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| 1 | Evidence chain-based causality identification in herb-induced liver injury: exemplification of a well-known liver-restorative herb Polygonum multiflorum显示文摘草药的药最近在美国作为导致药的肝损害(DILI ) 的第二个很普通的原因被认出了。然而,识别一些植物的 DILI 诱发性的可靠方法例如 Heshouwu (蓼 multiflorum 的弄干的根) ,留下缺乏。在这研究,有肝机能障碍和 Heshouwu DILI 的 147 个报导文学的案例的 12 307 个住院病人的一个总数被屏蔽。一个一般算法仅仅显示了那 22.5%(9/40 ) 并且(45/147 ) 分别地, 30.6% 所有住院和文学案例报告表明 Heshouwu 的 DILI 诱发性的高概率。由对比,(19/20 )95% 生药学,植物化学,和 metabolomic 有希望地调查的所有情况测试展出高度可能的诱发性,包括不正确地以前被归因的一个病人和从由 pharmacognostic 证据的 Heshouwu 诱发性被排除的一个案例。污染也是的毒素(重金属,杀虫剂,和 mycotoxins ) 从 Heshouwu DILI 诱发性排除了。为 Heshouwu DILI 诊断地址安全的这些屏蔽方法的客观性担心考虑包含芪的草药的药和饮食的补充。 | Jiabo Wang Zhijie Ma Ming Niu Yun Zhu Qingsheng Liang Yanling Zhao Jingyuan Song Zhaofang Bai Yaming Zhang Ping Zhang Na Li Yakun Meng Qi Li Lushan Qin Guangju Teng Junling Cao Baosen Li Shilin Chen Yonggang Li Zhengsheng Zou Honghao Zhou Xiaohe Xiao | 2015 | Frontiers of Medicine2015，9，4： | 47 |
| 2 | Heterotic Group Classification of 63 Inbred Lines and Hybrid Purity Identification by Using SSR Markers in Winter Cabbage(Brassica Oleracea L. var. capitata)显示文摘Winter cabbage is an important crop cultivated through winter in the region near the Yangtze River, enabling the supply of fresh cabbage there at that time of year. However, a problem has emerged regarding the newly developed parents of winter cabbage, which is completely different from spring and autumn cabbage, namely, how to combine these parents to breed an elite hybrid. To classify the heterotic groups and improve the efficiency of parent selection in winter cabbage breeding, 20 polymorphic SSR markers were selected to screen 63 winter cabbage inbred lines. Seventeen pairs among the 20 SSR markers amplified polymorphic bands. These primers amplified two to six bands,with an average of 2.8 bands per primer, and a total of 47 polymorphic bands were generated in the 63 inbred lines. These lines included flatheaded morphotype and round-headed morphotype, thus they were separately classified into heterotic groups based on the SSR markers. The flat-headed morphotype contained 21 inbred lines and was classified into three heterotic groups, named Hanchun 4, Jiali, and Dongsheng, in accordance with the representative germplasm contained in each group. The round-headed morphotype contained 42 inbred lines and was classified into five heterotic groups, named Parte, Bejo1039, YK-143, SCA002, and Golden B90. Meanwhile, parent analysis of 20 developed elite combinations showed that their parents were all distributed in different heterotic groups, indicating that the group classification was reasonable,which can provide a basis for further parent selection in winter cabbage breeding. Furthermore, polymorphic SSR primers were successfully used to identify the hybrid purity of three elite varieties. | LI Xing YU Hailong LI Zhiyuan LIU Xiaoping FANG Zhiyuan LIU Yumei YANG Limei ZHUANG Mu LV Honghao ZHANG Yangyong | 2018 | Horticultural Plant Journal2018，4，4： | 11 |
| 3 | Spinel + quartz-bearing ultrahigh-temperature granulites from Xumayao,Inner Mongolia Suture Zone,North China Craton:Petrology,phase equilibria and counterclockwise p-T path显示文摘在在北方中国 Craton 的内部蒙古缝术地区(IMSZ ) 以内的 Khondalite 带是为 Paleoproterozoic 的一个经典例子超离频温度(UHT ) 变态。这里,我们在 IMSZ 的南部的领域以内在 Xumayao 从一个新地区报导新忍受尖晶石的 metapelitic granulites。Petrological 研究并且尖晶石 + 的热力学的建模忍受石英的集合证明这些岩石以 UHT 条件经历了极端变态。尖晶石组织上发生在二背景:1 ) 高 XZn (Zn/(Mg +FeII + Zn )= 0.0710.232 ) 有在岩石矩阵的 perthitic K 长石,矽线石和石英的尖晶石;并且 2 ) 低 XZn (0.0450.070 ) 尖晶石作为在与石英和矽线石联合的石榴石 porphyroblasts 以内的包括。我们当模特儿的阶段 equilibria 在这些岩石的变形进化期间显示二个主要阶段: 1 )从 975 的在等压附近的冷却????畘慭慹?????????????朠慲畮楬整????????????????慲潴????????煥極楬牢慩?????????????胴?? | Huatian Zhang Jianghai Li Shoujie Liu Wenshan Li M. Santosh Honghao Wang | 2012 | Geoscience Frontiers2012，3，5： | 8 |
