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| 1 | Late Palaeogene emplacement and late Neogene-Quaternary exhumation of the Kuril island-arc root (Kunashir island) constrained by multi-method thermochronometry显示文摘The Kuril islands constitute a volcanic island arc-trench system,stretching from eastern Hokkaido(Japan)to Kamchatka(Russia) along the northwestern Pacific subduction system.The current arc consists of several volcanic islands mainly with Neogene basement and capped by several,predominantly andesitic,active subduction stratovolcanoes.Kunashir Island is the southwestern-most island of the arc,just off the Hokkaido coast and represents the study area in this paper.The island is composed of a Lower Complex of mainly late Miocene to Pliocene volcanic rocks,covered by an Upper Complex of younger(basaltic)andesitic lava flows and tuffs on which currently four active volcanic edifices are built.In the Lower Complex sub-volcanic and deeper-seated intrusives of the so-called Prasolov and Dokuchaev magmatic complexes are found.More differentiated,tonalitic-granodioritic rocks were collected from these small intrusive bodies.An early Oligocene zircon LA-ICP-MS U/Pb age of 31 Ma for the Prasolov Complex was obtained,showing that the basement of Kunashir Island is older than previously thought.Thermochronometry(apatite fission-track and U-Th-Sm/He and zircon U-Th/He analyses) further shows that the magmatic basement of the island was rapidly exhumed in the Pleistocene to present levels in a differential pattern,with He-ages ranging from 1.9 to 0.8 Ma.It is shown that the northern section of the island was hereby exhumed more intensely. | J.De Grave F.I.Zhimulev S.Glorie G.V.Kuznetsov N.Evans F.Vanhaecke B.McInnes | 2016 | Geoscience Frontiers2016，7，2： | 2 |
| 2 | Interleukin‐33: a novel mediator with a role in distinct disease pathologies显示文摘 | M.Kurowska‐Stolarska A.Hueber B.Stolarski I. B.McInnes | 2010 | Journal of Internal Medicine2010，，1： | 1 |
| 3 | IL‐35 is a novel cytokine with therapeutic effects against collagen‐induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells显示文摘 | WandaNiedbala Xiao‐qingWei BeileiCai Axel?JHueber Bernard?P.Leung Iain?B.McInnes Foo?Y.Liew | 2007 | Eur J Immunol2007，，11： | 1 |
| 4 | The nuclear cytokine IL-37a controls lethal cytokine storms primarily via IL-1R8-independent transcriptional upregulation of PPARγ显示文摘Cytokine storms are crucial in the development of various inflammatory diseases,including sepsis and autoimmune disorders.The immunosuppressive cytokine INTERLEUKIN(IL)-37 consists of five isoforms(IL-37a-e).We identified IL-37a as a nuclear cytokine for the first time.Compared to IL-37b,IL-37a demonstrated greater efficacy in protecting against Toll-like receptor-induced cytokine hypersecretion and lethal endotoxic shock.The full-length(FL)form of IL-37a and the N-terminal fragment,which is processed by elastase,could translocate into cell nuclei through a distinctive nuclear localization sequence(NLS)/importin nuclear transport pathway.These forms exerted their regulatory effects independent of the IL-1R8 receptor by transcriptionally upregulating the nuclear receptor peroxisome proliferator-activated receptor(PPARγ).This process involved the recruitment of the H3K4 methyltransferase complex WDR5/MLL4/C/EBPβand H3K4me1/2 to the enhancer/promoter of Pparg.The receptor-independent regulatory pathway of the nuclear IL-37a–PPARγaxis and receptor-dependent signaling by secreted IL-37a maintain homeostasis and are potential therapeutic targets for various inflammatory diseases,including sepsis. | Rongfei Wei Xiao Han Mengyuan Li Yuan Ji Lianfeng Zhang Maria-Ioanna Christodoulou Najwa Jameel Hameed Aga Caiyan Zhang Ran Gao Jiangning Liu Jinrong Fu Guoping Lu Xiaojun Xiao Xiaoyu Liu Ping-Chang Yang Iain B.McInnes Ying Sun Peisong Gao Chuan Qin Shau-Ku Huang Yufeng Zhou Damo Xu | 2023 | Cellular & Molecular Immunology2023，20，12： | 0 |
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