|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 中国与西伯利亚黄土磁化率古气候记录-氧化和还原条件下的两种成土模式分析显示文摘近20多年来随着中国黄土深入研究,揭示了中国黄土地层磁化率与成土古气候温湿程度基本成正比例关系,黄土地层磁化率也因此成为一个重要的古气候参考指标在第四纪古气候研究中,不仅在黄土堆积物而且也在湖相和海相沉积物中广泛应用.但是中国黄土地层磁化率与古土壤成壤强度(古气候温湿程度)呈正比的模式却不是到处都适用,黄土高原的周边地区就有不少例外的报道.而西伯利亚和阿拉斯加黄土则显示出另一极端的情形,一个完全相反的磁化率特点:在气候干冷期的黄土层获高值,而在气候温湿期的古土壤层获低值.过去的研究一直认为,其磁化率主要是反映古风力大小的变化,与成土作用基本无关.磁学测量研究发现,西伯利亚黄土和古土壤的差别,不仅有颗粒从大到小的变化,而且还有矿物组分变化:如磁赤铁矿从多到少,最后完全消失并取而代之出现了完全不同热磁行为的另一种矿物.这种矿物相变现象难以用单纯的风力强弱来解释.说明中国黄土和西伯利亚黄土可能存在两种不同的机制模式:中国黄土高原大部分处于蒸发量大于降雨量的干旱氧化环境,适当的水分或降雨有利于细小的磁铁矿和磁赤铁矿的形成,使得磁化率与古气候呈正比.而西伯利亚以及相应的高纬度地区,地理上属苔原或苔缘地区,湿润是该区域基本特点.间冰期更加温湿的气候使其湿润增加以致过剩,导致地表成土环境向还原方向移动.它使得喜氧化的强磁性矿物磁赤铁矿和磁铁矿渐趋不稳定,并逐渐转化形成适合其还原环境的弱磁性矿物如褐铁矿或其他铁的硫化物.间冰期气候越潮湿,还原程度也越高,强磁性矿物就被损耗得越多.正是这种高纬度的成土作用可能是导致其古土壤磁化率比黄土更低的主导因素之一. | 刘秀铭 刘东生 夏敦胜 HESSE Paul JIRI Chlachula 王冠 | 2007 | 中国科学(D辑)2007，37，10： | 75 |
| 2 | Small intestinal bacterial overgrowth syndrome显示文摘Human intestinal microbiota create a complex polymi-crobial ecology. This is characterised by its high population density, wide diversity and complexity of interaction. Any dysbalance of this complex intestinal microbiome, both qualitative and quantitative, might have serious health consequence for a macro-organism, including small intestinal bacterial overgrowth syndrome (SIBO).SIBO is defined as an increase in the number and/or alteration in the type of bacteria in the upper gastro-intestinal tract. There are several endogenous defence mechanisms for preventing bacterial overgrowth: gastric acid secretion, intestinal motility, intact ileo-caecal valve, immunoglobulins within intestinal secretion and bacte-riostatic properties of pancreatic and biliary secretion. Aetiology of SIBO is usually complex, associated with disorders of protective antibacterial mechanisms (e.g. achlorhydria, pancreatic exocrine insuff iciency, immuno-deficiency syndromes), anatomical abnormalities (e.g. small intestinal obstruction, diverticula, f istulae, surgical blind loop, previous ileo-caecal resections) and/or motility disorders (e.g. scleroderma, autonomic neuropathy in diabetes mellitus, post-radiation enteropathy, small intestinal pseudo-obstruction). In some patients more than one factor may be involved. Symptoms related to SIBO are bloating, diarrhoea, malabsorption, weight loss and malnutrition. The gold standard for diagnosing SIBO is still microbial investigation of jejunal aspirates. Noninvasive hydrogen and methane breath tests are most commonly used for the diagnosis of SIBO using glucose or lactulose. Therapy for SIBO must be com-plex, addressing all causes, symptoms and complica-tions, and fully individualised. It should include treatment of the underlying disease, nutritional support and cyclical gastro-intestinal selective antibiotics. Prognosis is usually serious, determined mostly by the underlying disease that led to SIBO. | Jan Bures Jiri Cyrany Darina Kohoutova Miroslav Frstl Stanislav Rejchrt Jaroslav Kvetina Viktor Vorisek Marcela Kopacova | 2010 | World Journal of Gastroenterology2010，16，24： | 52 |
| 3 | Two pedogenic models for paleoclimatic records of magnetic susceptibility from Chinese and Siberian loess显示文摘The magnetic susceptibility (MS) of Chinese loess showing a general proportional relationship to pedogenic grade has been widely recognized and used for reconstruction of paleoclimate by Quaternary scientists. The in-situ pedogenic enhancement of ferrimagnetic content is normally believed to be the main reason for the increase of susceptibility in soil units. However, this pattern of high magnetic susceptibility in palaeosols, and low values in loess, are not replicated in some loess deposits. Siberian loess