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| 1 | Benefit of neoadjuvant concurrent chemoradiotherapy for locally advanced perihilar cholangiocarcinoma显示文摘AIM To clarify the role of neoadjuvant concurrent chemoradiotherapy(NACCRT) followed by surgical resection for localized or locally advanced perihilar cholangiocarcinoma(CCA).METHODS We retrospectively reviewed 57 patients who underwent surgical resection with or without NACCRT for perihilar CCA; 12 patients received NACCRT and 45 patients did not received NACCRT. Patients with locally advanced perihilar CCA requiring NACCRT were defined as follows:(1) a mass involving unilateral branches of the portal vein or hepatic artery with insufficient volume of the anticipated remnant lobe; or(2) an infiltrating mass in the main portal vein that was too long for reconstruction, identified at preoperative staging. RESULTS The median disease-free survival(DFS) durations of the neoadjuvant and non-neoadjuvant CCRT groups were26.0 and 15.1 mo, respectively(P = 0.91). The median overall survival(OS) durations of the neoadjuvant and non-neoadjuvant CCRT groups were 32.9 and 27.1 mo, respectively(P = 0.26). The NACCRT group showed a downstaging tendency compared to the non-NACCRT group as compared with the tumor stage confirmed by histological examination after surgery and the tumor stage confirmed by imaging test at the time of diagnosis(P = 0.01). CONCLUSION NACCRT does not prolong DFS and OS in localized or locally advanced perihilar CCA. However, NACCRT may allow tumor downstaging and improve tumor resectability. | Jang Han Jung Hyun Jik Lee Hee Seung Lee Jung Hyun Jo In Rae Cho Moon Jae Chung Jeong Youp Park Seung Woo Park Si Young Song Seungmin Bang | 2017 | World Journal of Gastroenterology2017，23，18： | 21 |
| 2 | Pretreated quercetin protects gerbil hippocampal CA1 pyramidal neurons from transient cerebral ischemic injury by increasing the expression of antioxidant enzymes显示文摘Quercetin(QE; 3,5,7,3′,4′-pentahydroxyflavone), a well-known flavonoid, has been shown to prevent against neurodegenerative disorders and ischemic insults. However, few studies are reported regarding the neuroprotective mechanisms of QE after ischemic insults. Therefore, in this study, we investigated the effects of QE on ischemic injury and the expression of antioxidant enzymes in the hippocampal CA1 region of gerbils subjected to 5 minutes of transient cerebral ischemia. QE was pre-treated once daily for 15 days before ischemia. Pretreatment with QE protected hippocampal CA1 pyramidal neurons from ischemic injury, which was confirmed by neuronal nuclear antigen immunohistochemistry and Fluoro-Jade B histofluorescence staining. In addition, pretreatment with QE significantly increased the expression levels of endogenous antioxidant enzymes Cu/Zn superoxide dismutase, Mn superoxide dismutase, catalase and glutathione peroxidase in the hippocampal CA1 pyramidal neurons of animals with ischemic injury. These findings demonstrate that pretreated QE displayed strong neuroprotective effects against transient cerebral ischemia by increasing the expression of antioxidant enzymes. | Bai Hui Chen Joon Ha Park Ji Hyeon Ahn Jeong Hwi Cho In Hye Kim Jae Chul Lee Moo-Ho Won Choong-Hyun Lee In Koo Hwang Jong-Dai Kim Il Jun Kang Jun Hwi Cho Bich Na Shin Yang Hee Kim Yun Lyul Lee Seung Min Park | 2017 | Neural Regeneration Research2017，12，2： | 9 |
| 3 | Ischemic colitis secondary to inferior mesenteric arteriovenous fistula and portal vein stenosis in a liver transplant recipient显示文摘Arteriovenous fistula (AVF) involving the inferior mesenteric vessels is rare, and the affected patients usually present with abdominal pain, mass, or features of established portal hypertension. Colonic ischemia is a less common and more serious manifestation of AVF. We report a case of ischemic colitis secondary to inferior mesenteric AVF in a patient who underwent a previous liver transplantation, subsequently developed portal vein stenosis, and then presented with acute lower gastrointestinal bleeding. He underwent percutaneous transhepatic placement of a portal vein stent and left colectomy. | In Hee Kim Dae Ghon Kim Hyo Sung Kwak Hee Chul Yu Baik Hwan Cho Ho Sung Park | 2008 | World Journal of Gastroenterology2008，14，26： | 2 |
| 4 | The Relationship Between Lower Urinary Tract Symptoms/Benign Prostatic Hyperplasia and the Number of Components of Metabolic Syndrome显示文摘 | Yeon Won Park Sung Bin Kim Hanna Kwon Hee Cheol Kang Kyunghee Cho Kung In Lee Yung Jung Kim Jun Ho Lee | 2013 | Urology2013，，3： | 2 |
