|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Morinda citrifolia (Noni): A literature review and recent advances in Noni research^1显示文摘Morinda citrifolia L(Noni) has been used in folk remedies by Polynesians for over 2000 years,and is reported to have a broad range of therapeutic effects,including antibacterial,antiviral,antifungal,antitumor,antihelmin,analgesic,hypotensive,anti-inflammatory,and immune enhancing effects.In order to reveal the nutritional and medicinal value of the Noni plant,and to summarize scientific evidence that supports the Polynesians' claim,a literature review and recent advances in Noni research is given below. | Brett J WEST CJarakae JENSEN Diane NOWICKI SU Chen Afa K PALU Gary ANDERSON | 2002 | Acta Pharmacologica Sinica2002，23，12： | 80 |
| 2 | MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells显示文摘 | Godlewski J Nowicki MO Bronisz A Nuovo G Palatini J De Lay M Van Brocklyn J Ostrowskl MC Chlocca EA Lawler SE. | 2010 | 中国神经肿瘤杂志2010，8，1： | 37 |
| 3 | Caspase-12 mediates carbon tetrachloride-induced hepatocyte apoptosis in mice显示文摘AIM:To investigate the role of caspase-12 and its downstream targets in carbon tetrachloride(CCl4)-induced hepatocyte apoptosis.METHODS:The role of caspase-12 was determined by using caspase-12 knock-out(-/-)mice.CCl4(300μL/kg body weight)or vehicle(corn oil)was administered to caspase-12+/+or caspase-12-/-mice as a single intraperitoneal injection.The animals were sacrificed24 h after the CCl4 treatment.Blood was collected to evaluate liver function by the measurement of the activity of alanine aminotransferase.Liver samples were used for the measurements of reactive oxygen species using plasma malondialdehyde as biomarker,hepatocyte apoptosis was evaluated via terminal transferasemediated d UTP nick-end labeling and controlled by morphologic study,and cytochrome C release and caspase activations were measured by Western blotting.RESULTS:Administration of a low dose of CCl4resulted in hepatocyte apoptosis and acute liver injury in wild-type mice.CCl4 also induced the generation of reactive oxygen species and induction of endoplasmic reticulum stress in the liver followed by activations of caspase-12,-9 and-3 as well as release of small amounts of cytochrome C.However,in the CCl4-treated caspase-12-/-mice,activation of caspase-9 and-3 were significantly attenuated(P<0.05);no effect was seen in cytochrome C release.CCl4-induced apoptosis and liver damage was markedly reduced in caspase-12-/-mice compared to caspase-12+/+mice(P<0.05).The active form of caspase-8 was not detected in either caspase-12+/+or caspase-12-/-mice.There was no significant different in the formation of reactive oxygen species in the livers of caspase-12+/+and caspase-12-/-mice treated with CCl4.CONCLUSION:Caspase-12 plays a pivotal role in CCl4-induced hepatic apoptosis through the activation of the downstream effector caspase-3 directly and/or indirectly via capase-9 activation. | Hua Liu Zhe Wang Michael J Nowicki | 2014 | World Journal of Gastroenterology2014，20，48： | 18 |
| 4 | Cirrhosis complicating Shwachman-Diamond syndrome: A case report显示文摘BACKGROUND The features of Shwachman-Diamond syndrome (SDS) include exocrine pancreatic insufficiency, skeletal abnormalities and bone marrow dysfunction;an often overlooked feature is hepatic involvement. CASE SUMMARY We report a child who initially presented with failure to thrive and mildly elevated transaminase levels and was determined to have pancreatic insufficiency due to SDS. During follow-up he had persistently elevated transaminase levels and developed hepatosplenomegaly. An investigation was performed to determine the etiology of ongoing liver injury, including a liver biopsy which revealed hepatic cirrhosis. CONCLUSION Cirrhosis has rarely been reported with SDS. While many of the hepatic disorders associated with SDS improve with age, there are rare exceptions with serious implications for long-term outcome. | Sandra M Camacho Lucille McLoughlin Michael J Nowicki | 2019 | World Journal of Clinical Cases2019，7，12： | 2 |
| 5 | On combining neuro-fuzzy architectures with the rough set theory to solve classification problems with incomplete data显示文摘 | Nowicki R | 2008 | IEEE Transactions on Knowledge and Data Engineering2008，20，9： | 1 |
| 6 | Targeting of the BMI-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal显示文摘 | Godlewski J Nowicki MO Bronisz A | 2008 | Cancer Res2008，68，22： | 1 |
| 7 | A Fast Tabu Search Algorithm for the Job Shop Problem显示文摘 | Eugeniusz Nowicki Czeslaw Smutnicki | 1996 | Management Science1996，42，6： | 1 |
| 8 | The permutation flow shop with buffers: a tabu search approach 显示文摘 | NOWICKI E | 1999 | European Journal of Operational Research1999，116，1： | 1 |
| 9 | Surgical managementof secondary tricuspid valve regurgitation:annulus,commissure,orleaflet procedure?显示文摘 | Navia JL Nowicki ER Blackstone EH | 2010 | J Thorac Cardiovasc Surg2010，139，6： | 1 |
| 10 | Multiple percutaneous coronary stent implantation due to myocardial bridging--a case report显示文摘 | Derkacz A Nowicki P Protasiewicz M | 2007 | Kardiol Pol2007，65，6： | 1 |
| 11 | Liver protective effects ofMorinda citrifolia (Noni)显示文摘 | WANG MY NOWICKI D ANDERSON G | 2008 | Plant Foods Hum Nutr2008，63，2： | 1 |
| 12 | A fast taboo search algorithm for the Job shop problem显示文摘 | NOWICKI E SMUTNICKI C | 1996 | Management Science1996，42，6： | 1 |
| 13 | n fast taboo search algorithm for the job shop problem显示文摘 | NOWICKI E SMUTNICKI C | 1996 | Management Science1996，42，6： | 1 |
| 14 | A fast taboo search algorithm for the job shop problem显示文摘 | Nowicki E Smutnicki C | 1996 | Management Science1996，42，： | 1 |
| 15 | Supra- molecular shuttle and protective agent: a multiple role of methylated cyclodextrins in the chemoselective hydrogena- tion of benzene derivatives with ruthenium nanoparticles 显示文摘 | Audrey Nowicki Yong Zhang Bastien Leger | 2006 | Chemical Communications2006，，3： | 1 |
| 16 | Retention of the Fu- sarium mycotoxin deoxynivalenol in wheat during processing and cooking of spaghetti and noodles 显示文摘 | Nowicki T W Gaba D G Dexter J E | 1988 | Journal of Cereal Science1988，8，2： | 1 |
| 17 | An Advanced Tabu Scarch Algorithm for the Job Shop Problem 显示文摘 | Nowicki E Smutnicki C | 2005 | Journal of Scheduling2005，8，2： | 1 |
| 18 | 显示文摘 | Gorak | 1988 | Chemie-Ingenieur -Technik1988，60，7： | 1 |
| 19 | Positive affect fa- cilitates creative problem solving显示文摘 | Isen A M Daubman K A Nowicki G P | 1987 | Jmmud d Personality and Social Psychology1987，52，： | 1 |
| 20 | Liver protective effects of Morinda citrifolia(Noni)显示文摘 | WANG M Y NOWICKI D ANDERSON G | 2008 | Plant Foods Hum Nutr2008，63，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员