deposits display a completely opposite susceptibility behavior: high values in loess and low values in palaeosols. This inverse relationship has been explained by the idea that magnetic susceptibility is reflecting the magnitude of an aeolian ferrimagnetic component of consistent mineralogy, the grain size of which is related to average wind velocity. Our magnetic study of Siberian samples in this paper suggests that there are notable differences in magnetic properties between Siberian loess and developed palaeosols, not only in magnetic grain-size and concentration but also in magnetic mineralogy. This evidence is difficult to explain fully through variation in wind strength alone, but implies that the low magnetic susceptibility values in the Siberian paleosol units are a reflection, at least in part, of the alteration of the ferrimagnetic content by post-depositional processes. The Loess Plateau is a very arid area where potential evaporation is always higher than precipitation; pedogenesis occurs under dry oxidising conditions. The Siberian Kurtak region is located on the edge of the tundra where it is always wet and saturation during interglacials will lead to a reducing pedogenic environment. Ferrimagnetic minerals under this condition will be destroyed, resulting in lower magnetic susceptibility. Therefore, great care should be taken when using susceptibility values for paleoclimatic reconstruction. | Paul HESSE Jiri CHLACHULA | 2008 | Science China Earth Sciences2008，51，2： | 25 |
| 4 | Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis显示文摘AIM To characterize the gut bacterial microbiota of patients with primary sclerosing cholangitis(PSC) and ulcerative colitis(UC).METHODS Stool samples were collected and relevant clinical data obtained from 106 study participants, 43 PSC patients with(n = 32) or without(n = 11) concomitant inflammatory bowel disease, 32 UC patients, and 31 healthy controls. The V3 and V4 regions of the 16 S ribosomal RNA gene were sequenced on Illumina Mi Seq platform to cover low taxonomic levels. Data were further processed in QIIME employing Ma As Lin and LEf Se tools for analysis of the output data.RESULTS Microbial profiles in both PSC and UC were characterized by low bacterial diversity and significant change in global microbial composition. Rothia, Enterococcus, Streptococcus, Veillonella, and three other genera were markedly overrepresented in PSC regardless of concomitant inflammatory bowel disease(IBD). Rothia, Veillonella and Streptococcus were tracked to the species level to identify Rothia mucilaginosa, Streptococcus infantus, S. alactolyticus, and S. equi along with Veillonella parvula and V. dispar. PSC was further characterized by decreased abundance of Adlercreutzia equolifaciens and Prevotella copri. Decrease in genus Phascolarctobacterium was linked to presence of colonic inflammation regardless of IBD phenotype. Akkermansia muciniphila, Butyricicoccus pullicaecorum and Clostridium colinum were decreased in UC along with genus Roseburia. Low levels of serum albumin were significantly correlated with enrichment of order Actinomycetales.CONCLUSION PSC is associated with specific gut microbes independently of concomitant IBD and several bacterial taxa clearly distinguish IBD phenotypes(PSC-IBD and UC). | Lukas Bajer Miloslav Kverka Martin Kostovcik Peter Macinga Jiri Dvorak Zuzana Stehlikova Jan Brezina Pavel Wohl Julius Spicak Pavel Drastich | 2017 | World Journal of Gastroenterology2017，23，25： | 22 |
