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| 1 | Ciliary parathyroid hormone signaling activates transforming growth factor-βto maintain intervertebral disc homeostasis during aging显示文摘Degenerative disc disease(DDD) is associated with intervertebral disc degeneration of spinal instability. Here, we report that the cilia of nucleus pulposus(NP) cells mediate mechanotransduction to maintain anabolic activity in the discs. We found that mechanical stress promotes transport of parathyroid hormone 1 receptor(PTH1 R) to the cilia and enhances parathyroid hormone(PTH) signaling in NP cells. PTH induces transcription of integrin α_vβ_6 to activate the transforming growth factor(TGF)-β-connective tissue growth factor(CCN2)-matrix proteins signaling cascade. Intermittent injection of PTH(iPTH) effectively attenuates disc degeneration of aged mice by direct signaling through NP cells, specifically improving intervertebral disc height and volume by increasing levels of TGF-β activity, CCN2, and aggrecan. PTH1 R is expressed in both mouse and human NP cells. Importantly,knockout PTH1 R or cilia in the NP cells results in significant disc degeneration and blunts the effect of PTH on attenuation of aged discs. Thus, mechanical stress-induced transport of PTH1 R to the cilia enhances PTH signaling, which helps maintain intervertebral disc homeostasis, particularly during aging, indicating therapeutic potential of iPTH for DDD. | Liwei Zheng Yong Cao Shuangfei Ni Huabin Qi Zemin Ling Xin Xu Xuenong Zou Tianding Wu Ruoxian Deng Bo Hu Bo Gao Hao Chen Yusheng Li Jianxi Zhu Francis Tintani Shadpour Demehri Amit Jain Khaled M.Kebaish Shenghui Liao Cheryle A.Séguin Janet L.Crane Mei Wan Hongbin Lu Paul D.Sponseller Lee H.RileyIII Xuedong Zhou Jianzhong Hu Xu Cao | 2018 | Bone Research2018，6，3： | 13 |
| 2 | Recent progress in advanced core-shell metal-based catalysts for electrochemical carbon dioxide reduction显示文摘Electrochemical carbon dioxide reduction(CO_(2)RR)plays an important role in solving the problem of high concentration of CO_(2)in the atmosphere and realizing carbon cycle.Core-shell structure has many unique features including tandem catalysis,lattice strain effect,defect engineering,which exhibit great potential in electrocatalysis.In this review,we focus on the advanced core-shell metal-based catalysts(CMCs)for electrochemical CO_(2)RR.The recent progress of CMCs in electrocatalytic CO_(2)RR is described as the follow-ing aspects:(1)The mechanism of electrochemical CO_(2)RR and evaluation parameters of electrocatalyst performance,(2)preparation methods of core-shell metal catalysts and core-shell structural advantages and(3)advanced CMCs towards electrochemical CO_(2)RR.Finally,we make a brief conclusion and propose the opportunities and challenges in the field of electrochemical CO_(2)RR. | Fengqi Wang Wenlong Zhang Hongbin Wan Chenxi Li Wankai An Xia Sheng Xiaoyu Liang Xiaopeng Wang Yunlai Ren Xin Zheng Dongcan Lv Yuchen Qin | 2022 | Chinese Chemical Letters2022，33，5： | 2 |
| 3 | Enhanced photoelectrocatalytic degradation of ammonia by in situ photoelectrogenerated active chlorine on TiO_2 nanotube electrodes显示文摘TiO_2 nanotube(Ti NT) electrodes anodized in fluorinated organic solutions were successfully prepared on Ti sheets. Field-emission scanning electron microscopy(FE-SEM) and X-ray diffraction(XRD) were performed to characterize the TiNT electrodes. The linear voltammetry results under irradiation showed that the TiNT electrode annealed at 450°C presented the highest photoelectrochemical activity. By combining photocatalytic with electrochemical process, a significantly synergetic effect on ammonia degradation was observed with Na_2SO_4 as supporting electrolyte at pH 10.7. Furthermore, the photoelectrocatalytic efficiency on the ammonia degradation was greatly enhanced in presence of chloride ions without the limitation of pH. The degradation rate was improved by 14.8 times reaching 4.98 × 10^(-2) min^(-1) at pH 10.7 and a faster degradation rate of 6.34 × 10^(-2) min^(-1)was obtained at pH 3.01. The in situ photoelectrocatalytic generated active chlorine was proposed to be responsible for the improved efficiency. On the other hand, an enhanced degradation of ammonia using TiNT electrode fabricated in fluorinated organic solution was also confirmed compared to TiNT electrode anodized in fluorinated water solution and TiO_2 film electrode fabricated by sol–gel method. Finally, the effect of chloride concentration was also discussed. | Shuhu Xiao Dongjin Wan Kun Zhang Hongbin Qu Jianfeng Peng | 2016 | Journal of Environmental Sciences2016，28，12： | 2 |
