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| 1 | Comparative analysis of clinicopathological correlations of cyclooxygenase-2 expression in resectable pancreatic cancer显示文摘AIM:To perform a comparative analysis of clinicopathological correlations of cyclooxygenase2 (COX2) expression in pancreatic cancer, examined by monoclonal and polyclonal antibodies.METHODS: The COX2 expression in 85 resection specimens of pancreatic ductal adenocarcinoma was immunohistochemically examined using both monoclonal and polyclonal antibodies. The final immunoscores were obtained by multiplying the percentage of positive cells with the numeric score reflecting the staining intensity.COX2 expression levels were classified into three categories (0, 1+, and 2+) and the clinicopathological correlations were statistically evaluated and analyzed.RESULTS: The positive tumor expression rates of COX2 were 80.5% using monoclonal antibody and 69.4% using polyclonal antibody. In the KaplanMeier analysis, no significant correlations were found between levels of COX2 expression and overall survival (OS), but trends to longer OS were found in COX2 negative cases using monoclonal antibody. Significantly longer disease free survival was revealed in COX2 negative cases using monoclonal antibody (P = 0.019). No correlations between COX2 expression levels and grade (G), tumor (T) status and nodal (N) status were demonstrated. Low histological grade showed a strong association with a longer OS (P < 0.001). Correlation of survival and T status revealed a shorter OS in T3 tumors, but the results reached only marginal statistical significance (P = 0.070). In the multivariate Cox proportional hazards regression model, histological grade, T and N status remained valuable predictors of a worse survival with borderline significance for T [hazards ratio (HR) = 4.18 for G (if G = 3, P < 0.001); HR = 1.64 for T (if T = 3, P = 0.065); HR = 2.53 for N (if N = 1, P = 0.006)]. Higher grade, T or N status was associated with a worse OS. CONCLUSION: The immunohistochemically assessed level of COX2 expression does not seem to represent a valuable independent prognostic factor and is not superior to the conventional prognostic factors. | Marketa Hermanova Petr Karasek Jiri Tomasek Jiri Lenz Jiri Jarkovsky Petr Dite | 2010 | World Journal of Gastroenterology2010，16，15： | 7 |
| 2 | Helicobacter pylori infection and other bacteria in pancreatic cancer and autoimmune pancreatitis显示文摘Helicobacter pylori(H.pylori)is an infectious agent influencing as much as 50%of the world’s population.It is the causative agent for several diseases,most especially gastric and duodenal peptic ulcer,gastric adenocarcinoma and mucosaassociated lymphoid tissue lymphoma of the stomach.A number of other,extragastric manifestations also are associated with H.pylori infection.These include neurological disorders,such as Alzheimer’s disease,demyelinating multiple sclerosis and Parkinson’s disease.There is also evidence for a relationship between H.pylori infection and such dermatological diseases as psoriasis and rosacea as well as a connection with infection and open-angle glaucoma.Generally little is known about the relationship between H.pylori infection and diseases of the pancreas.Most evidence about H.pylori and its potential role in the development of pancreatic diseases concerns pancreatic adenocarcinoma and autoimmune forms of chronic pancreatitis.There is data(albeit not fully consistent)indicating modestly increased pancreatic cancer risk in H.pylori-positive patients.The pathogenetic mechanism of this increase is not yet fully elucidated,but several theories have been proposed.Reduction of antral Dcells in H.pylori-positive patients causes a suppression of somatostatin secretion that,in turn,stimulates increased secretin secretion.That stimulates pancreatic growth and thus increases the risk of carcinogenesis.Alternatively,H.pylori,as a part of microbiome dysbiosis and the so-called oncobiome,is proven to be associated with pancreatic adenocarcinoma development via the promotion of cellular proliferation.The role of H.pylori in the inflammation characteristic of autoimmune pancreatitis seems to be explained by a mechanism of molecular mimicry among several proteins(mostly enzymes)of H.pylori and pancreatic tissue.Patients with autoimmune pancreatitis often show positivity for antibodies against H.pylori proteins.H.pylori,as a part of microbiome dysbiosis,also is viewed as a potential trigger of autoimmune inflammation of the pancreas.It is precisely these relationships(and associated equivocal conclusions)that constitute a center of attention among pancreatologists,immunologists and pathologists.In order to obtain clear and valid results,more studies on sufficiently large cohorts of patients are needed.The topic is itself sufficiently significant to draw the interest of clinicians and inspire further systematic research.Next-generation sequencing could play an important role in investigating the microbiome as a potential diagnostic and prognostic biomarker for pancreatic cancer. | Lumir Kunovsky Petr Dite Petr Jabandziev Jiri Dolina Jitka Vaculova Martin Blaho Martina Bojkova Jana Dvorackova Magdalena Uvirova Zdenek Kala Jan Trna | 2021 | World Journal of Gastrointestinal Oncology2021，13，8： | 5 |
| 3 | One week esomeprazole-based triple therapy eradicatication Helicobacter pylori and heals patients with duodenal ulcer disease 显示文摘 | Zsolt T Puldrzej K Petr Dite | 2001 | Eur J Gastroenterol Hepatol2001，13，12： | 1 |
| 4 | Dietary habits of colorectal neoplasia patients in comparison to their first-degree relatives显示文摘AIM:To compare the dietary habits between colorectal neoplasia patients,their first-degree relatives,and unrelated controls.METHODS:From July 2008 to April 2011,we collected epidemiological data relevant to colorectal cancer from patients with colorectal neoplasias,their first-degree relatives,and also from a control group consisting of people referred for colonoscopy with a negative family history of colorectal cancer and without evidence of neoplasia after colonoscopic examination.The first-degree relatives were divided into two groups following the colonoscopic examination:(1)patients with neoplasia or(2)patients without neoplasia.Dietary habits of all groups were compared.Aχ2 test was used to assess the association between two dichotomous categorical variables.RESULTS:The study groups consisted of 242 patients with colorectal neoplasias(143 men,99 women;mean age:64±12 years)and 160 first-degree relatives(66men,94 women;mean age:48±11 years).Fifty-five of the first-degree relatives were found to have a neoplastic lesion upon colonoscopy,while the remaining105 were without neoplasia.The control group contained 123 individuals with a negative family history for neoplastic lesions(66 men,57 women;mean age:54±12 years).Two hypotheses were tested.In the first,the dietary habits of first-degree relatives with neoplasia were more similar to those of patients with neoplasia,while the dietary habits of first-degree relatives without neoplasia were similar to those of the control group.In the second,no sex-related differences in dietary habits were expected between the particular groups.Indeed,no significant differences were observed in the dietary habits between the groups of patients,controls and first-degree relatives with/without neoplastic lesions.Nevertheless,statistically significant sex-related differences were observed in all groups,wherein women had healthier dietary habits than men.CONCLUSION:In all groups examined,women had healthier dietary habits than men.Modification of screening guidelines according to sex may improve the efficiency of screening programs. | Ivana Mikoviny Kajzrlikova Petr Vitek Josef Chalupa Petr Dite | 2014 | World Journal of Gastroenterology2014，20，17： | 0 |
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