|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Severe acute pancreatitis: Clinical course and management显示文摘Severe acute pancreatitis (SAP) develops in about 25% of patients with acute pancreatitis (AP). Severity of AP is linked to the presence of systemic organ dysfunctions and/or necrotizing pancreatitis pathomorphologically. Risk factors determining independently the outcome of SAP are early multi-organ failure, infection of necrosis and extended necrosis (> 50%). Up to one third of patients with necrotizing pancreatitis develop in the late course infection of necroses. Morbidity of SAP is biphasic, in the first week strongly related to early and persistence of organ or multi-organ dysfunction. Clinical sepsis caused by infected necrosis leading to multi-organ failure syndrome (MOFS) occurs in the later course after the first week. To predict sepsis, MOFS or deaths in the first 48-72 h, the highest predictive accuracy has been objectified for procalcitonin and IL-8; the Sepsis- Related Organ Failure Assessment (SOFA)-score predicts the outcome in the first 48 h, and provides a daily assessment of treatment response with a high positive predictive value. Contrast-enhanced CT provides the highest diagnostic accuracy for necrotizing pancreatitis when performed after the first week of disease. Patients who suffer early organ dysfunctions or at risk of developing a severe disease require early intensive care treatment. Early vigorous intravenous fluid replacement is of foremost importance. The goal is to decrease the hematocrit or restore normal cardiocirculatory functions. Antibiotic prophylaxis has not been shown as an effective preventive treatment. Early enteral feeding is based on a high level of evidence, resulting in a reduction of local and systemic infection. Patients suffering infected necrosis causing clinical sepsis, pancreatic abscess or surgical acute abdomen are candidates for early intervention. Hospital mortality of SAP after interventional or surgical debridement has decreased in high volume centers to below 20%. | Hans G Beger Bettina M Rau | 2007 | World Journal of Gastroenterology2007，13，38： | 122 |
| 2 | 急性胰腺炎的外科治疗显示文摘 | Hans Guenther Beger Bettina Rau Rainer Isenmann Jens Mayer 刘斌 吴在德 | 2001 | 中华外科杂志2001，39，4： | 28 |
| 3 | Chemokine expression in hepatocellular carcinoma versus colorectal liver metastases显示文摘AIM: To evaluate and compare the expression profiles of CXCL12 (SDF-1), CCL19 (MIP-3β), CCL20 (MIP-3α) and CCL21 (6Ckine, Exodus2) and their receptors on RNA and protein levels in hepatocellular carcinoma (HCC) versus colorectal liver metastases (CRLM) and to elucidate their impact on the carcinogenesis and progression of malignant liver diseases. METHODS: Chemokine expression was analyzed by RT-PCR and ELISA in 11 cases of HCC specimens and in 23 cases of CRLM and corresponding adjacent non- tumorous liver tissues, respectively. Expressions of their receptors CXCR4, CCR6 and CCR7 were analyzed by RT- PCR and Western blot analysis in the same cases of HCC and CRLM. RESULTS: Significant up-regulation for CCL20/CCR6 was detected in both cancer types. Moreover, CCL20 demonstrated significant overexpression in CRLM in relation to the HCC tissues. Being significantly up- regulated only in CRLM, CXCR4 displayed an aberrant expression pattern with respect to the HCC tissues. CONCLUSION: Correlation of CXCR4 expression with CRLM suggests CXCR4 as a potential predictive factor for CRLM. High level expression of CCL20 and its receptor CCR6 in HCC and CRLM with marked up- regulation of CCL20 in CRLM in relation to HCC tissues indicates involvement of the CCL20/CCR6 ligand-receptor pair in the carcinogenesis and progression of hepatic malignancies. | Claudia Rubie Vilma Oliveira Frick Mathias Wagner Christina Weber Bianca Kruse Katja Kempf Jochen Knig Bettina Rau Martin Schilling | 2006 | World Journal of Gastroenterology2006，12，41： | 24 |
