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| 1 | 早期干预促进早产儿智能发育显示文摘目的改善早产儿的预后,进行早期干预的协作研究。方法将103例早产儿随机分为干预组(52例)和常规育儿组(51例)。正常对照组(53例)。干预组从新生儿期开始接受智能早期干预,早产儿两组的围产期情况相似。结果纠正年龄1岁半、2岁时干预组精神发育指数(MDI)比常规育儿组平均高138和146(P<0.001),达正常组水平(P>0.05)。而常规育儿组MDI比正常对照组分别低115分和89分(P<0.05)。其中智力低下4例(7.8%)(4/51),干预组中无一例智力低下。结论早期干预可以促进早产儿智能发育,有利于防治其智力低下。 | Early Intervention of Premature Infant Coorperative Research Group, Beijing 100730 | 1998 | 中华儿科杂志1998，36，10： | 47 |
| 2 | 早期干预促进窒息新生儿智能发育的观察显示文摘将64例足月窒息儿(阿氏评分5分钟≤6分)随机分为干预组(34例)和常规育儿组(30例)。另设正常对照组38例。干预组从新生儿期开始接受早期干预,三组在性别、母亲文化、环境条件及体格发育方面无明显差别。1.5岁智能测查结果,窒息干预级精神发育指数比常规育儿组平均高14.6分(F=18.86,P<0.01),达正常对照组水平(F=2.17P>0.05),而窒息常规育儿组精神发育指数比正常对照组低9.7分(F=10.14P<0.01),其中智力低下者2例(6.7%),干预组中无1例智力低下。结果显示早期干预可促进窒息儿智能发育,有利于防治其智能低下。 | (EarlyIntrvention of Asphyxiated Newborn Infants Cooperative Research Group, Beijing 100730) | 1996 | 中华儿科杂志1996，34，1： | 16 |
| 3 | Optimized Nonbismuth Quadruple Therapies Cure Most Patients With Helicobacter pylori Infection in Populations With High Rates of Antibiotic Resistance显示文摘 | Javier Molina–Infante Marco Romano Miguel Fernandez–Bermejo Alessandro Federico Antonietta G. Gravina Liliana Pozzati Elena Garcia–Abadia Gema Vinagre–Rodriguez Carmen Martinez–Alcala Moises Hernandez–Alonso Agnese Miranda Maria Rosaria Iovene Carmen Pazo | 2013 | Gastroenterology2013，，1： | 8 |
| 4 | 2-D智能纳米黑卡稳定乳状液的机理显示文摘为揭示二维纳米片状材料(黑卡)对乳状液稳定性的影响,以扶余油田长春岭和三队区块原油为例,在水油体积比为7∶3的条件下,研究质量分数为0.005%的2-D智能纳米黑卡流体对原油乳状液稳定性的影响。通过稳定性分析仪和界面流变仪表征乳状液稳定性大小和界面膜强度,通过观察乳状液的微观形状和粒径分布分析黑卡增强乳状液稳定性的机理。研究结果表明,黑卡尺寸约为70×100(nm),厚度为0.65数1.2 nm。在原油和0.01%稳定剂十六烷基三甲基溴化铵(CTAB)组成的乳状液中加入黑卡后形成Pickering乳状液,乳状液的析水速度变慢,乳状液的稳定析水率从75.71%数78.57%降至65.71%数72.86%;乳状液稳定性提高,稳定性指数(TSI)值由4.73数5.64降至2.71数3.84;乳状液膜的强度增强,体系流变学特征由黏性转变为明显的弹性。黑卡作用的Pickering乳状液的背散射光曲线可分为乳状液破乳区、过渡区和乳状液聚并区3个区域。黑卡能改变稳定剂亲水-亲油平衡,将W/O型乳状液转变为O/W型乳状液,形成液滴尺寸为0.1数5μm大小的乳状液,大幅降低原油黏度。黑卡同时具有亲水-亲油两亲性质,可通过自吸附定向排布于液膜上,增加液膜强度,提高乳状液稳定性。图21表3参22。 | 梁拓 侯吉瑞 屈鸣 闻宇晨 RAJ Infant 杨景斌 肖立晓 丁乙桐 | 2020 | 油田化学2020，37，2： | 6 |
| 5 | Durable, superhydrophobic, antireflection, and low haze glass surfaces using scalable metal dewetting nanostructuring显示文摘在这份报纸,我们在第一次,联合的玻璃上报导多功能的 nanostructured 表面大量光,弄湿并且耐久性性质,包括的低全向的反射率,低薄雾,高传播, superhydrophobicity, oleophobicity,和高度机械抵抗。Nanostructures 被反应离子通过 nanomask 蚀刻在玻璃表面上制作了,它被 dewetting ultrathin 金属电影形成(< 10 nm 厚度) 使遭到了到快速的热退火(RTA ) 。nanostructures 强烈减少起始的表面反射率(4%) ,当在低价值保留薄雾时,在 390800 nm 波长变化到不到 0.4%(<0.9%) 。相应的水接触角度(c ) 是 24.5 敶愠朠晩吗?? | Daniel Infante Karl W. Koch Prantik Mazumder Lili Tian Albert Carrilero Domenico Tullit David Baker Valerio Pruneri | 2013 | Nano Research2013，6，6： | 6 |
| 6 | Long-term metformin therapy and vitamin B12 deficiency: An association to bear in mind显示文摘To date,metformin remains the first-line oral glucose-lowering drug used for the treatment of type 2 diabetes thanks to its well-established long-term safety and efficacy profile.Indeed,metformin is the most widely used oral insulinsensitizing agent,being prescribed to more than 100 million people worldwide,including patients with prediabetes,insulin resistance,and polycystic ovary syndrome.However,over the last decades several observational studies and meta-analyses have reported a significant association between long-term metformin therapy and an increased prevalence of vitamin B12 deficiency.Of note,evidence suggests that long-term and high-dose metformin therapy impairs vitamin B12 status.Vitamin B12(also referred to as cobalamin)is a water-soluble vitamin that is mainly obtained from animal-sourced foods.At the cellular level,vitamin B12 acts as a cofactor for enzymes that play a critical role in