|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Clinicopathological features of alpha-fetoprotein producing early gastric cancer with enteroblastic differentiation显示文摘AIM To investigate clinicopathological features of early stage gastric cancer with enteroblastic differentiation(GCED).METHODS We retrospectively investigated data on 6 cases of early stage GCED and 186 cases of early stage conventional gastric cancer(CGC: well or moderately differentiated adenocarcinoma) who underwent endoscopic submucosal dissection or endoscopic mucosal resection from September 2011 to February 2015 in our hospital.GCED was defined as a tumor having a primitive intestine-like structure composed of cuboidal or columnar cells with clear cytoplasm and immunohistochemical positivity for either alpha-fetoprotein, Glypican 3 or SALL4. The following were compared between GCED and CGC: age, gender, location and size of tumor, macroscopic type, ulceration, depth of invasion, lymphatic and venous invasion, positive horizontal and vertical margin, curative resection rate.RESULTS Six cases(5 males, 1 female; mean age 75.7 years; 6 lesions) of early gastric cancer with a GCED component and 186 cases(139 males, 47 females; mean age 72.7 years; 209 lesions) of early stage CGC were investigated. Mean tumor diameters were similar but rates of submucosal invasion, lymphatic invasion, venous invasion, and non-curative resection were higher in GCED than CGC(66.6% vs 11.4%, 33.3% vs 2.3%, 66.6% vs 0.4%, 83.3% vs 11% respectively, P < 0.01). Deep submucosal invasion was not revealed endoscopically or by preoperative biopsy. Histologically, in GCED the superficial mucosal layer was covered with a CGC component. The GCED component tended to exist in the deeper part of the mucosa to the submucosa by lymphatic and/or venous invasion, without severe stromal reaction. In addition, Glypican 3 was the most sensitive marker for GCED(positivity, 83.3%), immunohistochemically.CONCLUSION Even in the early stage GCED has high malignant potential, and preoperative diagnosis is considered difficult. Endoscopists and pathologists should know the clinicopathological features of this highly malignant type of cancer. | Kohei Matsumoto Hiroya Ueyama Kenshi Matsumoto Yoichi Akazawa Hiroyuki Komori Tsutomu Takeda Takashi Murakami Daisuke Asaoka Mariko Hojo Natsumi Tomita Akihito Nagahara Yoshiaki Kajiyama Takashi Yao Sumio Watanabe | 2016 | World Journal of Gastroenterology2016，22，36： | 20 |
| 2 | 采用共轭梯度法的管内壁温度导热反问题求解显示文摘建立了采用共轭梯度法的非稳态二维导热反问题数学模型,并利用FORTRAN语言编写了程序进行计算求解,由同心圆管外壁温度随时间的变化得到管内壁温度随时间的变化。计算结果表明,计算值与准实验值吻合,共轭梯度法能够准确地计算得到管内壁不同位置温度随时间的变化。 | 张有为 李辉 姜培学 KIMINOBU Hojo MAYUMI Ochi KOICHI Tanimoto | 2009 | 工程热物理学报2009，30，7： | 12 |
| 3 | Molecular evidence for biochemical diversification of phenolamide biosynthesis in rice plants显示文摘Two phenolamides(PAs), p-coumaroylputrescine and feruloylputrescine strongly accumulate in rice(Oryza sativa cv. Nipponbare) leaves subjected to attack of chewing and sucking herbivores. Here we identified and characterized in vitro three novel rice genes that mediated coumaroyl-Co A/feruloyl-Co A conjugation to polyamines, putrescine and agmatine. Interestingly, two genes were highly specific for their polyamine substrates, encoding putrescine N-hydroxycinnamoyltransferase and agmatine N-hydroxycinnamoyltransferase, while the third enzyme could use both polyamines and it was therefore annotated as putrescine/agmatine N-hydroxycinnamoyltransferase. All genes were preferentially expressed in rice roots and developing flowers,and