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82篇 您的检索式：作者名="Zhelev"

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	题名	作者	年代	出处	被引量
1	Overproduction of reactive oxygen species–obligatory or not for induction of apoptosis by anticancer drugs显示文摘Many studies demonstrate that conventional anticancer drugs elevate intracellular level of reactive oxygen species(ROS) and alter redox-homeostasis of cancer cells. It is widely accepted that anticancer effect of these chemotherapeutics is due to induction of oxidative stress and ROS-mediated apoptosis in cancer. On the other hand, the harmful side effects of conventional anticancer chemotherapy are also due to increased production of ROS and disruption of redox-homeostasis of normal cells and tissues. This article describes the mechanisms for triggering and modulation of apoptosis through ROS-dependent and ROS-independent pathways. We try to answer the question: 'Is it possible to induce highly specific apoptosis only in cancer cells, without overproduction of ROS, as well as without harmful effects on normal cells and tissues?' The review also suggests a new therapeutic strategy for selective killing of cancer cells, without significant impact on viability of normal cells and tissues, by combining anticancer drugs with redox-modulators, affecting specific signaling pathways and avoiding oxidative stress.	Donika Ivanova Zhivko Zhelev Ichio Aoki Rumiana Bakalova Tatsuya Higashi	2016	Chinese Journal of Cancer Research2016，28，4：	3
2	Quantum dot anti-CD conju- gates:are they potential photosensitizersor potentiators of classical photosensitizing agents in photodynamic therapy of cancer 显示文摘	Bakalovar Ohba H Zhelev Z	2004	Nano Letters2004，4，9：	1
3	Chemical nature and structure of organic coating of quantum dots is crucial for their application in imaging diagnostics显示文摘	Bakalova R Zhelev Z Kokuryo D	2011	Int J Nanomedicine2011，6，：	1
4	Cleaner flue gas and energy recovery through pinch analysis显示文摘	Zhelev T K Semkov K A	2004	Journal of Cleaner Production2004，12，2：	1
5	Quantum dots as photosensitizers? 显示文摘	Bakalova R Ohba H Zhelev Z	2004	Nat Bioteeh2004，22，11：	1
6	Quantum dots as photosensitizers显示文摘	Bakalova R Ohba H Zhelev Z	2004	Nat Biotechnol2004，22，：	1
7	Distributed generation: Toward a new energy paradigm 显示文摘	GUERRERO J M BLAABJERG F ZHELEV T	2010	Industrial Electronics Magazine2010，14，1：	1
8	Chemoattractant receptor-stimulated F-actin polymerization in the human neutrophil is signaled by 2 distinct pathways显示文摘	Chodniewicz D Zhelev DV	2003	Blood2003，101，3：	1
9	Suppression of bcr-abl synthesis by siRNAs or tyrosine kinase activity by Glivec alters different oncogenes,apoptotic/antiapoptotic genes and cell proliferation factors (microarray study) 显示文摘	ZHELEV Z BAKALOVA R OHBA H	2004	FEBS Lett2004，570，：	1
10	Quantum dots as photosensitizers 显示文摘	Bakalova R Ohba H Zhelev Z Ishikawa M Baba Y	2004	Nature biotechnology2004，22，11：	1
11	Distributed generation:toward a new energy paradigm显示文摘	Guerrero J M Blaabjerg F Zhelev T		0，，01：	1
12	Phenothiazines suppress proliferation and induce apoptosis in cultured leukemic cells without any influence on the viability of normal lymphocytes显示文摘	Zhelev Z Ohba H Bakalova R	2004	Phenothiazines Leukemia Cancer Chemother Pharmacol2004，53，3：	1
13	Nitroxyl radicals as low toxic spin-labels for non-invasive magnetic resonance ima- ging of blood-brain barrier permeability for conventional therapeutics 显示文摘	Zhelev Z Bakalova R Aoki 1	2009	Chem Commun2009，7，1：	1
14	Suppression of bcr-abl synthesis by siRNAs or tyrosine kinase activity by Glivec alters different oncogenes,apoptotic/antiapoptotic genes and cell proliferation (actors (microarray study)显示文摘	Zhelev Z Bakalova R Ohba H	2004	FEBS Lett2004，570，13：	1
15	Energy recovery and environmental concerns addressed through emergy-pinch analysis显示文摘	Zhelev T K Ridolfi R	2006	Energy2006，31，13：	1
16	The conceptual design approach- A process integration approach on the move显示文摘	Zhelev T K	2007	Resources Conservation and Recycling2007，50，2：	1
17	Emissions targeting and planning: an application of CO2 emissions pinch analysis (CEPA) to the Irish electricity generationsector显示文摘	Damien Crilly Toshko Zhelev	2008	Energy2008，5，：	1
18	Chemically modified symmetric and asymmetric duplex RNAs: An enhanced stability to nuclease degradation and gene silencing effect 显示文摘	Kubo T Zhelev Z Ohba H	2008	Biochem Biophys Res Commun2008，365，1：	1
19	Free radical reactions might contribute to severe alpha amanitin hepatotoxicity--a hypothesis 显示文摘	Zheleva A Tolekova A Zhelev M	2007	Med Hypotheses2007，69，2：	1
20	Suppression of bcr-abl synthesis by siRNAs or tyrosine kinase activity by Glivec alters different oncogenes,apoptotic/antiapoptotic genes and cell proliferation factors(microarray study)显示文摘	Zhelev Z Bakalova R Ohba H	2004	FEBS Lett2004，570，13：	1

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