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| 1 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 3 |
| 2 | Strategies to tackle the challenges of external beam radiotherapy for liver tumors显示文摘Primary and metastatic liver cancer is an increasingly common and difficult to control disease entity.Radiation offers a non-invasive treatment alternative for these patients who often have few options and a poor prognosis.However,the anatomy and aggressiveness of liver cancer poses significant challenges such as accurate localization at simulation and treatment,management of motion and appropriate selection of dose regimen.This article aims to review the options available and provide information for the practical implementation and/or improvement of liver cancer radiation programs within the context of stereotactic body radiotherapy and image-guided radiotherapy guidelines.Specific patient inclusion and exclusion criteria are presented given the significant toxicity found in certain sub-populations treated with radiation.Indeed,certain sub-populations,such as those with tumor thrombosis or those with larger lesions treated with transarterial chemoembolization,have been shown to have significant improvements in outcome with the addition of radiation and merit special consideration.Implementing a liver radiation programrequires three primary challenges to be addressed:(1) immobilization and motion management;(2) localization;and(3) dose regimen and constraint selection.Strategies to deal with motion include simple internal target volume(ITV) expansions,non-gated ITV reduction strategies,breath hold methods,and surrogate marker methods to enable gating or tracking.Localization of the tumor and organs-at-risk are addressed using contrast infusion techniques to take advantage of different normal liver and cancer vascular anatomy,imaging modalities,and margin management.Finally,a dose response has been demonstrated and dose regimens appear to be converging.A more uniform approach to treatment in terms of technique,dose selection and patient selection will allow us to study liver radiation in larger and,hopefully,multicenter randomized studies. | Michael I Lock Jonathan Klein Hans T Chung Joseph M Herman Edward Y Kim William Small Nina A Mayr Simon S Lo | 2017 | World Journal of Hepatology2017，9，14： | 2 |
| 3 | Outlook for ellulase improvement: Screening and selection strategies 显示文摘 | Zhang Y H P Michael E H Jonathan R M | 2006 | Biotechnology Advances2006，24，： | 1 |
| 4 | Side resistance of large diameter bored piles socketed into decomposed rock显示文摘 | Charles W W N Terence L Y Y Jonathan H M L | 2001 | Journal of Geotechnical and Geoenvironmental Engineering ASCE2001，127，8： | 1 |
| 5 | Differential responses of normal,premalignant,and malignant human bronchial epithelial cells to receptor-selective retinoids显示文摘 | Shi-Yong S Jonathan M K Ping Y | 1999 | Clin Cancer Res1999，5，： | 1 |
| 6 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 1 |
| 7 | Mutational analysis of the complement receptor type 2 (CR2/CD21) C3d interaction reveals a putative charged SCR1 binding site for C3d显示文摘 | Jonathan P H Kendra A Y Joel M G | 2005 | J Mol Biol2005，346，： | 1 |
| 8 | Co ( III ) porphyrin/DMAP: An efficient catalyst system for the synthesis of cyclic carbonates from CO2 and epoxides 显示文摘 | Paddock R L Hiyama Y Jonathan M | 2004 | Tetrahedron Letters2004，45，： | 1 |
| 9 | Outlook for cellulase improvement screening and selection strategies显示文摘 | Zhang Y H Michael E H Jonathan R M | 2006 | Biotech-nology Advances2006，24，： | 1 |
| 10 | In vivo glucose measurement by surface-enhanced raman spectroscopy显示文摘 | DOUGLAS A S JONATHAN M Y NILAM S | 2006 | Anal Chem2006，78，20： | 1 |
| 11 | Isolation by prepara- tive free-flow electrophoresis and aqueous two-phaso partition from rat adipocytes of an insulin-responsive small vesicle fraction with glu- cose transport activity 显示文摘 | Dorothy M M David W S Jonathan Y | 1996 | J Chromatography B1996，680，： | 1 |
| 12 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 1 |
| 13 | Circulating [alpha]Klotho influences phosphate handling by controlling FGF23 production显示文摘 | Smith Rosamund C O’Bryan Linda M Farrow Emily G Summers Lelia J Clinkenbeard Erica L Roberts Jessica L Cass Taryn A Saha Joy Broderick Carol Ma Y Linda Zeng Qing Qiang Kharitonenkov Alexei Wilson Jonathan M Guo Qianxu Sun Haijun Allen Matt | 2012 | Journal of Clinical Investigation2012，，12： | 1 |
| 14 | Outlook for cellulase improvement:screening and selection strategies显示文摘 | Zhang Y H Michael E H Jonathan R M | 2006 | Biotechnology Advances2006，24，： | 1 |
| 15 | Outlook for ellulase improvement: Screening and selection strategies显示文摘 | Zhang Y H P Michael E H Jonathan R M | 2006 | Biotechnology Advances2006，，24： | 1 |
| 16 | Side resistance of large diameter piles socketed into decomposed rocks显示文摘 | CHARLES W W N TERENCE L Y Y JONATHAN H M L | 2001 | Journal of Geotechnical and Geoenvironmental Engineering2001，127，8： | 1 |
| 17 | Outlook for cellulase improvement: screening and selection strategies 显示文摘 | ZHANG Y H MICHAEL E H JONATHAN R M | 2006 | Bioteelmol Adv2006，24，5： | 1 |
| 18 | Co(III) porphyrin/ DMAP: An efficient catalyst system for the synthesis of cyclic carbonates from CO2 and epoxides显示文摘 | Paddock R L Hiyama Y Jonathan M | 2004 | Tetrahedron Letters2004，45，： | 1 |
| 19 | Bmp signaling regulates proximal-distal differentiation of endoderm in mouse lung development 显示文摘 | MOLLY W JONATHAN M Y DUNN R N | 1999 | Development1999，126，： | 1 |
| 20 | Outlook for cellulase improvement : Screening and selection strategies 显示文摘 | Zhang Y HP Michael E H Jonathan R M | 2006 | Biotechnology Advances2006，，24： | 1 |
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