| 5 | Effect of hyperthermia on calbindin-D 28k immunoreactivity in the hippocampal formation following transient global cerebral ischemia in gerbils显示文摘Calbindin D-28K(CB), a Ca2+-binding protein, maintains Ca2+ homeostasis and protects neurons against various insults. Hyperthermia can exacerbate brain damage produced by ischemic insults. However, little is reported about the role of CB in the brain under hyperthermic condition during ischemic insults. We investigated the effects of transient global cerebral ischemia on CB immunoreactivity as well as neuronal damage in the hippocampal formation under hyperthermic condition using immunohistochemistry for neuronal nuclei(Neu N) and CB, and Fluoro-Jade B histofluorescence staining in gerbils. Hyperthermia(39.5 ± 0.2°C) was induced for 30 minutes before and during transient ischemia. Hyperthermic ischemia resulted in neuronal damage/death in the pyramidal layer of CA1–3 area and in the polymorphic layer of the dentate gyrus at 1, 2, 5 days after ischemia. In addition, hyperthermic ischemia significantly decreaced CB immunoreactivity in damaged or dying neurons at 1, 2, 5 days after ischemia. In brief, hyperthermic condition produced more extensive and severer neuronal damage/death, and reduced CB immunoreactivity in the hippocampus following transient global cerebral ischemia. Present findings indicate that the degree of reduced CB immunoreactivity might be related with various neuronal damage/death overtime and corresponding areas after ischemic insults. | Jae-Chul Lee Jeong-Hwi Cho Tae-Kyeong Lee In Hye Kim Moo-Ho Won Geum-Sil Cho Bich-Na Shin In Koo Hwang Joon Ha Park Ji Hyeon Ahn Il Jun Kang Young Joo Lee Yang Hee Kim | 2017 | Neural Regeneration Research2017，12，9： | 2 |
| 6 | Determination and validation of tetrodotoxin in human whole blood using hydrophilic interaction liquid chromatography–tandem mass spectroscopy and its application显示文摘 | Hwang Eui Cho Su Youn Ahn In Seop Son Sangwhan In Ran Seon Hong Dong Woo Kim Sang Hee Woo Dong Cheul Moon Suncheun Kim | 2011 | Forensic Science International (-)2011，，1： | 2 |
| 7 | Nanofiber alignment and direction of mechanical strain affect the ECM production of human ACL fibroblast显示文摘 | Chang Huu Lee Ho Joon Shin In Hee Cho | 2005 | Biomaterial2005，26，： | 1 |
| 8 | Aroma active compounds of bulgogi 显示文摘 | Hye Sungko Tae Hwan Kim In Hee Cho | 2005 | Food Chemistry and Toxicology2005，70，8： | 1 |
| 9 | Endothelial dysfunction, increased carotid artery intima-media thickness and pulse wave velocity, and increased level of inflammatory markers are associated with variant angina显示文摘 | Sook Hee Cho Myung Ho Jeong In Hyae Park Jin Soo Choi Hyun Ju Yoon Kye Hun Kim Young Joon Hong Hyung Wook Park Ju Han Kim Youngkeun Ahn Jeong Gwan Cho Jong Chun Park Jung Chaee Kang | 2009 | Journal of Cardiology2009，，2： | 1 |
| 10 | Neuroprotective effects of ischemic preconditioning on hippocampal CA1 pyramidal neurons through maintaining calbindin D28k immunoreactivity following subsequent transient cerebral ischemia显示文摘Ischemic preconditioning elicited by a non-fatal brief occlusion of blood flow has been applied for an experimental therapeutic strategy against a subsequent fatal ischemic insult. In this study, we investigated the neuroprotective effects of ischemic preconditioning(2-minute transient cerebral ischemia) on calbindin D28k immunoreactivity in the gerbil hippocampal CA1 area following a subsequent fatal transient ischemic insult(5-minute transient cerebral ischemia). A large number of pyramidal neurons in the hippocampal CA1 area died 4 days after 5-minute transient cerebral ischemia. Ischemic preconditioning reduced the death of pyramidal neurons in the hippocampal CA1 area. Calbindin D28k immunoreactivity was greatly attenuated at 2 days after 5-minute transient cerebral ischemia and it was hardly detected at 5 days post-ischemia. Ischemic preconditioning maintained calbindin D28 k immunoreactivity after transient cerebral ischemia. These findings suggest that ischemic preconditioning can attenuate transient cerebral ischemia-caused damage to the pyramidal neurons in the hippocampal CA1 area through maintaining calbindin D28k immunoreactivity. | In Hye Kim Yong Hwan Jeon Tae-Kyeong Lee Jeong Hwi Cho Jae-Chul Lee Joon Ha Park Ji Hyeon Ahn Bich-Na Shin Yang Hee Kim Seongkweon Hong Bing Chun Yan Moo-Ho Won Yun Lyul Lee | 2017 | Neural Regeneration Research2017，12，6： | 1 |