| 4 | 生态现代化理论:回顾和展望显示文摘生态现代化已经成为环境治理研究的主流理论,横跨经济学、社会学和管理学等多个学科,受到越来越多的关注。生态现代化的核心目标就是实现经济发展与环境退化的脱钩,它的六大假设已经或正在不同地区、不同层次被检验。生态现代化最为基本的要求就是解放生态,包括两大机制:通过技术创新实现经济生态化、通过制度创新实现生态经济化。生态现代化与可持续发展的不同主要体现在对代际公平的偏好程度,以及在对未来发展的乐观或悲观态度上。生态现代化理论对于指导中国社会发展的转型具有重大意义,展望其研究命题主要包括:国家生态现代化战略、环境治理模式改革、提升企业国际竞争力等。 | 金书秦 Arthur P.J.Mol Bettina Bluemling | 2011 | 理论学刊2011，，7： | 24 |
| 5 | 居民对文化林生态系统服务功能的认知与态度显示文摘文化林是按照文化传统和风俗习惯来保护和管理的森林,在保护生物多样性的同时也维持了生态系统服务功能。采用半结构式访谈法调查了文化林周边村民对文化林的生态系统服务功能的认知及保护意愿,结果表明:(1)村民认为文化林提供的最重要的服务功能为固碳释养、水源涵养及美学价值,并与最满意的服务功能间存在正相关关系。最期望提高的服务功能是文化功能,例如:生态旅游,美学价值。(2)相对周边其他森林村民对文化林的资源利用较小,主要是非林木产品,平均26.3%的被访村民在文化林中获得过收入,40.6%的被访者获得山野菜、竹子、中药材、薪柴等。但90.1%被访者从其他森林中得到薪柴等林产品,开展旅游村落的村民获得林产品比例相对较小,但管护意愿相对较低。(3)村民对文化林的保护积极性较高,70.4%的被访者愿意花时间来管护森林,距文化林越近、家庭收入越高,管护意愿越高。38.9%的被访者愿意支付费用来维持服务功能不变化,距文化林越近,管护意愿越低的被访者,支付意愿越高。(4)通过了解村民对文化林的态度和认知,对我国农村森林生态系统服务功能和天然林保护具有重要意义。建议大力宣传文化林的生态系统服务功能,尤其是文化功能,并寻找替代生计提高居民收入,雇佣当地男性村民看护森林,充分利用村民的传统知识加强共管力度,完善村规民约,在今后规划中尽量将村落沿着文化林布局,积极支持对文化林的保护和发展。 | 高虹 欧阳志云 郑华 Bettina Bluemling | 2013 | 生态学报2013，33，3： | 15 |
| 6 | Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer显示文摘AIM: To investigate the expression profile of IL-8 in inflammatory and malignant colorectal diseases to evaluate its potential role in the regulation of colorectal cancer (CRC) and the development of colorectal liver metastases (CRLM). METHODS: IL-8 expression was assessed by quantitative real-time PCR (Q-RT-PCR) and the enzyme-linked immunosorbent assay (ELISA) in resected specimens from patients with ulcerative colitis (UC, n = 6) colorectal adenomas (CRA, n = 8), different stages of colorectal cancer (n = 48) as well as synchronous and metachronous CRLM along with their corresponding primary colorectal tumors (n = 16). RESULTS: IL-8 mRNA and protein expression was significantly up-regulated in all pathological colorectal entities investigated compared with the corresponding neighboring tissues. However, in the CRC specimens IL-8 revealed a significantly more pronounced overexpression in relation to the CRA and UC tissues with an average 30-fold IL-8 protein up-regulation in the CRC specimens in comparison to the CRA tissues. Moreover, IL-8 expression revealed a close correlation with tumor grading. Most interestingly, IL-8 up-regulation was most enhanced in synchronous and metachronous CRLM, if compared with the corresponding primary CRC tissues. Herein, an up to 80-fold IL-8 overexpression in individual metachronous metastases compared to normal tumor neighbor tissues was found. CONCLUSION: Our results strongly suggest an association between IL-8 expression, induction and progression of colorectal carcinoma and the development of colorectal liver metastases. | Claudia Rubie Vilma Oliveira Frick Sandra Pfeil Mathias Wagner Otto Kollmar Berit Kopp Stefan Grber Bettina M Rau Martin K Schilling | 2007 | World Journal of Gastroenterology2007，13，37： | 12 |
