|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A unique sequence in the N-terminal regulatory region controls the nuclear localization of KLF8 by cooperating with the C-terminal zinc-fingers显示文摘Kr 眉 p 像像素的因素 8 (KLF8 ) 抄写因素在房间周期前进起一个关键作用, oncogenic 转变,对间充质的转变和侵略上皮。然而,它的原子本地化信号(NLS ) 没被识别。有另外的 KLF monopartite NLS (mNLS ) 和 C2H2 锌手指(ZF ) 的 KLF8 份额,哪个被显示了是为一些另外的 KLF 的 NLS。在这份报告,用指导 PCR 的 mutagenesis 和 immunofluorescent 显微镜学,我们显示出 mNLSs,任何单个 ZF 的删除,或变化的那混乱 Zn2+ 有约束力或联系 DNA 主题没影响 KLF8 的原子本地化。删除 > 然而,从 C 终点的 1.5 ZF 引起了 KLF8 的细胞质的累积。令人惊讶地,氨基酸(aa ) 的删除 151-200 区域几乎从原子核消除了 KLF8。有 PKC 禁止者的 S165A, K171E 或 K171R 变化,或处理导致了部分细胞质的累积。Co-immunoprecipitation 证明 KLF8 与 importin- 交往了,这个相互作用要求了 ZF 主题。aa 1-150 或 201-261 区域的删除独自没改变原子本地化。BrdU 加入和 cyclin D1 倡导者酶试金作为野类型的 KLF8 证明在原子本地化的 KLF8 异种有缺陷者不能支持 DNA 合成或 cyclin D1 倡导者激活。一起拿,这些结果建议 KLF8 有二 NLS,一包围 S165 和 K171 并且另外的是二双人脚踏车 ZF,它为 KLF8 原子本地化和它的细胞的功能的规定是批评的。 | Tina S Mehta Heng Lu Xianhui Wang Alison M Urvalek Kim-Hang H Nguyen Farah Monzur Jojo D Hammond Jameson Q Ma Jihe Zhao | 2009 | Cell Research2009，19，9： | 10 |
| 2 | 小麦TILLING突变体检测中基因组DNA提取方法的优化显示文摘为了优化小麦高通量TILLING突变体扫描所需基因组DNA提取的方法,对利用SDS法、改良SDS法、CTAB法、改良CTAB法、AxyPrep DNA提取试剂盒、Qiagen DNeasy Plant Mini Kit试剂盒以及再生Qiagen硅胶柱方法提取的小麦基因组DNA进行了系统比较。结果表明,尽管7种方法所提取DNA的纯度及琼脂糖凝胶电泳检测结果均良好,但再生Qiagen硅胶柱方法、CTAB法和改良SDS法的DNA浓度显著高于其他方法。根据小麦细胞分裂素氧化酶基因1(TaCKX1)的DNA序列设计引物,以新鲜DNA样品用于PCR扩增大于1 000bp的片段时,后4种方法扩增效果优于前3种方法;DNA在-20℃下保存100d后重新进行PCR扩增时,则只有Qiagen试剂盒和再生Qiagen硅胶柱2种方法提取的DNA能扩增出大于1 000bp的片段。采用本实验室与新西兰坎特伯雷大学合作建立的再生硅胶柱与自配提取液提取小麦基因组DNA,既保证了DNA的高质量,又降低了使用试剂盒的成本,为小麦TILLING库的构建及其他相关试验提供了一种经济有效的DNA提取方法。 | 徐艳 徐继法 陈磊 赵吉强 FU Zeyu JAMESON Paula E 宋建成 | 2017 | 麦类作物学报2017，37，2： | 8 |
| 3 | Effects of selenomethionine on acute toxicities from concurrent chemoradiation for inoperable stage Ⅲ nonsmall cell lung cancer显示文摘AIM: To prospectively determine the safety and tolerability of oral L-selenomethionine(SLM) with concurrent chemoradiation(CCRT) for Stage Ⅲ non-small cell lung cancer(NSCLC) and estimate if the incidence and/or severity of adverse events could be reduced by its use.METHODS: Sixteen patients with stage Ⅲ NSCLC were accrued to this single arm, phase Ⅱ study. CCRT consisted of radiation given at 2 Gy per fraction for 30-33 fractions, 5 d per week with concurrent weekly Ⅳ paclitaxel 50 mg/m2 followed by carboplatin dosed at an area under the time-concentration curve of 2. SLM was dosed in a loading phase at 4800 μg twice daily for one week prior to CCRT followed by once daily dosing during treatment. RESULTS: No selenium-related toxicity was observed. Analysis revealed grade 3 or higher esophagitis in 3 of 16 patients(19%), pneumonitis in 0, leukopenia in 2(12.5%), and anemia in 1(6%); the latter two were significantly reduced when compared to the protocolstated expected rate of 35%(P = 0.045 for leukopenia, and P < 0.01 for anemia). Median overall survival was 14.9 mo and median failure-free survival was 9 mo(95%CI: 3.3-21.5).CONCLUSION: There may be some protective benefit of selenium in the setting of CCRT for inoperable NSCLC. The data suggests decreased rates of myelosuppression when compared to similarly-treated historical and contemporary controls. Further evaluation of selenium in this setting may be warranted. | Michael Mix Nithya Ramnath Jorge Gomez Charles de Groot Saju Rajan Shiva Dibaj Wei Tan Youcef Rustum Michael B Jameson Anurag K Singh | 2015 | World Journal of Clinical Oncology2015，6，5： | 4 |
