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| 1 | p16 promoter hypermethylation:A useful serum marker for early detection of gastric cancer显示文摘AIM: To determine p16 promoter hypermethylation in gastric tumoral tissue and serum samples, its impact on p16-protein expression, and correlation with clinical and histological features. METHODS: Samples were obtained from 52 histologically confirmed cases of gastric adenocarcinoma. Gastric tissue and serum of 50 age- and sex-matched individuals with normal gastroscopy and biopsy were obtained as control samples. Methylation-specific polymerase chain reaction (MSP) was used to evaluate methylation status of p16 promoter. p16-protein expression was analyzed by immunohistochemical staining on paraffin-embedded sections. RESULTS: Methylation was detected in 44.2% (23/52) of tumoral tissues. 60.9% of them were also methylated in serum, i.e., 26.9% of all patients (14/52). Methylation was not detected in tissue and sera of control samples. p16-protein expression was decreased in 61.5% of cases (32/52), and was significantly associated with promoter hypermethylation (P < 0.001). Methylation was significantly more frequent in higher pathological grades (P < 0.05). Methylation was not associated with other clinicopathological features and environmental factors including H pylori infection and smoking. CONCLUSION: p16 promoter hypermethylation is an important event in gastric carcinogenesis. It is the principle mechanism of p16 gene silencing. It is related to malignant tumor behavior. Detection of DNA methylation in serum may be a biomarker for early detection of gastric cancer. | Mohammad Reza Abbaszadegan Omeed Moaven Hamid Reza Sima Kamran Ghafarzadegan Azadeh A'rabi Mohammad Naser Forghani Hamid Reza Raziee Ali Mashhadinejad Mostafa Jafarzadeh Ehsan Esmaili-Shandiz Ezzat Dadkhah | 2008 | World Journal of Gastroenterology2008，14，13： | 50 |
| 2 | Expression of cell adhesion molecule CD44 in gastric adenocarcinoma and its prognostic importance显示文摘AIM: To evaluate the relation of cluster of differentiation 44 (CD44) expression with clinicopathological features of gastric adenocarcinoma, and also its effect on prognosis with an emphasis on the differences between intestinal and diffuse types. METHODS: From 2000 to 2006, 100 patients with gastric adenocarcinoma, who had undergone total or subtotal gastrectomy without any prior treatment, were studied. Haematoxylin & eosin (HE) staining was used for histological evaluation, including the type (Lauren's classifi cation) and grading of the tumor. The expression of CD44 in the gastric adenocarcinoma mucosa and the adjacent mucosa were determined by immunohistochemistry. The survival analysis was obtained using the Kaplan-Meier test. RESULTS: Of 100 patients, 74 (74%) patients were male. The tumors were categorized as intestinal type (78%) or diffuse type (22%). Sixty-five percent of patients were CD44-positive. CD44 expression was not detected in normal gastric mucosa. Rather, CD44 was more commonly expressed in the intestinal subtype (P = 0.002). A signifi cant relation was seen between the grade of tumor and the expression of CD44 (P = 0.014). The survival analysis showed a poor prognosis of patients with CD44-positive tumors (P = 0.008); and this was more prominent in the intestinal (P = 0.001) rather than diffuse type. CONCLUSION: Cell adhesion molecule CD44 is highly expressed in gastric adenocarcinoma. CD44 expression is correlated with a poor prognosis in patients with the intestinal type of gastric adenocarcinoma. CD44 can, therefore, be utilized as a prognostic marker for this group of patients. | Kamran Ghaffarzadehgan Mostafa Jafarzadeh Hamid Reza Raziee Hamid Reza Sima Ehsan Esmaili-Shandiz Hanieh Hosseinnezhad Ali Taghizadeh Kermani Omeed Moaven Maryam Bahrani | 2008 | World Journal of Gastroenterology2008，14，41： | 18 |
