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| 1 | Probing the sulfur content in gasoline quantitatively with terahertz time-domain spectroscopy显示文摘Terahertz time-domain spectroscopy(THz-TDS)was used for the quantitative detection of sulfur content in gasoline.Models of chemo metrics methods and partial least squares(PLS)were built to measure THz-TDS and the sulfur content.All of the samples were divided into two parts.One part was used for calibration and the other one for validation.In order to evaluate the quality of the models,the correlation coefficient(R)and root-mean-square errors(RMSE)of calibration and validation models were calculated.The value of R and RMSE were close to 1 and 0 within acceptable levels,respectively,indicating that the combination of THz-TDS and PLS is a potential method for further quantitative detection. | QIN FangLi LI Qian ZHAN HongLei JIN WuJun LIU HongLan ZHAO Kun | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，7： | 8 |
| 2 | Investigation of tribological performances of MCMB显示文摘Tribological properties of Meso-carbon Microbeads (MCMB) powders as a special addi-tive in pentaerythritol were investigated on an Optimal SRV tribotester at 300℃. The coarsely dis-persed lubricant system demonstrates fine lubricious effectiveness at the operation temperature.The friction coefficient dropped from 0.2 to circa 0.12 in the presence of MCMB in pentaerythritolfor the No.45 carbon steel tribomate. Raman spectroscopy analysis indicated the partial transfor-mation of MCMB into increased ordered structures that contributed to the lowering of friction. | CUI Xiaohao LI Shenghua SONG Huaihe JIN Yuansheng FU Honglan 1. National Tribology Laboratory, Tsinghua University, Beijing 100084, China 2. Institute of Carbon Fibers & Composites, Beijing University of Chemical Technology, Beijing 100029, China 3. Department of Biology, Peking University, Beijing 100871, China | 2001 | Science China Mathematics2001，44，S1： | 6 |
| 3 | Improved adaptive genetic algorithm based RFID positioning显示文摘The existing active tag-based radio frequency identi-fication(RFID)localization techniques show low accuracy in practical applications.To address such problems,we propose a chaotic adaptive genetic algorithm to align the passive tag ar-rays.We use chaotic sequences to generate the intersection points,the weakest single point intersection is used to ensure the convergence accuracy of the algorithm while avoiding the optimization jitter problem.Meanwhile,to avoid the problem of slow convergence and immature convergence of the algorithm caused by the weakening of individual competition at a later stage,we use adaptive rate of change to improve the optimiza-tion efficiency.In addition,to remove signal noise and outliers,we preprocess the data using Gaussian filtering.Experimental results demonstrate that the proposed algorithm achieves high-er localization accuracy and improves the convergence speed. | LI Yu WU Honglan SUN Youchao | 2022 | Journal of Systems Engineering and Electronics2022，33，2： | 4 |
| 4 | Microstructural characteristics and mechanical behavior of B4Cp/6061Al composites synthesized at different hot-pressing temperatures显示文摘B4Cp/6061Al composites have become important structural and functional materials and can be fabricated by powder metallurgy and subsequent hot rolling. In this work, the effects of the hot-pressing temperature on microstructures and mechanical behaviors of the B4Cp/6061Al composites were investigated. The results showed that compared with the T4 heat treated B4Cp/6061Al composite hot pressed at 560℃, the yield strength and failure strain of the composites hot pressed at 580℃ were increased to 235 MPa and 18.4%, respectively. This was associated with the interface bonding strength between the B4C particles and the matrix. However, the reaction products, identified to be MgAl2O4 phases, were detected in the composites hot pressed at 600℃. The formation of the MgAl2O4 phases resulted in the Mg depletion, thus reducing the yield strength to 203.5 MPa after the T4 heat treatment due to the effect of the solid solution strengthening being weakened. In addition, the variation of hardness and electrical conductivity was mainly related to the Mg content in the matrix. Based on the as-rolled microstructures observed by SEM, SR-μCT and fracture surfaces, the deformation schematic diagram was depicted to reflect the tensile deformation process of the composites. | Minqiang Gao Zongning Chen Huijun Kang Enyu Guo Rengeng Li Ying Fu Honglan Xie Tongmin Wang | 2019 | Journal of Materials Science & Technology2019，35，8： | 4 |