| 7 | The Isogene 1-Deoxy-D-Xylulose 5-Phosphate Synthase 2 Controls Isoprenoid Profiles, Precursor Pathway Allocation, and Density of Tomato Trichomes显示文摘植物 isoprenoids 从先锋被形成由 mevalonate (MVA ) 综合了在 cytosol 或由 methyl-D-erythritol 4 磷酸盐(MEP ) 的小径在质体的小径。尽管先锋的一些交换发生, cytosolic sesquiterpenes 被假定主要源于 MVA,当 plastidial monoterpenes 从 MEP 先锋优先地被生产时。另外的复杂性在 MEP 小径的第一步产生,它被二分叉的 1-deoxy-D-xylulose 5 磷酸盐 synthase isoforms 典型地催化(DXS1, DXS2 ) 。在西红柿(茄属 lycopersicum ) , SlDXS1 基因无所不在地在而 SlDXS2 抄本充满仅仅很少纸巾,成熟的水果期间与高水平被表示,包括年轻叶子,花瓣,和孤立的毛状体。SlDXS2 表示的特定的下面规定被 RNA 干扰在转基因的植物执行调查反馈机制。SlDXS2 下面规定在在二 sesquiterpenes 的 monoterpene -phellandrene 和毛状体的增加导致了减少。而且,进剩余 monoterpenes 并且进 sesquiterpenes 的导出 MVA 的先锋的加入是由 13C 的比较决定了到 12C 天赋同位素比率被提高。SlDXS1 的一条补偿起来规定没被观察。也展出的下面调整的线增加了毛状体密度并且由喂叶的 Spodoptera littoralis 毛虫显示出更少的损坏。结果在 isoprenoid 先锋分配在 modulating isoprenoid 新陈代谢和显著粘性揭示 DXS2 的新奇、非冗余的角色。 | Heike Paetzold Stefan Garms Stefan Bartram Jenny Wieczorek Eva-Maria Uros-Gracia Manuel Rodriguez-Concepcion Wilhelm Boland Dieter Strack Bettina Hause Michael H. Walter | 2010 | Molecular Plant2010，3，5： | 11 |
| 8 | Broken hearts:Iron overload,ferroptosis and cardiomyopathy显示文摘In a recently published paper in Proc Natl Acad Sci USA,Fang et al.elegantly demonstrated that doxorubicin treatment or transient ischemia/reperfusion in mice triggers ferroptosis,a distinctive form of necrotic cell death marked by iron-dependent lipid peroxidation,which is the main underlying mechanism in the pathogenesis of cardiomyopathy. | Marcus Conrad Bettina Proneth | 2019 | Cell Research2019，29，4： | 11 |
| 9 | Plants as concept generators for biomimetic light-weight structures with variable stiffness and self-repair mechanisms显示文摘Plants possess many structural and functional properties that have a high potential to serve as concept generators for the production of biomimetic technical materials and structures. We present data on two features of plants (variable stiffness due to pressure changes in cellular structures and rapid self-repair functions) that may be used as models for biomimetic projects. | Thomas Speck Tom Masselter Bettina Prüm Olga Speck Rolf Luchsinger Siegfried Fink | 2004 | Journal of Bionic Engineering2004，1，4： | 10 |
| 10 | 放牧强度对内蒙古半干旱草原地气间能量和物质交换的影响显示文摘利用涡度相关技术,于2006年7月27日至8月10日在内蒙古半干旱草原三种放牧强度的下垫面进行微气象观测。本文分析了放牧强度对内蒙古半干旱草原地气间能量和物质交换的影响,发现:(1)放牧降低植被覆盖率,使地表反射率增大。(2)放牧使潜热通量减小。而放牧强度最大的锡林河河道潜热通量最大,表明土壤水分状况是半干旱草原地表能量收支的决定性因素。(3)羊草和冬季放牧观测点日平均CO2通量分别为-1.92g·m-2·d-1和0.73g·m-2·d-1,表明放牧可以使草地由CO2的汇转变为源。锡林河河道为CO2的汇,日平均CO2通量-3.35g·m-2·d-1,与羊草比较,锡林河河道吸收CO2更多,表明土壤湿度是影响半干旱草原CO2通量交换的重要因素。(4)放牧通过减小叶面积指数,减弱植被的光合作用能力。 | 王雷 刘辉志 Bettina KETZER David SCHAFFRATH Christian BERNHOFER | 2009 | 大气科学2009，33，6： | 10 |
| 11 | Estimating steatosis and fibrosis: Comparison of acoustic structure quantification with established techniques显示文摘AIM:To compare ultrasound-based acoustic structure quantification(ASQ) with established non-invasive techniques for grading and staging fatty liver disease.METHODS:Type 2 diabetic patients at risk of nonalcoholic fatty liver disease(n = 50) and healthy volunteers(n = 20) were evaluated using laboratory analysis and anthropometric measurements, transient elastography(TE), controlled attenuation parameter(CAP), proton magnetic resonance spectroscopy(1H-MRS; only available for the diabetic cohort), and ASQ.ASQ parameters mode, average and focal disturbance(FD) ratio were compared with:(1) the extent of liver fibrosis estimated from TE and nonalcoholic fatty liver disease(NAFLD) fibrosis scores; and(2) the amount of steatosis, which was classified according to CAP values.RESULTS:Forty-seven diabetic patients(age 67.0±8.6 years;body mass index 29.4±4.5 kg/m2)with reliable CAP measurements and all controls(age 26.5±3.2 years;body mass index 22.0±2.7 kg/m2)were included in the analysis.All ASQ parameters showed differences between healthy controls and diabetic