DNA synthesis and neuroprotection.Thus,vitamin B12 deficiency can lead to a number of clinical consequences that include hematologic abnormalities(e.g.,megaloblastic anemia and formation of hypersegmented neutrophils),progressive axonal demyelination and peripheral neuropathy.Nevertheless,no definite guidelines are currently available for vitamin B12 deficiency screening in patients on metformin therapy,and vitamin B12 deficiency remains frequently unrecognized in such individuals.Therefore,in this“field of vision”article we propose a list of criteria for a cost-effective vitamin B12 deficiency screening in metformin-treated patients,which could serve as a practical guide for identifying individuals at high risk for this condition.Moreover,we discuss additional relevant topics related to this field,including:(1)The lack of consensus about the exact definition of vitamin B12 deficiency;(2)The definition of reliable biomarkers of vitamin B12 status;(3)Causes of vitamin B12 deficiency other than metformin therapy that should be identified promptly in metformin-treated patients for a proper differential diagnosis;and(4)Potential pathophysiological mechanisms underlying metformin-induced vitamin B12 deficiency.Finally,we briefly review basic concepts related to vitamin B12 supplementation for the treatment of vitamin B12 deficiency,particularly when this condition is induced by metformin. | Marco Infante Martina Leoni Massimiliano Caprio Andrea Fabbri | 2021 | World Journal of Diabetes2021，12，7： | 6 |
| 7 | Novel epigenetic-based therapies useful in cardiovascular medicine显示文摘Epigenetic modifications include DNA methylation, his-tone modifications, and micro RNA. Gene alterations have been found to be associated with cardiovascular diseases, and epigenetic mechanisms are continuously being studied to find new useful strategies for the clinical management of afflicted patients. Numerous cardiovascular disorders are characterized by the abnormal methylation of Cp G islands and so specific drugs that could inhibit DNA methyltransferase directly or by reducing its gene expression(e.g., hydralazine and procainamide) are currently under investigation. The anti-proliferative and anti-inflammatory properties of histone deacetylase inhibitors and their cardio-protective effects have been confirmed in preclinical studies. Furthermore, the regulation of the expression of micro RNA targets through pharmacological tools is still under development. Indeed, large controlled trials are required to establish whether current possible candidate antisense micro RNAs could offer better therapeutic benefits in clinical practice. Here, we updated therapeutic properties, side effects, and feasibility of eme-rging epigenetic-based strategies in cardiovascular diseases by highlighting specific problematic issues that still affect the development of large scale novel therapeutic protocols. | Claudio Napoli Vincenzo Grimaldi Maria Rosaria De Pascale Linda Sommese Teresa Infante Andrea Soricelli | 2016 | World Journal of Cardiology2016，8，2： | 5 |
| 8 | Prevalence and dietetic management of mild gastrointestinal disorders in milk-fed infants显示文摘AIM: To assess the prevalence of mild gastrointestinal disorders in milk-fed infants in paediatric practice, and to evaluate the effectiveness and satisfaction with dietetic treatment.METHODS: A cross-sectional epidemiological study was first carried out. A total of 285 paediatricians included 3487 children seen during a period of one week. In a second phase an observational, prospective and multicentre study was conducted and 2069 milk-fed infants