| 4 | Utilization of Ogura CMS germplasm with the clubroot resistance gene by fertility restoration and cytoplasm replacement in Brassica oleracea L显示文摘Clubroot disease,a major plant root disease caused by Plasmodiophora brassicae,has become one of the most destructive diseases among cultivated cruciferous vegetables.However,clubroot-resistant Brassica oleracea materials are rare.A few clubroot-resistant cabbage varieties are available on the market,but all are Ogura cytoplasmic male sterile(CMS)types.Therefore,in this study,to reutilize the clubroot-resistant Ogura CMS germplasm of cabbage,a new fertility-restored Ogura CMS material,16Q2-11,was used as a bridge to transfer the clubroot resistance(CR)gene from the Ogura CMS cytoplasm to the normal cytoplasm by a two-step method(a fertility restoration and cytoplasm replacement method).In the first cross for fertility restoration of Ogura CMS clubroot-resistant cabbage(FRCRC),16Q2-11 was used as a restorer to cross with Ogura CMS materials containing the CR gene CRb2.Eleven Rfo-positive progenies were generated,of which four contained CRb2:F8-514,F8-620,F8-732 and F8-839.After inoculation with race 4 of P.brassicae,these four CRb2-positive individuals showed resistance.Furthermore,F8-514 and F8-839 were then used as male parents in the second cross of FRCRC to cross with cabbage inbred lines,resulting in the successful introgression of the CRb2 gene into the inbred lines.All offspring produced from this step of cross,which had a normal cytoplasm,showed a high resistance to race 4 of P.brassicae and could be utilized for the breeding of clubrootresistant cabbage varieties in the future.This is the first time that the Ogura CMS restorer has been used to restore the fertility of Ogura CMS clubroot-resistant cabbages,which could improve germplasm diversity in cabbage and provide a reference method for using CMS germplasm in Brassica crops. | Wenjing Ren Zhiyuan Li Fengqing Han Bin Zhang Xing Li Zhiyuan Fang Limei Yang Mu Zhuang Honghao Lv Yumei Liu Yong Wang Hailong Yu Yangyong Zhang | 2020 | Horticulture Research2020，7，1： | 7 |
| 5 | Cells derived from iPSC can be immunogenic -- Yes or No?显示文摘导致的 pluripotent 干细胞(iPSCs ) ,在体的房间由 reprogramming 因素的宫外的表示发源,能潜在地为再生药提供无限的自体同源的房间。在理论,没有任何有免疫力的拒绝,从耐心的 iPSCs 导出的自体同源的房间应该是由主人容忍的免疫者。然而,我们的最近的研究发现了那平 syngeneic 导出 iPSC 的细胞能在由使用一个 teratoma 移植模型的 syngeneic 宿主产生免疫性(自然 474:212215, 2011 ) 。最近,二个研究组区分了 iPSCs 进不同细菌层或房间,移植了那些房间到 syngeneic 主人,并且评估了那些房间的 immunogenicity。尽管他们在 iPSC 衍生物宣称可以忽略的任何一个或 immunogenicity 的缺乏,两个都,二,研究支持我们肯定的一些然而并非从 iPSCs 导出的所有纸巾能是产生免疫性的结论(自然 494:100104, 2013;房间干细胞 12:407412, 2013 ) 。到测试,区分开来与人的 iPSCs 的临床上珍贵的房间的 immunogenicity 突现地为 iPSC 技术的翻译被要求到诊所。 | Jiani Cao Xiaoyan Li Xiao Lu Chao Zhang Honghao Yu Tongbiao Zhao | 2014 | Protein & Cell2014，5，1： | 6 |
