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| 1 | Microfluidic actuators based on temperature-responsive hydrogels显示文摘The concept of using stimuli-responsive hydrogels to actuate fluids in microfluidic devices is particularly attractive,but limitations,in terms of spatial resolution,speed,reliability and integration,have hindered its development during the past two decades.By patterning and grafting poly(N-isopropylacrylamide)PNIPAM hydrogel films on plane substrates with a 2μm horizontal resolution and closing the system afterward,we have succeeded in unblocking bottlenecks that thermo-sensitive hydrogel technology has been challenged with until now.In this paper,we demonstrate,for the first time with this technology,devices with up to 7800 actuated micro-cages that sequester and release solutes,along with valves actuated individually with closing and opening switching times of 0.6±0.1 and 0.25±0.15 s,respectively.Two applications of this technology are illustrated in the domain of single cell handling and the nuclear acid amplification test(NAAT)for the Human Synaptojanin 1 gene,which is suspected to be involved in several neurodegenerative diseases such as Parkinson’s disease.The performance of the temperature-responsive hydrogels we demonstrate here suggests that in association with their moderate costs,hydrogels may represent an alternative to the actuation or handling techniques currently used in microfluidics,that are,pressure actuated polydimethylsiloxane(PDMS)valves and droplets. | Loïc D'Eramo Benjamin Chollet Marie Leman Ekkachai Martwong Mengxing Li Hubert Geisler Jules Dupire Margaux Kerdraon Clémence Vergne Fabrice Monti Yvette Tran Patrick Tabeling | 2018 | Microsystems & Nanoengineering2018，4，1： | 3 |
| 2 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 3 | Differential control of T regulatory cell proliferation and suppressive activity by mature plasmacytoid versus conventional spleen dendritic cells 显示文摘 | Ouabed A Hubert F X Chabannes D | 2008 | J Im- munol2008，180，9： | 1 |
| 4 | Technology and The Loss of Internal Controls显示文摘 | Jean T Wells Hubert D Glover | 2006 | internal Auditing2006，22，1： | 1 |
| 5 | Randomised comparison of combined step-down prednisolone, methotrexate and sulphasalazine with sulphasalazine alone in early rheumatoid arthritis显示文摘 | Maarten Boers Arco C Verhoeven Harry M Markusse Mart AFJ van de Laar Rene Westhovens J Christiaan van Denderen Derkjen van Zeben Ben AC Dijkmans Andre J Peeters Piet Jacobs Hans R van den Brink Hubert JA Schouten Désirée MFM van der Heijde Annelies Boonen | 1997 | The Lancet1997，，9074： | 1 |
| 6 | Role of the CLOCK protein in the mammalian circadian mechanism 显示文摘 | Gekakis N Staknis D Hubert BN | 1998 | Science1998，280，： | 1 |
| 7 | Chalcopyrite thin film solar cells by electrodeposition 显示文摘 | LINCOT D GUILLEMOLESA J F TAUNIER S GUIMARD D SICX-KURDI J CHAUMONT A ROUSSEL O RAMDANI O HUBERT C FAUVARQUE J P BODEREAU N PARISSI L PANHELEUX P FANOUILLERE P NAGHAVI N GRAND P P BENFARAH M MOGENSEN P KERREC O | 2004 | Solar Energy2004，77，： | 1 |
| 8 | How to optimize the economic via- bility of thyroid surgery in a French public hospital显示文摘 | D'Hubert E Proske JM | 2010 | Visc Surg2010，147，4： | 1 |
| 9 | Impact of cattle on soil physical properties and nutrient concentrations in overland flow from pasture in Ireland显示文摘 | Isabelle K Colin D R Hubert T | 2006 | Agriculture Ecosystems and Environment2006，113，： | 1 |
| 10 | Cytosolic HSP90 associates with and modulates the Arabidopsis RPM1 disease resistance protein显示文摘 | Hubert D A Tornero P Belkhadir Y | 2003 | The EMBO Journal2003，22，： | 1 |
| 11 | A genetic linkage map of 100 microsatellite markers for the Pacific oyster Crassostrea gigas显示文摘 | Hedgecock D Hubert S Li G | 2002 | J SheUfish Res2002，21，1： | 1 |
| 12 | An anisotropic phase-field crystal model for heterogeneous nucleation of ellipsoidal colloids显示文摘 | Prieler R Hubert J Li D | | 0，，： | 1 |
| 13 | Steady-state pharmacokinetics of fluvastatin in healthy subjects following a new extended release fluvastatin tablet, Lescol XL 显示文摘 | BARILLA D PRASAD P HUBERT M | 2004 | Biopharm Drug Dispos2004，25，2： | 1 |
| 14 | Angiotensin-converting enzyme C-terminal catalytic domain is the main site of angiotensin 显示文摘 | FUCHS S XIAO H D HUBERT C | 2008 | Hypertension2008，51，： | 1 |
| 15 | CART peptides as modulators of dopamine and psychostimula nts and interactions with the mesolimbic dopaminergic system 显示文摘 | Hubert G W Jones D C Moffett M C Rogge G Kuhar M J | 2008 | Biochem Pharmacol2008，75，： | 1 |
| 16 | Hydrophobically Modified Alginate Hydrogels as Protein Carriers with Specific Controlled Release Properties显示文摘 | Leonard M Boisseson M R D Hubert P | 2004 | Journal of Controlled Release2004，98，1： | 1 |
| 17 | Neutron-induced SEU in SRAMs:Simulations with n-Si and n-O interactions显示文摘 | LAMBERT D BAGGIO J HUBERT G | 2005 | IEEE Trans Nucl Sci2005，52，6： | 1 |
| 18 | Variability of venom components in immune suppressive parasitoid wasps:from a phylogenetic to a population approach显示文摘 | Colinet D Mathé-Hubert H Allemand R | 2013 | Journal of Insect Physiology2013，59，2： | 1 |
| 19 | A study of the physi- cal and mechanical properties of wheat straw 显示文摘 | ODOUGHERTY M J HUBERT J A D | 1995 | Journal of Engineering Research1995，62，： | 1 |
| 20 | In vitro hepatoprotective and antioxidant activities of crude extract and i- solated compounds from Ficus gnaphalocarpa显示文摘 | Hubert D J Dawe A Florence N T | 2011 | Inflammop- harmacology2011，19，1： | 1 |
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