with mild gastrointestinal disorders (colic, constipation, regurgitation and diarrhoea) were included. There was a baseline visit (start of treatment) and a final visit four weeks later. The effectiveness of the various Novalac formulas, as well as the satisfaction of the parents/tutors and paediatricians with the dietetic treatment were assessed at the final visit.RESULTS: The prevalence of mild gastrointestinal disorders was 27.8% of all paediatrician consultations (9.2%, 7.8%, 6.1% and 4.6% in relation to colic, constipation, regurgitation and diarrhoea, respectively). The several Novalac adapted milk formulas resolved 88.4% of the mild gastrointestinal disorders. Depending on the type of disorder, differences in response rate were observed. The highest effectiveness was recorded with respect to diarrhoea (92.6%), followed by constipation (91.6%), colic (87.6%) and regurgitation (81%). Overall, 91% of the paediatricians and 88.8% of the parents/tutors were satisfied or very satisfied with the Novalac adapted milk formulas.CONCLUSION: Mild gastrointestinal disorders show a high prevalence in paediatric practice. The Novalac adapted milk formulas have been shown to be effective in treating mild gastrointestinal disorders in milk-fed infants in the context of routine clinical practice. | D Infante Pina X Badia Llach B Ario-Armengol V Villegas Iglesias | 2008 | World Journal of Gastroenterology2008，14，2： | 5 |
| 9 | Nonbismuth Quadruple (Concomitant) Therapy: Empirical and Tailored Efficacy versus Standard Triple Therapy for Clarithromycin‐Susceptible Helicobacter pylori and versus Sequential Therapy for Clarithromycin‐Resistant Strains显示文摘 | Javier Molina‐Infante Carmen Pazos‐Pacheco Gema Vinagre‐Rodriguez Belen Perez‐Gallardo Carmen Due?as‐Sadornil Moisés Hernandez‐Alonso Guadalupe Gonzalez‐Garcia Jose M. Mateos‐Rodriguez Miguel Fernandez‐Bermejo Javier P. Gisbert | 2012 | Helicobacter2012，，4： | 4 |
| 10 | A randomised, double-blind, placebo-controlled trial of trametinib, an oral MEK inhibitor, in combination with gemcitabine for patients with untreated metastatic adenocarcinoma of the pancreas显示文摘 | Jeffrey R. Infante Bradley G. Somer Joon Oh Park Chung-Pin Li Max E. Scheulen Saifuddin M. Kasubhai Do-Youn Oh Yuan Liu Suman Redhu Klaudia Steplewski Ngocdiep Le | 2014 | European Journal of Cancer2014，，： | 4 |
| 11 | Portable adaptive optics for exoplanet imaging显示文摘The portable adaptive optics(PAO)device is a low-cost and compact system,designed for 4-meter class telescopes that have no adaptive optics(AO)system,because of the physical space limitation at the Nasmyth or Cassegrain focus and the historically high cost of conventional AO.The initial scientific observations of the PAO are focused on the direct imaging of exoplanets and sub-stellar companions.This paper discusses the concept of PAO and the associated high-contrast imaging performance in our recent observational runs.PAO deliver a Strehl ratio better than 60%in H band under median seeing conditions of 1'.Combined with our dedicated image rotation and subtraction(IRS)technique and the optimized IRS(O-IRS)algorithm,the averaged contrast ratio for a 5≤V_(mag)≤9 primary star is 1.3×10^(-5)and3.3×10^(-6)at angular distance of 0.36'with exposure time of 7 minutes and 2 hours,respectively.PAO has successfully revealed the known exoplanet ofκAnd b in our recent observation with the 3.5-meter ARC telescope at Apache Point Observatory.We have performed the associated astrometry and photometry analysis of the recoveredκAnd b planet,which gives a projected separation of 0.98'±0.05',a position angle of 51.1°±0.5°and a mass of 10.15_(-1.255)^(+2.19) MJup.These results demonstrate that PAO can be used for direct imaging of exoplanets with medium-sized telescopes. | Yong-Tian Zhu Jiang-Pei Dou Xi Zhang Gang Zhao Jing Guo Leopoldo Infante | 2021 | Research in Astronomy and Astrophysics2021，21，4： | 4 |