in addition, the putrescine/agmatine N-hydroxycinnamoyltransferase transcripts were strongly induced by wounding in the young rice leaves. Because the wound response of this gene was only partially suppressed in the jasmonoyl-L-isoleucine deficient plants(Osjar1), it suggests that its upregulation(as well as inducible PAs in rice) may be largely independent of jasmonoyl-L-isoleucine signaling pathway. The finding of three closely related genes with a similar and/or overlapping activity in PA biosynthesis provides another striking example of rapid diversification of plant metabolism in response to environmental stresses in nature. | Kimiaki Tanabe Yuko Hojo Tomonori Shinya Ivan galis | 2016 | Journal of Integrative Plant Biology2016，58，11： | 3 |
| 4 | Characteristic pathological findings and effects of ecabet sodium in rat reflux esophagitis显示文摘AIM:To explore the pathological flndings in the entire esophagus in rats with reflux esophagitis, and the effects of ecabet sodium(ES).METHODS:A rat model of chronic acid reflux esophagitis was used.In the treatment group, ES was administered after surgery(n = 16).No drug was administered postoperatively to the esophagitis group(n = 9).Shamoperated rats were used as a control group(n = 5).Rats were sacriflced on day 7 after the operation.The epithelial thickness and leukocyte inflltration were examined in the upper, middle and lower areas of the esophagus.The survival rate, incidence of esophageal ulcer, and mean surface area and number of esophageal ulcers were determined in the esophagitis and ES groups.Esophageal histology was assessed in all three groups.RESULTS:Leukocyte infiltration in the esophagitis group was 26.3 ± 22.0 in the middle esophagus and 8.2 ± 4.9 in the upper esophagus, which was signiflcantly greater than that in the controls(1.3 ± 1.1 and 1.4 ± 1.0, respectively)(P < 0.05).The thickness of the epithelium in the esophagitis group was 210.8 ± 47.7 μm in the lower esophagus and 204.2 ± 60.1 μm in the middle esophagus, which was significantlygreater than that in the controls(26.0 ± 5.5 and 21.0 ± 6.5 μm, respectively)(P < 0.05).The mean number of ulcers per animal in the ES group in the entire esophagus was 5.4 ± 2.5, which was signiflcantly less than that in the esophagitis group(9.0 ± 3.5)(P < 0.05).The epithelial thickness in the ES group was 97.5 ± 32.2 μm in the lower esophagus, which was decreased compared with that in the esophagitis group(210.8 ± 47.7 μm)(P < 0.05).CONCLUSION:Mucosal inflammation extended to the upper esophagus close to the hypopharynx.Our study suggested that ES may have a useful defensive role in reflux esophagitis. | Daisuke Asaoka Akihito Nagahara Masako Oguro Yuko Izumi Akihiko Kurosawa Taro Osada Masato Kawabe Mariko Hojo Michiro Otaka Sumio Watanabe | 2009 | World Journal of Gastroenterology2009，15，28： | 2 |
| 5 | Protein release from collagen matrices 显示文摘 | FUJIOKA K MAEDA M HOJO T | 1998 | Advance d Drug Delivery Reviews1998，31，： | 2 |
| 6 | Mesophilic methane fermentation of chicken manure at a wide range of ammonia concentration: Stability, inhibition and recovery显示文摘 | Qigui Niu Wei Qiao Hong Qiang Toshimasa Hojo Yu-You Li | 2013 | Bioresource Technology2013，，： | 2 |
