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| 1 | Pathogenesis and management issues for non-alcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease (NAFLD) has, although it is a very common disorder, only relatively recently gained broader interest among physicians and scientists. Fatty liver has been documented in up to 10 to 15 percent of normal individuals and 70 to 80 percent of obese individuals. Although the pathophysiology of NAFLD is still subject to intensive research, several players and mechanisms have been suggested based on the substantial evidence. Excessive hepatocyte triglyceride accumulation resulting from insulin resistance is the first step in the proposed 'two hit' model of the pathogenesis of NAFLD. Oxidative stress resulting from mitochondrial fatty acids oxidation, NF-κB-dependent inflammatory cytokine expression and adipocytokines are all considered to be the potential factors causing second hits which lead to hepatocyte injury, inflammation and fibrosis. Although it was initially believed that NAFLD is a completely benign disorder, histologic follow-up studies have showed that fibrosis progression occurs in about a third of patients. A small number of patients with NAFLD eventually ends up with end-stage liver disease and even hepatocellular carcinoma. Although liver biopsy is currently the only way to confirm the NAFLD diagnosis and distinguish between fatty liver alone and NASH, no guidelines or firm recommendations can still be made as for when and in whom it is necessary. Increased physical activity, gradual weight reduction and in selected cases bariatric surgery remain the mainstay of NAFLD therapy. Studies with pharmacologic agents are showing promising results, but available data are still insufficient to make specific recommendations; their use therefore remains highly individual. | Marko Duvnjak Ivan Leroti Neven Bari Vedran Tomai Lucija Virovi Juki Vedran Velagi | 2007 | World Journal of Gastroenterology2007，13，34： | 74 |
| 2 | Role of Ki-67 as a prognostic factor in gastrointestinal stromal tumors显示文摘AIM:To investigate primarily the prognostic value of Ki-67,as well as other parameters,in gastrointestinal stromal tumors(GISTs).METHODS:Ki-67,c-KIT,platelet-derived growth factor receptor-alpha(PDGFRα),smooth muscle actin(SMA),CD34,S100 were stained for immunohistochemistry which was performed on formalin-fixed,paraffinembeded sections on representative block from each case.Proliferation index counted by Ki-67 antibody was calculated as a number of positive nuclear reaction over 100 cells.Immunoreactivity for c-KIT and PDGFRα was evaluated semiquantitatively(weak,intermediate,strong) and for c-KIT type of reactivity was analyzed(cytoplasmic,membrane and 'dot-like' staining).Immunoreactivity for SMA,CD34 and S100 were was evaluated as positive or negative antigen expression.Pathologic parameters investigated in this study included tumor size,cell type(pure spindle,pured epitheloid mixed spindle and epitheloid),mitotic count,hemorrhage,necrosis,mucosal ulceration.Clinical data included age,gender,primary tumor location and spread of disease.χ 2 test and Student's t-test were used for comparisons of baseline characteristics.The Cox's proportional hazard model was used for univariable and multivariable analyses.Survival rates were calculated by Kaplan-Meier method and statistical significance was determined by the log-rank test.RESULTS:According to the stage of disease,there were 36 patients with localized disease,29 patients with initially localized disease but with its recurrence in the period of follow up,and finally,35 patients had metastatic disease from the very beginning of disease.Tumor originated most commonly in the stomach(41%),small intestine was the second most common location(36%).The mean size of primary tumors was 6.5 cm.The mean duration of follow-up was 60 mo.Multiple parameters were analyzed for their effect on overall survival,but no one reached statistical significance(P = 0.06).Analysis of time to progression/relapse in initially localized disease(univariate analysis),tumor size,mitotic count,Ki-67 and type of d-KIT distribution(cytoplasmic vs membrane/'dot-like') showed statistically significant correlation.In multivariate analysis in the group of patients with localized disease,there were only 2 parameters that have impact on relapse,Ki-67 and SMA(P < 0.0001 and P < 0.034,respectively).Furthermore,Ki-67 was analyzed in localized diseasevs localized with recurrence and metastatic disease.It was shown that there is a strict difference between these 2 groups of patients(median value was 2.5 for localized disease vs 10.0 for recurrent/metastatic disease,P < 0.0001).It was also shown that the cut-off value which is still statistically significant in terms of relapse on the level of 6%.The curves for survival on that cut-off level are significantly different(P < 0.04,Cox F).CONCLUSION:Ki-67 presents a significant prognostic factor for GIST recurrence which could be of great importance in evaluating malignant potential of disease. | Borislav Belev Iva Bri Juraj Prejac Zrna Antunac Golubi Damir Vrbanec Jadranka Bozikov Ivan Aleri Marko Boban Jasminka Jaki Razumovi | 2013 | World Journal of Gastroenterology2013，19，4： | 14 |
| 3 | Acute necrotizing pancreatitis as fi rst manifestation of primary hyperparathyroidism显示文摘We report the case of a female patient with severe acute necrotizing pancreatitis associated with hypercalcemia as first manifestation of primary hyperparathyroidism caused by a benign parathyroid adenoma.Initially the acute pancreatitis was treated conservatively.The patient subsequently underwent surgical resection of the parathyroid adenoma and surgical clearance of a large infected pancreatic pseudocyst.Although the association of parathyroid adenoma-induced hypercalcemia and acute pancreatitis is a known medical entity,it is very uncommon.The pathophysiology of hypercalcemia-induced acute pancreatitis is therefore not well known,although some mechanisms have been proposed.It is important to treat the provoking factor.Therefore,the cause of hypercalcemia should be identif ied early.Surgical resection of the parathyroid adenoma is the ultimate therapy. | Jeroen I Lenz Jimmy M Jacobs Bart Op de Beeck Ivan A Huyghe Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，23： | 9 |
| 4 | Overview and developments in noninvasive diagnosis of nonalcoholic fatty liver disease显示文摘High prevalence of non-alcoholic fatty liver disease (NAFLD) and very diverse outcomes that are related to disease form and severity at presentation have made the search for noninvasive diagnostic tools in NAFLD one of the areas with most intense development in hepatology today.Various methods have been investigated in the recent years,including imaging methods like ultrasound and magnetic resonance imaging,different forms of liver stiffness measurement,various biomarkers of necroinflammatory processes (acute phase reactants,cytokines,markers of apoptosis),hyaluronic acid and other biomarkers of liver fibrosis.Multicomponent tests,scoring systems and diagnostic panels were also developed with the purposes of differentiating non-alcoholic steatohepatitis from simple steatosis or discriminating between various fibrosis stages.In all of the cases,performance of noninvasive methods was compared with liver biopsy,which is still considered to be a gold standard in diagnosis,but is by itself far from a perfect comparative measure.We present here the overview of the published data on various noninvasive diagnostic tools,some of which appear to be very promising,and we address as well some of still unresolved issues in this interesting field. | Neven Bari Ivan Leroti Lea Smiri-Duvnjak Vedran Tomai Marko Duvnjak | 2012 | World Journal of Gastroenterology2012，18，30： | 7 |