| 5 | Combined detection and subclass characteristics analysis of CTCs and CTECs by SE-iFISH in ovarian cancer显示文摘Objective:Hematogenous metastasis is essential for the progression of ovarian cancer(OC),and circulating tumor cells(CTCs)are part of the metastatic cascade.However,the detection rate of CTC is low due to the use of less sensitive detection methods.Therefore,this study aimed to detect CTCs and circulating tumorigenic endothelial cells(CTECs)in patients with OC using subtraction enrichment and immunostaining and fluorescence in situ hybridization(SE-iFISH).Methods:We enrolled a total of 56 subjects,including 20 OC patients and 36 ovarian benign tumor patients.CTCs and CTECs were captured by subtraction enrichment(SE)and counted and classified according to immunofluorescence staining of tumor markers(TMs)carbohydrate antigen 125(CA125)and human epididymis protein 4(HE4)combined with fluorescence in situ hybridization(iFISH)of chromosome 8(Chr8)aneuploidy.The diagnostic value and subtype characteristics of CTCs and CTECs were investigated.Results:The detection rate of CTCs by SE-iFISH was high.Compared with CA125 and HE4,Chr8 aneuploidy was the major identification feature of CTC.CTC counts in OC were statistically higher than those in benign groups.CTC and CTEC with≥pentaploidy were detected in both groups,illustrating the poor diagnostic value of CTC or CTEC.Distributions of triploid and tetraploid CTC subtypes were significantly different,and combined detection of triploid and tetraploid CTCs showed the best diagnostic value.In contrast,the distribution of CTECs in the OC and benign groups had no statistically significant difference.Small CTCs accounted for over 1/3 of the total CTC count.We also found that small CTCs and CTECs primarily comprised triploid cells,while large CTCs and CTECs mainly comprised pentaploidy and beyond.Conclusions:The application of SE-iFISH offered a more comprehensive understanding of heterogeneous CTCs and CTECs in OC.Analysis of subclass characteristics of the CTCs and CTECs according to Chr8 aneuploidy and cell size may broaden their potential clinical utility and deepen mechanistic studies in OC. | Hongyan Cheng Shang Wang Wenqing Luan Xue Ye Sha Dou Zhijian Tang Honglan Zhu Peter Ping Lin Yi Li Heng Cui Xiaohong Chang | 2021 | Chinese Journal of Cancer Research2021，33，2： | 3 |
| 6 | Diet, Helicobacter pylori Strain-Specific Infection, and Gastric Cancer Risk Among Chinese Men显示文摘 | Meira Epplein Wei Zheng Honglan Li Richard M. Peek Pelayo Correa Jing Gao Angelika Michel Michael Pawlita Qiuyin Cai Yong-Bing Xiang Xiao-Ou Shu | 2014 | Nutrition and Cancer2014，，： | 2 |
| 7 | Yizhining elixation improves sustained attention deficit and impulsiveness of spontaneous hypertensive rats显示文摘BACKGROUND: The core symptoms of attention deficit, impulsiveness, hyperactivity of attention deficit hyperactivity disorders (ADHD) can concurrently present in spontaneous hypertensive rats. Neuropathological, biochemical and pharmacological studies also support it. Spontaneous hypertensive rats are one kind of best ADHD animal models, which has been accepted at present. Yizhining elixation can reinforce kidney and calm liver, strengthen spleen and nourish heart, benefit intelligence and focus attention, but its therapeutic effect on treatment of ADHD needs to be further investigated. OBJECTIVE: To observe the effect of Yizhining elixation on the persistent active attention deficit and impulsiveness of rats with spontaneous hypertension. DESIGN: Observational and controlled analysis. SETTING: Department of Pediatrics, the First