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| 1 | CD28/CTLA-4/B7 and CD40/CD40L costimulation and activation of regulatory T cells显示文摘Costimulatory signals are crucial for T cell activation. Attempts to block costimulatory pathways have been effective in preventing unwanted immune reactions. In particular, blocking the CD28/cytotoxic T lymphocyte antigen(CTLA)-4/B7 interaction(using CTLA-4Ig) and the CD40/CD40 L interaction(using anti-CD40 L antibodies) prevents T cell mediated autoimmune diseases, transplant rejection and graft vs host disease in experimental models. Moreover, CTLA-4Ig is in clinical use to treat rheumatoid arthritis(abatacept) and to prevent rejection of renal transplants(belatacept). Under certain experimental conditions, this treatment can even result in tolerance. Surprisingly, the underlying mechanisms of immune modulation are still not completely understood. We here discuss the evidence that costimulation blockade differentially affects effector T cells(Teff) and regulatory T cells(Treg). The latter are required to control inappropriate and unwanted immune responses, and their activity often contributes to tolerance induction and maintenance. Unfortunately, our knowledge on the costimulatory requirements of Treg cells is very limited. We therefore summarize the current understanding ofthe costimulatory requirements of Treg cells, and elaborate on the effect of anti-CD40 L antibody and CTLA-4Ig treatment on Treg cell activity. In this context, we point out that the outcome of a treatment aiming at blocking the CD28/CTLA-4/B7 costimulatory interaction can vary with dosing, timing and underlying immunopathology. | Isabel T Vogel Stefaan W Van Gool Jan L Ceuppens | 2014 | World Journal of Immunology2014，4，2： | 3 |
| 2 | Assessment of MRI and MRCP in diagnosis of biliary cystadenoma and cystadenocarcinoma显示文摘 | Ma?té Lewin Najat Mourra Isabelle Honigman Jean-Fran?ois Fléjou Rolland Parc Lionel Arrivé Jean-Michel Tubiana | 2006 | European Radiology2006，，2： | 2 |
| 3 | Sentinel lymph node metastasis after neoadjuvant treatment in breast cancer:Any size matters?显示文摘One of the advantages of neoadjuvant chemotherapy(NAC) treatments is its ability to convert patients who need a mastectomy in breast conservative surgery. NAC has also increased the conversion of node positive patients into node negative in around 40% allowing the use of sentinel node biopsy(SLN) in this setting. Timing of SLN biopsy after NAC has been a subject of debate. In patients with clinically node negative before NAC,rates of success and false negative rates of SLN after NAC are similar to those in the adjuvant setting,so SLN after NAC in previous negative axilla has been incorporated in the staging of the axilla. More controversial is its use in patients with positive axillary nodes before NAC who convert to node negative after NAC. Several randomized studies have reported the identification rates and the false negative rates of the SLN after NAC,concordant in the importance of surgical technique. As there is an agreement in the abandon of the immunohistochemistry(IHC) for SLN in the adjuvant setting as SLN IHC detected metastasis appear to have no impact on overall survival,in patients with SLN after NAC the inclusion of isolated tumor cell(ITC) as positive nodes lowers the false negative rates of the technique,suggesting the importance of assessing the SLN by IHC after NAC and considering it as residual disease. Longer follow up is needed to determine the prognostic implications of ITC in the SLN after NAC. | Isabel T Rubio | 2015 | World Journal of Clinical Oncology2015，6，6： | 2 |