| 6 | Balancing the anionic framework polarity for enhanced thermoelectric performance in YbMg_(2)Sb_(2) Zintl compounds显示文摘1-2-2-type Zintl phase compound has aroused great interest for potential thermoelectric applications.However,YbMg_(2)Sb_(2) is seldom studied due to the very low electrical conductivity resulting from the large difference in the electronegativity between Mg and Sb.In this paper,we adjust the covalently bonded network of MgeSb by replacing part of the Mg with Zn which has the electronegativity closer to that of Sb.The decreased polarity in the anionic framework offers more free distance for electrons for the enhanced Hall mobility and electrical conductivity.Together with the increased point defect and the decreased lattice thermal conductivity by introduction of Zn,the maximum ZT value of ~0.8 at 773 K is achieved in YbMg_(0.9)Zn_(1.1)Sb_(2) which is~100% enhancement compared with that of YbMg_(2)Sb_(2). | Zongwei Zhang Xinyu Wang Yijie Liu Chen Chen Honghao Yao Li Yin Xiaofang Li Shan Li Fan Zhang Fengxian Bai Jiehe Sui Bo Yu Feng Cao Xingjun Liu Jun Mao Guoqiang Xie Qian Zhang | 2019 | Journal of Materiomics2019，5，4： | 3 |
| 7 | Carbonaceous Nanofibers-titanium Dioxide Nanocomposites: Synthesis and Use as a Platform for Removal of Dye Pollutants显示文摘A mild chemistry route was developed to prepare carbonaceous nanofibers-titanium dioxide(CNF-TiO_2) nanocomposites for removal of dye pollutants. In the process of the template-directed hydrothermal carbonization(HTC), ultrathin Te nanowires were adopted as templates and glucose as the carbon source, and TiO_2 was decorated on CNF via the hydrolysis of tetrabutyltitanate in the presence of CNF in ethanol. The as-prepared materials were characterized by scanning electron microscopy(SEM), transmission electron microscopy(TEM), energy-dispersive X-ray(EDX) and X-ray diffraction(XRD). SEM and TEM observations displayed that TiO_2 nanoparticles were anchored on the CNF. EDX and XRD data confirmed that the assynthesized samples were CNF-TiO_2, and TiO_2 belonged to anatase titania. Taking advantage of combined benefits of carbonaceous nanofibers and titanium dioxide, these CNF-TiO_2 nanocomposites exhibited higher removal efficiency in a short time and showed good reusability. It was showed that over 97% of Rhodamine B could be removed in 15 min without generating the solid and liquid wastes. The removal efficiency of dyes was still over 80% after reuse in five cycles. All the results demonstrate that the as-prepared CNF-TiO_2 composites are effective materials for fast and effective removal of dye pollutants and thus can provide a new platform for dye decontamination. | 郭洪影 JIANG Shan WANG Chaoyuan LI Shenwan FENG Jianjian 孙红梅 ZHU Hongda GUO Huiling LIU Mingxing SUN Honghao | 2019 | Journal of Wuhan University of Technology(Materials Science)2019，34，2： | 3 |
| 8 | Gold nanoparticles with surface-anchored chiral poly(acryloyI-L(D)-valine) induce differential response on mesenchymal stem cell osteogenesis显示文摘 | Jun Deng Honghao Zheng Xiaowen Zheng Mengyun Yao Zheng Li Changyou Gao | 2016 | Nano Research2016，9，12： | 2 |
| 9 | Energy Absorption and Deformation Mechanism of Lotus-type Porous Coppers in Perpendicular Direction显示文摘As metallic foams used for energy absorption in the automotive and aerospace industries, recently invented lotus-type porous metals are viewed as potential energy absorbers. Yet, solid conclusion on their eligibility as energy absorbers is still in question, particularly when compression is in the direction perpendicular to the axial orientation of cylindrical pores. In this work, the energy absorption of lotus-type porous coppers in the perpendicular direction is investigated at strain rates from 0.001 s^(-1) to^2400 s^(-1). The energy absorption capacity and the energy absorption efficiency are calculated to be4–16 k J/kg and 0.32–0.7, respectively, slightly inferior to metal foams and the same porous solid compressed in the parallel direction due to the shortened extent of the plateau stress region. The deformation mechanism is examined experimentally in conjunction with finite element modeling. Both suggest that gradual squeeze and collapse of pores are the mechanisms accommodating the energy absorption. The deformation is generally evenly distributed over pore ligaments and independent of strain rate. | Weidong Li Kai Xu Honghao Li Haoling Jia Xinhua Liu Jianxin xie | 2017 | Journal of Materials Science & Technology2017，33，11： | 2 |
