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| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | Heterotopic pancreatic tissue in the gastric cardia: A case report and literature review显示文摘The heterotopic pancreas, which is usually described as an untypical presence of pancreatic tissue without any anatomic or vascular continuity with the pancreas, is relatively rare. Clinical manifestations may include bleeding, inflammation, pain and obstruction; however, in most cases it remains silent and is diagnosed during autopsy. Here, we report a case of ectopic pancreatic lesion located in the gastric cardia. The patient was a 73-year-old woman who had a history(over four months) of chronic epigastric pain accompanied by heartburn. Esophagogastroduodenoscopy revealed inflammatory changes throughout the stomach and lower esophagus, as well as a flat polypoid mass with benign features located in the gastric cardia, approx. 10 mm below the 'Z' line, measuring approx. 7 mm in diameter. Endoscopic biopsy forceps were used to remove the lesion. Histological examination of the lesion revealed the presence of heterotopic pancreatic tissue in the gastric mucosa. On the basis of the presented case, we suggest that pancreatic ectopia should be a part of differential diagnosis, not only when dealing with submucosal gastric lesions, but also with those that are small, flat and/or untypically located. | Rafa? Filip Ewa Walczak Jacek Huk Rados?aw P Radzki Marek Bieńko | 2014 | World Journal of Gastroenterology2014，20，44： | 12 |
| 3 | Treatment of Fourteen Chronic Active HBSAg^+ ,HBeAg^+ Hepatitis Patients with Low Dose Nature Human Interferon Alpha Administered Orally 显示文摘 | Wladyslawa Z Jacek P Anna K | 1993 | Arch lmmunol Ther Exp1993，41，： | 1 |
| 4 | Effects of soil compaction on root elongation and anatomy of different cereal plant species显示文摘 | Jerzy L Rainer H Jacek P | 2012 | Soil & Tillage Research2012，121，： | 1 |
| 5 | Depletion of annexin A5, annexin A6, and collagen X causes no gross changes in matrix vesicle–mediated mineralization, but lack of collagen X affects hematopoiesis and the Th1/Th2 response显示文摘 | Ivan Grskovic Anna Kutsch Christian Frie Gergely Groma Jacek Stermann Ursula Schl?tzer‐Schrehardt Anja Niehoff Stephen E Moss Sabrina Rosenbaum Ernst P?schl Markus Chmielewski Gunter Rappl Hinrich Abken John F Bateman Kathryn SE Cheah Mats Paulsson Bent B | 2012 | J Bone Miner Res2012，，11： | 1 |
| 6 | On-line preconcentration techniques in determination of melatonln and its preeursors/metabolites using micellar electrokinetic chromatography 显示文摘 | Jacek M Ewa P Marek T | 2006 | J ChromatogrA2006，1104，12： | 1 |
| 7 | Economics of exhaust air heat recovery systems for mine ventilation显示文摘 | Hugo D S Kostas F Jacek P | 2012 | Reclamation and Environment2012，26，3： | 1 |
| 8 | Sampling and analysis of volatile organic compounds in bovine breath by solid-phase microextraction and gas chromatography-mass spectrometry显示文摘 | JARETT P SPINHIRNE JACEK A | 2003 | Journal of Chromatography A2003，，： | 1 |
| 9 | Automated diagnostics of analog systems using fuzzy logic approach显示文摘 | BILSKI P JACEK M W | 2007 | IEEE Transactions on Instrumention and Measurement2007，56，6： | 1 |
| 10 | Two-and three-dimensional cadmium-organic frameworks with trimesic acid and 4,4′-trimethylenedipyridine显示文摘 | Filipe A Almeida P Jacek K | 2004 | Inorg Chem2004，43，： | 1 |
| 11 | Directionality and coordination of dehydration and ring formation during biosynthesis of the lantibiotic nisin 显示文摘 | Lubelski Jacek Khusainov Rustem and Kuipers Oscar P | 2009 | Journal of Biological Chemistry2009，284，25： | 1 |
| 12 | Continuous veno-venous hemodiafiltration in children after cardiac surgery显示文摘 | Anna Jander Marcin Tkaczyk Izabela P?gowska-Klimek Witold Pietrzykowski Jacek Moll Wojciech Krajewski Micha? Nowicki | 2007 | European Journal of Cardio-Thoracic Surgery2007，，6： | 1 |
| 13 | P-glycoprotein activity predicts outcome in childhood acute lymphoblastic leukemia 显示文摘 | Jacek B Ewa B Amma P | 2009 | J Pediatr Hematol Oncol2009，31，7： | 1 |
| 14 | Porous carbon material containing CaO for acidic gas capture : Preparation and properties 显示文摘 | Jacek P Adam C Robert P | 2013 | J Hazard Mat2013，263，： | 1 |
| 15 | Filtered particle tracking in isotropic turbulence and stochastic modeling of subgrid-scale dispersion 显示文摘 | Jacek P Sourabh V A | 2009 | International Journal of Multiphase Flow2009，35，2： | 1 |
| 16 | Isolation and properties of Aspergillus niger IBT-90 xylanase for bakery显示文摘 | Irena R Jacek P Slanislaw B | 2006 | Appl Microbiol Biotechnol2006，69，： | 1 |
| 17 | New polymorphism of ENFP1 (PC - 1) is associated with increased risk of type 2 diabetes among obese individuals显示文摘 | Jacek B Grzegorz P Krzysztof W | 2006 | Diabetes2006，55，9： | 1 |
| 18 | Identification of a silver hydroxymethyl radical in Ag - NaA zeolite using electron spin echo envelope modulation spectroscopy显示文摘 | ANDREVANDER P JACEK MICHALIK EDUARD REIJERSE | 1996 | J Phys Chem1996，100，9： | 1 |
| 19 | Diversity flfpmperties among cataases 显示文摘 | Jacek S Loewen P C | 2002 | Archivers of biochemistry and biophysiscs2002，401，： | 1 |
| 20 | Diversity of properties among catalases 显示文摘 | JACEK US LOEWEN P C | 2002 | Ar- chivers of Biochemistry and Biophysiscs2002，401，： | 1 |
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