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| 1 | Neoadjuvant chemotherapy for locally advanced cervical cancer显示文摘Neoadjuvant chemotherapy followed by surgery(NCS) has not been fully evaluated clinically. Currently, the main regimen of neoadjuvant chemotherapy(NAC) used in NCS includes cisplatin. The antitumor effects of NAC reduce lymph node metastasis and the tumor diameter in patients prior to surgery, and this can reduce the number of high risk patients who require postoperative radiation therapy. Many randomized controlled trials(RCTs) have examined the long-term prognosis of NCS compared to primary surgery, but the utility of NCS remains uncertain. The advent of concurrent chemoradiotherapy(CCRT) has markedly improved the outcome of radiotherapy(RT), and CCRT is now used as a standard method in many cases of advanced bulky cervical cancer. NCS gives a better treatment outcome than radiation therapy alone, but it is important to verify that NCS gives a similar or better outcome compared to CCRT. | Takashi Iwata Azumi Miyauchi Yukako Suga Hiroshi Nishio Masaru Nakamura Akiko Ohno Nobumaru Hirao Tohru Morisada Kyoko Tanaka Hiroki Ueyama Hidemichi Watari Daisuke Aoki | 2016 | Chinese Journal of Cancer Research2016，28，2： | 20 |
| 2 | Hydrogen peroxide mobilizes Ca^2+ through two distinct mechanisms in rat hepatocytes显示文摘 | Hirohiko SATO Teruko TAKEO Qiang LIU Kyoko NAKANO Tomohiro OSANAI Sechiko SUGA Makoto WAKUI Jie WU | 2009 | Acta Pharmacologica Sinica2009，30，1： | 7 |
| 3 | 固定化酶-离子交换组合系统进行青霉素G水解生产6-APA的模型化研究显示文摘采用固定化青霉素酰化酶(Penicillin acylase)在反应器中进行青霉素G水解生产6-APA,同时与离子交换柱相组合以连续地去除反应混合液中的苯乙酸。建立了离子交换柱的分格模型(Compartment model),在确定了青霉素G和苯乙酸沿柱高的浓度分布的基础上,与描述固定化酶反应器的状态方程相结合,得到了固定化酶-离子交换组合系统的数学模型。在将计算机模拟值与实验值进行验证后,探讨了组合系统中树脂量、循环流速和组合起始时间对青霉素G酶解过程的影响。 | 陈坚 Takeshi Omasa Yoshio Katakura Suteaki Shioya Ken-ichi Suga | 1995 | 生物工程学报1995，11，4： | 6 |
| 4 | Exploration of the enhanced performances for silk fibroin/sodium alginate composite coatings on biodegradable Mg-Zn-Ca alloy显示文摘To expand the future clinic applications of biodegradable magnesium alloy,polymer coatings with excellent biocompatibility are the keys to solve the local alkalinity and rapid hydrogen release.Natural-organic silk fibroin provides an approach to fabricate a protective coating on biomedical Mg-Zn-Ca alloy,however,the adhesion force and mechanical properties of the coating on substrates are ought to be further improved without any chemical conversion/intermediate layer.Hereby,based on VUV/O;surface activation,a hybrid of silk fibroin and sodium alginate is proposed to enhance the adhesion force and mechanical properties of the composite coatings on hydrophilic Mg-Zn-Ca alloy surfaces.Various mass ratios of sodium alginate addition were investigated to achieve the optimum coating strategy.The nanoscratch test and nanoindentation test confirmed that the adhesion force was tripled and mechanical properties index was significantly improved when the mass ratio of silk fibroin/sodium alginate was 70/30 compared to pure silk fibroin or sodium alginate coatings.Meanwhile,the corrosion rate of the coated Mg-Zn-Ca alloy was significantly delayed with the addition of sodium alginate,resulting in a reaction layer during corrosion process.Furthermore,the mechanisms for both adhesion and corrosion processes were discussed in detail.Our findings offer more possibilities for the controllable surface performance of degradable metals. | Hui Fang Chenxi Wang Shicheng Zhou Ge Li Yanhong Tian Tadatomo Suga | 2021 | Journal of Magnesium and Alloys2021，9，5： | 3 |