Affiliated Hospital of Guangzhou University of Chinese Medicine. MATERIALS: Thirty-six male rats with spontaneous hypertension, of clean grade, were involved in this experiment. The involved rats were provided by Shanghai SLAC Laboratory Animal Co., Ltd., and they did not undergo any experiments; Yizhining elixation was composed by Guiban, Shenglonggu, Yuanzhi, Shichangpu, Yejiaoteng, Shudi, Dangshen, Yunling, Fuxiaomai, Wueizi, etc. Crude drug, provided by Outpatient Dispensary, Affiliated Hospital of Guangzhou University of Chinese Medicine, was prepared into water elixation, which contained crude drug of 1.154 g/mL. METHODS: This experiment was carried out in the Department of Pediatrics, First Affiliated Hospital of Guangzhou University of Chinese Medicine between March and July 2005. The involved rats were randomized into 3 groups: Yizhining high dose group, Yizhining low dose group and blank control group, with 12 rats in each. Changes in sustained attention and impulsiveness of rats were detected before and after administration of Yizhining elixation by '5-choice serial response time task' method. Following above-mentioned training and detection, rats in each group were daily drenched with Yizhining elixation once for 14 days successively. Rats in the Yizhining high-dose and low-dose groups were drenched with 12.6 mL/kg and 6.3 mL/kg Yizhining elixation (diluted to 25 mL/kg) respectively, and those in the blank control group were drenched with 12.5 mL/kg normal saline. On the 14th day after administration, the ratios of correct and immature response of rats were re-detected for 3 days successively by formal detection method for later analysis. The sustained attention of rats was evaluated with ratio of correct response: Ratio of correct response=[times of correct response/(times of correct response + times of incorrect response)]; impulsiveness was evaluated with the ratio of immature response: ratio of immature response=[times of immature response/ (times of correct response+times of incorrect response+times of omission+times of immature response)]. MAIN OUTCOME MEASURES: The effects of different doses of Yizhining elixation on the sustained attention (ratio of correct response) and impulsiveness (ratio of immature response) of spontaneous hypertensive rats. RESULTS: Thirty-six spontaneous hypertensive rats were involved in the final analysis. The ratio of correct response of rats in the Yizhining high dose and low dose groups after administration was (98.9±2.30)% and (96.6±4.00)%, respectively, which was significantly higher than that before administration [(80.4±11.5)%, (83.9±8.90)%,P < 0.01] and that in the blank control group[(83.3±6.30)%,P < 0.01]. The ratio of immature response of rats in the Yizhining high dose and low dose groups after administration was (5.04±1.04)%, (7.23±1.22)%, respectively, which was lower than that before administration [(9.85±2.50)%,(9.40±1.73)%,P < 0.05] and that in the blank control group [(9.42±1.64)%,P < 0.01]. CONCLUSION: Yizhining elixation can improve the sustained attention and impulsiveness of spontaneous hypertensive rats. | Xiaogang Chen Hui Tian Donglan Lai Yan Tang Honglan Jiang Hualun Zeng Yirui Li | 2007 | Neural Regeneration Research2007，2，1： | 2 |
| 8 | Desiccation tolerance in bryophytes: the rehydration proteomes of Bryum argenteum provide insights into the resuscitation mechanism显示文摘Bryum argenteum Hedw. is a desiccation tolerant bryophyte and belongs to one of the most important components of the biological soil crusts(BSCs) found in the deserts of Central Asia. Limited information is available on rehydration-responsive proteins in desiccation tolerant plants. As a complement to our previous research analyzing the rehydration transcriptome, we present a parallel quantitative proteomic effort to study rehydration-responsive proteins. Bryophyte gametophores were desiccated(Dry) and rehydrated for 2 h(R2) and 24 h(R24). Proteins from Dry, R2 and R24 gametophores were labeled by isobaric tags for relative and absolute quantitation(iTRAQ) to determine the relative abundance of rehydration-responsive