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| 1 | Influence of South China Sea SST and the ENSO on Winter Rainfall over South China显示文摘The present study investigates the influence of South China Sea (SCS) SST and ENSO on winter (January-February-March; JFM) rainfall over South China and its dynamic processes by using station observations for the period 1951-2003, Met Office Hadley Center SST data for the period 1900-2008, and ERA-40 reanalysis data for the period 1958-2002. It is found that JFM rainfall over South China has a sig- nificant correlation with Nio-3 and SCS SST. Analyses show that in El Nio or positive SCS SST anomaly years, southwesterly anomalies at 700 hPa dominate over the South China Sea, which in turn transports more moisture into South China and favors increased rainfall. A partial regression analysis indicates that the independent ENSO influence on winter rainfall occurs mainly over South China, whereas SCS SST has a larger independent influence on winter rainfall in northern part of South China. The temperature over South China shows an obvious decrease at 300 hPa and an increase near the surface, with the former induced by Nio-3 and the latter SCS SST anomalies. This enhances the convective instability and weakens the potential vorticity (PV), which explains the strengthening of ascending motion and the increase of JFM rainfall over South China. | 周连童 Chi-Yung TAM 周文 Johnny C. L. CHAN | 2010 | Advances in Atmospheric Sciences2010，27，4： | 34 |
| 2 | Interannual and Interdecadal Variability of Winter Precipitation over China in Relation to Global Sea Level Pressure Anomalies显示文摘Based on the method of rotated principal component (RPC) analysis and wavelet transforms, the win-ter precipitation from 36 stations over China for the period 1881-1993 is examined. The results show thatthe three leading space-time modes correspond, in sequence, to winter rainfall anomalies over the reaches ofthe Yangtze River, the bend of the Yellow River, and the northeastern region of China. The three modes ex-hibit interannual oscillations with quasi-biennial and 8-year periods as well as interdecadal oscillationswith 16- and 32-year periods. The interannual oscillation (< 10 years) occurs in phase over the differentareas, and its maximum amplitude migrates northward considerably with prominent interdecadal variations.However, the interdecadal oscillations (10-32 years) are out of phase over the different regions, and theamplitude variations have the characteristics of stationary waves.The rainfall anomalies appear to be closely re lated to the anti-phase changes of mean sea-level pres-sure (SLP) over the Asian mainland and the North Pacific. When the SLP rises over the North Pacific anddecreases over the Asian mainland, the precipitation over East China increases noticeably. The linkage be-tween the rainfall over China and the SLP anomalies apparently results from the strength of the East Asianwinter monsoon and its associated temperature and moisture advection. | Jianjun Xu Johnny C.L Chan | 2002 | Advances in Atmospheric Sciences2002，19，5： | 15 |
| 3 | Mesoscale Vortex Generation and Merging Process: A Case Study Associated with a Post-Landfall Tropical Depression显示文摘An observational analysis of satellite blackbody temperature (TBB) data and radar images suggests that the mesoscale vortex generation and merging process appeared to be essential for a tropical-depression-related heavy rain event in Shanghai, China. A numerical simulation reproduced the observed mesoscale vortex generation and merging process and the corresponding rain pattern, and then the model outputs were used to study the related dynamics through diagnosing the potential vorticity (PV) equation. The tropical depression (TD) was found to weaken first at lower levels and then at upper levels due to negative horizontal PV advection and diabatic heating effects. The meso-vortices developed gradually, also from the lower to the upper levels, as a result of positive horizontal PV advection and diabatic heating effects in the downshear left quadrant of the TD. One of these newly-generated vortices, V1, replaced the TD ultimately, while the other two, V2 and V3, merged due to the horizontal PV advection process. Together with the redevelopment of V1, the merging of V2 and V3 triggered the very heavy rain in Shanghai. | 喻自凤 梁旭东 余晖 Johnny C. L. CHAN | 2010 | Advances in Atmospheric Sciences2010，27，2： | 7 |