patients(P<0.001,respectively).The ASQ FD ratio(logarithmic)correlated with the CAP(r=-0.81,P<0.001)and 1H-MRS(r=-0.43,P=0.004)results.The FD ratio[CAP<250 d B/m:107(102-109),CAP between 250 and 300 d B/m:106(102-114);CAP between 300 and 350 d B/m:105(100-112),CAP≥350 d B/m:102(99-108)]as well as mode and average parameters,were reduced in cases with advanced steatosis(ANOVA P<0.05).However,none of the ASQ parameters showed a significant difference in patients with advanced fibrosis,as determined by TE and the NAFLD fibrosis score(P>0.08,respectively).CONCLUSION:ASQ parameters correlate with steatosis,but not with fibrosis in fatty liver disease.Steatosis estimation with ASQ should be further evaluated in biopsy-controlled studies. | Thomas Karlas Joachim Berger Nikita Garnov Franziska Lindner Harald Busse Nicolas Linder Alexander Schaudinn Bettina Relke Rima Chakaroun Michael Trltzsch Johannes Wiegand Volker Keim | 2015 | World Journal of Gastroenterology2015，21，16： | 9 |
| 12 | The Nuclear Factor KappaB(NF-kB)signaling in cancer development and immune diseases显示文摘The nuclear factor kappa B(NF-kB)family of transcription factors plays an essential role as stressors in the cellular environment,and controls the expression of important regula-tory genes such as immunity,inflammation,death,and cell proliferation.NF-kB protein is located in the cytoplasm,and can be activated by various cellular stimuli.There are two path-ways for NF-kB activation,as the canonical and non-canonical pathways,which require com-plex molecular interactions with adapter proteins and phosphorylation and ubiquitinase enzymes.Accordingly,this increases NF-kB translocation in the nucleus and regulates gene expression.In this study,the concepts that emerge in different cellular systems allow the design of NF-kB function in humans.This would not only allow the development for rare dis-eases associated with NF-kB,but would also be used as a source of useful information to elim-inate widespread consequences such as cancer or inflammatory/immune diseases. | Mohammad Reza Zinatizadeh Bettina Schock Ghanbar Mahmoodi Chalbatani Peyman Kheirandish Zarandi Seyed Amir Jalali Seyed Rouhollah Miri | 2021 | Genes & Diseases2021，8，3： | 8 |
| 13 | 成层土中地下水渗流对盾构隧道开挖面稳定影响上限分析(英文)显示文摘目的:盾构隧道在成层土中掘进时,地下水渗流容易引起盾构开挖面失稳破坏。本文提出考虑地下水渗流的机动场模型,探讨成层土中地下水渗流规律,研究渗流对开挖面稳定性的影响,并提出渗流条件下成层土中盾构支护压力的计算方法。创新点:1.提出考虑地下水渗流盾构开挖面失稳机动场的模型;2.建立成层土中地下水渗流模型;3.推导考虑地下水渗流的盾构开挖面极限支护压力上限解。方法:1.根据已有工程案例,对渗流条件下成层土中盾构开挖面失稳进行受力分析(图5),并提出开挖面失稳机动场模型(图6);2.通过上限分析,推导得到盾构开挖面失稳极限支护压力计算公式(公式29);3.对成层土中地下水渗流进行数值模拟,并采用理论模型(图15)对渗流规律进行表征;4.研究极限支护压力对地下水渗流因素的敏感性。结论:1.地下水渗流在失稳土体内部产生渗流力作用,在盾构开挖面上也对支护压力产生抵消作用。2.提出成层土中考虑地下水渗流的失稳机动场模型,并推导出极限支护压力上限解;3.在盾构土舱未进行渗透性改良的条件下,成层土中地下水渗流在1200 s内达到稳定,其中,穿越层渗流方向主要为水平向,而覆土层中主要为竖向渗流;4.考虑渗流影响,本文上限解预测的支护压力值更为合理。 | Wei LIU Bettina ALBERS Yu ZHAO Xiao-wu TANG | 2016 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2016，17，11： | 8 |
| 14 | Enhanced migration of tissue inhibitor of metalloproteinase overexpressing hepatoma cells is attributed to gelatinases: Relevance to intracellular signaling pathways显示文摘AIM: To study the effect of gelatinases (especially MMP-9)on migration of tissue inhibitor of metalloproteinase (TIMP-1) overexpressing hepatoma cells.METHODS: Wild type HepG2 cells, cells stably transfected with TIMP-1 and TIMP-1 antagonist (MMP-9-H401A, a catalytically inactive matrix metalloproteinase (MMP) which still binds and neutralizes TIMP-1) were incubated in Boyden chambers either with or without Galardin (a synthetic inhibitor of MMP-1, -2, -3, -8, -9) or a specific