| 10 | Exploiting transmission opportunities in heterogeneous wireless networks:a transmission power saving perspective显示文摘Exploiting transmission opportunities in dimensions of user equipments(UEs),radio access networks(RANs),and radio resource units(RRUs),in heterogeneous wireless networks(HWNs),we focus on a new perspective of saving the uplink transmission power,so as to lengthen the battery life time of UEs.Moreover,to ensure the quality of service for each UE,we guarantee each a minimal transmission rate.To achieve the above HWN control objective,we have to make an efcient matching among UEs,RANs,and RRUs,which is formulated as a binary linear optimization problem.Due to its NP-hard complexity,we develop a rate-power efciency based HWN control algorithm with low computational complexity.We verify the performance of our HWN control scheme through simulation.Extensive simulation results demonstrate the advantage of our HWN control method in saving the uplink transmission power and guaranteeing the UE transmission rate requirement. | JU HongHao LI JianDong LONG Yan YANG XiaoNiu | 2014 | Science China(Information Sciences)2014，57，2： | 1 |
| 11 | Unfi)lded protein response and activated degradative pathways regulation in GNE myopathy 显示文摘 | Honghao Li Qi Chen Fuchen Liu | 2013 | PLoS One2013，8，58： | 1 |
| 12 | Structural engineering design of carbon dots for lubrication显示文摘Carbon dots(CDs)have opened up a new field of carbon nanomaterials and successively attracted increasing attention since their discovery in 2004.Owing to their ultrasmall size,tunable surface functional groups,excellent dispersibility,attractive stability,low toxicity,environmental friendliness,facile synthesis and low-cost precursors,CDs have been developed as green and promising frictionreducing and anti-wear materials in lubrication science,applied to energy conservation and extension of mechanical service life in recent years.However,there are few reviews focusing on the application of CDs in the important field of lubrication.In this review,we comprehensively summarize the development of CDs in lubrication for the first time.Firstly,three strategies for structural engineering design of CDs to improve their tribological characteristics are fully analyzed,in terms of size and shape control,surface modification and heteroatom doping.Secondly,the advance in lubrication application of CDs,including CDs as additives for lubricants,greases,gel and magnetorheological fluids as well as CDs as lubricating coatings,is systematically highlighted.Thirdly,the lubricating mechanisms of CDs as additives are introduced in detail.Furthermore,the remaining major challenges and opportunities for CDs in lubrication field are discussed and outlined. | Chuang He Shuang E Honghao Yan Xiaojie Li | 2021 | Chinese Chemical Letters2021，32，9： | 1 |
| 13 | An alternative thin-plate welding technology using underwater shock wave显示文摘 | Sun Wei Li Xiaojie Yan Honghao | 2012 | Journal of Adhesion Science b- Technology2012，26，10： | 1 |