| 4 | A striking local esophageal cytokine expression profile in eosinophilic esophagitis显示文摘 | Carine Blanchard Emily M. Stucke Beatriz Rodriguez-Jimenez Karen Burwinkel Margaret H. Collins Annette Ahrens Eileen S. Alexander Bridget K. Buckmeier Butz Sean C. Jameson Ajay Kaul James P. Franciosi Jonathan P. Kushner Philip E. Putnam J. Pablo Abonia M | 2010 | The Journal of Allergy and Clinical Immunology2010，，1： | 3 |
| 5 | Automatic adaptive grid refine ment for the euler equations 显示文摘 | Berger M Jameson A | 1985 | AIAA J1985，23，： | 2 |
| 6 | Gastric Electrical Stimulation Improves Outcomes of Patients With Gastroparesis for up to 10 Years显示文摘 | Richard W. McCallum Zhiyue Lin Jameson Forster Katherine Roeser Qingjiang Hou Irene Sarosiek | 2011 | Clinical Gastroenterology and Hepatology2011，，4： | 2 |
| 7 | Absence of the interstitial cells of Cajal in patients with gastroparesis and correlation with clinical findings显示文摘 | Jameson Forster Ivan Damjanov Zhiyue Lin Irene Sarosiek Paul Wetzel Richard W. McCallum | 2005 | Journal of Gastrointestinal Surgery2005，，1： | 2 |
| 8 | Numerical uncertainty management in user and student modeling: an overview of systems and issues显示文摘 | Anthony Jameson | 1996 | User Modeling and User-Adapted Interaction1996，5，： | 2 |
| 9 | New directions in flotation machine design显示文摘 | Graeme J. Jameson | 2010 | Minerals Engineering2010，，11： | 2 |
| 10 | Mobilization of lead from the skeleton during the postnatal period is large than during pregnaney显示文摘 | Gulson BL Mahaffey KR Jameson CW | 1998 | J Lab Cclin Med1998，131，4： | 1 |
| 11 | 显示文摘 | Goebel Dan M Watkins Ron M Jameson Kristina K | 2007 | Propul Power2007，23，3： | 1 |
| 12 | The antigenic index: a novel algo- rithm for predicting antigenic determinants显示文摘 | Jameson B A Wolf H | 1988 | Cornput Ap- plBiosci1988，4，1： | 1 |
| 13 | The antigenic index:a novel algorithmfor predicting antigenic determinants显示文摘 | Jameson B A Wolf H | 1988 | Comput Appl Biosci1988，4，1： | 1 |
| 14 | Estradiol increases proliferation and down-regulates the sodium/iodide symporter gene in FRTL-5 cells显示文摘 | Furlanetto T W Nguyen L Q Jameson J L | 1999 | Endocrinology1999，140，12： | 1 |
| 15 | Patient and implant survival following 4323 total hip replacements for acute fem- oral neck fracture: a retrospective cohort study using Na- tional Joint Registry data显示文摘 | Jameson SS Kyle J Baker PN | 2012 | J Bone Joint Surg Br2012，94，： | 1 |
| 16 | Lower-upper symmetric-Gauss- seidel method for the Euler and Navier-Stokes equations 显示文摘 | YOON S JAMESON A | 1988 | AIAAJournal1988，26，9： | 1 |
| 17 | Endocardial pacemak- ers in children: lead length and allowance for growth 显示文摘 | O'Sullivan J J Jameson S Gold RG | 1993 | Pa cing Clin Electrophysiol1993，16，2： | 1 |
| 18 | Auxin in a seaweed extract:identification and quantitation of indole-3-acetic acid by gas chromatography-mass spectrometry显示文摘 | Sanderson K J Jameson P E Zabkiewicz J A | 1987 | Journal of Plant Physiology1987，129，34： | 1 |
| 19 | The antigenic index: a novel algorithm for predicing antigenic determinants显示文摘 | JAMESON B A WOLF H | 1988 | Comput Appl Biosci1988，4，1： | 1 |
| 20 | Postmodemism, or the Cultural Logic of Late Capitalism 显示文摘 | Jameson Fredric | 1984 | New Left Review1984，，146： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员