inhibitor of gelatinases.RESULTS: Compared to wild type HepG2 cells, the cells overexpressing TIMP-1 showed 115% migration (P<0.05)and the cells overexpressing MMP-9-H401A showed 62% migration (P<0.01). Galardin reduced cell migration dose dependently in all cases. The gelatinase inhibitor reduced migration in TIMP-1 overexpressing cells predominantly.Furthermore, we examined intracellular signal transduction pathways of TIMP-1-dependent HepG2 cells. TIMP-1deactivates cell signaling pathways of MMP-2 and MMP-9involving p38 mitogen-activated protein kinase. Specific blockade of the ERK pathway suppresses gelatinase expression either in the presence or absence of TIMP-1.CONCLUSION: Overexpressing functional TIMP-1-enhanced migration of HepG2-TIMP-1 cells depends on enhanced MMP-activity, especially MMP-9. | Elke Roeb Anja-Katrin Bosserhoff Sabine Hamacher Bettina Jansen Judith Dahmen Sandra Wagner Siegfried Matern | 2005 | World Journal of Gastroenterology2005，11，8： | 7 |
| 15 | Wound-Induced Shoot-to-Root Relocation of JA-Ile Precursors Coordinates Arabidopsis Growth显示文摘Multicellular organisms rely on the movement of signaling molecules across cells,tissues,and organs to communicate among distal sites.In plants,localized leaf damage activates jasmonic acid(JA)-dependent transcriptional reprogramming in both harmed and unharmed tissues.Although it has been indicated that JA species can translocate from damaged into distal sites,the identity of the mobile compound(s),the tissues through which they translocate,and the effect of their relocation remain unknown.Here,we found that following shoot wounding,the relocation of endogenous jasmonates through the phloem is essential to initiate JA signaling and stunt growth in unharmed roots of Arabidopsis thaliana.By employing grafting experiments and hormone profiling,we uncovered that the hormone precursor cis-12-oxo-phytodienoic acid(OPDA)and its derivatives,but not the bioactive JA-Ile conjugate,translocate from wounded shoots into undamaged roots.Upon root relocation,the mobile precursors cooperatively regulated JA responses through their conversion into JA-Ile and JA signaling activation.Collectively,our findings demonstrate the existence of long-distance translocation of endogenous OPDA and its derivatives,which serve as mobile molecules to coordinate shoot-to-root responses,and highlight the importance of a controlled redistribution of hormone precursors among organs during plant stress acclimation. | Adina Schulze Marlene Zimmer Stefan Mielke Hagen Stellmach Charles WMelnyk Bettina Hause Debora Gasperini | 2019 | Molecular Plant2019，12，10： | 7 |
| 16 | IL-8在食管癌中表达对肿瘤血管形成及患者预后的影响显示文摘目的研究白细胞介素8(IL8)在食管癌组织中的表达变化,以及此变化对肿瘤血管形成、患者预后的影响。方法利用实时逆转录聚合酶链反应(realtimeRT PCR)和免疫组织化学技术检测食管癌及正常组织中IL8mRNA和蛋白表达,并采用Ⅷ因子相关抗原(FⅧRAg)检测微血管密度。结果食管癌组织中IL8mRNA及蛋白表达显著高于正常组织。IL8mRNA高表达与远处淋巴结转移、微血管高密度、生存时间短(<26个月)、早期复发(<16个月)有关(均P<0.05)。癌组织中微血管密度比周围正常组织高(P<0.01)。结论在食管癌中,IL8mRNA高表达的患者发生转移机率高,复发早,生存时间短;IL8可以作为一个判定食管癌预后的指标。 | 苏铁芬 Bettina Tilton 袁永辉 李娜萍 Martin Schilling 吴人亮 | 2005 | 华中科技大学学报(医学版)2005，34，4： | 7 |