| 3 | On the role of topographic ampli fi cation in seismic slope instabilities显示文摘Surface wave generation due to body wave propagation near ground surface has been discussed in the literature.This phenomenon,typically occurring in topographic changing areas,along with its interaction with body waves(SV),decreases precision of formulas for evaluation of slope displacement.This signi fi cant fact caused the researchers not only to investigate the combined surface and SV waves motion pattern,but also to consider its effect on structures built on the slopes.In order to reveal the phenomenon,several fi nite element numerical studies have been performed by ABAQUS programme.Besides,two physical model slopes simulating the landslide occurrence have been constructed and tested by shaking table device.The results of induced and calculated accelerations obtained by two approaches have been compared and Rayleigh wave generation has been proved.Furthermore,the slope displacements have been calculated by various empirical methods and the results were compared with numerical ones.The results proved that in order to increase the precision of empirical formulas for displacement prediction,surface wave effect should be taken into account.Finally,a concept of'effective depth of sur fi cial ampli fi cation'is introduced and its effect on dynamic slope stability is analysed. | Fardin Jafarzadeh Mohammad Mahdi Shahrabi Hadi Farahi Jahromi | 2015 | Journal of Rock Mechanics and Geotechnical Engineering2015，7，2： | 3 |
| 4 | Supramolecular synthesis of 3,4-dihydropyrimidine-2(1H)-one/thiones under neat conditions显示文摘有效溶剂为各种各样的 3,4-dihydropyrimidin-2 (1H ) 的合成的免费方法在把 sulfonated -cyclodextrine 用作 recyclable 催化剂的优秀收益的 -one/thiones 被描述。Sulfonated -cyclodextrine 被发现有效,异构的催化剂和显示出的率改进,高收益和短反应在这转变预定的 recyclable。 | Sekineh Asghari Mahmood Tajbakhsh Behnam Jafarzadeh Kenari Samad Khaksar | 2011 | Chinese Chemical Letters2011，22，2： | 3 |
| 5 | An optimized preparation of bismaleimide–diamine co‐polymer matrices显示文摘 | Coswald S. Sipaut Vejayakumaran Padavettan Ismail Ab. Rahman Rachel F. Mansa Jedol Dayou Mohammad Jafarzadeh | 2014 | Technol2014，，6： | 1 |
| 6 | Serum levels of high - sen- sitivity C -reactive protein (hs -CRP)in Helicobacter pylori -infected peptic ulcer patients and its association with bacterial CagA virulence factor显示文摘 | Jafarzadeh A Hassanshahi GH Nemati M | 2009 | Dig Dis Sci2009，54，12： | 1 |
| 7 | The flow simulation of a low-specific-speed high-speed centrifugal pump 显示文摘 | Jafarzadeh B Hajari A Alishahi M M | 2011 | Applied Mathematical Modelling2011，35，1： | 1 |
| 8 | Cimetidine enhances delayed-type hypersensitivity responses and serum interleukin (IL)-2, -10, -12, and IL-17 levels after burn injury in an animal model显示文摘 | Jafarzadeh A Nemati M Rezayati M T Ebrahimi M Hassan Z M | 2013 | J Immunotoxicol2013，10，： | 1 |
| 9 | Opium addiction decreases T3 uptake amount显示文摘 | Shahsavar F Ghanadi K Jafarzadeh M | 2013 | Life Sci J2013，10，5： | 1 |
| 10 | Low dose revaccination in- duces robust protective anti-HBs antibody response in the majority of healthy non-responder neonates 显示文摘 | Jafarzadeh A Zarei S Shokri F | 2008 | Vaccine2008，26，2： | 1 |
| 11 | The Flow Simulation of a Low Specific Speed High Speed Centrifugal Pump 显示文摘 | Jafarzadeh B | 2010 | Elsevier Applied Mathematical Mod- elling2010，，： | 1 |
| 12 | Cracked tooth syndrome: charac-teristics and distribution among adults in a Nigerian teachinghospital显示文摘 | Udoye Cl Jafarzadeh H | 2009 | J Endod2009，35，3： | 1 |
| 13 | Morphological characterization of AA5083-H321 aluminum alloy corrosion in NaC1 solution under hydro- dynamic conditions, Anti-Corros显示文摘 | JAFARZADEH K SHAHRABI T HADAVI S M M | 2009 | Methods Mater2009，56，： | 1 |
| 14 | Cracked tooth syndrome : characteristics and distribution among adults in a Nigerian teaching hospital显示文摘 | Udoye CI Jafarzadeh H | 2009 | J Endod2009，35，3： | 1 |
| 15 | The C-shaped root canal configuration: a review 显示文摘 | Jafarzadeh H Wu YN | 2007 | J Endod2007，33，5： | 1 |
| 16 | Cracked tooth syndrome:characteristics and distribution among adults in a Nigerian teaching hospital显示文摘 | Udoye CI Jafarzadeh H | 2009 | J Endod2009，35，3： | 1 |
| 17 | Cracked tooth syndrome: character- istics and distribution among adults in a Nigerianteaching hospital显示文摘 | Udoye CI Jafarzadeh H | 2009 | J Endod2009，35，3： | 1 |
| 18 | The properties of a new endodontic material显示文摘 | Asgary S Shahabi S Jafarzadeh T | 2008 | J Endod2008，34，8： | 1 |
| 19 | Square root unscented kalman filters for state estimation of induction motor drives显示文摘 | JAFARZADEH S LASCU C FADALI M S | 2013 | IEEE Transactions on Industry Applications2013，49，1： | 1 |
| 20 | Association of the CagA status of Helicobacter pylori and ser- um levels of interleukin (IL)-17 and IL-2a in duodenal ulcer patients显示文摘 | JAFARZADEH A MIRZAEE V AHMAD-BEYGI H | 2009 | J Dig Dis2009，10，2： | 1 |
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