proteins. A total of 5503 non-redundant protein sequences were identified and 4772(86.7%) protein sequences were annotated using Gene Ontology(GO) terms and Pfam classifications. Upon rehydration 239 proteins were elevated and 461 proteins were reduced as compared to the desiccated protein sample. Differentially up-regulated proteins were classified into a number of categories including reactive oxygen species scavenging enzymes, detoxifying enzymes, Late Embryogenesis Abundant(LEA) proteins, heat shock proteins, proteasome components and proteases, and photosynthesis and translation related proteins. Furthermore, the results of the correlation between transcriptome and proteome revealed the discordant changes in the expression between protein and mRNA. | GAO Bei ZHANG Daoyuan LI Xiaoshuang YANG Honglan LIANG Yuqing CHEN Moxian ZHANG Yuanming ZHANG Jianhua Andrew WOOD | 2018 | Journal of Arid Land2018，10，1： | 2 |
| 9 | Cytokine nanosponges suppressing overactive macrophages and dampening systematic cytokine storm for the treatment of hemophagocytic lymphohistiocytosis显示文摘Hemophagocytic lymphohistiocytosis(HLH)is a highly fatal condition with the positive feedback loop between continued immune cell activation and cytokine storm as the core mechanism to mediate multiple organ dysfunction.Inspired by macrophage membranes harbor the receptors with special high affinity for proin-flammation cytokines,lipopolysaccharide(LPS)-stimulated macrophage membrane-coated nanoparticles(LMNP)were developed to show strong sponge ability to both IFN-γand IL-6 and suppressed overactivation of macrophages by inhibiting JAK/STAT signaling pathway both in vitro and in vivo.Besides,LMNP also efficiently alleviated HLH-related symptoms including cytopenia,hepatosplenomegaly and hepatorenal dysfunction and save the life of mouse models.Furthermore,its sponge effect also worked well for five human HLH samples in vitro.Altogether,it’s firstly demonstrated that biocompatible LMNP could dampen HLH with high potential for clinical transformation,which also provided alternative insights for the treatment of other cytokine storm-mediated pathologic conditions such as COVID-19 infection and cytokine releasing syndrome during CAR-T therapy. | Honglan Wang Huiwen Liu Jia Li Chunying Liu Hui Chen Junying Li Chunyan Sun Tao Guo Zhiqing Pang Bo Zhang Yu Hu | 2023 | Bioactive Materials2023，，3： | 1 |
| 10 | Dietary fat intake and liver cancer risk: A prospective cohort study in Chinese women显示文摘Objective:This study aimed to determine whether dietary fat intake increased liver cancer risk in Chinese women from a prospective population-based cohort.Methods:A total of 72,704 Chinese women were followed up from the time of baseline recruitment(1996–2000)to the end of 2016.Dietary fat intake was calculated using a validated food frequency questionnaire.The Cox regression model was used to assess the hazard ratio(HR)and 95%confidence intervals(CI)for dietary fat intake and liver cancer risk.Results:We identified 252 incident liver cancer cases out of 1,267,845 person-years during the overall follow-up time.Null associations,neither in quartiles nor per standard deviation(SD)increment,were detected between liver cancer risk and dietary total fat,fat subtypes and subtype ratios,and food sources.The HR(95%CI)of the 1-SD increment was 1.03(0.90–1.17)for total fat,1.06(0.93–1.20)for saturated fat,1.06(0.93–1.21)for monounsaturated fat,and 1.00(0.89–1.13)for polyunsaturated fat.Similar null associations were observed in stratification analyses according to body mass index and menopausal status.Conclusions:In our prospective cohort study,no significant association was observed in Chinese women between dietary fat and liver cancer risk,and in stratification and sensitivity analyses. | Xiaowei Ji Jing Wang Zhuoying Li Qiuming Shen Jiayi Tuo Jinghao Bi Yuting Tan Honglan Li Yongbing Xiang | 2022 | Cancer Biology & Medicine2022，19，3： | 1 |
| 11 | Amperometric third-generation hydrogen peroxide biosensor incorporating multiwall carbon nanotubes and hemoglobin显示文摘 | Qi Honglan Zhang Chengxiao Li Xiaorong | 2006 | Sensors and Actuators B:Chemical2006，114，1： | 1 |
