering and gradient forces.Interestingly,in aged blood samples(with lysed cells),a notably different nonlinear behavior is observed due to the presence of free hemoglobin.We use a theoretical model with an optical force-mediated nonlocal nonlinearity to explain the experimental observations.Our work on light self-guiding through scattering biosoft-matter may introduce new photonic tools for noninvasive biomedical imaging and medical diagnosis. | Rekha Gautam Yinxiao Xiang Josh Lamstein Yi Liang Anna Bezryadina Guo Liang Tobias Hansson Benjamin Wetzel Daryl Preece Adam White Matthew Silverman Susan Kazarian Jingjun Xu Roberto Morandotti Zhigang Chen | 2019 | Light(Science & Applications)2019，8，1： | 3 |
| 14 | Risk for Immune-Mediated Graft Dysfunction in Liver Transplant Recipients With Recurrent HCV Infection Treated With Pegylated Interferon显示文摘 | Josh Levitsky Maria Isabel Fiel John P. Norvell Edward Wang Kymberly D. Watt Michael P. Curry Sumeet Tewani Timothy M. McCashland Maarouf A. Hoteit Abraham Shaked Samuel Saab Amanda C. Chi Amy Tien Thomas D. Schiano | 2012 | Gastroenterology2012，，5： | 3 |
| 15 | The Intestinal Microbiota Affect Central Levels of Brain-Derived Neurotropic Factor and Behavior in Mice显示文摘 | Premysl Bercik Emmanuel Denou Josh Collins Wendy Jackson Jun Lu Jennifer Jury Yikang Deng Patricia Blennerhassett Joseph Macri Kathy D. McCoy Elena F. Verdu Stephen M. Collins | 2011 | Gastroenterology2011，，2： | 2 |
| 16 | Telaprevir- and Boceprevir-based Triple Therapy for Hepatitis C in Liver Transplant Recipients With Advanced Recurrent Disease: A Multicenter Study显示文摘 | Elizabeth C. Verna Varun Saxena James R. Burton Jacqueline G. O’Leary Jennifer L. Dodge Richard T. Stravitz Josh Levitsky James F. Trotter Gregory T. Everson Robert S. Brown Norah A. Terrault | 2015 | Transplantation2015，，8： | 2 |
| 17 | Disbond detection with piezoelectric wafer active sensors in RC structures strengthened with FRP composite overlays显示文摘The capability of embedded piezoelectric wafer active sensors (PWAS) to perform in-situ nondestructive evaluation (NDE) for structural health monitoring (SHM) of reinforced concrete (RC) structures strengthened with fiber reinforced polymer (FRP) composite overlays is explored. First, the disbond detection method were developed on coupon specimens consisting of concrete blocks covered with an FRP composite layer. It was found that the prescnce of a disbond crack drastically changes the electromecbanical (E/M) impedance spectrum measured at the PWAS terminals. The spectral changes depend on the distance between the PWAS and the crack tip. Second, large scale experiments were conducted on a RC beam strengthened with carbon fiber reinforced polymer (CFRP) composite overlay. The beam was subject to an acccleratcd fatigue load regime in a three-point bending configuration up to a total of807,415 cycles. During these fatigue tests, the CFRP overlay experienced disbonding beginning at about 500,000 cycles. The PWAS were able to detect the disbonding before it could be reliably seen by visual inspection. Good correlation between the PWAS readings and the position and extent of disbond damage was observed. These preliminary results demonstrate the potential of PWAS technology for SHM of RC structures strengthened with FRP composite ovcrlays. | Victor Giurgiutiu Kent Harries Michael Petrou Joel Bost Josh B.Quattlebaum | 2003 | Earthquake Engineering and Engineering Vibration2003，2，2： | 2 |
| 18 | Silymarin Ascending Multiple Oral Dosing Phase I Study in Noncirrhotic Patients With Chronic Hepatitis C显示文摘 | Roy L. Hawke Sarah J. Schrieber Tedi A. Soule Zhiming Wen Philip C. Smith Rajender K. Reddy Abdus S. Wahed Steven H. Belle Nezam H. Afdhal Victor J. Navarro Josh Berman Qi-Ying Liu Edward Doo Michael W. Fried | 2010 | Journal of Clinical Pharmacology2010，，4： | 2 |
| 19 | Towards high strength cast Mg-RE based alloys:Phase diagrams and strengthening mechanisms显示文摘Mg-rare earth(RE)based systems provide several important commercial alloys and many alloy development opportunities for high strength applications,especially in aerospace and defense industries.The phase diagrams,microstructure,and strengthening mechanisms of these multicomponent systems are very complex and often not well understood in literature.We have calculated phase diagrams of important binary,ternary,and multicomponent RE-containing alloy systems,using CALPHAD(CALculation of PHAse Diagrams).Based on these phase diagrams,this paper offers a critical overview on phase equilibria and strengthening mechanisms in these alloy systems,including precipitation,long period stacking order(LPSO),and other intermetallic phases.This review also summarized several promising Mg-RE based cast alloys in comparison with commercial WE54 and WE43 alloys;and explored new strategies for future alloy development for high strength applications.It is pointed out that the combination of precipitation and LPSO phases can lead to superior strength and ductility in Mg-RE based cast alloys.The precipitates and LPSO phases can form a complex three-dimensional network that effectively impedes dislocation motion on the basal and non-basal planes.The LPSO phases can also prevent the coarsening of precipitates when they interact,thus providing good thermal stability at elevated temperatures.Future research is needed to determine how the combination of these two types of phases can be used in alloy design and industrial scale applications. | Janet M.Meier Josh Caris Alan A.Luo | 2022 | Journal of Magnesium and Alloys2022，10，6： | 2 |
| 20 | Cell-Type-Based Analysis of MicroRNA Profiles in the Mouse Brain显示文摘 | Miao He Yu Liu Xiaowo Wang Michael Q. Zhang Gregory J. Hannon Z. Josh Huang | 2012 | Neuron2012，，1： | 2 |
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