| 5 | Genetic polymorphisms in non-alcoholic fatty liver disease:Clues to pathogenesis and disease progression显示文摘The spectrum of non-alcoholic fatty liver disease(NAFLD) ranges from simple steatosis through steatohepatitis to advanced f ibrosis and cirrhosis.Although the reason why only a minority of patients develop progressive forms of disease still remains largely unclear,recent research has identified genetic factors as a possible basis for this variation in disease presentation.Most of the studies have been focused on f inding associations between advanced disease forms and selected single nucleotide polymorphisms in genes encoding various proteins involved in disease pathogenesis.Although there are many limitations regarding the study design and interpretation of published data,further carefully planned studies together with implementation of new genetic technologies will likely bring new insights into disease pathogenesis and potential benefits to the management of patients with NAFLD. | Marko Duvnjak Neven Bari Vedran Tomai Ivan Leroti | 2009 | World Journal of Gastroenterology2009，15，48： | 4 |
| 6 | Fate and Transport of Antibiotic Residues and Antibiotic Resistance Genes following Land Application of Manure Waste显示文摘 | Chee-Sanford Joanne C Mackie Roderick I Koike Satoshi Krapac Ivan G Lin Yu-Feng Yannarell Anthony C Maxwell Scott Aminov Rustam I | 2009 | Journal of Environmental Quality2009，，3： | 3 |
| 7 | Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner显示文摘遇到 hypoxic 应力的房间由 downregulating 保存资源和精力蛋白质合成。这里我们 demonstratethat 在这回答的一机制是最高的 mRNAs 的翻译压抑编码 translationalapparatus 的部件。规定的这个模式包含 TSC 和 Rheb,当 Rheb 的 TSC1 或 TSC2 或 overexpression 的大美人在剥夺氧的房间救了最高的 mRNA 翻译。导致压力的翻译 repressionof 这些 mRNAs 密切与 4E-BP 的 hypophosphorylated 状态相关,一个翻译抑压者。然而, seriesof 4E-BP loss-of-function 和 gain-of-function 实验在氧或生长因素剥夺下面反驳在 phosphorylation statusof 4E-BP 和最高的 mRNAs 的翻译压抑之间的一种 cause-and-effect 关系。而且,血缺氧的 repressiveeffect 类似于由 Torin 1,而是更多 pronouncedthan 猛禽或 rictor 大美人由 mTOR 活动的有效抑制到达了那。同样,猛禽或 rictor 的缺乏它温和地 downregulated TOPmRNAs 的基础翻译效率,没能压制最高的 mRNAs 的调停氧的翻译激活。最后, TIA-1 和 TIAR co 击倒,二 RNA 有约束力的蛋白质以前在氨基的酸饥饿的房间在最高的 mRNAs 的翻译压抑含有, failedto 在另外的压力条件下面减轻最高的 mRNA 翻译。因此,近似翻译管理者 ofTOP mRNAs 的性质留下逃犯。 | Rachel Miloslavski Elad Cohen Adam Avraham Yifat I luz Zvi Hayouka Judith Kasir Rajini Mudhasani Stephen N. Jones Nadine Cybulski Markus A. Ruegg Ola Larsson Valentina Gandin Arjuna Rajakumar Ivan Topisirovic Oded Meyuhas | 2014 | Journal of Molecular Cell Biology2014，8，3： | 3 |
| 8 | Biliary leakage after urgent cholecystectomy: Optimization of endoscopic treatment显示文摘AIM: To investigate the results of endoscopic treatment of postoperative biliary leakage occurring after urgent cholecystectomy with a long-term follow-up.METHODS: This is an observational database study conducted in a tertiary care center. All consecutive patients who underwent endoscopic retrograde cholangiography(ERC) for presumed postoperative biliary leakage after urgent cholecystectomy in the period between April 2008 and April 2013 were considered for this study. Patients with bile duct transection and biliary strictures were excluded. Biliary leakage was suspected in the case of bile appearance from either percutaneous drainage of abdominal collection or abdominal drain placed at the time of cholecystectomy. Procedural and main clinical characteristics of all consecutive patients with postoperative biliary leakage after urgent cholecystectomy, such as indication for cholecystectomy, etiology and type of leakage, ERC findings and post-ERC complications, were collected from our electronic database. All patients in whom the leakage was successfully treated endoscopically were followed-up after they were discharged from the hospital and the main clinical characteristics, laboratory data and common bile duct diameter were electronically recorded. RESULTS: During a five-year period, biliary leakage was recognized in 2.2% of patients who underwent urgent cholecystectomy. The median time from cholecystectomy to ERC was 6 d(interquartile range, 4-11 d). Endoscopic interventions to manage biliary leakage included biliary stent insertion