| 11 | Analysis of fra- grance volatiles of Korean Rosa hybrida using gas chromatography-Mass spectrometry显示文摘 | Yong Sik Cho In Hee Cho Hong Ju Park | 2006 | Agric Chem Biotechnol2006，49，4： | 1 |
| 12 | Relationship between Environmental Phthalate Exposure and the Intelligence of School-Age Children显示文摘 | Cho Soo-Churl Bhang Soo-Young Hong Yun-Chul Shin Min-Sup Kim Boong-Nyun Kim Jae-Won Yoo Hee-Jung Cho In Hee Kim Hyo-Won | 2010 | Environmental Health Perspectives2010，，7： | 1 |
| 13 | Subclinical atherosclerosis in a community-based elderly cohort: The Korean Longitudinal Study on Health and Aging显示文摘 | Soo Lim Hyung Jin Choi Hayley Shin Ah Reum Khang Seon Mee Kang Ji Won Yoon Sung Hee Choi In Kyong Jeong Sung Il Cho Kyong Soo Park Hak Chul Jang | 2011 | International Journal of Cardiology2011，，1： | 1 |
| 14 | Changes in serum histologic surrogate markers and procollagen III N-terminal peptide as independent predictors of HBeAg loss in patients with chronic hepatitis B during entecavir therapy显示文摘 | Jee Hoon Koo Myoung Hee Lee Soon Sun Kim Dong Hoon Kim In Sung Kim Kee Myung Lee Byung Moo Yoo Kwang Jae Lee Jin Hong Kim Sung Won Cho Jae Youn Cheong | 2011 | Clinical Biochemistry2011，，1： | 1 |
| 15 | Predictive Factors for Node Metastasis in Patients With Clinical Stage I Non-Small Cell Lung Cancer显示文摘 | Sukki Cho In Hag Song Hee Chul Yang Kwhanmien Kim Sanghoon Jheon | 2013 | The Annals of Thoracic Surgery2013，，1： | 1 |
| 16 | Analysis of fragrance volatiles of korean rosa hybrida using gas chromatography-mass spectrometry显示文摘 | Yong Sik Cho In Hee Cho Hong Ju Park | 2006 | Agric Chem Biotechnol2006，49，4： | 1 |
| 17 | A nationwide seroepidemiology of hepatitis C virus infection in South Korea显示文摘 | Do Young Kim In Hee Kim Sook‐Hyang Jeong Yong Kyun Cho Joon Hyoek Lee Young‐Joo Jin Don Lee Dong Jin Suh Kwang‐Hyub Han Neung Hwa Park Ha Yan Kang Young Kul Jung Young Seok Kim Kyung‐Ah Kim Youn Jae Lee Byung Seok Lee Hyung Joon Yim Heon Ju Lee Soon Koo B | 2013 | Liver Int2013，，4： | 1 |
| 18 | FOLFIRINOX vs gemcitabine/nab-paclitaxel for treatment of metastatic pancreatic cancer: Single-center cohort study显示文摘BACKGROUND FOLFIRINOX and gemcitabine plus nab-paclitaxel(Gem+nabPTX)were recently introduced for metastatic pancreatic cancer treatment.However,studies that compared these two regimens and studies in Asian populations are lacking.AIM To compare the treatment outcomes of FOLFIRINOX and Gem+nabPTX regimen for metastatic pancreatic cancer treatment in Korean population.METHODS Patients with metastatic or recurrent pancreatic cancer treated with FOLFIRINOX(n=86)or Gem+nabPTX(n=81)as the first-line since January 2015 were identified using the Severance Hospital Pancreatic Cancer Cohort Registry.Treatment efficacy,treatment-related adverse events and economic aspects were compared.RESULTS Patients in the FOLFIRINOX group were significantly younger(54 vs 65 years;P<0.001)and had better performance statuses at diagnosis.The median overall survival(10.7 vs 12.1 mo;P=0.157),progression-free survival(8.0 vs 8.4 mo;P=0.134),and objective response rates(33.7%vs 46.9%;P=0.067)were not significantly different when compared with Gem+nabPTX group.Grade≥3 neutropenia and gastrointestinal adverse events were more common in the FOLFIRINOX group.The drug costs of both regimens were similar.CONCLUSION Treatment efficacy and economic burdens were comparable between the two regimens.But,the details of adverse event were different.Gem+nabPTX regimen might be considered preferentially in certain conditions. | In Rae Cho Huapyong Kang Jung Hyun Jo Hee Seung Lee Moon Jae Chung Jeong Youp Park Seung Woo Park Si Young Song Chansik An Mi-Suk Park Seungmin Bang | 2020 | World Journal of Gastrointestinal Oncology2020，12，2： | 1 |
| 19 | Metabolomic discrimination of different grades of pine-mushroom ( Tricholoma matsutake Sing.) using 1 H NMR spectrometry and multivariate data analysis显示文摘 | In Hee Cho Young-Suk Kim Hyung-Kyoon Choi | 2006 | Journal of Pharmaceutical and Biomedical Analysis2006，，3： | 1 |
| 20 | Effect of a peroxisome proliferator-activated receptor γ sumoylation mutant on neointimal formation after balloon injury in rats显示文摘 | Soo Lim Byung Yong Ahn Sung Soo Chung Ho Seon Park Bong Jun Cho Min Kim Sung Hee Choi In Kyu Lee Sang-Won Lee Soo Joon Choi Chin Ha Chung Young Min Cho Hong Kyu Lee Kyong Soo Park | 2009 | Atherosclerosis2009，，2： | 1 |
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