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| 1 | Tenascin C upregulates interleukin-6 expression in human cardiac myofibroblasts via toll-like receptor 4显示文摘AIM:To investigate the effect of Tenascin C(TNC)on the expression of pro-inflammatory cytokines and matrixmetalloproteinases in human cardiac myofibroblasts(CMF).METHODS:CMF were isolated and cultured from patients undergoing coronary artery bypass grafting.Cultured cells were treated with either TNC(0.1μmol/L,24 h)or a recombinant protein corresponding to different domains of the TNC protein;fibrinogen-like globe(FBG)and fibronectin typeⅢ-like repeats(TNⅢ5-7)(both 1μmol/L,24 h).The expression of the proinflammatory cytokines;interleukin(IL)-6,IL-1β,TNFαand the matrix metalloproteinases;MMPs(MMP1,2,3,9,10,MT1-MMP)was assessed using real time RT-PCR and western blot analysis.RESULTS:TNC increased both IL-6 and MMP3(P<0.01)mR NA levels in cultured human CMF but had no significant effect on the other markers studied.The increase in IL-6 mR NA expression was mirrored by an increase in protein secretion as assessed by enzymelinked immunosorbant assay(P<0.01).Treating CMF with the recombinant protein FBG increased IL-6mR NA and protein(P<0.01)whereas the recombinant protein TNⅢ5-7 had no effect.Neither FBG nor TNⅢ5-7 had any significant effect on MMP3 expression.The expression of toll-like receptor 4(TLR4)in human CMF was confirmed by real time RT-PCR,western blot and immunohistochemistry.Pre-incubation of cells with TLR4neutralising antisera attenuated the effect of both TNC and FBG on IL-6 mR NA and protein expression.CONCLUSION:TNC up-regulates IL-6 expression in human CMF,an effect mediated through the FBG domain of TNC and via the TLR4 receptor. | Azhar Maqbool Emma J Spary Iain W Manfield Michaela Ruhmann Lorena Zuliani-Alvarez Filomena O Gamboa-Esteves Karen E Porter Mark J Drinkhill Kim S Midwood Neil A Turner | 2016 | World Journal of Cardiology2016，8，5： | 4 |
| 2 | A sting in the tail: the N-terminal domain of the androgen receptor as a drug target显示文摘在前列腺癌症(PCa ) 的开始和前进的雄激素受体(AR ) 的角色很好被建立。AR ligand 有约束力的领域(LBD ) 的竞争抑制是采用在最近的年里与疾病作斗争的 antiandrogen 治疗的主食。然而,他们的功效被抵抗的出现经常限制了,通过点变化,和受体截断调停了。作为结果,为病人与的预后恶意阉割抵抗疾病遗体穷人。AR 的氨基终端的域(NTD ) 被显示了为 AR 功能批评。它的模块化的激活功能(AF-1 ) 在蛋白质蛋白质相互作用为基因规定和参予是重要的。由于领域的内在地混乱的结构,然而,它的潜力在过去被斥为治疗学的干预的一个候选人。小分子 EPI-001 的最近的出现提供了 AR-NTD 能治疗学地被指向的证据,独立于 LBD。AR-NTD 指向有潜力破坏在 AR 和它的 coregulatory 绑定搭挡之间的多重分子间的相互作用,除了在 AR 的领域之间的 intramolecular 串音。直接指向这些蛋白质蛋白质相互作用或 NTD 的治疗学应该也对新兴的 AR 有功效拼接可以在 PCa 起一个作用的变体前进。这评论将在 AR 功能讨论内在的混乱的角色并且说明新兴的治疗怎么可能在 PCa 指向 NTD。 | Amy E Monaghan Iain J McEwan | 2016 | Asian Journal of Andrology2016，18，5： | 3 |
| 3 | A Reviewand Analysis of Current Computer-Aided Fixture DesignApproaches 显示文摘 | B O Y L E Iain R O N G Yiming B R O W N David C | 2011 | Robotics and Computer-Integrated Manufacturiiig2011，27，1： | 1 |
| 4 | 难治性类风湿关节炎的临床特点:一项国际问卷调查研究显示文摘目的尽管按照目前欧洲抗风湿联盟(EULAR)的推荐对类风湿关节炎(rheumatoid arthritis,RA)患者进行治疗,难治性RA患者的临床症状却仍然没有得到完全控制,目前EULAR指南主要关注的是RA的早期治疗和药物治疗。本研究的目的在于分析难治性RA患者的临床特点,以及在患者管理中需要探索然而现有EULAR指南并未涉及的问题。方法对多个国家的风湿科医生进行问卷调查,分析难治性RA的临床特点。问卷包括多选题以及开放性问题,从开放性问题的回答中发现需要进一步阐明的问题以及现有EULAR指南需要增加的内容。结果410名受访者完成了调查问卷,关于难治性RA的特点:50%受访者认为基于28个关节评估的疾病活动评分(disease activity score assessing 28 joints,DAS28)>3.2或存在疾病活动的征象;42%受访者认为疲劳是其特点;48%认为至少两种传统合成改变病情抗风湿药(DMARDs)以及使用至少两种生物制剂或靶向合成DMARDs治疗失败;89%认为糖皮质激素不能减量到5 mg/天或泼尼松不能减量到10 mg/天或同等剂量的其他激素。另外,现有EULAR指南中应增加合并症和关节外表现的干预以及多种药物联合治疗等重要内容。结论目前风湿科医生对难治性RA的定义有很大争议。难治性RA患者的很多重要问题目前EULAR指南中均没有涉及。 | Nadia MT Roodenrijs Maria J H de Hair Marlies C van der Goes Johannes WG Jacobs Paco MJ Welsing Désirée van der Heijde Daniel Aletaha Maxime Dougados Kimme L Hyrich Iain B McInnes Ulf Mueller-Ladner Ladislav Senolt Zoltan Szekanecz Jacob Mvan Laar Nagy Gyorgy 黄艳荣(译) 张卓莉(审校) | 2019 | 英国医学杂志中文版2019，22，2： | 1 |
