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| 1 | Theories and technologies for duplicating hypersonic flight conditions for ground testing显示文摘INTRODUCTION The development of aeronautics and astronautics,from its practical beginning with the Wright brothers’first airplane on 17 December 1903,has been driven by one primary aim to fly faster。 | Zonglin Jiang Hongru Yu | 2017 | National Science Review2017，4，3： | 12 |
| 2 | On theory and methods for advanced detonation-driven hypervelocity shock tunnels显示文摘This study describes theory and methods for developing detonation-driven shock tunnels in hypervelocity test facilities.The primary concept and equations for high-enthalpy shock tunnels are presented first to demonstrate the unique advantage of shock tubes for aerodynamic ground-based testing.Then,the difficulties in simulating flight conditions in hypervelocity shock tunnels are identified,and discussed in detail to address critical issues underlying these difficulties.Theory and methods for developing detonation drivers are proposed,and relevant progress that has advanced the state of the art in large-scale hypersonic test facilities is presented with experimental verifications.Finally,tailored conditions for detonation-driven shock tunnels are described,laying a solid foundation to achieve long test duration.This interface-matching key issue encountered in developing shock tunnels has been investigated for decades,but not solved for detonation drivers in engineering applications. | Zonglin Jiang Jinping Li Zongmin Hu Yunfeng Liu Hongru Yu | 2020 | National Science Review2020，7，7： | 6 |
| 3 | Double detonation drivers for a shock tube/tunnel显示文摘ARecent progress on detonation drivers is reviewed. Performances of the forward detonation driver and backward detonation driver have been observed. To eliminate occurrence of a Taylor wave following the detonation wave in the primary driver and to improve the performance of the detonation driver, an additional backward detonation driver was proposed to attach to the end of the forward detonation driver. When the ratio of the initial pressures between the additional and the primary drivers becomes larger than or equal to a critical value, the Taylor wave will disappear, and thus a homogeneous driving gas with high pressure and high temperature can be generated. Furthermore, an over-driving detonation wave will be also obtained, which can increase the driving capability. | CHEN Hong FENG Heng YU Hongru | 2004 | Science China(Physics,Mechanics & Astronomy)2004，47，4： | 4 |
| 4 | LIN28 coordinately promotes nucleolar/ribosomal functions and represses the 2C-like transcriptional program in pluripotent stem cells显示文摘LIN28 is an RNA binding protein with important roles in early embryo development,stem cell differentiation/re-programming,tumorigenesis and metabolism.Previous studies have focused mainly on its role in the cytosol where it interacts with Let-7 microRNA precursors or mRNAs,and few have addressed LIN28's role within the nucleus.Here,we show that LIN28 displays dynamic temporal and spatial expression during murine embryo development.Maternal LIN28 expression drops upon exit from the 2-cell stage,and zygotic LIN28 protein is induced at the forming nucleolus during 4-cell to blas-tocyst stage development,to become dominantly expressed in the cytosol after implantation.In cultured pluripotent stem cells(PSCs),loss of LIN28 led to nucleolar stress and activation of a 2-cell/4-cell-like transcriptional program characterized by the expression of endogenous retrovirus genes.Mechanistically,LIN28 binds to small nucleolar RNAs and rRNA to maintain nucleolar integrity,and its loss leads to nucleolar phase separation defects,ribosomal stress and activation of P53 which in turn binds to and activates 2C transcription factor Dux.LIN28 also resides in a complex containing the nucleolar factor Nucleolin(NCL)and the transcrip-tional repressor TRIM28,and LIN28 loss leads to