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| 1 | 循证指南更新:成人发作性偏头痛预防的药物治疗显示文摘目的提供偏头痛预防治疗的指南更新推荐,所提出的临床问题是什么样的药物治疗可有效预防偏头痛发作?方法作者对1999年6月—2009年5月间发表的研究使用结构式的评价程序来分类不同(美国可获得)药物对偏头痛预防的效果。结果和推荐作者评价了284篇摘要,最后对29篇包含Ⅰ类或Ⅱ类证据的文章进行综述。双丙戊酸、丙戊酸钠、托吡酯、美托洛尔、普萘洛尔和噻吗洛尔能有效预防偏头痛,应该用于偏头痛患者以减少发作频率及程度(A级证据)。夫罗曲坦可有效预防月经性偏头痛(A级证据)。拉莫三嗪对偏头痛预防无效(A级证据)。 | 邹静 李颖 冯智英 李焰生 Silberstein SD Holland S Freitag F Dodick DW Argoff C Ashman E | 2012 | 神经病学与神经康复学杂志2012，9，2： | 38 |
| 2 | Radiation resistance and stem-like cells in brain tumors显示文摘The concepts of stem cells being resistant to therapy, stem-like cells existing in brain tumors, and these tumors initially responding | Hambardzumyan D Squartro M Holland EC | 2006 | 中国神经肿瘤杂志2006，4，4： | 34 |
| 3 | 世界生物精神病学会联合会(WFSBP)关于焦虑障碍、强迫症和创伤后应激障碍的药物治疗指南显示文摘这篇文章根据现有的随机、安慰剂或参照药物对照临床研究 ,向大家推荐焦虑障碍、强迫症的药物治疗。 5-HT再摄取抑制剂 (SSRI)是治疗惊恐障碍的一线药物。三环类抗抑郁药 (TCA)与SSRI疗效相当 ,但耐受性差。难治性患者 ,如没有药物依赖和耐受史 ,则可使用苯二氮 艹卓 类药物如阿普唑仑。由于单胺氧化酶抑制剂 (MAOI)苯乙肼会产生严重的不良反应 ,且会与其他药物和食物成分相互作用 ,因此只有当一线药物无效时才使用。广泛性焦虑者可用万拉法新和SSRI,也可选用丁螺环酮和丙咪嗪。SSRI可作为社交恐怖症的一线药物 ,MAOI、吗氯贝胺和苯二氮 艹卓 类药物作为二线药物。强迫症最好用SSRI或氯丙咪嗪治疗。 | Borwin Bandelow Josef Zohar Eric Hollander Siegfried Kasper Hans-J¨urgen M¨oller WFSBP Task 项志清 何燕玲 | 2003 | 中国心理卫生杂志2003，17，7： | 30 |
| 4 | Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGF-induced glioma cells显示文摘 | Charles N Ozawa T Squatrito M Bleau AM Brennan CW Hambardzumyan D Holland EC. | 2010 | 中国神经肿瘤杂志2010，8，1： | 24 |
| 5 | Regulation of the G1 phase of the mammalian cell cycle显示文摘In any multi-cellular organism, the balance between cell division and cell death maintains a constant cell number. Both cell division cycle and cell death are highly regulated events. Whether the cell will proceed through the cycle or not, depends upon whether the conditions required at the checkpoints during the cycle are fulfilled. In higher eucaryotic cells, such as mammalian cells, signals that arrest the cycle usually act at a G1 checkpoint. Cells that pass this restriction point are committed to complete the cycle. Regulation of the GI phase of the cell cycle is extremely complex and involves many different families of proteins such as retinoblastoma family cyclin dependent kinases, cyclins, and cyclic kinase inhibitors. | DONJERKOVIC DUBRRAVKA DAVID W SCOTT (Department of Immunology, Holland Laboratory for the Biomedical Sciences, American Red Cross, 15601 Crabbs Branch Way, Rockville, MD) | 2000 | Cell Research2000，10，1： | 18 |
| 6 | 循证指南更新:非甾体类抗炎药和其他辅助治疗预防成人发作性偏头痛显示文摘目的为偏头痛预防性治疗提供最新循证推荐。所提出的临床问题是非甾体类抗炎药(NSAIDs)或其他辅助治疗是否对偏头痛预防有效?方法作者对1999年6月—2009年5月间发表的研究使用结构式的评价程序来分类不同药物对偏头痛预防的效果。结果作者总共回顾了284篇摘要,包括49篇偏头痛预防治疗的Ⅰ级或Ⅱ级证据,其中15篇为涉及非传统治疗、NSAIDs及其他辅助治疗的研究,予以了评价。推荐蜂斗菜对偏头痛预防治疗有效,应被用于偏头痛患者以降低偏头痛发作频率及严重程度(A级推荐)。非诺洛芬、布洛芬、酮洛芬、萘普生、萘普生钠、雏菊、镁剂、核黄素及组胺皮下注射对偏头痛预防很可能有效(B级推荐)。认为可能有效的药物包括赛庚啶、辅酶Q10、雌激素、甲芬那酸及氟比洛芬(C级推荐)。矛盾不一致或不足以支持或反对使用的药物包括阿司匹林、吲哚美辛、ω-3及高压氧。孟鲁司特对偏头痛预防治疗很可能无效(B级证据)。 | 华驾略 蒋仙国 季伟华 李焰生 Holland S Silberstein SD Freitag F Dodick DW Argoff C Ashman E | 2012 | 神经病学与神经康复学杂志2012，9，2： | 17 |
