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| 1 | Preventive effect of a pectic polysaccharide of the common cranberry Vaccinium oxycoccos L. on acetic acid-induced colitis in mice显示文摘AIM: To study isolation and chemical characterization of pectin derived from the common cranberry Vaccinium oxycoccos L. (oxycoccusan OP) and the testing of its preventive effect on experimental colitis.METHODS: Mice were administrated orally with OP two days prior to a rectal injection of 5% acetic acid and examined for colonic damage 24 h later. Colonic inflammation was characterized by macroscopical injury and enhanced levels of myeloperoxidase activity measured spectrophotometrically with o-phenylene diamine as the substrate. The mucus contents of the colon were determined by the Alcian blue dye binding method. Vascular permeability was estimated using 4% Evans blue passage after i.p. injection of 0.05 mol/L acetic acid. RESULTS: In the mice treated with OP, colonic macroscopic scores (1.1 ± 0.4 vs 2.7, P < 0.01) and the total square area of damage (10 ± 2 vs 21 ± 7, P < 0.01) were significantly reduced when compared with the vehicle-treated colitis group. OP was shown to decrease the tissue myeloperoxidase activity in colons (42 ± 11 vs 112 ± 40, P < 0.01) and enhance the amount of mucus of colitis mice (0.9 ± 0.1 vs 0.4 ± 0.1, P < 0.01). The level of colonic malondialdehyde was noted to decrease in OP-pretreated mice (3.6 ± 0.7 vs 5.1 ± 0.8, P < 0.01). OP was found to decrease the inflammatory status of mice as was determined by reduction of vascular permeability (161 ± 34 vs 241 ± 21, P < 0.01). Adhesionof peritoneal neutrophils and macrophages was also shown to decrease after administration of OP (141 ± 50 vs 235 ± 37, P < 0.05).CONCLUSION: Thus, a preventive effect of pectin from the common cranberry, namely oxycoccusan OP, on acetic acid-induced colitis in mice was detected. A reduction of neutrophil infiltration and antioxidant action may be implicated in the protective effect of oxycoccusan. | Sergey V Popov Pavel A Markov Ida R Nikitina Sergey Petrishev Vasily Smirnov Yury S Ovodov | 2006 | World Journal of Gastroenterology2006，12，41： | 9 |
| 2 | Long term recurrence,pain and patient satisfaction after ventral hernia mesh repair显示文摘AIM: To compare long term outcomes of laparoscopic and open ventral hernia mesh repair with respect to recurrence, pain and satisfaction.METHODS: We conducted a single-centre follow-up study of 194 consecutive patients after laparoscopic and open ventral hernia mesh repair between March 2000 and June 2010. Of these, 27 patients(13.9%) died and 12(6.2%) failed to attend their follow-up appointment. One hundred and fifty-three(78.9%) patients attended for follow-up and two patients(1.0%) were interviewed by telephone. Of those who attended the follow-up appointment, 82(52.9%) patients had received laparoscopic ventral hernia mesh repair(LVHR) while 73(47.1%) patients had undergone open ventral hernia mesh repair(OVHR), including 11 conversions. The follow-up study included analyses of medical records, clinical interviews, examination of hernia recurrence and assessment of pain using a 100 mm visual analogue scale(VAS) ruler anchored by word descriptors. Overall patient satisfaction was also determined. Patients with signs of recurrence were examined by magnetic resonance imaging or computed tomography scan.RESULTS: Median time from hernia mesh repair to follow-up was 48 and 52 mo after LVHR and OVHR respectively. Overall recurrence rates were 17.1% after LVHR and 23.3% after OVHR. Recurrence after LVHR was associated with higher body mass index. Smoking was associated with recurrence after OVHR. Chronic pain(VAS > 30 mm) was reported by 23.5% in the laparoscopic cohort and by 27.8% in