| 5 | 铜颗粒低温烧结技术的研究进展显示文摘金属纳米材料因具有良好的导电导热性以及能够在较低温度下进行烧结,是功率器件在高温高压高频等工作环境下服役所需的关键电子封装材料之一.文中对应用于功率器件封装领域的铜颗粒实现烧结的研究进行了综述,阐明了目前通过铜颗粒烧结技术实现低温键合的研发背景.从铜颗粒烧结材料的制备、工艺参数和还原方法等关键影响因素出发,讨论、归纳了基于不同烧结机理的低温烧结铜颗粒材料接头的力学性能和电学性能.此外,介绍了铜颗粒烧结技术在贴片封装和全铜互连领域中应用的优良特性.通过对该领域研究成果的分析,结果表明,目前铜烧结材料仍然受到氧化问题的挑战,需要进一步在接头性能的精准调控方面深入研究. | 李俊龙 徐杨 赵雪龙 王英辉 Tadatomo Suga | 2022 | 焊接学报2022，43，3： | 3 |
| 6 | 高等植物光系统Ⅰ-捕光天线Ⅰ(PSⅠ-LHCⅠ)超分子复合物的晶体结构和能量传递途径显示文摘光合作用光能的吸收、传递和转化是由位于光合膜上具有特定的分子排列和空间构象的色素蛋白复合物光系统Ⅱ(PSⅡ)和光系统Ⅰ(PSⅠ)所推动的.其中PSⅠ是一个具有极高效率的太阳能转化系统,其量子转化效率几乎为100%,但其高效吸能、传能和转能的结构基础尚不清楚.从高等植物碗豆的叶片提取了高纯度的光系统Ⅰ-捕光天线Ⅰ(PSⅠ-LHCⅠ)色素蛋白超分子复合物,并制备和解析了其2.8?的晶体结构[1].PSⅠ-LHCⅠ超分子复合物由16个蛋白亚基组成,总分子量约600 k D.本结构全面解析了高等植物PSⅠ-LHCⅠ的精细结构,揭示了PSⅠ-LHCⅠ的4个不同的捕光天线(Lhca1,Lhca2,Lhca3,Lhca4)在与PSⅠ核心复合物结合状态下的结构和它们的异同,以及它们之间的相互关系;揭示了LHCⅠ全新的色素网络系统,辨别了叶绿素a和b的不同位置,并阐明了4对红叶绿素(red Chls)和13个类胡萝卜素的结合位点和结构.根据所解析的结构,提出了由LHCⅠ向PSⅠ核心复合物能量传递的4条重要的可能途径.这些结果为揭示高等植物PSⅠ高效吸能、传能和转能的机理奠定了坚实的结构基础.本文将介绍所解析的高等植物PSⅠ-LHCⅠ的精细结构,并讨论PSⅠ-LHCⅠ能量传递机制. | 秦晓春 SUGA Michihiro 匡廷云 沈建仁 | 2016 | 科学通报2016，61，19： | 2 |
| 7 | The carbon content of Japan–US trade显示文摘 | Frank Ackerman Masanobu Ishikawa Mikio Suga | 2007 | Energy Policy2007，，9： | 2 |
| 8 | Regulation of multiple ageing-like phenotypes by inducible klotho gene expression in klotho mutant mice显示文摘 | Hiroaki Masuda Hirotaka Chikuda Tatsuo Suga Hiroshi Kawaguchi Makoto Kuro-o | 2005 | Mechanisms of Ageing and Development2005，，12： | 2 |
| 9 | 固定化青霉素酰化酶水解青霉素G的研究显示文摘研究了固定化青霉素酰化酶的部分性质,包括酶的最佳温度、pH,酶的反应动力学常数,酶的稳定性等,探讨了固定化酶反应器中青霉素G的酶解过程,建立了酶解过程的数学模型,并对此过程进行了计算机模拟和预测。 | 陈坚 Suga,KI | 1995 | 无锡轻工大学学报(食品与生物技术)1995，14，2： | 2 |
| 10 | Perforating veins in recurrent esophageal varices evaluated by endoscopic color Doppler ultrasonography with a galactose-based contrast agent显示文摘 | Takahiro Sato Katsu Yamazaki Jouji Toyota Yoshiyasu Karino Takumi Ohmura Jun Akaike Yasuaki Kuwata Toshihiro Suga | 2004 | Journal of Gastroenterology2004，，5： | 2 |
| 11 | An investigation of water-gas transport processes in the gas-diffusion-layer of a PEM fuel cell by a multiphase multiple-relaxation-time lattice Boltzmann model显示文摘 | Xiao-Dong Niu Toshihisa Munekata Shi-Aki Hyodo Kazuhiko Suga | 2007 | Journal of Power Sources2007，，2： | 2 |
| 12 | Influence of drinking green tea on breast cancer malignancy among Japanese patients 显示文摘 | NAKACHI K SUEMASU K SUGA K | 1998 | Japanese Journal of Cancer Research1998，89，3： | 1 |
| 13 | Clinical significance ofMCP-1 levels in BALF and serum in patients with interstitial lungdiseases显示文摘 | Suga M Iyonaga K Ichiyasu H | 1999 | Eur Respir J1999，14，2： | 1 |
| 14 | Role of monocyte chemoattractant protein-1 in Propionibacterium acnes-induced pulmonary granulomatosis 显示文摘 | Ichiyasu H Suga M Iyonaga K | 2001 | Microsc Res Tech2001，53，4： | 1 |
| 15 | Clinical study of radiation pneumonitis over 10 years显示文摘 | Watanabe H Suga A Tsuchihashi Y | 1995 | Nippon Kyobu Shikkan Gakkai Zasshi1995，33，4： | 1 |
| 16 | Molecular biology and biochemistry of the natriuretic peptide system显示文摘 | Nakao K Ogawa Y Sugas L | 1992 | J Hypertension1992，10，： | 1 |
| 17 | Physiological role of peroxisomal beta-oxidation in liver of fasted rats显示文摘 | Ishii H Horie S Suga T | 1980 | J Biochem1980，87，： | 1 |
| 18 | Hydrolysis of penicillin-G by combination of immobilized penicillin acylase and electrodialysis 显示文摘 | Ishimura F Suga K I | 1992 | Biotechnol Bioeng1992，39，2： | 1 |
| 19 | Linear and nonlinear optical properties of sol-gel-derived Au nanometer-particle-doped alumina显示文摘 | Hosoya Y Suga T Yanagawa T | 1997 | JAppl Phys1997，81，： | 1 |
| 20 | Effects of combination ther- apy with angiotensin II type 1 receptor blockers and calcium chan- nel blockers on renal function in hypertensive patients/a retrospec- tive, 'real-world' comparative study显示文摘 | Yamada H Suga N Maeda K | 2010 | Arzneimittelforsehung2010，60，2： | 1 |
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