| 7 | Management of gastroesophageal reflux disease: Patient and physician communication challenges and shared decision making显示文摘Gastroesophageal reflux disease(GERD) is a common upper esophageal condition and typical symptoms can include heartburn and sensation of regurgitation while atypical symptoms include chronic cough, asthma, hoarseness, dyspepsia and nausea. Typically, diag-nosis is presumptive given the presence of typical and atypical symptoms and is an indication for empiric therapy. Treatment management can include lifestyle modifications and/or medication therapy with proton pump inhibitor(PPI) class being the preferred and most effective. Complete symptom resolution is not always achieved and long-term PPI therapy can put patients at risk for serious side effects and needless expense. The brain-gut connection and hypervigilance plays an important role in symptom resolution and treatment success, especially in the case of non-PPI responders. Hypervigilance is a combination of increased esophageal sensory sensitivity in combination with exaggerated threat perception surrounding esophageal symptoms. Hypervigilance requires a different approach to GERD managements, where continued PPI therapy and surgery are usually not recommended. Rather, helping physicians and patients understand the brain-gut connection can guide and improve care.Education and reassurance should be the main pillars or treatment. However, it is important not to suggest the symptoms are due to anxiety alone, this often leads to patient dissatisfaction. Patient dissatisfaction with treatment reveals the need for a more patient-centered approach to GERD management and better communication between patients and providers. Shared decision making(SDM) with the incorporation of patient-reported outcomes(PRO) promotes patient adherence and satisfaction. SDM is a joint discussion between clinician and patient in which a mutually shared solution is explored for GERD symptoms. For SDM to work the physician needs to capture patients' perceptions which may not be obtained in the standard interview. This can be done through the use of PROs which promote a dialogue with patients about their symptoms and treatment priorities in the context of the SDM patient encounter. SDM could potentially help in the management of patient expectations for GERD treatment, ultimately positively impacting their health-related quality of life. | Scott Klenzak Igor Danelisen Grace D Brannan Melissa A Holland Miranda AL van Tilburg | 2018 | World Journal of Clinical Cases2018，6，15： | 10 |
| 8 | 金黄色葡萄球菌菌血症诊治策略显示文摘美国每年金黄色葡萄球菌(金葡菌)菌血症发生率约为4.3/10万--38.2/10万。自20世纪90年代以来,此类感染者30 d全因病死率高达20%,其中甲氧西林耐药是金葡菌菌血症致死的独立危险因素。金葡菌菌血症患者易并发细菌性心内膜炎,治疗不充分常可危及生命。因此,如何早期诊断感染性心内膜炎,确诊后治疗方案(药物、疗程)的优化成为金葡菌菌血症诊治的关键。 | Holland TL Arnold C Fowler VG Jr 傅祝英杰 汪复 | 2015 | 中国感染与化疗杂志2015，15，2： | 9 |
| 9 | 宁夏银北干旱半干旱地区水盐动态和调控措施显示文摘通过对宁夏惠农县东永固试验区地下水盐动态和土壤水盐剖面分布变化的实际观测 ,分析得出以蒸发积盐为主要影响因素的宁夏银北干旱半干旱地区年内地下水和土壤水盐运动变化特征 。 | 李福祥 王少丽 方树星 张学文 Peter Hollanders | 2001 | 灌溉排水2001，20，3： | 8 |