reduced occupancy of the NCL/TRIM28 complex on the Dux and rDNA loci,and thus de-repressed Dux and reduced rRNA expression.Lin28 knockout cells with nucleolar stress are more likely to assume a slowly cycling,translationally inert and anabolically inactive state,which is a part of previously unappreciated 2C-like transcriptional program.These findings elucidate novel roles for nucleolar LIN28 in PSCs,and a new mechanism linking 2C program and nucleolar functions in PSCs and early embryo development. | Zhen Sun Hua Yu Jing Zhao Tianyu Tan Hongru Pan Yuqing Zhu Lang Chen Cheng Zhang Li Zhang Anhua Lei Yuyan Xu Xianju Bi Xin Huang Bo Gao Longfei Wang Cristina Correia Ming Chen Qiming Sun Yu Feng Li Shen Hao Wu Jianlong Wang Xiaohua Shen George Q.Daley Hu Li Jin Zhang | 2022 | Protein & Cell2022，13，7： | 4 |
| 5 | A super pan-genomic landscape of rice显示文摘Pan-genomes from large natural populations can capture genetic diversity and reveal genomic complexity.Using de novo longread assembly,we generated a graph-based super pan-genome of rice consisting of a 251-accession panel comprising both cultivated and wild species of Asian and African rice.Our pan-genome reveals extensive structural variations(SVs)and gene presence/absence variations.Additionally,our pan-genome enables the accurate identification of nucleotide-binding leucine-rich repeat genes and characterization of their inter-and intraspecific diversity.Moreover,we uncovered grain weight-associated SVs which specify traits by affecting the expression of their nearby genes.We characterized genetic variants associated with submergence tolerance,seed shattering and plant architecture and found independent selection for a common set of genes that drove adaptation and domestication in Asian and African rice.This super pan-genome facilitates pinpointing of lineage-specific haplotypes for trait-associated genes and provides insights into the evolutionary events that have shaped the genomic architecture of various rice species. | Lianguang Shang Xiaoxia Li Huiying He Qiaoling Yuan Yanni Song Zhaoran Wei Hai Lin Min Hu Fengli Zhao Chao Zhang Yuhua Li Hongsheng Gao Tianyi Wang Xiangpei Liu Hong Zhang Ya Zhang Shuaimin Cao Xiaoman Yu Bintao Zhang Yong Zhang Yiqing Tan Mao Qin Cheng Ai Yingxue Yang Bin Zhang Zhiqiang Hu Hongru Wang Yang Lv Yuexing Wang Jie Ma Quan Wang Hongwei Lu Zhe Wu Shanlin Liu Zongyi Sun Hongliang Zhang Longbiao Guo Zichao Li Yongfeng Zhou Jiayang Li Zuofeng Zhu Guosheng Xiong Jue Ruan Qian Qian | 2022 | Cell Research2022，32，10： | 3 |
| 6 | TRIM47 is a novel endothelial activation factor that aggravates lipopolysaccharide-induced acute lung injury in mice via K63-linked ubiquitination of TRAF2显示文摘Endothelial activation plays an essential role in the pathogenesis of sepsis-induced acute lung injury,however,the detailed regulatory mechanisms remain largely unknown.Here,we reported that TRIM47,an E3 ubiquitin ligase of the tripartite motifcontaining protein family,was highly expressed in vascular endothelial cells.TRIM47-deficient mice were effectively resistant to lipopolysaccharide(LPS)-induced acute lung injury and death by attenuating pulmonary inflammation.TRIM47 was upregulated during TNFα-induced endothelial activation in vitro.Knockdown of TRIM47 in endothelial cells inhibited the transcription of multiple pro-inflammatory cytokines,reduced monocyte adhesion and the expression of adhesion molecules,and suppressed the secretion of IL-1βand IL-6 in endothelial cells.By contrast,overexpression of TRIM47 promoted inflammatory response and monocyte adhesion upon TNFαstimulation.In addition,TRIM47 was able to activate the NF-κB and MAPK signaling pathways during endothelial activation.Furthermore,our experiments revealed that TRIM47 resulted in endothelial activation by promoting the K63-linked ubiquitination of TRAF2,a key component of the TNFαsignaling pathway.Taken together,our studies demonstrated that TRIM47 as a novel activator of endothelial cells,promoted LPS-induced pulmonary inflammation and acute lung injury through potentiating the K63-linked ubiquitination of TRAF2,which in turn activates NF-κB and MAPK signaling pathways to trigger an inflammatory response in endothelial cells. | Yisong Qian Ziwei Wang Hongru Lin Tianhua Lei Zhou Zhou Weilu Huang Xuehan Wu Li Zuo Jie Wu Yu Liu Ling-Fang Wang Xiao-Hui Guan Ke-Yu Deng Mingui Fu Hong-Bo Xin | 2022 | Signal Transduction and Targeted Therapy2022，7，6： | 2 |