| 4 | The Effect of Three-Dimensional Variational Data Assimilation of QuikSCAT Data on the Numerical Simulation of Typhoon Track and Intensity显示文摘In this paper, the three-dimensional variational data assimilation scheme (3DVAR) in the mesoscale model version 5 (MM5) of the US Pennsylvania State University/National Center for Atmospheric Research is used to study the effect of assimilating the sea-wind data from QuikSCAT on the prediction of typhoon track and intensity. The case of Typhoon Dujuan (2003) is first tested and the results show appreciable improvements. Twelve other cases in 2003 are then evaluated. The assimilation of the QuikSCAT data produces significant impacts on the structure of Dujuan in terms of the horizontal and vertical winds, sealevel pressure and temperature at the initial time. With the assimilation, the 24-h (48-h) track prediction of 11 (10) out of the 12 typhoons is improved. The 24-h (48-h) prediction of typhoon intensity is also improved in 10 (9) of the 12 cases. These experiments therefore demonstrate that assimilation of the QuikSCAT sea-wind data can increase the accuracy of typhoon track and intensity predictions through modification of the initial fields associated with the typhoon. | 曾智华 端义宏 梁旭东 马雷鸣 Johnny Chung-leung CHAN 陈仲良 | 2005 | Advances in Atmospheric Sciences2005，22，4： | 5 |
| 5 | Health Emergency and Disaster Risk Management (Health-EDRM):Developing the Research Field within the Sendai Framework Paradigm显示文摘The intersection of health and disaster risk reduction(DRR) has emerged in recent years as a field of critical inquiry.Health is recognized as an outcome and a goal of DRR,and the integration of both fields is essential to ensure the implementation of the Sendai Framework for Disaster Risk Reduction 2015–2030.Health Emergency and Disaster Risk Management(Health-EDRM) has emerged as an umbrella field that encompasses emergency and disaster medicine,DRR,humanitarian response,community health resilience,and health systems resilience.In September 2016,an international group of experts met in Hong Kong to assess the current status and potential of the Health-EDRM research field,a research area that these scholars characterized as underdeveloped and fragmented.Key challenges identified include research overlap,lack ofstrategic research agenda,absence of consensus regarding terminology,and limited coordination between stakeholders.The Sendai Framework provides a useful paradigm within which to shape the research field's strategic development.The WHO Thematic Platform for Health-EDRM Research Group was established to coordinate activities,promote information-sharing,develop partnerships,and provide technical advice to strengthen the Health-EDRM research field.This group will promote the generation of robust and scientific health research to support the meaningful implementation of the Sendai Framework. | Sharon Tsoon Ting Lo Emily Ying Yang Chan Gloria Kwong Wai Chan Virginia Murray Jonathan Abrahams Ali Ardalan Ryoma Kayano Johnny Chung Wai Yau | 2017 | International Journal of Disaster Risk Science2017，8，2： | 3 |
| 6 | The East Asian summer monsoon: an overview显示文摘 | Ding Yihui Johnny C. L. Chan | 2005 | Meteorology and Atmospheric Physics (-)2005，，1： | 2 |
| 7 | Oncogene GAEC1 regulates CAPN10 expression which predicts survival in esophageal squamous cell carcinoma显示文摘AIM: To identify the downstream regulated genes of GAEC1 oncogene in esophageal squamous cell carcinoma and their clinicopathological significance. METHODS: The anti-proliferative effect of knocking down the expression of GAEC1 oncogene was stud-ied by using the RNA interference (RNAi) approach through transfecting the GAEC1 -overexpressed esophageal carcinoma cell line KYSE150 with the pSilencer vector cloned with a GAEC1 -targeted sequence, followed by MTS cell proliferation assay and cell cycle analysis using flow cytometry. RNA was then extracted from the parental, pSilencer-GAEC1 -targeted sequence transfected and pSilencer negative control vector transfected KYSE150 cells for further analysis of different patterns in gene expression. Genes differentially expressed with suppressed GAEC1 expression were then determined using Human Genome U133 Plus 2.0 cDNA microarray analysis by comparing with the parental cells and normalized with the pSilencer negative control vector transfected cells. The most prominently regulated genes were then studied by immunohistochemical staining using tissue microarrays to determine their clinicopathological correlations in esophageal squamous cell carcinoma by statistical analyses. RESULTS: The RNAi approach of knocking down gene expression showed the effective suppression of GAEC1 expression in esophageal squamous cell carcinoma cell line KYSE150 that resulted in the inhibition of cell proliferation and increase of apoptotic population. cDNA microarray analysis for identifying differentially expressed genes detected the greatest levels of downregulation of calpain 10 (CAPN10 ) and upregulation of trinucleotide repeat containing 6C (TNRC6C ) transcripts when GAEC1 expression was suppressed. At