| 4 | Evaluation of SARS-CoV-2-Neutralizing Nanobody Using Virus Receptor Binding Domain-Administered Model Mice显示文摘Due to the rapid spread of coronavirus disease 2019(COVID-19),there is an urgent requirement for the development of additional diagnostic tools for further analysis of the disease.The isolated nanobody Nb11-59 binds to the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)reeptor-binding domain[RBD]with high afinity to neutralize the virus and block the angiotensin-converting enzyme 2-(ACE2-)RBD interaction.Here,we introduce a novel nanobody-based radiotracer named^(68)Ga-Nb1159.The radiotracer retained high affinity for the RBD and showed reliable radiochemical characteristics both in vitro and in vivo.Predinical positron emission tomography(PET)studies of Ga-Nb1159 in mice revealed is rapid dearance from circulation and robust uptake into the renal and urinary systems.Fortunately,^(68)Ga-Nb1159 could speifcally reveal the distribution of the RBD in mice.This sudy also helped to evaluate the pharmacodynamic efects of the neutralizing nanobody.Moreover,^(68)Ga-Nb1159 may be a promising l0ol lo explore the distribution of the RBD and improve the understanding of the virus.In particular,this study identified a novel molecular radioagent and established a reliable evaluation method for speifially investigating the RBD through noninvasive and visual PET technology. | Song Liu Guanghui Li Lei Ding Jin Ding Qian Zhang Dan Li Xingguo Hou Xiangxing Kong Jing Zou Shiming Zhang Hongbin Han Yakun Wan Zhi Yang Hua Zhu | 2022 | Research2022，，2： | 2 |
| 5 | CO2 Laser Beam Modulating for Surface Texturing Machining 显示文摘 | Daping Wan Hongbin Liu Yuming Wang | 2008 | Optics & Laser Technology2008，40，1： | 1 |
| 6 | Lowing the energy loss of organic solar cells by molecular packing engineering via multiple molecular conjugation extension显示文摘The central unit(benzo[c][1,2,5]thiadiazole) in Y6 series of molecules plays a determining role in their unique intermolecular packing for a three-dimensionally(3D) network, largely endowing their organic solar cells(OSCs) with so far the best power conversion efficiencies(PCEs) and also largely suppressed energy losses(Eloss). Despite its vital role in molecular packing, very few explorations for central unit have been conducted due to possibly the constructing challenge of central heterocyclic units.Herein, a highly efficient acceptor-donor-acceptor(A-D-A) type electron acceptor, CH17, has been designed and constructed,featured with a prominent π extension in both directions of the central and end units with respect to Y6 series. Such a multiple and much enhanced conjugation extension in CH17 enables a much more effective and compact 3D molecular packing compared with that of Y6 supported by X-ray single crystal and other analysis, mainly caused by a newly observed distinctive dual “end unit to central unit” packing mode. This much favorable molecular packing, also kept in its blends with donor materials, leads a larger electron and hole transfer integrals and hence much improved charge transport, and reduced energetic disorders in CH17blends. More importantly, the observed upshifted charge transfer(CT) state of CH17 blends compared with that of Y6, due to its increased molecular conjugation extension in both directions, further enhances the hybridization between its CT and local exciton(LE) states, resulting in higher luminescence efficiency, much suppressed non-radiative recombination loss and smaller Elosswith respect to that of Y6. Consequently, an excellent PCE of 17.84% is achieved with PM6 as the donor in a binary device compared with a PCE of 16.27% for the controlled Y6 device. Furthermore, a further improved PCE of 18.13% is achieved by CH17-based ternary single-junction OSCs along with a markedly reduced Elossof 0.49 e V and larger open-circuit voltage(Voc) of0.89 V, compared with that(16.27% of PCE, 0.85 V of Voc, and 0.53 e V of Eloss) of the control device using Y6. This significantly improved photovoltaic performance caused by molecular multiple conjugation extension, especially through the largely unexplored central unit, indicates that there is still much room to further enhance OSC performance by addressing the most important issue for OSC, i.e, the smaller Voccaused by larger Eloss, through engineering molecular packing by designing/tuning molecule more dedicatedly. | Hongbin Chen Yalu Zou Huazhe Liang Tengfei He Xiaoyun Xu Yunxin Zhang Zaifei Ma Jing Wang Mingtao Zhang Quanwen Li Chenxi Li Guankui Long Xiangjian Wan Zhaoyang Yao Yongsheng Chen | 2022 | Science China Chemistry2022，65，7： | 1 |