| 7 | A potent PGK1 antagonist reveals PGK1 regulates the production of IL-1βand IL-6显示文摘Glycolytic metabolism enzymes have been implicated in the immunometabolism field through changes in metabolic status. PGK1 is a catalytic enzyme in the glycolytic pathway. Here, we set up a high-throughput screen platform to identify PGK1 inhibitors. DC-PGKI is an ATPcompetitive inhibitor of PGK1 with an affinity of Kd= 99.08 nmol/L. DC-PGKI stabilizes PGK1in vitro and in vivo, and suppresses both glycolytic activity and the kinase function of PGK1. In addition,DC-PGKI unveils that PGK1 regulates production of IL-1β and IL-6 in LPS-stimulated macrophages.Mechanistically, inhibition of PGK1 with DC-PGKI results in NRF2(nuclear factor-erythroid factor 2-related factor 2, NFE2L2) accumulation, then NRF2 translocates to the nucleus and binds to the proximity region of Il-1β and Il-6 genes, and inhibits LPS-induced expression of these genes. DC-PGKI ameliorates colitis in the dextran sulfate sodium(DSS)-induced colitis mouse model. These data support PGK1 as a regulator of macrophages and suggest potential utility of PGK1 inhibitors in the treatment of inflammatory bowel disease. | Liping Liao Wenzhen Dang Tingting Lin Jinghua Yu Tonghai Liu Wen Li Senhao Xiao Lei Feng Jing Huang Rong Fu Jiacheng Li Liping Liu Mingchen Wang Hongru Tao Hualiang Jiang Kaixian Chen Xingxing Diao Bing Zhou Xiaoyan Shen Cheng Luo | 2022 | Acta Pharmaceutica Sinica B2022，12，11： | 2 |
| 8 | Amorphous NiO_(n)coupled with trace PtO_(x)toward superior electrocatalytic overall water splitting in alkaline seawater media显示文摘Developing corrosion resistance bifunctional electrocatalysts with high activity and stability toward both hydrogen evolution reaction(HER)and oxygen evolution reaction(OER),especially electrolysis in seawater,is of prime significance but still pressingly challenging.Herein,in-situ introduced PtO_(x)on the derivative amorphous NiO_(n)is prepared via heat treatment of Ni ZIFL nanosheets on nickel foam under low temperature(PtO_(x)-NiO_(n)/NF).The synthesized PtO_(x)-NiO_(n)/NF possesses suprahydrophilic and aerophilic surface,then in favor of intimate contact between the electrode and electrolyte and release of the generated gas bubbles during the electrocatalysis.As a result,the in-situ PtO_(x)-NiO_(n)/NF electrode presents outstanding bifunctional activity,which only requires extremely low overpotentials of 32 and 240 mV to reach a current density of 10 mA·cm^(-2)for HER and OER,respectively,which exceeds most of the electrocatalysts previously developed and even suppresses commercial Pt/C and RuO_(2)electrodes.As for two-electrode cell organized by PtO_(x)-NiO_(n)/NF,the voltages down to 1.57 and 1.58 V are necessary to drive 10 mA·cm^(-2)with remarkable durability in 1 M KOH and alkaline seawater,respectively,along with remarkable stability.Moreover,a low cell voltage of 1.88 V is needed to achieve 1,000 mA·cm^(-2)toward water-splitting under industrial conditions.This study provides a new idea for designing in-situ amorphous metal oxide bifunctional electrocatalyst with strong Pt–support interaction for overall water splitting. | Wenli Yu Hongru Liu Ying Zhao Yunlei Fu Weiping Xiao Bin Dong Zexing Wu Yongming Chai Lei Wang | 2023 | Nano Research2023，16，5： | 2 |