| 4 | Thin-film transmission IR spectroscopy as an in situ probe of the gas solid interface in photocatalytic processes显示文摘 | SHO K Isabel M Tejedor T | 2004 | Journal of Photochemistry and Photobiology A:Chemistry2004，163，： | 1 |
| 5 | Molecular, biochemical and physiological characterization of gibberellin biosynthesis and catabolism genes from Neriurn oleander显示文摘 | Susana U T Jose L Isabel L D | 2006 | J Plant Growth Regul2006，25，： | 1 |
| 6 | Cloned plasmid DNA fragments as calibrators for controlling GMOs: Different real-time duplex quantitative PCR methods显示文摘 | ISABEL T ERIK V B MARC D L | 2004 | Anal Bioanal Chem2004，378，5： | 1 |
| 7 | Hydroxyl radical mediated degradation of azo ayes: Evidence for benzene generation 显示文摘 | Spadaro J T Isabelle L Renganathan V | 1994 | Environ Sci Technol1994，28，： | 1 |
| 8 | Impact of cattle on soil physical properties and nutrient concentrations in overland flow from pasture in Ireland显示文摘 | Isabelle K Colin D R Hubert T | 2006 | Agriculture Ecosystems and Environment2006，113，： | 1 |
| 9 | PAX6 mutations:genotype-phenotype correlations显示文摘 | Ioanna T Ian MSW Isabel MH | | 0，，01： | 1 |
| 10 | An approachfor determining air pollution monitoring sites 显示文摘 | Enrique G F MaMa D M Isabel M M T | 2010 | Atmospheric1 Environment2010，44，2122： | 1 |
| 11 | Determination of a wide range of volatile organic compounds in ambient air using multisorbent adsorption/thermal desorption and gas chromatography mass spectrometry显示文摘 | Pankow J F Luo W T Isabelle L M | 1998 | Analytical Chemistry1998，70，24： | 1 |
| 12 | Air Pollution and Heart Rate Variability Among the Elderly in Mexico City显示文摘 | Fernando Holguín Marta M. Téllez-Rojo Mauricio Hernández Marlene Cortez Judith C. Chow John G. Watson David Mannino Isabelle Romieu | 2003 | Epidemiology2003，，5： | 1 |
| 13 | An inter- national review of sponsorship research 显示文摘 | CORNWELL T BETTINA MAIGNAN ISABELLE | 1998 | J Advertising1998，27，1： | 1 |
| 14 | Effect of progensterone on bovine sperm capacitation and acrosome reaction显示文摘 | Isabelle T Puttaswamy M | 2007 | Biol Reprod2007，69，： | 1 |
| 15 | Distribution and speciation of ambient selenium in contrasted soils, from mineral to organic rich显示文摘 | Julie Tolu Yves Thiry Ma?té Bueno Claudy Jolivet Martine Potin-Gautier Isabelle Le Hécho | 2014 | Science of the Total Environment2014，，： | 1 |
| 16 | Brain Perfusion Correlates of Visuoperceptual Deficits in Mild Cognitive Impairment and Mild Alzheimer’s Disease显示文摘 | Montserrat Alegret Georgina Vinyes-Junqué Mercè Boada Pablo Martínez-Lage Gemma Cuberas Ana Espinosa Isabel Roca Isabel Hernández Sergi Valero Maitée Rosende-Roca Ana Mauleón James T. Becker and Lluís Tárraga | 2010 | Journal of Alzheimer’s Disease2010，，2： | 1 |
| 17 | Interleukin- 17 is a negative regulator of established allergic asthma 显示文摘 | Silvia S C Dieudonnee T Isabelle C | 2006 | J Exp Med2006，203，11： | 1 |
| 18 | Should decompressive surgery be performed in malignant cerebral venous thrombosis:a series of 12 patients 显示文摘 | Marie T Isabelle C Damien B | 2010 | Stroke2010，41，4： | 1 |
| 19 | Deformation/recovery cycle of the periodontal ligament in human teeth with single or dual contact points 显示文摘 | Brosh T Isabelle H Machol T | 2002 | Archives of Oral Biology2002，47，1： | 1 |
| 20 | Distribution of pigments and fatty acid biomarkers in particulate matter from the frontal structure of the Alboran Sea显示文摘 | IMMA T ISABELLE V NATHALIE L | 2004 | Marine Chemistry2004，88，： | 1 |
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