| 7 | A Low Reorganization Energy and Two-dimensional Acceptor with Four End Units for Organic Solar Cells with Low E_(loss)显示文摘A novel two-dimensional A-D-A acceptor named as CH8 with four electron-withdrawing end units has been successfully designed and synthesized.The enlarged conjugation in two directions renders CH8 exhibit an extremely low electron reorganization energy of 98 meV,which makes CH8 a potential candidate for outstanding organic semiconductor material.When blended with PM6,a considerate power conversion efficiency of 9.37%along with a high open-circuit voltage(V_(oc))0.889 V and low energy loss(E_(loss))below 0.6 eV is achieved.These results indicate that the two-dimensional A-D-A molecule with four electron-withdrawing end units is an effective molecular design strategy to achieve lower voltage loss and also possible high performance for organic photovoltaics if ideal morphology could be achieved. | Hongbin Chen Xiangjian Cao Xiaoyun Xu Chenxi Li Xiangjian Wan Zhaoyang Yao Yongsheng Chen | 2022 | Chinese Journal of Polymer Science2022，40，8： | 1 |
| 8 | CO2 laser beam modulating for surface texturing machining显示文摘 | Wan Daping Liu Hongbin Wang Yuming | 2008 | Optics & Laser Technology2008，40，： | 1 |
| 9 | Theoretical and Experimental Studies of Coupled Seepage-Pipe Flow to a Horizontal Well 显示文摘 | Chen Chongxi Wan Junwei Zhan Hongbin | 2003 | Journal of Hydrology2003，281，12： | 1 |
| 10 | High-speed flexible near-infrared organic photodiode for optical communication显示文摘Optical communication is a particularly compelling technology for tackling the speed and capacity bottlenecks in data communication in modern society.Currently,the silicon photodetector plays a dominant role in high-speed optical communication across the visible-near-infrared spectrum.However,its intrinsic rigid structure,high working bias and low responsivity essentially limit its application in next-generation flexible optoelectronic devices.Herein,we report a narrow-bandgap non-fullerene acceptor(NFA)with a remarkableπ-extension in the direction of both central and end units(CH17)with respect to the Y6 series,which demonstrates a more effective and compact 3D molecular packing,leading to lower trap states and energetic disorders in the photoactive film.Consequently,the optimized solution-processed organic photodetector(OPD)with CH17 exhibits a remarkable response time of 91 ns(λ=880 nm)due to the high charge mobility and low parasitic capacitance,exceeding the values of most commercial Si photodiodes and all NFA-based OPDs operating in self-powered mode.More significantly,the flexible OPD exhibits negligible performance attenuation(<1%)after bending for 500 cycles,and maintains 96% of its initial performance even after 550 h of indoor exposure.Furthermore,the high-speed OPD demonstrates a high data transmission rate of 80 MHz with a bit error rate of 3.5×10^(-4),meaning it has great potential in next-generation high-speed flexible optical communication systems. | Yu Zhu Hongbin Chen Ruiman Han Hao Qin Zhaoyang Yao Hang Liu Yanfeng Ma Xiangjian Wan Guanghui Li Yongsheng Chen | 2024 | National Science Review2024，11，3： | 0 |
| 11 | Diagnosis and Treatment of a Case of Leydig Cell Tumor in Dogs显示文摘Based on such diagnostic measures as clinical diagnosis and lab etiological examination,the disease was diagnosed as Leydig cell tumor in dogs. Combined with the clinical examination results of the dog,testicular tumor removal operation was conducted,and the prognosis was favorable. | Xiang Jinmei Yin Hongbin Li Wenqing Wan Chunyun | 2014 | Animal Husbandry and Feed Science2014，6，4： | 0 |
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