| 5 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 6 | Buried bumper syndrome:A complication of percutaneousendoscopic gastrostomy显示文摘Percutaneous endoscopic gastrostomy(PEG) is a widely used method of nutrition delivery for patients with longterm insufficiency of oral intake. The PEG complication rate varies from 0.4% to 22.5% of cases, with minor complications being three times more frequent. Buried bumper syndrome(BBS) is a severe complication of this method, in which the internal fixation device migrates alongside the tract of the stoma outside the stomach. Excessive compression of tissue between the external and internal fixation device of the gastrostomy tube is considered the main etiological factor leading to BBS. Incidence of BBS is estimated at around 1%(0.3%-2.4%). Inability to insert, loss of patency and leakage around the PEG tube are considered to be a typical symptomatic triad. Gastroscopy is indicated in all cases in which BBS is suspected. The depth of disc migration in relation to the lamina muscularis propria of the stomach is critical for further therapy and can be estimated by endoscopic or transabdominal ultrasound. BBS can be complicated by gastrointestinal bleeding, perforation, peritonitis, intra-abdominal and abdominal wall abscesses, or phlegmon, and these complications can lead to fatal outcomes. The most important preventive measure is adequate positioning of the external bolster. A conservative approach should be applied only in patients with high operative risk and dismal prognosis. Choice of the method of release is based on the type of the PEG set and depth of disc migration. A disc retained inside the stomach and completely covered by the overgrowing tissue can be released using some type of endoscopic dissection technique(needle knife, argon plasma coagulation, or papillotome through the cannula). Proper patient selection and dissection of the overgrowing tissue are the major determinants for successful endoscopic therapy. A disc localized out of the stomach(lamina muscularis propria) should be treated by a surgeon. | Jiri Cyrany Stanislav Rejchrt Marcela Kopacova Jan Bures | 2016 | World Journal of Gastroenterology2016，22，2： | 9 |
| 7 | 非木浆OQP漂白及其与CEH漂白的比较显示文摘进行了芦苇、麦草和蔗渣烧碱-蒽醌法纸浆OQP漂白的研究,并与常规的CEH漂白结果作了比较。研究结果表明,3种非木材纸浆经OQP和CEH流程漂白,白度均可达到80%ISO以上。与CEH漂白浆相比,OQP漂白浆的白度略低,但白度稳定性较好,粘度和强度较高,而且O段废液可送至碱回收系统进行回收,QP漂白废水的污染负荷比CEH漂白废水的污染负荷低得多。 | 詹怀宇 李兵云 李建军 Jiri Basta Lillemor Holtinger Christian Blom | 2003 | 中国造纸2003，22，10： | 9 |
| 8 | Prevalence and determinants of delayed gastric emptying in hospitalised Type 2 diabetic patients显示文摘AIM: To determine the prevalence of delayed gastric emptying (GE) in older patients with Type 2 diabetes mellitus. METHODS: One hundred and forty seven patients with Type 2 diabetes, of whom 140 had been hospitalised, mean age 62.3 ± 8.0 years, HbA1c 9.1% ± 1.9%, treated with either oral hypoglycemic drugs or insulin were studied. GE of a solid meal (scintigraphy), autonomic nerve function, upper gastrointestinal symptoms, acute and chronic glycemic control were evaluated. Gastric emptying results were compared to a control range of hospitalised patients who did not have diabetes. RESULTS: Gastric emptying was delayed (T50 > 85 min) in 17.7% patients. Mean gastric emptying was slower in females (T50 72.1 ± 72.1 min vs 56.9 ± 68.1 min, P = 0.02) and in those reporting nausea (112.3 ± 67.3 vs 62.7 ± 70.0 min, P < 0.01) and early satiety (114.0 ± 135.2 vs 61.1 ± 62.6 min, P = 0.02). There was no correlation between GE with age, body weight, duration of diabetes, neuropathy, current glycemia or the total score for upper gastrointestinal symptoms. CONCLUSION: Prolonged GE occurs in about 20% of hospitalised elderly patients with Type 2 diabetes when compared to hospitalised patients who do not have diabetes. Female gender, nausea and early satiety areassociated with higher probability of delayed GE. | Vladimir Kojecky Jaromir Bernatek Michael Horowitz Stanislav Zemek Jiri Bakala Ales Hep | 2008 | World Journal of Gastroenterology2008，14，10： | 8 |