| 17 | Metabolic diversity in sweet potato (Ipomoea batatas, Lam.) leaves and storage roots显示文摘Sweet potato(Ipomoea batatas,Lam.)is an important root vegetable in developing countries.After its domestication in Neotropical America,human migration led to the distribution of the sweet potato plant throughout the world.Both leaf and storage root are high in compounds of nutritional value.Yet,the storage roots are of particular value due to their significant content of provitamin A(β-carotene).The breeding effort for elite sweet potato lines led to the reduction of genetic diversity and the potential to improve other traits.The focus of the present study was to assess the metabolic diversity of 27 sweet potato cultivars including landraces and improved varieties.A metabolite profiling approach was optimised for sweet potato leaf and storage root tissue and 130 metabolites identified with three different analysis platforms.The data highlighted a lack of correlation between storage root phenotype and leaf metabolism.Furthermore,the metabolic diversity of storage roots was based on the secondary metabolism,including phenylpropanoids and carotenoids.Three cultivars of three different flesh colouration(yellow,orange and purple)showed a significant difference of the primary metabolism.This data demonstrates the value of metabolite profiling to breeding programs as a means of identifying differences in phenotypes/chemotypes and characterising parental material for future pre-breeding resources. | Margit Drapal Genoveva Rossel Bettina Heider Paul D.Fraser | 2019 | Horticulture Research2019，6，1： | 6 |
| 18 | Diagnosis of focal liver lesions with deep learning-based multichannel analysis of hepatocyte-specific contrast-enhanced magnetic resonance imaging显示文摘BACKGROUND The nature of input data is an essential factor when training neural networks.Research concerning magnetic resonance imaging(MRI)-based diagnosis of liver tumors using deep learning has been rapidly advancing.Still,evidence to support the utilization of multi-dimensional and multi-parametric image data is lacking.Due to higher information content,three-dimensional input should presumably result in higher classification precision.Also,the differentiation between focal liver lesions(FLLs)can only be plausible with simultaneous analysis of multisequence MRI images.AIM To compare diagnostic efficiency of two-dimensional(2D)and three-dimensional(3D)-densely connected convolutional neural networks(DenseNet)for FLLs on multi-sequence MRI.METHODS We retrospectively collected T2-weighted,gadoxetate disodium-enhanced arterial phase,portal venous phase,and hepatobiliary phase MRI scans from patients with focal nodular hyperplasia(FNH),hepatocellular carcinomas(HCC)or liver metastases(MET).Our search identified 71 FNH,69 HCC and 76 MET.After volume registration,the same three most representative axial slices from all sequences were combined into four-channel images to train the 2D-DenseNet264 network.Identical bounding boxes were selected on all scans and stacked into 4D volumes to train the 3D-DenseNet264 model.The test set consisted of 10-10-10 tumors.The performance of the models was compared using area under the receiver operating characteristic curve(AUROC),specificity,sensitivity,positive predictive values(PPV),negative predictive values(NPV),and f1 scores.RESULTS The average AUC value of the 2D model(0.98)was slightly higher than that of the 3D model(0.94).Mean PPV,sensitivity,NPV,specificity and f1 scores(0.94,0.93,0.97,0.97,and 0.93)of the 2D model were also superior to metrics of the 3D model(0.84,0.83,0.92,0.92,and 0.83).The classification metrics of FNH were 0.91,1.00,1.00,0.95,and 0.95 using the 2D and 0.90,0.90,0.95,0.95,and 0.90 using the 3D models.The 2D and 3D networks'performance in the diagnosis of HCC were 1.00,0.80,0.91,1.00,and 0.89 and 0.88,0.70,0.86,0.95,and 0.78,respectively;while the evaluation of MET lesions resulted in 0.91,1.00,1.00,0.95,and 0.95 and 0.75,0.90,0.94,0.85,and 0.82 using the 2D and 3D networks,respectively.CONCLUSION Both 2D and 3D-DenseNets can differentiate FNH,HCC and MET with good accuracy when trained on hepatocyte-specific contrast-enhanced multi-sequence MRI volumes. | Róbert Stollmayer Bettina K Budai Ambrus Tóth IldikóKalina Erika Hartmann Péter Szoldán Viktor Bérczi Pál Maurovich-Horvat Pál N Kaposi | 2021 | World Journal of Gastroenterology2021，27，35： | 6 |