| 10 | Activation-induced cell death in B lymphocytes显示文摘Upon encountering the antigen (Ag), the immune system can either develop a specific immune response or enter a specific state of unresponsiveness, tolerance. The response of B cells to their specific Ag can be activation and proliferation, leading to the immune response, or anergy and activation-induced cell death (AICD), leading to tolerance. AICD in B lymphocytes is a highly regulated event initiated by crosslinking of the B cell receptor (BCR). BCR engagement initiates several signaling events such as activation of PLCr, Ras, and PI3K, which generally speaking, lead to survival. However, in the absence of survival signals (CD40 or IL-4R engagement), BCR crosslinking can also promote apoptotic signal transduction pathways such as activation of effector caspases, expression of pro-apoptotic genes, and inhibition of pro-survival genes. The complex interplay between survival and death signals determines the B cell fate and, consequently, the immune response. | DONJERKOVIC DUBRAVKA, DAVID W SCOTT (Department of Immunology, Holland Laboratory for the Biomedical Sciences, American Red Cross, 15601 Crabbs Branch Way, Rockville, MD, 20855. USA) | 2000 | Cell Research2000，10，3： | 6 |
| 11 | 高龄妊娠显示文摘本文复习了美国妇女自七十年代开始并稳定持续增长的晚育趋势,探讨了病人和医生均为关注的高龄妊娠的有关问题。一、人口统计学趋势美国卫生统计中心的调查表明,早在三十年代中期,妇女平均生育年龄就开始延迟。1979年30岁以上初产妇女有40,000名,1980年人数增加250%以上,30岁以上未育妇女也成倍增加。1970~1979年30~44岁初产妇女由4%增至8%。其中,30~34岁组由7.3‰增至12.1‰(1982年又增至14.6‰),35~39岁组由1.8‰增至3.3‰。生命统计资料、人口普查数据和史料证明。 | Hollander D Breen JL 姚培元 | 1990 | 国外医学(妇产科学分册)1990，17，5： | 5 |
| 12 | Nitrogen Cycles: Past, Present, and Future显示文摘 | J. N. Galloway F. J. Dentener D. G. Capone E. W. Boyer R. W. Howarth S. P. Seitzinger G. P. Asner C. C. Cleveland P. A. Green E. A. Holland D. M. Karl A. F. Michaels J. H. Porter A. R. Townsend C. J. V?osmarty | 2004 | Biogeochemistry2004，，2： | 4 |
| 13 | Costimulation of resting B lymphocytes alters the IL-4-activated IRS2 signaling pathway in a STAT6 independent manner: implications for cell survival and proliferation显示文摘IL-4 is an important B cell survival and growth factor. IL-4 induced the tyrosine phosphorylation of IRS2 in resting B lymphocytes and in LPS- or CD40L-activated blasts. Phosphorylated IRS2 coprecipitated with the p85 subunit of PI 3’ kinase in both resting and activated cells. By contrast, association of phosphorylated IRS2 with GRB2 was not detected in resting B cells after IL-4 treatment although both proteins were expressed. However, IL-4 induced association of IRS2 with GRB2 in B cell blasts. The pattern of IL-4- induced recruitment of p85 and GRB2 to IRS2 observed in B cells derived from STAT6 null mice was identical to that observed for normal mice. While IL-4 alone does not induce activation of MEK, a MEKI inhibitor suppressed the IL-4-induced proliferative response of LPS-activated B cell blasts. These results demonstrate that costimulation of splenic B cells alters IL-4-induced signal transduction independent of STAT6 leading to proliferation. Furthermore, proliferation induced by IL-4 in LPS-activated blasts is dependent upon the MAP kinase pathway. | ZAMORANO JOSE,Unidad de Investigacion, Hospital San Pedro de Alcantara, Avda Millan Astray, 10003 Caceres ANN E KELLY, JONATHAN AUSTRIAN, HELEN Y WANG, ACHSAH D KEEGAN (Department of Immunology, Jerome Holland Labs, American Red Cross, Rockville, MD, USA | 2001 | Cell Research2001，11，1： | 4 |
