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| 1 | Evolving concepts in bone infection: redefining “biofilm”,“acute vs. chronic osteomyelitis”, “the immune proteome” and “local antibiotic therapy”显示文摘Osteomyelitis is a devastating disease caused by microbial infection of bone. While the frequency of infection following elective orthopedic surgery is low, rates of reinfection are disturbingly high. Staphylococcus aureus is responsible for the majority of chronic osteomyelitis cases and is often considered to be incurable due to bacterial persistence deep within bone. Unfortunately, there is no consensus on clinical classifications of osteomyelitis and the ensuing treatment algorithm. Given the high patient morbidity,mortality, and economic burden caused by osteomyelitis, it is important to elucidate mechanisms of bone infection to inform novel strategies for prevention and curative treatment. Recent discoveries in this field have identified three distinct reservoirs of bacterial biofilm including: Staphylococcal abscess communities in the local soft tissue and bone marrow, glycocalyx formation on implant hardware and necrotic tissue, and colonization of the osteocyte-lacuno canalicular network(OLCN) of cortical bone. In contrast, S.aureus intracellular persistence in bone cells has not been substantiated in vivo, which challenges this mode of chronic osteomyelitis. There have also been major advances in our understanding of the immune proteome against S. aureus, from clinical studies of serum antibodies and media enriched for newly synthesized antibodies(MENSA), which may provide new opportunities for osteomyelitis diagnosis, prognosis, and vaccine development. Finally, novel therapies such as antimicrobial implant coatings and antibiotic impregnated 3D-printed scaffolds represent promising strategies for preventing and managing this devastating disease. Here, we review these recent advances and highlight translational opportunities towards a cure. | Elysia A. Masters Ryan P. Trombetta Karen L. de Mesy Bentley Brendan F Boyce Ann Lindley Gill Steven R. Gill Kohei Nishitani Masahiro Ishikawa Yugo Morita Hiromu Ito Sheila N. Bello-Irizarry Mark Ninomiya James D. Brodell Jr. Charles C. Lee Stephanie P. Hao Irvin Oh Chao Xie Hani A. Awad John L. Daiss John R. Owen Stephen L. Kates Edward M. Schwarz Gowrishankar Muthukrishnan | 2019 | Bone Research2019，7，3： | 19 |
| 2 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 3 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 4 | Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells显示文摘 | Ito K Hirao A Arai F | 2006 | Nat Med2006，12，： | 1 |
| 5 | Antitumor reactivity of anti-CD3/antiCD28 bead-activated lymphoid cells: implications for cell therapy in a murine model 显示文摘 | Ito F Cart A Svenssson H | 2003 | J Immunother2003，26，3： | 1 |
| 6 | Antitumor effects of combined therapy of recombinant heat shock protein 70 and hyperthermia using magnetic nanoparticles in an experimentalsubcutaneous murine melanoma 显示文摘 | Ito A Matsuoka F Honda H | 2004 | Cancer Immunol Immunother2004，53，： | 1 |
| 7 | Myosin light chain phosphatase: subunit composition, interactions and regulation显示文摘 | Hartshorne DJ Ito M Erddi F | 1998 | J Mus Research Cell Motil1998，19，： | 1 |
| 8 | Anti-HIV activity of moronic acidderivatives and the new melliferonerelate triterpenoid isolated from Brazilian Propohs显示文摘 | ITO J CHANG F R WANG H K | 2001 | J Nat Prod2001，64，10： | 1 |
| 9 | Phase-noise-compensated optical frequency-domain reflectometry显示文摘 | FAN X KOSHIKIYA Y ITO F | 2009 | IEEE Journal of Quantum Electronics2009，45，6： | 1 |
| 10 | Novel type V staphylococcal cassette chromosome mec driven by a novel cassette chromosome recombinase,ccrC显示文摘 | Ito T Ma XX Takeuchi F | 2004 | Antimicrob Agents Chemother2004，48，7： | 1 |
| 11 | Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells 显示文摘 | Ito K Hirao A Arai F | 2004 | Nature2004，431，： | 1 |
| 12 | Correlation between the growth of uterine leiomyomata and progesterone receptor content in needle bioopsy specimens 显示文摘 | Kawamura N Ito F | 1998 | Feril Steril1998，70，： | 1 |
| 13 | The effects of corn peptide ingestion on facilitating alcohol metabolism in healthy men显示文摘 | Yamaguchi M Nishikiori F Ito M | 1997 | Biosci Biotech Biochem1997，61，9： | 1 |
| 14 | Clinical and histopathological features of colonic stromal tumor in a child显示文摘 | Terada R Ito S Akama F | 2000 | Gastroenterol2000，35，6： | 1 |
| 15 | Surgical treatment of comminuted fractures of the distal clavicle using Wolter clavicular plates显示文摘 | Mizue F Shirai Y Ito H | 2000 | Journal of Nippon Medical School = Nihon Ika Daigaku zasshi2000，67，1： | 1 |
| 16 | Surgical resection for pancreatic cancer combined with preoperative carbon ion radiotherapy irridiation显示文摘 | Ito H Kimura F Shimizu H | 2004 | Gan To Kagaku Ryoho2004，31，11： | 1 |
| 17 | Meteor Shower or Heat Waves? Heteroskedastic Intra - Daily Volatility in The Foreign Exchange Market显示文摘 | Engle R F T Ito W Lin | 1990 | Econometrica1990，，58： | 1 |
| 18 | The miR-106b-25 polycistron,activated by genomic amplification,functions as an oncogene by suppressing p21 and Bim显示文摘 | Kan T Sato F Ito T | | 0，，05： | 1 |
| 19 | An ultra performance liquid chromatographic method for determining phytosterol uptake by Caco- 2 cells显示文摘 | ITO N OHTSUBO T KUSU F | 2012 | Analytical Biochemistry2012，421，1： | 1 |
| 20 | Mechanical response of single filamin A (ABP-280) molecules and its role in the actin cytoskeleton显示文摘 | Yamazaki M Shou F Ito T | 2003 | Journal of Muscle Research and Cell Motility2003，23，56： | 1 |
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