with or without biliary sphincterotomy. In 23(77%) patients after first endoscopic treatment bile flow through existing surgical drain ceased within 11 d following biliary therapeutic endoscopy(median, 4 d; interquartile range, 2-8 d). In those patients repeat ERC was not performed andthe biliary stent was removed on gastroscopy. In seven(23%) patients repeat ERC was done within one to fourth week after their first ERC, depending on the extent of the biliary leakage. In two of those patients common bile duct stone was recognized and removed. Three of those seven patients had more complicated clinical course and they were referred to surgery and were excluded from long-term follow-up. The median interval from endoscopic placement of biliary stent to demonstration of resolution of bile leakage for ERC treated patients was 32 d(interquartile range, 28-43 d). Among the patients included in the follow-up(median 30.5 mo, range 7-59 mo), four patients(14.8%) died of severe underlying comorbid illnesses.CONCLUSION: Our results demonstrate the great efficiency of the endoscopic therapy in the treatment of the patients with biliary leakage after urgent cholecystectomy. | Neven Ljubii Alen Bianin Tajana Pavi Marko Nikoli Ivan Budimir August Miji Ana Duzel | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，5： | 3 |
| 9 | Listeria monocytogenes following orthotopic liver transplantation:Central nervous system involvement and review of the literature显示文摘Listeria monocytogene is a well-recognized cause of bacteremia in immunocompromised individuals,including solid organ transplant recipients,but has been rarely reported following orthotopic liver transplantation. We describe a case of listeria meningitis that occurred within a week after liver transplantation. The patient developed a severe headache that mimicked tacrolimus encephalopathy,and was subsequently diagnosed with listeria meningitis by cerebrospinal fluid culture. The infection was successfully treated with three-week course of intravenous ampicillin. Recurrent hepatitis C followed and was successfully treated with interferon alfa and ribavirin. Fourteen cases of listeriosis after orthotopic liver transplantation have been reported in the English literature. Most reported cases were successfully treated with intravenous ampicillin. There were four cases of listeria meningitis,and the mortality of them was 50%. Early detection and treatment of listeria meningitis are the key to obtaining a better prognosis. | Shugo Mizuno Ivan R Zendejas Alan I Reed Robin D Kim Richard J Howard Alan W Hemming Denise C Schain Consuelo Soldevila-Pico Roberto J Firpi Shiro Fujita | 2007 | World Journal of Gastroenterology2007，13，32： | 2 |
| 10 | Renewable Energy Policies and Technological Innovation: Evidence Based on Patent Counts显示文摘 | Nick Johnstone Ivan Ha??i? David Popp | 2010 | Environmental and Resource Economics2010，，1： | 2 |
| 11 | Using new physics and technology to advance electrostimulated rolling of metals and alloys显示文摘Electrostimulated deformation of metals and alloys, using groove or smooth rolling, requires that several important conditions are satisfied. (1) The deformation site must geometrically overlap with the flow of electric current passing through a strip between the rolls; (2) The density of direct or alternating electric current supplied to deformation site must be sufficiently high (of an order of 104-106А/cm^2); (3) An efficient heat removal from the deformation site must be achieved. In general, the temperature of a strip must be within the range of 100-300℃. (4) The electric resistance at the roll-strip interface must be minimized. Our recent studies also indicate that the electrostimulated rolling in the shortcut regime is a further condition for obtaining high quality rolling of metals. In this regime, the rolls are placed in physical contact even in the absence of a strip that ensures an uninterrupted passage of electric current between the rolls. | Konstantin M. Kli mov Ivan I . Novikov | 2005 | 广东有色金属学报2005，15，2： | 2 |