| 9 | Genomic decoding of breeding history to guide breeding-by-design in rice显示文摘Deciphering the intrinsic molecular logic of empirical crop breeding from a genomic perspective is a decisive prerequisite for breeding-by-design(BbD),but remains not well established.Here,we decoded the historical features of past rice breeding by phenotyping and haplotyping 546 accessions covering the majority of cultivars bred in the history of Northeast China(NEC).We revealed that three groups founded the genetic diversities in NEC rice with distinct evolution patterns and traced and verified the breeding footprints to known or genome-wide association study(GWAS)-detected quantitative trait loci(QTLs),or introgressions from indica sub-species with chronological changes in allele frequencies.Then we summarized a rice breeding trend/principle in NEC,and combined with the successful example in breeding and application of Zhongkefa5 to demonstrate the guiding value of our conclusion for BbD in practice.Our study provides a paradigm for decoding the breeding history of a specific crop to guide BbD,which may have implications in different crop breeding. | Zhuo Chen Qingyun Bu Guifu Liu Maoqing Wang Hongru Wang Huazhao Liu Xiufeng Li Hong Li Jun Fang Yan Liang Zhenfeng Teng Sai Kang Hong Yu Zhukuan Cheng Yongbiao Xue Chengzhi Liang Jiuyou Tang Jiayang Li Chengcai Chu | 2023 | National Science Review2023，10，5： | 1 |
| 10 | New Supercritical Fluid Extraction Treatment Method for Determination of Tripterine in Tripterygium wilfordii Hook. F显示文摘 | Hongru Li Shufen Li Yu Zhang Hongquan Duan | 2008 | Journal of Liquid Chromatography & Related Technologies2008，，10： | 1 |
| 11 | Adaptive Inverse Control of Discrete System Using Online PSO - IIR Filters 显示文摘 | Jianchang LIU Xia YU Hongru LI | 2010 | Journal of Computational Information Sys- tems2010，6，10： | 1 |
| 12 | Adaptive Inveme Control of Discrete System Using Online PSO - IIR Filters 显示文摘 | Jianchang LIU Xia YU Hongru LI | 2010 | Journal of Computational Information Sys- tems2010，6，10： | 1 |
| 13 | High performance removal of sulfamethoxazole using large specific area of biochar derived from corncob xylose residue显示文摘To remove antibiotics from waste water,an alkali active porous biochar,850BC,was prepared from corncob xylose residue.In preparation,NaOH dipping was used for silicon removal and KOH activation was operated at 850℃.Further characterization containing BET,SEM,and FTIR were confirmed.850BC possessed a huge specific surface area of 3043 m^(2)·g^(−1),developed pore structure and abundant oxygen functional groups.The adsorption performance of sulfamethoxazole on 850BC was quick and efficient,and the adsorption capacity reached 1429 mg·g^(−1),which was significantly higher than other adsorbents reported previously.While pseudo-second-order kinetic model and Langmuir model could better describe the adsorption,chemisorp-tion dominated the SMX adsorption onto 850BC.In virtue of pore-filling andπ-πinteraction as major mechanism,a large surface area and rich oxygen-containing functional groups led to an excellent adsorption performance.Thus,this preparation method provided a biochar-based adsorbent with enhanced specific surface for efficient removal of antibiotic pollutants. | Yinxue Li Hongru Shang Yongna Cao Chunhui Yang Yujie Feng Yanling Yu | 2022 | Biochar2022，4，1： | 1 |
| 14 | Design and experiments of 4CJ-1200 self-propelled tea plucking machine显示文摘As agricultural labor is decreasing,famous tea production is nearly hard to sustain and is getting more and more expensive in China.To improve the mechanization of tea plucking,this paper designs a self-propelled track-type tea plucking machine that integrates mechanic,hydraulic and electronics.The main parameters of chassis were optimized based on conditions of tea garden.And,three different kinds of cutter blades were designed and analyzed about vibration performance with finite element software.Also,a rigid-flex mixed motion model was established.Based on the model and plots,it is explicit that:(1)the blades move in a sine law;(2)the blades take a symmetrical deform from middle to end while moving;(3)the deformation increases along the blade from the