| 12 | Nonlinear dynamics of heart rate variability in response to orthostatism and hemodialysis in chronic renal failure patients: Recurrence analysis approach显示文摘 | Hortensia González Oscar Infante Héctor Pérez-Grovas Marco V. Jose Claudia Lerma | 2012 | Medical Engineering and Physics2012，，： | 2 |
| 13 | Suitability and limitations of mesenchymal stem cells to elucidate human bone illness显示文摘Functional impairment of mesenchymal stem cells(MSCs),osteoblast progenitor cells,has been proposed to be a pathological mechanism contributing to bone disorders,such as osteoporosis(the most common bone disease)and other rare inherited skeletal dysplasias.Pathological bone loss can be caused not only by an enhanced bone resorption activity but also by hampered osteogenic differentiation of MSCs.The majority of the current treatment options counteract bone loss,and therefore bone fragility by blocking bone resorption.These socalled antiresorptive treatments,in spite of being effective at reducing fracture risk,cannot be administered for extended periods due to security concerns.Therefore,there is a real need to develop osteoanabolic therapies to promote bone formation.Human MSCs emerge as a suitable tool to study the etiology of bone disorders at the cellular level as well as to be used for cell therapy purposes for bone diseases.This review will focus on the most relevant findings using human MSCs as an in vitro cell model to unravel pathological bone mechanisms and the application and outcomes of human MSCs in cell therapy clinical trials for bone disease. | Izaskun Mitxitorena Arantza Infante Blanca Gener Clara I Rodríguez | 2019 | World Journal of Stem Cells2019，11，9： | 2 |
| 14 | 城市母亲孕期睡眠健康认知现状研究显示文摘【目的】了解城市地区孕妇对婴儿睡眠健康的认知情况及人群分布特点。【方法】采用自填式问卷调查469名孕妇对婴儿睡眠健康相关知识的认知情况。选择多元logistic回归模型探索母亲孕期认知的社会人口学分布特征。【结果】城市孕妇对婴儿期睡眠时间变化趋势、睡眠/觉醒状态判断知晓率分别为75.3%和55.9%,88.3%的母亲选择同室独床或单独卧室,67.0%的母亲认为应在婴儿完全清醒或犯困未睡着时将婴儿放到床上睡觉,68.7%的母亲认为应在婴儿夜醒后不安抚或先观察再安抚。母亲学历、年龄及家庭收入与孕期母亲的睡眠健康认知水平存在相关性。【结论】城市地区母亲孕期在婴儿睡眠健康认知方面状况较好,但仍有相当比例母亲尤其是低学历者存在一定误区,相关睡眠健康教育有待强化。 | Chinese Infants Sleep Development Study Group. | 2012 | 中国儿童保健杂志2012，20，12： | 2 |
| 15 | Treatment of H elicobacter pylori Infection 2013显示文摘 | Anthony O’Connor Javier Molina‐Infante Javier P. Gisbert Colm O’Morain | 2013 | Helicobacter2013，，： | 2 |
| 16 | Enhancing the outcomes of low birth weight or premature infants 显示文摘 | Infant health and development program | 1990 | JAMA1990，263，： | 1 |
| 17 | Newborn and infant hearing loss: Detection and intervention显示文摘 | American Academy of Pediatrics-- task force on newborn and infant hearing | 1999 | Pediatrics1999，103，： | 1 |
| 18 | Complete mitochondrial genome of the blackspot seabream,Pagellus bogaraveo(Perciformes:Sparidae),with high levels of length heteroplasmy in the WANCY region显示文摘 | Ponce M Infante C Jiménez-Cantizano R M | 2008 | Gene2008，15，409： | 1 |
| 19 | Activities of selected digestive enzymes during larval development of large yellow croaker(Pseudosciaena crocea)显示文摘 | Ma HM Cahu C Zambonino Infante JL | 2005 | Aquaculture2005，245，14： | 1 |
| 20 | Year 2007 Position Statement: Principles and Guidelines for Early Hearing Detection and Intervention Programs 显示文摘 | Joint Committee on Infant Heating | 2007 | Pediatrics2007，2，： | 1 |
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