| 9 | Technological advances in radiotherapy for esophageal cancer显示文摘Radiotherapy with concurrent chemotherapy and surgery represent the main treatment modalities in esophageal cancer.The goal of modern radiotherapy approaches,based on recent technological advances,is to minimize post-treatment complications by improving the gross tumor volume definition (positron emission tomography-based planning),reducing interfraction motion (image-guided radiotherapy) and intrafraction motion (respiratory-gated radiotherapy),and by better dose delivery to the precisely defined planning target volume (intensity-modulated radiotherapy and proton therapy).Reduction of radiotherapy-related toxicity is fundamental to the improvement of clinical results in esophageal cancer,although the dose escalation concept is controversial. | Milan Vosmik Jiri Petera Igor Sirak Miroslav Hodek Petr Paluska Jiri Dolezal Marcela Kopacova | 2010 | World Journal of Gastroenterology2010，16，44： | 8 |
| 10 | Comparative analysis of clinicopathological correlations of cyclooxygenase-2 expression in resectable pancreatic cancer显示文摘AIM:To perform a comparative analysis of clinicopathological correlations of cyclooxygenase2 (COX2) expression in pancreatic cancer, examined by monoclonal and polyclonal antibodies.METHODS: The COX2 expression in 85 resection specimens of pancreatic ductal adenocarcinoma was immunohistochemically examined using both monoclonal and polyclonal antibodies. The final immunoscores were obtained by multiplying the percentage of positive cells with the numeric score reflecting the staining intensity.COX2 expression levels were classified into three categories (0, 1+, and 2+) and the clinicopathological correlations were statistically evaluated and analyzed.RESULTS: The positive tumor expression rates of COX2 were 80.5% using monoclonal antibody and 69.4% using polyclonal antibody. In the KaplanMeier analysis, no significant correlations were found between levels of COX2 expression and overall survival (OS), but trends to longer OS were found in COX2 negative cases using monoclonal antibody. Significantly longer disease free survival was revealed in COX2 negative cases using monoclonal antibody (P = 0.019). No correlations between COX2 expression levels and grade (G), tumor (T) status and nodal (N) status were demonstrated. Low histological grade showed a strong association with a longer OS (P < 0.001). Correlation of survival and T status revealed a shorter OS in T3 tumors, but the results reached only marginal statistical significance (P = 0.070). In the multivariate Cox proportional hazards regression model, histological grade, T and N status remained valuable predictors of a worse survival with borderline significance for T [hazards ratio (HR) = 4.18 for G (if G = 3, P < 0.001); HR = 1.64 for T (if T = 3, P = 0.065); HR = 2.53 for N (if N = 1, P = 0.006)]. Higher grade, T or N status was associated with a worse OS. CONCLUSION: The immunohistochemically assessed level of COX2 expression does not seem to represent a valuable independent prognostic factor and is not superior to the conventional prognostic factors. | Marketa Hermanova Petr Karasek Jiri Tomasek Jiri Lenz Jiri Jarkovsky Petr Dite | 2010 | World Journal of Gastroenterology2010，16，15： | 7 |
| 11 | 不同基因型欧洲梨离体繁殖研究显示文摘试验用12个基因型欧洲梨茎尖作外植体,以MS作基本培养基进行高体繁殖试验。结果表明,不同基因型外植体增殖和形态分化显著不同。其中Koporeka仅经过28d便获得了5.6倍的增殖。生根培养14d后,生根率达88.65%,每植株生根2.86条。Vila连续培养60d,仅有少量的外植体形成了愈伤组织,无芽和根分化。参试的12个基因型,只有5个类型可以进行规模离体繁殖。 | 李昌珠 Sedlak Jiri Jan Blazek | 2002 | 果树学报2002，19，4： | 6 |