| 14 | Critical involvement of lysyl oxidase in seizure-induced neuronal damage through ERK-Alox5-dependent ferroptosis and its therapeutic implications显示文摘Recent insights collectively suggest the important roles of lysyl oxidase(LysOX)in the pathological processes of several acute and chronic neurological diseases,but the molecular regulatory mechanisms remain elusive.Herein,we explore the regulatory role of LysOX in the seizure-induced ferroptotic cell death of neurons.Mechanistically,LysOX promotes ferroptosis-associated lipid peroxidation in neurons via activating extracellular regulated protein kinase(ERK)-dependent 5-lipoxygenase(Alox5)signaling.In addition,overexpression of LysOX via adeno-associated viral vector(AAV)-based gene transfer enhances ferroptosis sensitivity and aggravates seizure-induced hippocampal damage.Our studies show that pharmacological inhibition of LysOX withβ-aminopropionitrile(BAPN)significantly blocks seizure-induced ferroptosis and thereby alleviates neuronal damage,while the BAPN-associated cardiotoxicity and neurotoxicity could further be reduced through encapsulation with bioresponsive amorphous calcium carbonate-based nanocarriers.These findings unveil a previously unrecognized LysOX-ERK-Alox5 pathway for ferroptosis regulation during seizure-induced neuronal damage.Suppressing this pathway may yield therapeutic implications for restoring seizure-induced neuronal injury. | Xiaoyuan Mao Xuan Wang Mingzhu Jin Qin Li Jining Jia Menghuan Li Honghao Zhou Zhaoqian Liu Weilin Jin Yanli Zhao Zhong Luo | 2022 | Acta Pharmaceutica Sinica B2022，12，9： | 1 |
| 15 | Modulating proton binding energy on the tungsten carbide nanowires surfaces for boosting hydrogen evolution in acid显示文摘ungsten carbides have attracted wide attentions as Pt substitute electrocatalysts for hydrogen evolution reaction (HER), due to their good stability in an acid environment and Pt-like behaviour in hydrolysis. However, quantum chemistry calculations predict that the strong tungsten-hydrogen bonding hinders hydrogen desorption and restricts the overall catalytic activity. Synergistic modulation of host and guest electronic interaction can change the local work function of a compound, and therefore, improve its electrocatalytic activity over either of the elements individually. Herein, we develop a creative and facile solid-state approach to synthesize self-supported carbon-encapsulated single-phase WC hybrid nanowires arrays (nanoarrays) as HER catalyst. The theoretical calculations reveal that carbon encapsulation modifies the Gibbs free energy of H* values for the WC adsorption sites, endowing a more favorable C@WC active site for HER. The experimental results exhibit that the hybrid WC nanoarrays possess remarkable Pt-like catalytic behavior, with superior activity and stability in an acidic media, which can be compared to the best non-noble metal catalysts reported to date for hydrogen evolution reaction. The present results and the facile synthesis method open up an exciting avenue for developing cost-effective catalysts with controllable morphology and functionality for scalable hydrogen generation and other carbide nanomaterials applicable to a range of electrocatalytic reactions. | Qjngshui Hong Tangyi Li Shisheng Zheng Haibiao Chen Wenju Ren Honghao Chu Kuangda Xu Zongwei Mei Feng Pan | 2021 | Journal of Energy Chemistry2021，30，11： | 1 |
