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| 1 | p16 promoter hypermethylation:A useful serum marker for early detection of gastric cancer显示文摘AIM: To determine p16 promoter hypermethylation in gastric tumoral tissue and serum samples, its impact on p16-protein expression, and correlation with clinical and histological features. METHODS: Samples were obtained from 52 histologically confirmed cases of gastric adenocarcinoma. Gastric tissue and serum of 50 age- and sex-matched individuals with normal gastroscopy and biopsy were obtained as control samples. Methylation-specific polymerase chain reaction (MSP) was used to evaluate methylation status of p16 promoter. p16-protein expression was analyzed by immunohistochemical staining on paraffin-embedded sections. RESULTS: Methylation was detected in 44.2% (23/52) of tumoral tissues. 60.9% of them were also methylated in serum, i.e., 26.9% of all patients (14/52). Methylation was not detected in tissue and sera of control samples. p16-protein expression was decreased in 61.5% of cases (32/52), and was significantly associated with promoter hypermethylation (P < 0.001). Methylation was significantly more frequent in higher pathological grades (P < 0.05). Methylation was not associated with other clinicopathological features and environmental factors including H pylori infection and smoking. CONCLUSION: p16 promoter hypermethylation is an important event in gastric carcinogenesis. It is the principle mechanism of p16 gene silencing. It is related to malignant tumor behavior. Detection of DNA methylation in serum may be a biomarker for early detection of gastric cancer. | Mohammad Reza Abbaszadegan Omeed Moaven Hamid Reza Sima Kamran Ghafarzadegan Azadeh A'rabi Mohammad Naser Forghani Hamid Reza Raziee Ali Mashhadinejad Mostafa Jafarzadeh Ehsan Esmaili-Shandiz Ezzat Dadkhah | 2008 | World Journal of Gastroenterology2008，14，13： | 50 |
| 2 | Serum levels of high - sen- sitivity C -reactive protein (hs -CRP)in Helicobacter pylori -infected peptic ulcer patients and its association with bacterial CagA virulence factor显示文摘 | Jafarzadeh A Hassanshahi GH Nemati M | 2009 | Dig Dis Sci2009，54，12： | 1 |
| 3 | The flow simulation of a low-specific-speed high-speed centrifugal pump 显示文摘 | Jafarzadeh B Hajari A Alishahi M M | 2011 | Applied Mathematical Modelling2011，35，1： | 1 |
| 4 | Cimetidine enhances delayed-type hypersensitivity responses and serum interleukin (IL)-2, -10, -12, and IL-17 levels after burn injury in an animal model显示文摘 | Jafarzadeh A Nemati M Rezayati M T Ebrahimi M Hassan Z M | 2013 | J Immunotoxicol2013，10，： | 1 |
| 5 | Low dose revaccination in- duces robust protective anti-HBs antibody response in the majority of healthy non-responder neonates 显示文摘 | Jafarzadeh A Zarei S Shokri F | 2008 | Vaccine2008，26，2： | 1 |
| 6 | Association of the CagA status of Helicobacter pylori and ser- um levels of interleukin (IL)-17 and IL-2a in duodenal ulcer patients显示文摘 | JAFARZADEH A MIRZAEE V AHMAD-BEYGI H | 2009 | J Dig Dis2009，10，2： | 1 |
| 7 | Asso- ciation of exon 9 but not intron 8 VDR polymorphisms with oc- cult HBV infection in south-eastem Iranian patients 显示文摘 | Arababadi M K Pourfathollah A A Jafarzadeh A | 2010 | J Gas- troenterol Hepatd2010，25，1： | 1 |
| 8 | Synthesis of organofunctionalized nanosilica via a co-condensation modification using g-aminopropyltriethoxysilane (APTES) 显示文摘 | Rahman I A Jafarzadeh M Sipaut C S | 2009 | Ceramics International2009，35，5： | 1 |
| 9 | The antibody response to HBs antigen is regulated by coontinated Th1 and Th2 cytokine production in healthy neonates显示文摘 | Jafarzadeh A Shokri F | 2003 | Clin Exp Immunol2003，131，3： | 1 |
| 10 | Expression of IP-10 chemokine is regulated by pro-inflammatory cytokines in cultured hepatocytes显示文摘 | Hassanshahi G Jafarzadeh A Chorashi Z | | 0，，03： | 1 |
| 11 | Acute phase proteins in the diagnosis of bovine subclinical mastitis 显示文摘 | Safi S Khoshvaghti A Jafarzadeh S R | 2009 | Veterinary Clinical Pathology2009，38，： | 1 |
| 12 | The flow simulation of a low-specic-speed high-speed centrifugal pump显示文摘 | Jafarzadeh B Hajari A Alishahi M M | 2011 | Applied Mathematical Modelling2011，，35： | 1 |
| 13 | On simple Kn -groups for n = 5, 6 显示文摘 | JAFARZADEH A IRANMANESH A | 2007 | London Mathematical Society Lecture Note Series2007，，： | 1 |
| 14 | The flow simulation of a low-specific-speed high-speed centrifugal pump显示文摘 | Jafarzadeh B Hajari A Alishahi M M | 2011 | Applied Mathematical Modelling2011，35，： | 1 |
| 15 | The antibody response to HBs antigen is regulated by coordinated Thl amd Th2 cytokine production in healthy nenates显示文摘 | Jafarzadeh A Shokri F | | 0，，03： | 1 |
| 16 | The flow simulation of a low-specific-speed high-speed centrifugal pump显示文摘 | Jafarzadeh B Hajari A Alishahi M M | 2011 | Applied Mathematical Modelling2011，35，1： | 1 |
| 17 | Taurodontism:A review of the condition and endodontic treatment challenges显示文摘 | Jafarzadeh H Azarpazhooh A Mayhall JT | | 0，，05： | 1 |
| 18 | Oxytocin im- proves proliferation and neural differentiation of adipose tis- sue-derived stem cells 显示文摘 | Jafarzadeh N Javeri A Khaleghi M | 2014 | Neurosci Lett2014，3，564： | 1 |
| 19 | An assessment of the variation in soil properties within and between landform in the Amol region, Iran 显示文摘 | Momtaz H R Jafarzadeh A A Torabi H | 2009 | Geoderma2009，102，1： | 1 |
| 20 | Synthesis of organo-functionalized nanosilica via a co-condensation modification using y-aminopropyltriethoxysilane (APTES)显示文摘 | Rahman I A Jafarzadeh M Sipaut C S | 2009 | Ceramics Interna- tional2009，35，5： | 1 |
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