|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Accumulation of Somatic Mutations in TP53 in Gastric Epithelium with Helicobacter pylori infection显示文摘 | Takahiro Shimizu Hiroyuki Marusawa Yuko Matsumoto Tadashi Inuzuka Atsuyuki Ikeda Yosuke Fujii Sachiko Minamiguchi Shin’ichi Miyamoto Tadayuki Kou Yoshiharu Sakai Jean E. Crabtree Tsutomu Chiba | 2014 | Gastroenterology2014，，： | 2 |
| 2 | Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle显示文摘Whether glucose is predomi nantly metabolized via oxidative phosphorylati on or glycolysis differs between quiesce nt versus proliferating cells,iincluding tumor cells.However,how glucose metabolism is coordinated with cell cycle in mammalian cells remains elusive.Here,we report that mammalian cells predominantly utilize the tricarboxylic acid(TCA)cycle in G1 phase,but prefer glycolysis in S phase.Mechanistically,coupling cell cycle with metabolism is largely achieved by timely destruction of IDH1/2,key TCA cycle enzymes,in a Skp2-dependent manner.As such,depleting SKP2 abolishes cell cycle-dependent fluctuation of IDH1 protein abundance,leading to reduced glycolysis in S phase.Furthermore,elevated Skp2 abundance in prostate cancer cells destabilizes IDH1 to favor glycolysis and subsequent tumorigenesis.Therefore,our study reveals a mechanistic link between two cancer hallmarks,aberrant cell cycle and addiction to glycolysis,and provides the underlying mechanism for the coupling of metabolic fluctuation with periodic cell cycle in mammalian cells. | Jing Liu Yunhua Peng Le Shi Lixin Wan Hiroyuki Inuzuka Jiangang Long Jianping Guo Jinfang Zhang Min Yuan Shuangxi Zhang Xun Wang Jing Gao Xiangpeng Dai Shozo Furumoto Lijun Jia Pier Paolo Pandolfic John M.Asara William G.Kaelin Jr. Jjankang Liu Wenyi Wei | 2021 | Cell Research2021，31，1： | 2 |
| 3 | Regulation of APC^cdh1 E3 ligase activity by the Fbw7/cyclin E signaling axis contributes to the tumor suppressor function of Fbw7显示文摘Fbw7 和 Cdh1 分别地是 SCF 类型和 APC 类型 E3 ubiquitin ligases 的底层识别子单元。新兴的证据由为破坏指向 oncoproteins 作为肿瘤 suppressors 正在建议那 Fbw7 和 Cdh1 功能。Fbw7 的损失,然而并非 Cdh1,经常在各种各样的人的肿瘤被观察。然而, Fbw7 怎么机械学地作为肿瘤 suppressor 工作并且是否在 Fbw7 和 Cdh1 之间有发信号的串音,仍然保持大部分未知。这里,我们报导那 Fbw7 缺乏的房间不仅显示 SCF Fbw7 底层包括 cyclin E,而且增加了各种各样的 APC Cdh1 底层。我们进一步把 cyclin E 定义为 Fbw7 由管理 APC Cdh1 活动,在 Fbw7 缺乏的房间的 cyclin E 的弄空导致 APC Cdh1 底层到比得上那些的层次在野类型(WT ) 房间。相反地, cyclin E 的宫外的表示概括异常 APC 在 Fbw7 缺乏的房间观察的 Cdh1 底层表示。更重要地,对 Cdk2/cyclin 电子 mediated phosphorylation 抵抗的 4A-Cdh1,然而并非 WT-Cdh1,颠倒了各种各样的 APC 在 Fbw7 缺乏的房间的 Cdh1 底层。4A-Cdh1 的 Overexpression 也导致了延迟的房间生长并且减少抛锚无关的殖民地形成。总的来说,我们识别了 Fbw7 以一种 cyclin 电子依赖者方式由管理 Cdh1 活动的新奇规章的机制。作为结果, Fbw7 的损失能在两 SCF Fbw7 和 APC Cdh1 底层。我们的学习提供 Fbw7 的肿瘤 suppressor 功能的更好的理解,并且建议禁止者能为治疗 Fbw7 缺乏的肿瘤作为有效治疗学的代理人服务的那 Cdk2/cyclin E。 | Alan WLau Hiroyuki Inuzuka Hidefumi Fukushima LixinWan Pengda Liu Daming Gao Yi Sun Wenyi Wei | 2013 | Cell Research2013，23，7： | 1 |
| 4 | SCFβ-TRCP E3 ubiquitin ligase targets the tumor suppressor ZNRF3 for ubiquitination and degradation显示文摘 | Yanpeng Ci Xiaoning Li Maorong Chen Jiateng Zhong Brian J. North Hiroyuki Inuzuka Xi He Yu Li Jianping Guo Xiangpeng Dai | 2018 | Protein & Cell2018，9，10： | 1 |
| 5 | Functional analysis of the emerging roles for the KISS1/KISS1R signaling pathway in cancer metastasis显示文摘Cancer metastasis, a process that primary tumor cells disseminate to secondary organs, is the most lethal and least effectively treated characteristic of human cancers. Kisspeptins are proteins encoded by the KISS1 gene that was originally described as a melanoma metastasis suppressor gene. Then, Kisspeptins were discovered as the natural ligands of the G-protein-coupled receptor 54(GPR54) that is also called KISS1R. The KISS1/KISS1R signaling is essential to control Gn RH secretion during puberty and to establish mammalian reproductive function through the hypothalamic-pituitary-gonadal(HPG) axis. Although KISS1primarily plays a suppressive role in the metastasis progression in several cancer types, emerging evidence indicates that the physiological effect of KISS1/KISS1R in cancer metastasis is tissue context-dependent and still controversial. Here, we will discuss the epigenetic mechanism involved in the regulation of KISS1 gene expression, the context-dependent role of KISS1/KISS1R, prometastasis/anti-metastasis signaling pathways of KISS1/KISS1R, and the perspective anticancer therapeutics via targeting KISS1/KISS1R. | Zhenxi Li Jing Liu Hiroyuki Inuzuka Wenyi Wei | 2022 | Journal of Genetics and Genomics2022，49，3： | 1 |
| 6 | Author Correction:Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle显示文摘The author affiliations were mixed up in the previous published version.In addition,the author contribution section missed a statement of The idea was conceived by J.K.L.,W.W.and This correction does not affect the description of the results or the conclusion of this work.We apologize for any inconvenience this may have caused. | Jing Liuc Yunhua Peng Le Shi Lixin Wanc Hiroyuki Inuzuka Jiangang Long Jianping Guo Jinfang Zhang Min Yuan Shuangxi Zhang Xun Wangc Jing Gao Xiangpeng Dai Shozo Furumoto Lijun Jia Pier Paolo Pandolfi John M.Asara William G.Kaelin Jr. Jiankang Liu Wenyi Wei | 2021 | Cell Research2021，31，1： | 0 |
| 7 | PCAF and SIRT1 modulateβTrCP1 protein stability in an acetylation-dependent manner显示文摘Ubiquitination plays critical roles in regulating various physiological events,such as protein degradation,activation,secretion,sorting and trafficking(Dang et al.,2021).The ubiquitination process involves three major steps,catalyzed by ubiquitin-activating enzymes(E1s),ubiquitin-conjugating enzymes(E2s),and ubiquitin ligases(E3s),respectively(Scheffner et al.,1995). | Fabin Dang Cong Jiang Tao Zhang Hiroyuki Inuzuka Wenyi Wei | 2021 | Journal of Genetics and Genomics2021，48，7： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员