center to sides.The single factor experiment revealed that both travel speed and speed ratio of cutting and travelling had a significant effect on quality indexes(integrity rate,unpicking rate,stubble unevenness)of plucked tea leaf.By universal rotary combination experiment of quadratic regression,the regression equations of three indexes about two experimental factors were established.And,the comprehensive optimization of three indexes was conducted with software Design expert.The optimal operating parameters of machine are as follow:travel speed is 0.41 m/s,speed ratio of cutting and travelling is 1.06;prediction of three indexes are that integrity rate could be reach to 78.26%,unpicking rate reduced to 0.82%,stubble unevenness reduced to 1.30 mm.The results of verification experiment are that:integrity rate could be reach to 77.41%,unpicking rate reduced to 0.87%,stubble unevenness reduced to 1.23 mm.These test indexes that are very close to the predicted values,all surpass the requests specified in the standard of tea plucking with machine.In all,the optimized parameter set is indeed synthetically optimal one that enables the wide use of this tea plucking machine,which can be used in the tea garden that has a lengthways slope less than 18°,a crosswise slope less than 20°,and a height of tea trees between 50-120 cm.From above,the tea plucking machine investigated in this paper provides an effective solution to present tea picking problem that is the bottleneck of tea industry.Further studies need to do for making this machine more automated and intelligent. | Yu Han Hongru Xiao Zhiyu Song Qiaomin Chen Wenqin Ding Song Mei | 2021 | International Journal of Agricultural and Biological Engineering2021，14，6： | 0 |
| 15 | Aerosol optical properties and its direct radiative forcing over Tibetan Plateau from 2006 to 2017显示文摘Studies on optical properties of aerosols can reduce the uncertainty for modelling direct radiative forcing(DRF)and improve the accuracy for discussing aerosols effects on the Tibetan Plateau(TP)climate.This study investigated the spatiotemporal variation of aerosol optical and microphysical properties over TP based on OMI and MERRA2,and assessed the influence of aerosol optical properties on DRF at NamCo station(30°46.44′N,90°59.31′E,4730 m)in the central TP from 2006 to 2017 based on a long measurement of AERONET and the modelling of SBDART model.The results show that aerosol optical depth(AOD)exhibits obvious seasonal variation over TP,with higher AOD500nm(>0.75)during spring and summer,and lower value(<0.25)in autumn and winter.The aerosol concentrations show a fluctuated rising from 1980 to 2000,significant increasing from 2000 to 2010 and slight declining trend after 2013.Based on sensitivity experiments,it is found that AOD and single scattering albedo(SSA)have more important impact on the DRF compared withαvalues and ASY.When AOD440nm increases by 60%,DRF at the TOA and ATM is increased by 57.2%and 60.2%,respectively.When SSA440nm increases by 20%,DRF at the TOA and ATM decreases by 121%and 96.7%,respectively. | Hongru Bi Siyu Chen Dan Zhao Fuquan Lu Yu Chen Yawen Guan | 2023 | Particuology2023，，3： | 0 |
| 16 | Quantifying the interannual litterfall variations in China’s forest ecosystems显示文摘凋落物是森林生物地化学循环和火险预测的关键参数。然而,森林凋落物如何随林龄变化仍不清楚。因此,量化森林生态系统凋落物年际变化对减少大尺度凋落物预测的不确定性至关重要。本论文基于中国人工林和次生林凋落物连续多年(≥2年)测定的数据集(N=318),采用变异系数(CV)、变化百分比(V_(P))和年际间比率量化凋落物的年际变化。研究结果表明,凋落物的年际变化随林龄增加(1–90年生)而呈下降趋势。其中,1–10年林龄的凋落物年际变化最大(平均CV=23.51%,平均V_(P)=-28.59%~20.89%),其主要原因在于树木早期快速生长,即下一年与当年凋落物比率平均为1.20。11–40年林龄的凋落物年际变化逐渐减小,但CV平均值仍在18%左右,V_(P)平均值在-17.69%~21.19%之间。41–90年林龄的凋落物年际变化最小,CV平均值仅为8.98%,V_(P)平均值维持在8%左右。因此,大于40年林龄的凋落物量较低且稳定。这一结果与已有研究的认知不同:即当林龄大于30年、20年甚至15年时,森林凋落物量达到相对稳定。本研究结果将有助于我们深入理解森林凋落物生态学,并为大尺度碳收支和生物地化学循环模型提供基础。 | Bingrui Jia Hongru Sun Wenying Yu Guangsheng Zhou | 2020 | Journal of Plant Ecology2020，13，3： | 0 |