| 12 | Polycyclic aromatic hydrocarbon in rain and street runoff in Amman, Jordan显示文摘Concentrations of polycyclic aromatic hydrocarbons(PAHs) were determined in the rain and street runoff samples from two sites in the vicinity of Amman City during the pluvial period 1999—2000. The results showed that elevated levels of PAHs were detected in the city center(site 1) than the residential area(site 2) and that the levels were higher in street runoff than rain samples of the same sites. The highest concentration of PAHs in both street runoff and rain samples were observed in the first rainy month(November 1999) which indicated a wash out effect of PAHs originating from vehicular emission accumulated during the long dry summer season before sampling. Within the investigated cold winter seasons, fluctuations in PAHs concentration were observed. The variation was attributed to the fossil combustion for heating purposes and to intervals between rainfalls: as the longer the intervals between rains were, the higher the PAH concentration were. Removal of PAHs from the atmosphere through precipitation over the investigated period varied with time and places depending on the amount of rainfall where higher rainfall removed higher amount of PAHs from the atmosphere. The amount of PAHs washed out through precipitation was estimated to be around 14.8 mg/m 2 and 21.1 mg/m 2 for sites 1 and 2 respectively. | Anwar. G. Jiries Helmi. H. Hussein Jutta Lintelmann | 2003 | Journal of Environmental Sciences2003，15，6： | 6 |
| 13 | MODDE分析软件用于桉木硫酸盐法蒸煮的研究显示文摘使用MODDE实验设计与分析软件对桉木硫酸盐法蒸煮的主要影响因素进行了研究,蒸煮条件为:有效碱用量17%~23%,硫化度25%~45%,最高温度150~160℃,保温时间45~135min。实验结果显示:有效碱用量、硫化度、温度和时间对成浆性质都有明显影响;蒸煮所得浆料的各项性能很难同时达到最佳。使用MODDE对实验结果进行优化,当目标卡伯值范围在15~25时,最适宜的蒸煮条件为:有效碱用量20%,硫化度45%,最高温度151℃,保温时间99min;MODDE显示该条件下所得浆料的卡伯值、细浆得率、白度和黏度分别为16、48.5%、46.4%和1498mL/g。 | 郭三川 詹怀宇 Jiri Basta 付时雨 | 2007 | 中国造纸2007，26，4： | 6 |
| 14 | 麦草浆和桉木浆的性能及其对比显示文摘对比研究了麦草烧碱-蒽醌浆和桉木硫酸盐浆的性能。结果表明,纤维性能是决定浆料打浆性能和纸张性能的主要因素。与桉木浆相比,麦草浆极易打浆,经打浆后麦草浆各项强度指标的提升幅度较桉木浆小得多,原因是打浆过程中麦草纤维位错值的增大以及大量细小组分的产生。麦草浆中的细小组分不利于纤维间的结合,将细小组分筛分除去后,麦草浆的滤水性能得到明显改善,且纸张的机械及光学性能都有所提高。 | 郭三川 詹怀宇 张成峰 Anette Heijnesson-Hulten Jiri Basta Thomas Greschik | 2008 | 中国造纸2008，27，9： | 5 |
| 15 | Cellular and Molecular Requirements for Polar PIN Targeting and Transcytosis in Plants显示文摘极,大头针植物生长素流出搬运人的亚 cellular 本地化决定细胞间的植物生长素流动的方向,因此定义植物生长素发信号的空间方面。动态,大头针蛋白质的象 transcytosis 一样本地化响应外部、内部的信号发生,在植物生长素分发把这些信号集成到变化。这里,我们检验极的大头针交货和 transcytosis 的细胞、分子的机制。机制 ARFGEF 依赖的极的指向和 transcytosis 很好在调整植物开发在与他们的基本重要性一致的多样的 Arabidopsis 生态型之中被保存并且出现小变化。在细胞的水平,我们在顶端、基础的大头针指向在肌动朊细胞骨架的角色上精制以前的调查结果,并且为微导管识别一个以前未知的角色,明确地在基础指向。到房间的不同方面的大头针蛋白质交货被 ARF 依赖的 trafficking 与不同 ARFGEF 泡 trafficking 管理者的以前未知的复杂水平调停。我们的数据建议由这些不同小径的大头针蛋白质的其他的招募能响应不同信号说明类型特定的房间和极的指向的货物特定的方面,以及为极性变化。结果动态大头针放到房间的不同方面在植物纸巾以内定义植物生长素流动的一个三维的模式。 | Jurgen Kleine-Vehn tukasz tangowski Justyna Wisniewska Pankaj Dhonukshe Philip B Brewer Jiri Friml | 2008 | Molecular Plant2008，1，6： | 5 |
| 16 | Case of morphine-induced ventricular fi brillation显示文摘Morphine is considered as a traditional and safemedication to relieve pain and dyspnea in the setting of acutecoronary syndrome and cardiogenic pulmonary edema.[1,2]It is also attributed to dispose an antiarrhythmic effect.[3] Wereport a case of morphine-induced ventricular fi brillation inthe prehospital emergency treatment. The patient presentedacute myocardial infarction with ST segment elevationscomplicated with uncontrolled hypertension and cardiogenicpulmonary edema. | Roman Skulec Jitka Callerova Jiri Knor Petr Ostadal Petr Kmonicek Vladimir Cerny | 2017 | World Journal of Emergency Medicine2017，8，4： | 5 |