| 5 | Characteristics of patients with columnar-lined Barrett's esophagus and risk factors for progression to esophageal adenocarcinoma显示文摘AIM: To determine the risk factors for the development of esophageal adenocarcinoma in these patients with columnar-lined esophagus (CLE).METHODS: Data collected retrospectively on 597consecutive patients diagnosed at endoscopy and histology to have CLE at Leeds General Infirmary between 1984 and 1995 were analyzed. Factors evaluated included age,sex, length of columnar segment, smoking, and drinking habits, history of non-steroidal ingestion, presence of endoscopic esophagitis, ulceration or benign strictures and presence of Helicobacter pylori in esophageal biopsies. Univariate and multivariate analyses were performed to identify risk factors for the development of adenocarcinoma.RESULTS: Forty-four patients presented or developed esophageal adenocarcinoma during follow-up.Independent risk factors for the development of adenocarcinoma in patients with CLE were males (OR 5.12,95%CI 2.04-12.84, P = 0.0005), and benign esophageal stricture (OR 4.37, 95%CI 2.02-9.45, P = 0.0002). Male subjects and patients who developed benign esophageal stricture constituted 86% (n = 38) of all patients who presented or developed esophageal adenocarcinoma.The presence of esophagitis was associated with a significant reduction in the development of esophageal carcinoma (OR 0.28, 95%CI 0.13-0.57, P = 0.0006). No other clinical characteristics differentiate between the non-malignant and malignant group.CONCLUSION: In patients with CLE, endoscopic surveillance for the early detection of adenocarcinoma may be restricted to male subjects, as well as patients who develop benign esophageal strictures. | Kamal E Bani-Hani Bayan K Bani-Hani Iain G Martin | 2005 | World Journal of Gastroenterology2005，11，43： | 1 |
| 6 | Regeneration of plants from leafexplants ofmicropropagated clonal Eucalyptus grandis 显示文摘 | Iaine E Dvid A | 1994 | Plant Cell Reports1994，，13： | 1 |
| 7 | C-reactive protein concentration in children: relationship to adiposity and other cardiovascular risk factors显示文摘 | Derek G Cook Mike A Mendall Peter H Whincup Iain M Carey Lydia Ballam Julia E Morris George J Miller David P Strachan | 2000 | Atherosclerosis2000，，1： | 1 |
| 8 | Successful salvage right upper lobectomy and flap repair of tracheaesophageal fistula due to severe neerotizing pneumonia 显示文摘 | Betsy E Iain M Charles M | 2009 | Interact Cardiovasc Thorac Surg2009，9，11： | 1 |
| 9 | Do open access articles have greater citation impact? : A critical review of the literature 显示文摘 | Craig Iain D Plume Andrew M McVeigh Marie E | 2007 | Journal of Informetrics2007，1，3： | 1 |
| 10 | Trends in the prevalence of diagnosed atrial fibrillation, its treatment with anticoagulation, and predictors of such treatment in UK primary care显示文摘 | Stephen DW Iain MC Cathy E | 2006 | Heart2006，92，1： | 1 |
| 11 | Golimumab in psoriatic arthritis: One‐year clinical efficacy, radiographic, and safety results from a phase III, randomized, placebo‐controlled trial显示文摘 | Arthur Kavanaugh Désirée van der Heijde Iain B. McInnes Philip Mease Gerald G. Krueger Dafna D. Gladman Juan Gómez‐Reino Kim Papp Anna Baratelle Weichun Xu Surekha Mudivarthy Michael Mack Mahboob U. Rahman Zhenhua Xu Julie Zrubek Anna Beutler | 2012 | Arthritis & Rheumatism2012，，8： | 1 |
| 12 | Hepatitis E vi- rus in blood components: a prevalence and transmis- sion study in southeast England显示文摘 | Hewitt Patricia E Ijaz Samreen Brailsford Su R Brett Rachel Dicks Steven Haywood Becky Kenne- dy Iain T R Kitchen Alan Patel Poorvi Poh John Russell Katherine Tettmar Kate I Tossell Joanne Ushiro-Lumb Ines Tedder Richard S | 2014 | Lancet2014，384，9956： | 1 |
| 13 | Avoiding drilling problems显示文摘 | Walt A Iain C Cengiz E | 2001 | Oilfield Review2001，13，2： | 1 |
| 14 | A chemokine-like viral protein enhances alpha interferon production by plasmacytoid dendritic ceils but delays C D8+T Cell activation and impairs viral clearance 显示文摘 | Wikstrom M E Fleming P Iain C | 2013 | Journal of Virology2013，87，14： | 1 |
| 15 | Long-distance signaling in nodulation directed by a CLAVATA1-Like receptor kinase 显示文摘 | Iain R Searle Artem E Men Titwki S Laniya | 2003 | Science2003，3，3： | 1 |
| 16 | Association between mitochondrial dysfunction and severity and outcome of septic shock显示文摘 | David Brealey Michael Brand Iain Hargreaves Simon Heales John Land Ryszard Smolenski Nathan A Davies Chris E Cooper Mervyn Singer | 2002 | 2002 (9328)2002，，9328： | 1 |
| 17 | Trends in the prevalence of diagnosed atrial fibrillation,its treatment with anticoagulation, and predictors of such treatment in UK primary care显示文摘 | Stephen DW Iain MC Cathy E | 2006 | Heart2006，92，8： | 1 |
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