共被期刊论文引用了2次
您的检索式：您选中1篇文献正在查看引证文献汇总
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Ganoderma lucidum spore powder modulates Bcl-2 and Bax expression in the hippocampus and cerebral cortex,and improves learning and memory in pentylenetetrazole-kindled rats显示文摘We studied the effects of Ganoderma lucidum spore powder on Bax and Bcl-2 expression and neuronal apoptosis in pentylenetetrazole-kindled epileptic rats.Sixty adult rats were randomly divided into a control group,an epileptic group (kindled) and three medication groups (150,300,450 mg/kg given to kindled rats).Bax and Bcl-2 immunohistochemistry and TUNEL labeling showed that the number of Bax-and TUNEL-positive cells in the hippocampus and cerebral cortex decreased significantly in the high-dose medication group,while the number of Bcl-2 immunoreactive cells increased.The Morris water maze test showed that high-dose treatment significantly shortened escape latency and increased spatial probe trial performance.Our findings indicate that a high dose of Ganoderma lucidum spore powder upregulates the expression of antiapoptotic Bcl-2 protein in the hippocampus and cerebral cortex,inhibits proapoptotic Bax expression,and decreases seizure-induced neuronal apoptosis.Further,Ganoderma lucidum appears to protect against epilepsy-related learning and memory impairments. | Shuang Zhao Shengchang Zhang Shuqiu Wang | 2011 | Neural Regeneration Research2011，6，30： | 2 |
| 2 | Melatonin restores normal Bax and Bcl-2 protein expression in the subgranular zone of the dentate gyrus in pinealectomized rats显示文摘In this study, we sought to elucidate the effects of melatonin on learning and memory as well as apoptosis and expression of the Bax or Bcl-2 proteins in the subgranular zone of the dentate gyrus in pinealectomized rats. Using the Morris water maze and the olfactory memory tests, we found that the average escape latency in pinealectomized rats was clearly increased compared with sham-operated rats. Moreover, the average escape latency in the melatonin-treated and pinealectomized rats was longer than that in the sham-operated rats and shorter than that in the pinealectomized and untreated rats. Immunohistochemistry and terminal-deoxynucleoitidyl transferase mediated nick end labeling (TUNEL) showed that there were fewer Bax immunoreactive cells and TUNEL-positive (apoptotic) cells but more Bcl-2 immunoreactive cells in the melatonin-treated rats compared with the pinealectomized rats. The sham-operated rats showed numbers of these cells similar to the melatonin-treated rats. These experimental findings demonstrate that melatonin treatment may reduce abnormal apoptosis by promoting gene expression of Bax and suppressing gene expression of Bcl-2 in the subgranular zone of the dentate gyrus in pinealectomized rats. These effects appear to result in the inhibition of cellular apoptosis and the improvement of spatial learning and memory in pinealectomized rats. | Shengchang Zhang Shuang Zhao Lu Bai Mingming Guan Jielin Mo Ling Lan | 2011 | Neural Regeneration Research2011，6，27： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员