| 17 | Helicobacter pylori infection and other bacteria in pancreatic cancer and autoimmune pancreatitis显示文摘Helicobacter pylori(H.pylori)is an infectious agent influencing as much as 50%of the world’s population.It is the causative agent for several diseases,most especially gastric and duodenal peptic ulcer,gastric adenocarcinoma and mucosaassociated lymphoid tissue lymphoma of the stomach.A number of other,extragastric manifestations also are associated with H.pylori infection.These include neurological disorders,such as Alzheimer’s disease,demyelinating multiple sclerosis and Parkinson’s disease.There is also evidence for a relationship between H.pylori infection and such dermatological diseases as psoriasis and rosacea as well as a connection with infection and open-angle glaucoma.Generally little is known about the relationship between H.pylori infection and diseases of the pancreas.Most evidence about H.pylori and its potential role in the development of pancreatic diseases concerns pancreatic adenocarcinoma and autoimmune forms of chronic pancreatitis.There is data(albeit not fully consistent)indicating modestly increased pancreatic cancer risk in H.pylori-positive patients.The pathogenetic mechanism of this increase is not yet fully elucidated,but several theories have been proposed.Reduction of antral Dcells in H.pylori-positive patients causes a suppression of somatostatin secretion that,in turn,stimulates increased secretin secretion.That stimulates pancreatic growth and thus increases the risk of carcinogenesis.Alternatively,H.pylori,as a part of microbiome dysbiosis and the so-called oncobiome,is proven to be associated with pancreatic adenocarcinoma development via the promotion of cellular proliferation.The role of H.pylori in the inflammation characteristic of autoimmune pancreatitis seems to be explained by a mechanism of molecular mimicry among several proteins(mostly enzymes)of H.pylori and pancreatic tissue.Patients with autoimmune pancreatitis often show positivity for antibodies against H.pylori proteins.H.pylori,as a part of microbiome dysbiosis,also is viewed as a potential trigger of autoimmune inflammation of the pancreas.It is precisely these relationships(and associated equivocal conclusions)that constitute a center of attention among pancreatologists,immunologists and pathologists.In order to obtain clear and valid results,more studies on sufficiently large cohorts of patients are needed.The topic is itself sufficiently significant to draw the interest of clinicians and inspire further systematic research.Next-generation sequencing could play an important role in investigating the microbiome as a potential diagnostic and prognostic biomarker for pancreatic cancer. | Lumir Kunovsky Petr Dite Petr Jabandziev Jiri Dolina Jitka Vaculova Martin Blaho Martina Bojkova Jana Dvorackova Magdalena Uvirova Zdenek Kala Jan Trna | 2021 | World Journal of Gastrointestinal Oncology2021，13，8： | 5 |
| 18 | Osmotic Stress Modulates the Balance between Exocytosis and Clathrin-Mediated Endocytosis in Arabidopsis thaliana显示文摘植物的无柄的生活方式创造需要处理经常不利的环境,在水,可获得性能在一个每日的基础上变化,质问细胞的生理学和正直。处于渗透的条件的变化破坏血浆膜的平衡:hypoosmotic 条件 increaseand hyperosmotic 环境减少房间卷。这里,我们证明短期的细胞外的渗透的处理被移动仔细在根分裂组织房间处于在 endocytosis 和 exocytosis 之间的平衡跟随。尖锐 hyperosmotic 处理(离子并且 nonionic ) 同时提高调停 clathrin 的 endocytosis attenuating exocytosis,而 hypoosmotic 处理有相反的效果。除了到血浆膜的 clathrin 招募,早 endocytic trafficking 的部件在 hyperosmotic 压力回答期间是必要的。因而,在 clathrin 或早 endocytic 机械的元素有缺点的幼苗的生长对 hyperosmotic 处理更敏感。我们也发现对在环境的渗透的地位的一个变化的 endocytotic 反应在植物荷尔蒙的大概进化的更最近的规章的效果上是主导的,例如植物生长素。这些结果暗示那渗透的不安影响在通过调停 clathrin 的 endocytosis 行动的 endocytosis 和 exocytosis 之间的平衡。我们建议血浆膜上的那紧张在房间表面决定膜的增加或移动,因此保存房间正直。 | Marta Zwiewka Tomasz Nodzynski Stephanie Robert Steffen Vanneste Jiri Friml | 2015 | Molecular Plant2015，8，8： | 5 |
