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| 1 | Gut-brain connection: The neuroprotective effects of the anti-diabetic drug liraglutide显示文摘Long-acting glucagon-like peptide-1(GLP-1) analogues marketed for type 2 diabetes(T2D) treatment have been showing positive and protective effects in several different tissues, including pancreas, heart or even brain. This gut secreted hormone plays a potent insulinotropic activity and an important role in maintaining glucose homeostasis. Furthermore, growing evidences suggest the occurrence of several commonalities between T2 D and neurodegenerative diseases, insulin resistance being pointed as a main cause for cognitive decline and increased risk to develop dementia. In this regard, it has also been suggested that stimulation of brain insulin signaling may have a protective role against cognitive deficits. As GLP-1 receptors(GLP-1R) are expressed throughout the central nervous system and GLP-1 may cross the blood-brain-barrier, an emerging hypothesis suggests that they may be promising therapeutic targets against brain dysfunctional insulin signaling-related pathologies. Importantly, GLP-1 actions depend not only on the direct effect mediated by its receptor activation, but also on the gut-brain axis involving an exchange of signals between both tissues via the vagal nerve, thereby regulating numerous physiological functions(e.g., energy homeostasis, glucose-dependent insulin secretion, as well as appetite and weight control). Amongst the incretin/GLP-1 mimetics class of anti-T2 D drugs with an increasingly described neuroprotective potential, the already marketed liraglutide emerged as a GLP-1R agonist highly resistant to dipeptidyl peptidase-4 degradation(thereby having an increased half-life) and whose systemic GLP-1R activity is comparable to that of native GLP-1. Importantly, several preclinical studies showed anti-apoptotic, anti-inflammatory, anti-oxidant and neuroprotective effects of liraglutide against T2 D, stroke and Alzheimer disease(AD), whereas several clinical trials, demonstrated some surprising benefits of liraglutide on weight loss, microglia inhibition, behavior and cognition, and in AD biomarkers. Herein, we discuss the GLP-1 action through the gut-brain axis, the hormone's regulation of some autonomic functions and liraglutide's neuroprotective potential. | Emanuel Monteiro Candeias Inês Carolina Sebastio Susana Maria Cardoso Sónia Catarina Correia Cristina Isabel Carvalho Ana Isabel Plácido Maria Sancha Santos Catarina Resende Oliveira Paula Isabel Moreira Ana Isabel Duarte | 2015 | World Journal of Diabetes2015，6，6： | 9 |
| 2 | 电镀污水净化新工艺——电浮选方法简介显示文摘综述了电浮选方法处理电镀污水的基本原理和提高电浮选净水技术的途径。重点介绍了俄罗斯门捷列夫化工大学的电浮选两种新工艺方法。 | 邵会波 S O Varaxin V A Kolesnikov VI Il’in | 2003 | 化学通报2003，66，12： | 6 |
| 3 | Second-line Therapy With Levofloxacin After Failure of Treatment to Eradicate Helicobacter pylori Infection: Time Trends in a Spanish Multicenter Study of 1000 Patients显示文摘 | Javier P. Gisbert ángeles Pérez-Aisa Fernando Bermejo Manuel Castro-Fernández Pedro Almela Jesús Barrio ángel Cosme Inés Modolell Felipe Bory Miguel Fernández-Bermejo Luis Rodrigo Jesús Ortu?o Pilar Sánchez-Pobre Sam Khorrami Alejandro Franco Albert Tomas | 2013 | Journal of Clinical Gastroenterology2013，，2： | 5 |