| 14 | 到达角与出发角方法显著提升蓝牙位置服务性能显示文摘尽管蓝牙位置服务目前已取得显著成功,但市场上需要具有更出色性能的解决方案,且部分实时定位服务(RTLS)要求厘米级的位置精度。幸运的是,蓝牙技术最近增加了一项新功能,使位置服务解决方案能够满足厘米级精度要求。 | Dave Hollander | 2019 | 电子产品世界2019，26，5： | 3 |
| 15 | 系统性药物治疗儿童银屑病的安全性显示文摘银屑病是一种常见的慢性炎症性皮肤病。成年人的发病率为2%~3%,其中大约有三分之一的患者在18岁之前发病。在儿童期,该病的发病率呈线性增长。从1970年至2000年,儿童银屑病的发病率增加了一倍多。尽管对许多轻度银屑病患儿而言,局部治疗已足够,但对更多可能影响生活质量的重度或顽固性的银屑病患儿,则往往需要系统性治疗。 | bronckers imgj seyger mmb west dp lara-corrales i tollefson m tom wl hogeling m belazarian l zachariae c mahé e siegfried e philipp s szalai z vleugels ra holland k murphy r baselga e cordoro k lambert j alexopoulos a mrowietz u kievit w paller as 邓婕(编译) 张锡宝(审校) 无 | 2017 | 皮肤性病诊疗学杂志2017，24，5： | 3 |
| 16 | 招募和培训英语标准化病人的实践探讨显示文摘医学教学和考核中,对英语相关能力的重视度逐渐提高,启用英语标准化病人是行之有效的举措。英文标准化病人在培训和使用阶段,将英语作为操作语言,包括脚本的撰写、交流以及反馈等阶段均使用英文。目前资源紧缺,培训相对困难,因此招募及培训的实际经验极为重要,是这项工作开展的重要保障。 | 曲艺 郭尚林 Jim Holland 马永健 侯甜甜 连雨晴 张永庆 | 2019 | 中国医疗管理科学2019，9，4： | 3 |
| 17 | Detection of specific polymerase chain reaction product by utilizing the 5'-3' exonuclease activity of Thermus aquaticus DNA polymerase 显示文摘 | Holland PM Abramson RD Watson R | 1991 | Proc Natl Acad Sci U S A1991，88，16： | 3 |
| 18 | Osteopontin-CD44 Signaling in the Glioma Perivascular Niche Enhances Cancer Stem Cell Phenotypes and Promotes Aggressive Tumor Growth显示文摘 | Alexander Pietras Amanda M. Katz Elin J. Ekstr?m Boyoung Wee John J. Halliday Kenneth L. Pitter Jillian L. Werbeck Nduka M. Amankulor Jason T. Huse Eric C. Holland | 2014 | Cell Stem Cell2014，，3： | 3 |
| 19 | Multi-scale magnetic resonance measurements and validation of Discrete Element Model simulations显示文摘This short review describes the capabilities of magnetic resonance (MR) to image opaque single-and two- phase granular systems, such as rotating cylinders and gasfluidized beds operated in different fluidization regimes. The unique capability of MR to not only image the solids' distribution (voidage) but also the velocity of the particulate phase is clearly shown. It is demonstrated that MR can provide measurements over different length and time scales. With the MR equipment used for the studies summarized here, temporal and spatial scales range from sub-millisecond to hours and from a few hundred micrometres to a few centimetres, respectively. Besides providing crucial data required for an improved understanding of the underlying physics of granular flows, multi-scale MR measurements were also used to validate numerical simulations of granular systems. It is shown that predictions of time-averaged properties, such as voidage and velocity of the particulate phase, made using the Discrete Element Model agree very well with MR measurements. | Christoph R. Müller Daniel J. Holland James R. Third Andrew J. Sederman John S. Dennis Lynn F. Gladden | 2011 | Particuology2011，9，4： | 3 |
| 20 | Nitrogen Cycles: Past, Present, and Future显示文摘 | J. N. Galloway F. J. Dentener D. G. Capone E. W. Boyer R. W. Howarth S. P. Seitzinger G. P. Asner C. C. Cleveland P. A. Green E. A. Holland D. M. Karl A. F. Michaels J. H. Porter A. R. Townsend C. J. V?osmarty | 2004 | Biogeochemistry2004，，2： | 2 |
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