| 19 | Clinical outcomes of radiofrequency catheter ablation of atrial fibrillation in octogenarians lO-year experience of a one high-volume center显示文摘Background Prevalence of atrial fibrillation (AF) increases with age. Radiofrequency catheter ablation (RFCA) is an establishedtreatment option superior to antiarrhythmics (AAs). In this study, we investigated safety and efficacy of RFCA of AF in octogenarians.Methods From our database, we extracted procedural and follow-up data for patients 〉 80 years with symptomatic AF undergoing RFCAand compared this population to RFCA patients 〈 50 years. All patients underwent pulmonary vein isolation (PVI) supplemented by linearlesions in PVI-nonresponders. Arrhythmia-free survival was assessed using seven day Holter every three months post procedure. All patientscompleted their 12 months follow-up. Results Fifty patients aged ≥80 years (80.5 ± 1.6 years) were compared to 259 patients aged 〈 50years (43.5±5.5 years). The RFCA complication rate did not vary between groups. No differences in procedural characteristics were seenafter being analyzed by type of AF. Among patients with paroxysmal AF, 71.4% octogenarian vs. 84.7% young patients was free of anyarrhythmia, without AAs, after single procedure. For non-paroxysmal AF, arrhythmia-free survival without AAs, was considerably lower(58.6% octogenarians vs. 81.2% younger patients, P = 0.023). If AAs were used, arrhythmia-free survival for paroxysmal AF increased to90.5% and 92.1% in octogenarians and younger patients, respectively; and in non-paroxysmal AF it increased to 79.3% vs. 88.4%. ConclusionsRFCA is a safe and effective strategy to achieve normal sinus rhythm in a highly selected group of octogenarians. Paroxysmal AF ablation inoctogenarians has similar clinical effectiveness as that seen in much younger patients. Non-paroxysmal AF ablation has lower, but still rea-sonable clinical effectiveness. | Alan Bulava Jiri Hanis Ladislav Dusek | 2017 | Journal of Geriatric Cardiology2017，14，9： | 5 |
| 20 | Exploring the depths of the global earth observation system of systems显示文摘This paper explores for the first time the contents,structure and relationships across institutions and disciplines of a global Big Earth Data cyber-infrastructure:the Global Earth Observation System of System(GEOSS).The analysis builds on 1.8 million metadata records harvested in GEOSS.Because this set includes almost all the major large data collections in GEOSS,the analysis represents more than 80%of all the data made available through this global system.We explore two major aspects:the collaborative networks and the thematic coverage in GEOSS.The first connects the contributing organisations through the more than 200,000 keywords used in the systems,and then explores who is citing whom,a proxy for of institutional thickness.The thematic coverage is analysed through neural network algorithms,first on the keywords,and then on the corpus of 653 million lemmatised lower case words built from the titles and abstracts of all 1.8 million metadata records.The findings not only give a good overview of the GEOSS data universe,but offer immediate priorities on how to increase the usability of GEOSS through improved data management,and the opportunity to augment the metadata with high level concept that synthetise well the contents of the data-set. | Max Craglia Jiri Hradec Stefano Nativi Mattia Santoro | 2017 | Big Earth Data2017，1，1： | 5 |
您所在的机构暂未开通此部分的功能，请联系管理员