| 4 | Effect of biofeedback accompanying occupational therapy and functional electrical stimulation in hemiplegic patients显示文摘 | Maria Inês Paes Louren??o Linamara Rizzo Battistella Christina May Moran de Brito Gracinda Rodrigues Tsukimoto Margarida Harumi Miyazaki | 2008 | International Journal of Rehabilitation Research2008，，1： | 2 |
| 5 | Molecular analysis of the root canal microbiota associated with endodontic treatment failures显示文摘 | Sakamoto M Siqueira JF Jr R(o)(c)as IN | 2008 | Oral Microbiol Immunol2008，23，4： | 1 |
| 6 | Producer Services in the Urban Core and Suburbs of Phoenix, Arizona显示文摘 | Breanda'n O'hUallacha'in Timothy F Leslie | 2007 | Urban Studies2007，，8： | 1 |
| 7 | Polar Organic Solvent Rem oval in Microcosm Constructed Wet lands 显示文摘 | Grove J K Ste in O R | 2005 | Water Research2005，39，： | 1 |
| 8 | Vitamin B biosynthesis in higher plants 显示文摘 | B6 status Nutricion sources in American Tambasco-Studart M Titiz O Raschle T | 2005 | Proceedings of the National Academy of Sciences of the United States of America2005，102，13： | 1 |
| 9 | Prognostic significance of the combined expression of matrix metalloproteinase-9, urokinase type plasminogen activator and its receptor in breast cancer as measured by Northern blot analysis 显示文摘 | Pacheco MM Nishimoto IN Mour? o Neto M | 2001 | Int J Biol Markers2001，16，1： | 1 |
| 10 | Gender and nasal shape: Measures for rhinoplasty显示文摘 | Springer IN Zernial O Nrlke F | 2008 | Plast Reconstr Surg2008，121，2： | 1 |
| 11 | DAP -kinase loss of expression invarious carcinoma and B - cell lymphoma cell lymphoma lines Possible implications for role as tumor suppressor 显示文摘 | Kissil J Feinste in E cohen O | 1997 | Oncogene1997，15，： | 1 |
| 12 | A nationwide study in Finland 显示文摘 | Arola A Jokinen E Ruuskanen O et aL Epidemiology of idiopathic cardiomyopathies in children and adolescents | 1997 | Am J Epidemiol1997，146，5： | 1 |
| 13 | Radical scavenging activity and antioxidant capacity of bay leaf extracts显示文摘 | ELMASTA- M Gt-L$IN I I-ILDAK O | 2006 | Journal of the Iranian Chemical Society2006，3，3： | 1 |
| 14 | Quantifying nuclear p65 as a parameter for NF-κB activation:Correlation between ImageStream cytometry,microscopy,and Western blot显示文摘 | Maguire O Col ins C O'Loughlin K | | 0，，06： | 1 |
| 15 | A randomized, controlled trial 显示文摘 | Tidemark J Ponzer S Svenson O Internal fixation compaired with total hip replacement for displaced femoral neck fractures in the elderly | 2003 | J Bone Joint Surg (Br)2003，85，： | 1 |
| 16 | El ement a r y Cl a s s r oomManagement:Lessons from Research and Practice显示文摘 | Ca r o l S imon Weins t e in | 2003 | Journal ofWomen’s Health2003，，： | 1 |
| 17 | Preva- the United States, UnitedKingdom, and Australia : Arousal and avoidance de- lays among adults 显示文摘 | Ferrari J R O Callaghan lence of procrastination in J & Newbegin I | 2005 | North American Journal of Psychology2005，，： | 1 |
| 18 | The levels of glutathione peroxidase,vitamin A,E,C and lipid peroxidation in patients with transitional cell carcinoma of the bladder显示文摘 | Yal in O Karata F Erula FA | 2013 | BJU Int2013，93，6： | 1 |
| 19 | T h e C ro sssectio n o f V olatility an d E x p ec ted R etu rn s 显示文摘 | A n g A H o d ric k R J X in g Y Z h an g X | 2006 | Jo u rn al o fFinance2006，61，1： | 1 |
| 20 | A single stage posterior approach and rigid fixation for preventing kyphosis in the treatment of spinal tuberculosis显示文摘 | Güven O Kumano K Yal(c)in S | | 0，，1976： | 1 |
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