the open surgery cohort. Recurrence and late complications were predictors of chronic pain after LVHR. Smoking was associated with chronic pain after OVHR. Sixty point five percent were satisfied with the outcome after LVHR and 49.3% after OVHR. Predictors for satisfaction were absence of chronic pain and recurrence. Old age and short time to follow-up also predicted satisfaction after LVHR.CONCLUSION: LVHR and OVHR give similar long term results for recurrence, pain and overall satisfaction. Chronic pain is frequent and is therefore important for explaining dissatisfaction. | Odd Langbach Ida Bukholm Jurate Saltyte Benth Ola Rφkke | 2015 | World Journal of Gastrointestinal Surgery2015，7，12： | 4 |
| 3 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 4 | Kinetics of carbon dioxide sorption on potassium-doped lithium zirconate 显示文摘 | Xiong R T Ida J I Lin Y S | 2003 | Chem Eng Sci2003，58，19： | 1 |
| 5 | Synthesis and CO2 sorption properties of pure and modified lithium zireonate 显示文摘 | Ida J I Xiong R T Lin Y S | 2004 | Sepa ration and Purification Technol ogy2004，36，1： | 1 |
| 6 | Synthesis and CO_2 sorption properties of pure and modified lithium zirconate显示文摘 | Ida J Xiong R T Lin V S | | 0，，01： | 1 |
| 7 | The mechanism of celtulase action on cotton fibers: evidence from atomic force microscopy显示文摘 | Ida Lee Barbara R Evans Jonathan Woodward | 2000 | Ultramicroscopy2000，82，： | 1 |
| 8 | Kinetics of carbon dioxide sorption on potassium-doped lithium zirconate显示文摘 | Xiong R Ida J Lin Y S | | 0，，19： | 1 |
| 9 | Kinetics of carbon dioxide sorption on potassium-doped lithium zirconate 显示文摘 | XIONG R IDA J I LIN Y S | 2003 | Chemical Engineering Science2003，58，19： | 1 |
| 10 | Synthesis and C02 sorption properties of pure and modified lithium zirconate 显示文摘 | IDA J I XIONG R LIN Y S | 2004 | Sep- aration and Purification Technology2004，36，1： | 1 |
| 11 | Lunar accretion from an impact-generated disk显示文摘 | Ida S Canup R M Stewart G R | 1997 | Nature1997，389，： | 1 |
| 12 | Synthesis and CO2 sorption properties of pure and modified lithium zirconate显示文摘 | Ida J I Xiong R T Lin Y S | 2004 | Separation and Purification Technology2004，36，1： | 1 |
| 13 | Reverse relationship between beta-amyloid precursor protein and beta-amyloid peptide plaques in Down's syndrome versus sporadic/familial Alzheimer's disease显示文摘 | Egensperger R Weggen S Ida N | 1999 | Acta Neuropathol (Berl)1999，97，2： | 1 |
| 14 | Neural network approach for multicriteria solid transportation problem显示文摘 | Li Y Ida K Gen M Kobuchi R | 1977 | Computers and Industrial Engineering1977，33，： | 1 |
| 15 | Identification of aminoglycoside-modifying enzymes by susceptibility testing:epidemiology of methicillin-resistant Staphylococcus aureus in Japan显示文摘 | Ida T Okamoto R Shimauchi C | 2001 | J Clin Microbiol2001，39，： | 1 |
| 16 | Cryptogenic fibros-ing alveolitis and lung cancer: the BTS study显示文摘 | Harris JM Johnston IDA Rudd R | 2010 | Thorax2010，65，1： | 1 |
| 17 | Chronic Japanese schistoso- miasis and hepatocellular carcinoma: ten years of follow-up in Yamanashi Prefecture, Japan显示文摘 | /ida F Iida R Kamijo H | 1999 | Bull World Health Organ1999，77，7： | 1 |
| 18 | A 3,4-seco-8βH-femadienoic acid and other constituents from Euphorbia chamaesyce 显示文摘 | Tanaka R Ida T Kita S | 1996 | Phytochemistry1996，41，4： | 1 |
| 19 | Immunohist ochemi calstudy of Muc1,Muc2 and human gastricmucin in breast carcinoma:relationship w ith prognostic factors显示文摘 | XU Y KIMURA N YOSH IDA R | | 0，，05： | 1 |
| 20 | Thiosemicarbazones, semicarbazones, dithiocarbazates and hydrazide/ hydrazones:Anti-Mycobacterium tuberculosis activity and cytotoxicity 显示文摘 | Fernando R P Pedro Ida S Maia | 2010 | Eur J Med Chem2010，45，5： | 1 |
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