| 17 | Mongolia Contributed More than 42%of the Dust Concentrations in Northern China in March and April 2023显示文摘Dust storms are one of the most frequent meteorological disasters in China,endangering agricultural production,transportation,air quality,and the safety of people’s lives and property.Against the backdrop of climate change,Mongolia’s contribution to China’s dust cannot be ignored in recent years.In this study,we used the Weather Research and Forecasting model coupled with Chemistry(WRF-Chem),along with dynamic dust sources and the HYSPLIT model,to analyze the contributions of different dust sources to dust concentrations in northern China in March and April 2023.The results show that the frequency of dust storms in 2023 was the highest observed in the past decade.Mongolia and the Taklimakan Desert were identified as two main dust sources contributing to northern China.Specifically,Mongolia contributed more than 42%of dust,while the Taklimakan Desert accounted for 26%.A cold high-pressure center,a cold front,and a Mongolian cyclone resulted in the transport of dust aerosols from Mongolia and the Taklimakan Desert to northern China,where they affected most parts of the region.Moreover,two machine learning methods[the XGBoost algorithm and the Synthetic Minority Oversampling Technique(SMOTE)]were used to forecast the dust storms in March 2023,based on ground observations and WRF-Chem simulations over East Asia.XGBoost-SMOTE performed well in predicting hourly PM10 concentrations in China in March 2023,with a mean absolute error of 33.8μg m−3 and RMSE of 54.2μg m−3. | Siyu CHEN Dan ZHAO Jianping HUANG Jiaqi HE Yu CHEN Junyan CHEN Hongru BI Gaotong LOU Shikang DU Yue ZHANG Fan YANG | 2023 | Advances in Atmospheric Sciences2023，40，9： | 0 |
| 18 | CPAL, as a New Mediator of Cardiomyocyte Metabolic Alterations and Pyroptosis, Regulates Myocardial Infarction Injury in Mice显示文摘Myocardial infarction (MI), the most serious of the ischemic heart diseases, is accompanied by myocardial metabolic disorders and the loss of cardiomyocytes. Increasing evidence has shown that long noncoding RNAs (lncRNAs) are involved in various pathological conditions such as cancer and cardiovascular diseases (CVDs), and are emerging as a novel biomarker for these disorders. This study aims to investigate the regulatory role and mechanisms of lncRNAs in myocardial remodeling in the setting of MI. We find that post-infarcted hearts exhibit a reduction of adenosine triphosphate (ATP) and an alteration of the glucose and lipid metabolism genes cluster of differentiation 36 (CD36), hexokinase 1 (HK1), and clucose transporter 4 (GLUT4), accompanied by cardiomyocyte pyroptosis. We then identify a previously unknown conserved lncRNA, AK009126 (cardiomyocyte pyroptosis-associated lncRNA, CPAL), which is remarkably upregulated in the myocardial border zone of MI mice. Importantly, the adeno-associated virus 9 (AAV9)-mediated silencing of endogenous CPAL by its short hairpin RNA (shRNA) partially abrogates myocardial metabolic alterations and cardiomyocyte pyroptosis during MI in mice. Mechanistically, CPAL is shown to bind directly to nuclear factor kappa B (NFκB) and to act as an activator of NFκB to induce NFκB phosphorylation in cardiomyocytes. We also find that CPAL upregulates caspase-1 expression at the transcriptional level and consequently promotes the release of interleukin (IL)-18 and IL-1β from cardiomyocytes. Collectively, our findings reveal the conserved lncRNA CPAL as a new regulator of cardiac metabolic abnormalities and cardiomyocyte pyroptosis in the setting of MI and suggest CPAL as a new therapeutic target to protect cardiomyocytes against ischemic injury in infarcted hearts. | Jiamin Li Hongru Xue Ning Xu Liling Gong Ming Li Sijia Li Di Huang Qingwei Zhang Pengyu Li Qingsui Li Hang Yu Yining Liu Yadong Xue Haixin Chen Jiali Liu Wanyu Zhang Mingbin Liu Siyu Chang Xianzhi Lang Xingmiao Zhao Weijie Du Benzhi Cai Ning Wang Baofeng Yang | 2023 | Engineering2023，，1： | 0 |
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