| 16 | Downstream signaling of reactive oxygen species,protein kinase C epsilon translocation and delayed neuroprotection in sevoflurane preconditioned rats following cerebral ischemia/reperfusion显示文摘BACKGROUND:Brief exposure to the anesthetic sevoflurane results in delayed neuroprotection. However,few studies have addressed delayed neuroprotection after preconditioning with a single administration of sevoflurane. OBJECTIVE:To explore the relationship between a single preconditioning administration of sevoflurane and reactive oxygen species production and protein kinase C-epsilon(PKC-ε) translocation. DESIGN,TIME,AND SETTING:The randomized,controlled,animal experiment was conducted at the Central Laboratory,Xiangya Hospital,Central South University,China from November 2007 to April 2008. MATERIALS:A total of 120 healthy,male,Sprague Dawley rats were equally and randomly assigned into five groups:sham operation,ischemia/reperfusion,sevoflurane,2-mercaptopropionylglycine (2-MPG,a selective reactive oxygen species scavenger) + sevoflurane(MPG + sevoflurane),and MPG.Sevoflurane(Baxter,USA) and MPG(Sigma,USA) were used in this study. METHODS:Intervention consisted of three procedures.(1) MPG injection:a selective reactive oxygen species scavenger,MPG(20 mg/kg),was infused into the rat caudal vein in the MPG and MPG + sevoflurane groups.(2) Sevoflurane preconditioning:30 minutes following MPG injection, rats in the sevoflurane and MPG + sevoflurane groups breathed a mixed gas of 2.4%sevoflurane and 97.6%oxygen for 60 minutes.Rats in the sham operation,ischemia/reperfusion,and MPG groups breathed 100%pure oxygen for 60 minutes.(3) Ischemia/reperfusion:24 hours after sevoflurane or pure oxygen preconditioning,middle cerebral artery occlusion models were established in the ischemia/reperfusion,sevoflurane,MPG + sevoflurane,and MPG groups. Following 2 hours ischemia/6 hours and 24 hours reperfusion,the carotid artery was separated,but the middle cerebral artery was not occluded,in the sham operation group. MAIN OUTCOME MEASURES:In the ischemic hemisphere,PKC-εtranslocation in the rat parietal cortex was measured by Western blot analysis.Infarct volume was calculated using the TTC assay.Neurological deficits were evaluated in rats using a scoring system of 8 points. RESULTS:After 6 hours reperfusion,the ratio of PKC-εin membrane/(cytosol + membrane) was significantly less in the sham operation group than in the ischemia/reperfusion,sevoflurane,MPG + sevoflurane),and MPG groups(P<0.05).The ratio of PKC-εin membrane/(cytosol + membrane) was significantly greater in the sevoflurane group than in the sham operation,ischemia/reperfusion, MPG + sevoflurane,and MPG groups(P<0.05).No significant differences were observed in the ischemia/reperfusion,MPG + sevoflurane,and MPG groups(P>0.05).Following 24 hours reperfusion, the ratio of PKC-εin membrane/(cytosol + membrane) was significantly less in the sham operation group than in the ischemia/reperfusion,sevoflurane,MPG + sevoflurane,and MPG groups(P<0.05). No significant differences were detected in the ischemia/reperfusion,sevoflurane,MPG + sevoflurane, and MPG groups(P>0.05).Compared with the ischemia/reperfusion,MPG + sevoflurane,and MPG groups,infarct volume was significantly smaller,and neurological deficits were significantly improved, in the sevoflurane group(P<0.05).No significant differences in infarct volume and neurological deficits were observed among the ischemia/reperfusion,MPG + sevoflurane,and MPG groups(P>0.05).Infarcts or neurological deficits were not detected in the sham operation group. CONCLUSION:A single preconditioning administration of sevoflurane reduced infarct volumes and improved neurological deficits in ischemic rats.Delayed neuroprotection may be mediated by reactive oxygen species and correlated to PKC-εactivation. | Zhi Ye Qulian Guo E Wang Yundan Pan Qing Li Honghao Zhou | 2009 | Neural Regeneration Research2009，4，3： | 1 |