| 12 | Electrochemical aptasensor for the determination of cocaine incorporating gold nanoparticles modification 显示文摘 | Li Xiaoxia Qi Honglan Shen Lihua | 2008 | Electroanalysis2008，20，： | 1 |
| 13 | Electrogenerated chemiluminescence aptamer-based method for the determination of thrombin incorporating quenching of tris(2,2′-bipyridine)ruthenium by ferrocene显示文摘 | Li Yan Qi Honglan Peng Yage | 2008 | Electrochemistry Communications2008，10，： | 1 |
| 14 | Hepatitis C virus envelope glycoproteins complementation patterns and the role of the ecto- and transmembrane domains显示文摘 | Xiaojing Lin Yonghui Zhang Shengli Bi Jian Lu Honglan Zhao Wenjie Tan Dexin Li Yue Wang | 2009 | Biochemical and Biophysical Research Communications2009，，2： | 1 |
| 15 | Broad-spectrum and powerful neutralization of bacterial toxins by erythroliposomes with the help of macrophage uptake and degradation显示文摘Anti virulence strategy has been considered as one of the most promising approaches to combat drug-rcesistant bacterial infections.Porc-forming toxins(PFTs)are the largest class of bacterial toxins,inficting their virulence ffect through creating pores on the cell membrane.However,curent solutions for eliminating PFTs are mostly designed based on their molecular structure,requiring customized design for different interactions.In the present study,we employed erythroliposome(denoted as RM-PL),a biomimetic platform constructed by artificial lipid membranes and natural erythrocyle membranes,to necutralize different hemolytic PFTs regardless of their molecular structure.When tested with model PFTs,including a-hemolysin,listeriolysin O,and streptolysin O,RM-PL could completely inhibit toxin-induced hemolysis in a concentration-dependent manner.In vivo studies further confirmed that RM-PL.could eficiently neuralize various toxins and save animals'lives without causing damage to 0rgans or tissues.In addition,we explored the underlying mechanisms of this efficient detoxification ability and found that it was mainly macrophages in the spleen and the liver that took up RM-PL-absorbed toxins through a variety of endocytosis pathways and digested them in lysosomes.In summary,the biomimetic RM-PL presented a promising system for broad-spectrum and powerful toxin neutralization with a mech-anism of lysosome-mediaed loxin degradation. | Chunying Liu Shuangrong Ruan Ying He Xuejing Li Yuefei Zhu Honglan Wang Hanwei Huang Zhiqing Pang | 2022 | Acta Pharmaceutica Sinica B2022，12，11： | 1 |
| 16 | Global pattern and trends of colorectal cancer survival: a systematic review of population-based registration data显示文摘This review will describe the global patterns and trends of colorectal cancer survival,using data from the population-based studies or cancer registration.We performed a systematic search of China National Knowledge Infrastructure(CNKI),Wanfang Data,PubMed,Web of Science,EMBASE,and SEER and collected all population-based survival studies of colorectal cancer(up to June 2020).Estimates of observed and relative survival rates of colorectal cancer by sex,period,and country were extracted from original studies to describe the temporal patterns and trends from the late 1990s to the early 21st century.Globally,5-year observed survival rates were higher in Seoul,Republic of Korea(1993–1997;56.8%and 54.3%for colon and rectum cancers,respectively),Zhejiang province(2005–2010;52.9%for colon cancer),Tianjin(1991–1999;52.5%for colon cancer),Shanghai(2002–2006;50.0%for rectum cancer)of China,and in Japan(1993–1996,59.6%for colorectal cancer).Five-year relative survival rates of colorectal cancer in the Republic of Korea(2010–2014),Queensland,Australia(2005–2012),and the USA(2005–2009)ranked at relatively higher positions compared to other countries.In general,colorectal cancer survival rates are improving over time worldwide.Sex disparities in survival rates were also observed in the colon,rectum,and colorectal cancers in most countries or regions.The poorest age-specific 5-year relative survival rate was observed in patients>75 years of age.In conclusion,over the past 3 decades,colorectal cancer survival has gradually improved.Geographic variations,sex differences,and age gradients were also observed globally in colorectal cancer survival.Further studies are therefore warranted to investigate the prognostic factors of colorectal cancer. | Yufei Jiang Huiyun Yuan Zhuoying Li Xiaowei Ji Qiuming Shen Jiayi Tuo Jinghao Bi Honglan Li Yongbing Xiang | 2022 | Cancer Biology & Medicine2022，19，2： | 1 |