| 12 | Synthesis of Gold Nanoparticles by Some Strains of Arthrobacter Genera显示文摘 | Tamaz Levan Kalabegishvi|i Elena Ivan Kirkesalt Alexander Nikoloz Rcheulishvili Etery Nikoloz Ginturi Ivane Giorgi Murusidze Dodo Trofim Pataraya Manana Amiran Gurielidze Giorgi Ilia Tsertsvadze Vakhtang Nikoloz Gabunia Levan Giorgi Lomidze David Nugzar Gvarialadze Marina VladimirovnaFrontasyeva Sergey Sergeevich Pavlov Inga Ivanovna Zinicovscaia Marianne Janette Raven Ntsoaki Maditselana Francinah Seaga Arnaud Faanhof | 2012 | 材料科学与工程(中英文A版)2012，2，2： | 2 |
| 13 | Uniform illumination of distant targets using a spherical light-emitting diode array显示文摘 | IVAN M JESUS M ROMEN I | 2007 | Optical Engineering2007，，46： | 1 |
| 14 | Erythrocytic transglutaminase inhibition hemolysis at presentation of celiac disease显示文摘Celiac disease (CD) is a common autoimmune condition.Previously it was considered to be a rare childhood disorder,but is actually considered a relatively common condition,present at any age,which may have multiple complications and manifestations.Hematological disorders of the disease are not uncommon.Among these disorders,the most frequently reported are anemias as a result of iron deficiency,often associated with folate and/or B12 deficiency.Anemias caused by hemolysis are very rarely reported in celiac patients.An 11-year-old girl with a previous uneventful medical history presented with severe hemolytic anemia.Hemolysis was Coombs negative,accompanied by inappropriate low reticulocyte count,despite exaggerated bone marrow hyperplasia of the erythroid precursors which showed normal maturation.Serology for recent infections,including EpsteinBarr virus,parvovirus B19,cytomegalovirus and mycoplasma,were all negative.Levels of serum IgA,IgG and IgM,were all within normal ranges for age.Screeningfor anti-DNA,antinuclear,antineutrophil cytoplasmic,antimicrosomal,antithyroglobulin,and antimitochondrial antibodies and lupus anticoagulants,was negative.She was also negative for human immunodeficiency virus.Conventional therapy with corticosteroids and intravenous immunoglobulin failed.CD was serendipitously discovered upon screening for anti-tissue transglutaminase autoantibodies.The disease was confirmed by biopsy of the small intestine mucosa.The patient recovered with gluten-free diet.A unique case of CD is presented.CD should be serologically screened in each patient with Coombs negative 'immune'hemolytic anemia,particularly if accompanied by 'reticulocytopenia'.A new hemolytic mechanism and very speculative explanation for 'reticulocytopenia'are discussed. | Petar Ivanovski Dimitrije Nikoli Nikola Dimitrijevi Ivan Ivanovski Vojislav Perii | 2010 | World Journal of Gastroenterology2010，16，44： | 1 |
| 15 | Improved methods and starting values to solve the matrix equations X 4- A * X - 1A = I 1 iteratively 显示文摘 | Ivanov Ivan G Hasanov Vejdi I Uhlig Rank | 2004 | Math Comput2004，74，： | 1 |
| 16 | Environmental policy stringency and technological innovation: evidence from survey data and patent counts显示文摘 | Nick Johnstone Ivan Ha??i? Julie Poirier Marion Hemar Christian Michel | 2012 | Applied Economics2012，，： | 1 |
| 17 | CS 22964-161:A double-lined carbon-and s-process-enhanced metal-poorbinary star显示文摘 | Thompson I B Ivans I I Bisterzo-S | 2008 | ApJ2008，677，： | 1 |
| 18 | NIST and IEEE Challenge for MagPieR: The fastest mobile microrobots in the world显示文摘 | Ivan I Hwang G Agnus J | 2013 | IEEE Robotics & Automa- tion Magazine2013，20，2： | 1 |
| 19 | Gron ingen orthopaedic exit strategy: Validation of a support program after total hip or knee arthroplasty显示文摘 | Ivan den Akker-Scheek I Zijlstra M Groothof J W | 2007 | Patient Educ Couns2007，65，2： | 1 |
| 20 | Fabrication and cold test of photonic band gap resonators and accelerator structures显示文摘 | Smirnova Evgenya I Mastovsky Ivan Shapiro Michael A | 2005 | Phys Rev ST AB2005，8，09： | 1 |
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