| 17 | Unsupervised machine learning for discovery of promising half-Heusler thermoelectric materials显示文摘hermoelectric materials can be potentially applied to waste heat recovery and solid-state cooling because they allow a direct energy conversion between heat and electricity and vice versa.The accelerated materials design based on machine learning has enabled the systematic discovery of promising materials.Herein we proposed a successful strategy to discover and design a series of promising half-Heusler thermoelectric materials through the iterative combination of unsupervised machine learning with the labeled known half-Heusler thermoelectric materials.Subsequently,optimized zT values of~0.5 at 925 K for p-type Sc_(0.7)Y_(0.3)NiSb_(0.97)Sn_(0.03)and~0.3 at 778 K for n-type Sc_(0.65)Y_(0.3)Ti_(0.05)NiSb were experimentally achieved on the same parent ScNiSb. | Xue Jia Yanshuai Deng Xin Bao Honghao Yao Shan Li Zhou Li Chen Chen Xinyu Wang Jun Mao Feng Cao Jiehe Sui Junwei Wu Cuiping Wang Qian Zhang Xingjun Liu | 2022 | npj Computational Materials2022，，1： | 1 |
| 18 | Pharmacokinetics of the new proton pump inhibitor ilaprazole in Chinese healthy subjects in relation to CYP3A5 and CYP2C19 genotypes显示文摘 | Yalin Li Wei Zhang Dong Guo Gan Zhou Honghao Zhou Zhousheng Xiao | 2008 | Clinica Chimica Acta2008，，1： | 1 |
| 19 | Increased mere-ory Th17 cells in patients with neuromyelitis optica and multiple sclerosis 显示文摘 | Ying Li Honghao Wang Youming Long | 2011 | J Neuroimmunol2011，234，12： | 1 |
| 20 | Haemorrhage risk of brain arteriovenous malformation during pregnancy and puerperium显示文摘Background This study aimed to assess whether pregnancy and puerperium were associated with the risk of brain arteriovenous malformation(bAVM)haemorrhage.Methods A retrospective review was conducted in Xiangya Hospital,Central South University from January 2012 to December 2021.A case-crossover design was adopted to calculate the incidence density of bAVM-related haemorrhage among female patients in risk(pregnancy and puerperium)and control(non-pregnancy and non-puerperium)periods,according to four scenarios observed in different populations scenario I:patients with haemorrhagic bAVM of all ages;scenario II:patients with haemorrhagic bAVM of all ages,with at least one previous pregnancy;scenario III:patients with haemorrhagic bAVM who are of reproductive age(15-45 years);scenario IV:patients with haemorrhagic bAVM of reproductive age(15-45 years),with at least one previous pregnancy.Next,a comprehensive literature aggregation(up to April 2022)was performed for evidence synthesis.Results Among the 311 female patients with haemorrhagic bAVM,a significant haemorrhage risk during pregnancy and puerperium was found in Scenarios I(relative risk[RR],2.08;95%CI,1.28 to 3.39),II(RR,3.21;95%CI,1.95 to 5.31)and IV(RR,2.92;95%CI,1.73 to 4.93);however,a suggestive risk was found in scenario III(RR,1.62;95%CI,0.99 to 2.67).Evidence synthesis revealed a consistent haemorrhage risk among patients of all ages(RR,3.15;95%CI,1.93 to 5.15)and those of reproductive age(RR,1.29;95%CI,0.89 to 1.86).Conclusion Compared with most previous studies,a higher but relatively moderate risk for bAVM-related haemorrhage was identified during pregnancy and puerperium.Individualised prevention and treatment strategies should be preferred when neurosurgeons make clinical decisions. | Junyu Liu Honghao Zhang Chun Luo Yuxin Guo Yifeng Li Dun Yuan Weixi Jiang Junxia Yan | 2023 | Stroke & Vascular Neurology2023，8，4： | 1 |
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