the tissue level, the high level expression of calpain 10 protein was significantly associated with longer patient survival (month) of esophageal squamous cell carcinoma compared to the patients with low level of calpain 10 expression (37.73 ± 16.33 vs 12.62 ± 12.44, P = 0.032). No significant correction was observed among the TNRC6C protein expression level and the clinocopathologcial features of esophageal squamous cell carcinoma. CONCLUSION: GAEC1 regulates the expression of CAPN10 and TNRC6C downstream. Calpain 10 expression is a potential prognostic marker in patients with esophageal squamous cell carcinoma. | Dessy Chan Miriam Yuen-Tung Tsoi Christina Di Liu SauHing Chan Simon Ying-Kit Law Kwok-Wah Chan Yuen-Piu Chan Vinod Gopalan Alfred King-Yin Lam Johnny Cheuk-On Tang | 2013 | World Journal of Gastroenterology2013，19，18： | 2 |
| 8 | Interannual and interdecadal variations of tropical cyclone activity over the western North Pacific显示文摘 | JOHNNY C L CHAN | 2005 | Meteorol Atmos Phys2005，89，： | 1 |
| 9 | Decadal variations of intense typhoon occurrence in the Western Northe Pacific 显示文摘 | Johnny C L Chan | 2009 | The Royal Society2009，，465： | 1 |
| 10 | Global warming and Western North Pacific typhoon activity from an observational perspective显示文摘 | CHAN JOHNNY C L LIU K S | 2004 | J Climate2004，17，23： | 1 |
| 11 | The east Asian summer monsoon:an overview显示文摘 | DING Y H JOHNNY C L CHAN | 2005 | Meteorol Atmos Phys2005，89，： | 1 |
| 12 | Interdecadal unstationary relationship between NAO and east China’s summer precipitation patterns显示文摘 | Gu Wei Li Chongyin Li Weijing Zhou Wen L. Chan Johnny C | 2009 | Geophysical Research Letters2009，，13： | 1 |
| 13 | Interannual and interdecadal variations of tropical cyclone activity over the western North Pacific显示文摘 | Johnny C. L. Chan | 2005 | Meteorology and Atmospheric Physics (-)2005，，1： | 1 |
| 14 | Numerical study on the development of asymmetric convection and vertical wind shear during tropical cyclone landfall显示文摘 | Yubin Li Kevin K. W. Cheung Johnny C. L. Chan | 2014 | 2014 (683)2014，，683： | 1 |
| 15 | Hepatocellular carcinoma masquerading as a bleeding gastric ulcer: A case report and a review of the surgical management显示文摘Hepatocellular Carcinoma (HCC) is a common malignancyworldwide. While bleeding from the gastrointestinal tract(BGIT) has a well known association with HCC, suchcases are mainly due to gastric and esophageal varices.BGIT as a result of invasion of the gastrointestinal tractby HCC is extremely rare and is reportedly associatedwith very poor prognosis. We describe a 67-year-oldmale who presented with BGIT. Endoscopy showed thesite of bleeding to be from a gastric ulcer, but endoscopictherapy failed to control the bleeding and emergencysurgery was required. At surgery, the ulcer was found tohave arisen from direct invasion of the gastrointestinaltract by HCC of the left lobe. Control of the bleedingwas achieved by surgical resection of the HCC en-bloc with the lesser curve of the stomach. The patientremains alive 33 mo after surgery. Direct invasion of thegastrointestinal tract by HCC giving rise to BGIT is veryuncommon. Surgical resection may offer significantlybetter survival over non-surgical therapy, especially if thepatient is a good surgical candidate and has adequatefunctional liver reserves. Prognosis is not uniformly grave. | Johnny CA Ong Pierce KH Chow Weng-Hoong Chan Alex YF Chung Choon Hua Thng Wai-Keong Wong | 2007 | World Journal of Gastroenterology2007，13，33： | 1 |
| 16 | Internal boundary layer structure under sea-breeze conditions in Hong Kong显示文摘 | LIU He-ping JOHNNY C L CHAN A ct al | 2001 | Atmospheric Environment2001，，： | 1 |
| 17 | Regional and Synoptic-scale Features Associated with Inactive Periods of the Summer Monsoon over South China显示文摘RegionalandSynoptic-scaleFeaturesAsociatedwithInactivePeriodsoftheSummerMonsoonoverSouthChina①C.H.SoandJohnnyC.L.ChanDepartme... | This research is supported by the Research Grants Council of the University Grants Committee of Hong Kong Grant 9040074. C. H. So and Johnny C. L. Chan Department of Physics and Materials Science, City University of Hong Kong | 1997 | Advances in Atmospheric Sciences1997，14，2： | 1 |
| 18 | Frequency of typhoon landfall over Guangdong province of China during the period 1470-1931 显示文摘 | Johnny C L Chan Jiu-en Shi | 2000 | International Journal of Climatology2000，20，： | 1 |
| 19 | A novel crosstalk isolation structure for bulk CMOS power IC's显示文摘 | Chan Wilson W T Sin Johnny K O Wong S Simon | 1998 | IEEE Trans on Electron Devices1998，45，7： | 1 |
| 20 | The East Asian summer monsoon: an overview显示文摘 | Ding Yihui Johnny C. L. Chan | 2005 | Meteorology and Atmospheric Physics (-)2005，，1： | 1 |
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