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| 1 | Pegylated interferon-alpha plus taurine in treatment of rat liver fibrosis显示文摘AIM: To investigate the antif ibrotic effects of peginterferon- alpha 2b and taurine on oxidative stress markers and hepatocellular apoptosis. METHODS: Sixty rats with CCl4-induced liver fibrosis were divided into 4 groups (n = 15). Group 1 was left for spontaneous recovery (SR). Groups 2-4 received peginterferon-alpha 2b, taurine, and their combination, respectively, for four weeks. Histological f ibrosis scores, histomorphometric analysis, tissue hydroxyproline, tissue MDA, GPx and SOD activities were determined. Activated stellate cells and hepatocellular apoptosis were also evaluated. RESULTS: The degree of f ibrosis decreased in all treatment groups compared to spontaneous recovery group. Taurine alone and in combination with peginterferon-alpha 2b reduced oxidative stress markers, but peginterferon-alpha 2b alone did not. Apoptotic hepatocytes and activated stellate cells were higher in groups 2-4 than in group 1. Combined taurine and peginterferon-alpha 2b further reduced fibrosis and increased activated stellate cell apoptosis, but could not improve oxidative stress more than taurine alone.CONCLUSION: Peginterferon-alpha 2b exerts anti- f ibrotic effects on rat liver fibrosis. It seems ineffective against oxidative stress in vivo. Peginterferon-alpha 2b in combination with taurine seems to be an antif ibrotic strategy. | Ilker Tasci Mehmet Refik Mas Sevil Atalay Vural Salih Deveci Bilgin Comert Gunay Alcigir Nuket Mas Cemal Akay Mithat Bozdayi Cihan Yurdaydin Hakan Bozkaya Ozden Uzunalimoglu Ahmet Turan Isik Harun M Said | 2007 | World Journal of Gastroenterology2007，13，23： | 7 |
| 2 | First dorsal metacarpal arte-ry adipofascial flap for thenar burn contracture releasing显示文摘 | CIL Y ESKI M ISIK S | 2008 | BURNS2008，34，1： | 1 |
| 3 | Dexmedetomidine decreases emergence agitation in pediatric patients after sevoflurane anesthesia without surgery 显示文摘 | Isik B Arslan M Tunga A D | 2006 | Paediatr Anaesth2006，16，7： | 1 |
| 4 | Dexmedetomidine decreaesemergence agitation in pediatric patients after sevofluraneanesthesia without surgery 显示文摘 | Isik B Arslan M Tunga AD | 2006 | Pediatric Anesthesia2006，16，7： | 1 |
| 5 | Relation of red cell distribution width with presence and severity of coronary artery ectasia显示文摘 | Isik T Kurt M Ayhan E | 2012 | Clin Appl Thromb Hemost2012，18，5： | 1 |
| 6 | Biological treatment of acid dyeing waste water using a sequential anaerobic/aerobic reactor sys- tem显示文摘 | ISIK M SPONZA D T | 2006 | Enzyme and Microbial Technology2006，38，7： | 1 |
| 7 | Relation of red cell distribution width with presence and severity of coronary artery ectasia显示文摘 | Isik T Kurt M Ayhan E | 2012 | Clin Appl Thromb Hemost2012，18，5： | 1 |
| 8 | Comparison of classifica- tion systems for congenital melanoeytic nevi显示文摘 | Turkmen A Isik D Bekereeioglu M | 2010 | Dermatol Surg2010，36，10： | 1 |
| 9 | Relation of red cell distri- bution width with presence and severity of coronary ar- tery ectasia 显示文摘 | Isik T Kurt M Ayhan E | 2012 | Clin Appl Thromb Hemost2012，18，5： | 1 |
| 10 | Business intelligence success:the roles of BI capabilities and decision environments显示文摘 | ISIK O JONES M C SIDOROVA A | 2013 | Information&Management2013，50，1： | 1 |
| 11 | Detecting tool breakage inturning aisi 1050 steel using Coated and uncoated cutting tools显示文摘 | Cakir M Cemal Isik Yahya | 2005 | Journal of Materials Processing Technology2005，159，： | 1 |
| 12 | Decolorization of azo dyes under batch anaerobic and sequential anaerobic/aerobic conditions显示文摘 | Isik M Sponza D T | 2004 | Environ Sci Health Past A2004，39，4： | 1 |
| 13 | Technical,scale and allocative efficiencies of Turkish banking industry显示文摘 | Isik I Hassan M K | 2002 | Journal of Banking and Finance2002，26，4： | 1 |
| 14 | Comparison of the rate of palatal fistulation after two-flap and four-flap palatoplasty 显示文摘 | Bekerecioglu M Isik D Bulut O | 2005 | Scand J Plast Reconstr Surg Hand Surg2005，39，5： | 1 |
| 15 | Audi- tory information coding by modeled cochlear nucleus neurons 显示文摘 | Wang H Isik M Borst A | 2011 | J Comput Neurosci2011，30，： | 1 |
| 16 | Reversible EEC changes during rotavirus gastroenteritis显示文摘 | Isik U Caliskan M | | 0，，01： | 1 |
| 17 | Cross layer load bal- anced forwarding schemes for video sensor networks 显示文摘 | ISIK S DONMEZ M Y ERSOY C | 2011 | Ad Hoc Networks2011，9，3： | 1 |
| 18 | The impact of admission red cell distribution width on the development of poor myocardial perfusion after primary percutaneous intervention显示文摘 | Isik T Kurt M Ayhan E | 2012 | Atherosclerosis2012，224，1： | 1 |
| 19 | Methotrexate has no antifi- brotic effect in bleomycin-induced experimental scleroderma 显示文摘 | Ozgen M Koca SS Isik A | 2010 | J Rheumatol2010，37，： | 1 |
| 20 | Dexraedetomidine decreases emergence agitation in pediatric patients after sevoflurane anesihesia without surgery显示文摘 | Isik B Arslan M Tunga AD | 2006 | Paediatr Anaesth2006，16，7： | 1 |
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