| 7 | Right anterior segmental hepatic duct emptying directly into the cystic duct in a living donor显示文摘A 35-year-old mother was scheduled to be the living donor for liver transplantation to her second son,who suffered from biliary atresia complicated with biliary cirrhosis at the age of 2 years.The operative plan was to recover the left lateral segment of the mother's liver for living donor transplantation.With the use of cholangiography at the time of surgery,we found the right anterior segmental duct(RASD) emptying directly into the cystic duct,and the catheter passed into the RASD.After repairing the incision in the cystic duct,transplantation was successfully performed.Her postoperative course was uneventful.Biliary anatomical variations were frequently encountered,however,this variation has very rarely been reported.If the RASD was divided,the repair would be very difficult because the duct will not dilate sufficiently in an otherwise healthy donor.Meticulous preoperative evaluation of the living donor's biliary anatomy,especially using magnetic resonance cholangiography and careful intraoperative techniques,is important to prevent bile duct injury and avoid the risk to the healthy donor. | Yasunao Ishiguro Masanobu Hyodo Takehito Fujiwara Yasunaru Sakuma Nobuyuki Hojo Koichi Mizuta Hideo Kawarasaki Alan T Lefor Yoshikazu Yasuda | 2010 | World Journal of Gastroenterology2010，16，29： | 2 |
| 8 | Deformation and fracture behavior of an Al 2 O 3 /YAG composite from room temperature to 2023 K显示文摘 | S. Ochiai T. Ueda K. Sato M. Hojo Y. Waku N. Nakagawa S. Sakata A. Mitani T. Takahashi | 2001 | Composites Science and Technology2001，，14： | 2 |
| 9 | Cyclosporine induces cancer progression by a cell-autonomous mechanism (see comments)显示文摘 | Hojo M Morimoto T Maluccio M | | 0，，： | 2 |
| 10 | Matrix metalloproteinase expression in the coronary circulation induced by coronary显示文摘 | Hojo Y Ikeda U Katsuki T | 2002 | Atherosclerosis2002，161，1： | 1 |
| 11 | Differents of acute and chronic dministration of amiodarone on E - 4031-sensitive component(Ikr) and chromanol 293B- sensitive conponent (Iks) on the delayed rectifier potassium cuttent in rabbit ventricular myocytes显示文摘 | Yoshida S Hojo M | 1998 | Circulation1998，98，： | 1 |
| 12 | Rupture of the gallbladder in a patient with acquired factor Ⅷ inhibitors and systemic lupus erythematosus显示文摘 | HOJO N SAKAI I | 2004 | Internal Medicine2004，43，： | 1 |
| 13 | Synthesis of zeolite from coal fly ashes with different silica-alumina composition显示文摘 | MiKi inada Yukari Eguchi Naoya Enomoto Junichui HoJo | 2005 | Fuel2005，84，23： | 1 |
| 14 | Elevation of plasma granzyme B levels after acute myocardial infarction显示文摘 | KONDO H HOJO Y TSURU R | 2009 | Circ J2009，73，： | 1 |
| 15 | Rapamycin blocks tumor progression: Unlinking immunosuppression from antitumor efficacy显示文摘 | Luan F Hojo M Maluccio M | 2002 | Transplantation2002，73，： | 1 |
| 16 | The fine structure in the field change produced by positive ground stroke 显示文摘 | Hojo J Ishii M Kawamura T | 1985 | J Geo- physRes1985，90，： | 1 |
| 17 | Preservation of urine voiding and sexual function after rectal cancer surgery显示文摘 | Dr. Keiichi Hojo M.D. Anthony M. Vernava M.D. Kenichi Sugihara M.D. Kenichi Katumata M.D | 1991 | Diseases of the Colon & Rectum1991，，7： | 1 |
| 18 | Screening of genes expressed in developing mandibles during soldier differentiation in the termite Hodotermopsis sjostedti 显示文摘 | Koshikawa S Cornette R Hojo M | 2005 | Febs Lett2005，579，6： | 1 |
| 19 | Chemoenzymatic synthesis of hydrophobic glycoprotein:synthesis of saposin c carrying complex–type carbohydrate显示文摘 | Hojo H Tanaka H Hagiwara M | 2012 | The Journal of Organic Chemistry2012，77，94： | 1 |
| 20 | Estrogen synthesis in the brainrole in synaptic plasticity and memory显示文摘 | Hojo Y Murakami G Mukai H | 2008 | Mol Cell Endocrinol2008，290，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员