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| 1 | EGFR and HER2 expression in advanced biliary tract cancer显示文摘AIM:To analyze the pathogenetic role and potential clinical usefulness of the epidermal growth factor receptor(EGFR)and the human epidermal growth factor receptor 2(HER2)in patients with advanced biliary tract cancer(BTC). METHODS:EGFR and HER2 expression was studied in biopsy samples from 124 patients(51%women; median age 64.8 years),with advanced BTC diagnosed between 1997 and 2004.Five micrometers sections of paraffin embedded tissue were examined by standard, FDA approved immunohistochemistry.Tumors with scores of 2+or 3+for HER2 expression on immunochemistry were additionally tested for HER2 gene amplification by fluorescence in situ hybridisation(FISH).RESULTS:34/124 patients(27.4%)had gallbladder cancer,47(37.9%)had intrahepatic BTC and 43(34.7%)had extrahepatic or perihilar BTC.EGFR expression was examined in a subset of 56 samples. EGFR expression was absent in 22/56 tumors(39.3%). Of the remaining samples expression was scored as 1+in 12(21.5%),2+in 13(23.2%)and 3+in 9(16%), respectively.HER2 expression was as follows:score 0 73/124(58.8%),score 1+27/124(21.8%),score 2+ 21/124(17%)and score 3+4/124(3.2%).HER2 gene amplification was present in 6/124,resulting in an overall amplification rate of 5%. CONCLUSION:Our data suggest that routine testing and therapeutic targeting of HER2 does not seem to be useful in patients with BTC,while targeting EGFR may be promising. | Jan Harder Oliver Waiz Florian Otto Michael Geissler Manfred Olschewski Brigitte Weinhold Hubert E Blum Annette Schmitt-Graeff Oliver G Opitz | 2009 | World Journal of Gastroenterology2009，15，36： | 18 |
| 2 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 3 | Surgical cure for early rectal carcinomas (T1)显示文摘 | Günther Winde M.D. Hubert Nottberg M.D. Ralph Keller M.D. Kurt W. Schmid M.D. Hermann Bünte M.D | 1996 | Diseases of the Colon & Rectum1996，，9： | 2 |
| 4 | Flow processes in a radiant tube burner: Isothermal flow 显示文摘 | TSIOUMANIS N BRAMMER J G HUBERT J | 2008 | Fuel2008，87，1： | 1 |
| 5 | Bioconversion of a L-carnitine precursor in a one-or two-phase system 显示文摘 | Bare G Jacques P Hubert J B | 1991 | Appl Biochem Biotechnol1991，2829，： | 1 |
| 6 | Management of congenital bile duct cysts显示文摘 | Mabrut JY Bozio G Hubert C | | 0，，01： | 1 |
| 7 | Management of congenital bile duct cysts显示文摘 | Mabrut JY Bozio G Hubert C | 2010 | Dig Surg2010，27，1： | 1 |
| 8 | Management of Congenital Bile Duct Cysts显示文摘 | Mabrut JY Bozio G Hubert C | | 0，，01： | 1 |
| 9 | Half-wavelength power transmis- sion lines显示文摘 | Hubert G J Gent M R | 1965 | IEEE Trans on Power Apparatus and Sys- tems1965，84，10： | 1 |
| 10 | An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels显示文摘 | RIGAT B HUBERT C ALHENC G F | 1990 | J Clin Invest1990，86，4： | 1 |
| 11 | Comparison of labora- tory diagnostic methods for the detection of infection with the vi- rus of classical swine fever in the early inspection phase:an exper- imental study显示文摘 | Kaden V Hubert P Strebelow G | 1999 | Berl Munch Tierarztl Wochenschr1999，112，： | 1 |
| 12 | Forecast of water demand in Weinan City in China using WDF-ANN model显示文摘 | Liu Junguo Hubert H G S Xu Jianxin | 2003 | Physics and Chemistry of the Earth2003，28，45： | 1 |
| 13 | Modes of foreign entry: A transaction cost analysis and propositions 显示文摘 | ANDERSON E HUBERT G | 1986 | Journal of international business studies1986，17，： | 1 |
| 14 | 显示文摘 | Hubert A Herzer G | 1991 | J Appl Phys1991，，69： | 1 |
| 15 | A genetic linkage map of 100 microsatellite markers for the Pacific oyster Crassostrea gigas显示文摘 | Hedgecock D Hubert S Li G | 2002 | J SheUfish Res2002，21，1： | 1 |
| 16 | Return stroke velocity measurements in two triggered lightning flashes显示文摘 | Hubert P Mouget G | 1981 | J Geophys Res1981，86，6： | 1 |
| 17 | CART peptides as modulators of dopamine and psychostimula nts and interactions with the mesolimbic dopaminergic system 显示文摘 | Hubert G W Jones D C Moffett M C Rogge G Kuhar M J | 2008 | Biochem Pharmacol2008，75，： | 1 |
| 18 | Evaluation of the emergency dispersion model at the Deutscher Wetterdienst using ETEX data 显示文摘 | Hubert G Barbara F Ingo J | 1998 | Atmospheric Environment1998，32，24： | 1 |
| 19 | Neutron-induced SEU in SRAMs:Simulations with n-Si and n-O interactions显示文摘 | LAMBERT D BAGGIO J HUBERT G | 2005 | IEEE Trans Nucl Sci2005，52，6： | 1 |
| 20 | Myticin, a novel cysteine-rich antimicrobial peptide isolated from haemocytes and plasma of the mussel Mytilus galloprovincialis显示文摘 | Mitta G Hubert F Noel T | 1999 | Eur J Biochem1999，265，： | 1 |
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