| 19 | Late biliary complications in human alveolar echinococcosis are associated with high mortality显示文摘AIM:To evaluate the incidence of late biliary complications in non-resectable alveolar echinococcosis(AE)under long-term chemotherapy with benzimidazoles.METHODS:Retrospective analysis of AE patients with biliary complications occurring more than three years after the diagnosis of AE.We compared characteristics of patients with and without biliary complications,analyzed potential risk factor for biliary complications and performed survival analyses.RESULTS:Ninety four of 148 patients with AE in Zurich had non-resectable AE requiring long-term benzimidazole chemotherapy,of which 26(28%)patients developed late biliary complications.These patients had a median age of 55.5(35.5-65)years at diagnosis of AE and developed biliary complications after 15(8.25-19)years of chemotherapy.The most common biliary complications during long-term chemotherapy were late-onset cholangitis(n=14),sclerosing cholangitis-like lesions(n=8),hepatolithiasis(n=5),affection of the common bile duct(n=7)and secondary biliary cirrhosis(n=7).Thirteen of the 26 patients had undergone surgery(including 12 resections)before chemotherapy.Previous surgery was a risk factor for late biliary complications in linear regression analysis(P=0.012).CONCLUSION:Late biliary complications can be observed in nearly one third of patients with non-resectable AE,with previous surgery being a potential risk factor.After the occurrence of late biliary complications,the median survival is only 3 years,suggesting that late biliary complications indicate a poor prognostic outcome. | Pascal Frei Benjamin Misselwitz Meher K Prakash Alain M Schoepfer Bettina M Prinz Vavricka Beat Müllhaupt Michael Fried Kuno Lehmann Rudolf W Ammann Stephan R Vavricka | 2014 | World Journal of Gastroenterology2014，20，19： | 5 |
| 20 | Can mouse models mimic sporadic Alzheimer’s disease?显示文摘Alzheimer’s disease(AD)is a progressive neurodegenerative disorder and the most common form of dementia worldwide.As age is the main risk factor,>97%of all AD cases are of sporadic origin,potentiated by various risk factors associated with life style and starting at an age>60 years.Only<3%of AD cases are of genetic origin caused by mutations in the amyloid precursor protein or Presenilins 1 or 2,and symptoms already start at an age<30 years.In order to study progression of AD,as well as therapeutic strategies,mouse models are state-of-the-art.So far many transgenic mouse models have been developed and used,with mutations in the APP or presenilin or combinations(3×Tg,5×Tg).However,such transgenic mouse models more likely mimic the genetic form of AD and no information can be given how sporadic forms develop.Several risk genes,such as Apolipoprotein E4 and TREM-2 enhance the risk of sporadic AD,but also many risk factors associated with life style(e.g.,diabetes,hypercholesterolemia,stress)may play a role.In this review we discuss the current situation regarding AD mouse models,and the problems to develop a sporadic mouse model of AD. | Bettina M.Foidl Christian Humpel | 2020 | Neural Regeneration Research2020，15，3： | 4 |
您所在的机构暂未开通此部分的功能，请联系管理员