| 17 | Effects of the layer thickness ratio on the enhanced ductility of laminated aluminum显示文摘The layered structural parameters have been reported to be critical for tuning the tensile properties of laminated metals.Here,we investigated the effects of the thickness ratio(rc/f)of coarse-grained layers(CLs)to fine-grained layers(FLs)on the enhanced ductility of the laminated Al.The local strain evolution demonstrates that the strain delocalization ability of laminated Al is improved with the decrease of rc/f.The interfacial strain gradients,which can produce extra work hardening,gradually approach and cover the CLs with the rc/fdecreasing,explaining the trend of uniform elongation in laminated Al with various rc/f.The integrated fracture morphology characterization reveals that the increase of the rc/fleads to an improvement in the tolerance of the interfacial microcracks,which is corresponding to the variation of fracture elongation in the laminated Al.Moreover,there is an evident transition of transverse propagation path of interfacial microcracks from the CLs to FLs with increasing the rc/f.Based on a geometrical criterion of microcracks connectivity,the preferential transverse propagation path of interfacial microcracks in these laminated Al was rationalized.The calculation based on this criterion also predicted the critical rc/fcorresponding to the optimal combination of strength and fracture elongation.This work deepens the understanding of the role of structural parameters of laminated metals in achieving the strength and ductility synergy. | Yiping Xia Hao Wu Kesong Miao Xuewen Li Chao Xu Lin Geng Honglan Xie Guohua Fan | 2022 | Journal of Materials Science & Technology2022，，16： | 1 |
| 18 | Electrochemical detection of DNA hybridization based on polypyrrole/ss-DNA/multi-wall carbon nanotubes oaste electrode显示文摘 | QI Honglan LI Xiaoxiao CHEN Pei | | 0，，03： | 1 |
| 19 | The persistent prevalence and evolution of cross-family recombinant coronavirus GCCDC1 among a bat population:a two-year follow-up显示文摘Bats are connected with the increasing numbers of emerging and re-emerging viruses that may break the species barrier and spread into the human population. Coronaviruses are one of the most common viruses discovered in bats, which were considered as the natural source of recent human-susceptible coronaviruses, i.e. SARS-COV and MERS-CoV. Our previous study reported the discovery of a bat-derived putative cross-family recombinant coronavirus with a reovirus gene p10, named as Ro-BatCoV GCCDC1. In this report, through a two-year follow-up of a special bat population in one specific cave of south China, we illustrate that Ro-BatCoV GCCDC1 persistently circulates among bats. Notably, through the longitudinal observation, we identified the dynamic evolution of Ro-BatCoV GCCDC1 in bats represented by continuously recombination events. Our study provides the first glimpse of the virus evolution in one longitudinally observed bat population cohort and underlines the surveillance and pre-warning of potential interspecies transmittable viruses in bats. | Joseph O.Obameso Hong Li Hao Jia Min Han Shiyan Zhu Canping Huang Yuhui Zhao Min Zhao Yu Bai Fei Yuan Honglan Zhao Xia Peng Wen Xu Wenjie Tan Yingze Zhao Kwok-Yung Yuen William J.Liu Lin Lu George F.Gao | 2017 | Science China(Life Sciences)2017，60，12： | 1 |
| 20 | Spontaneous Vesicle formation in aqueous mixtures of cationic surfactants and partially hydrolyzed polyacrylamide显示文摘 | Huang Jianbin Zhu Ying Zhu Buyao Li Runkai Fu Honglan | 2001 | Journal of Colloid and Interface Science2001，236，： | 1 |
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