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| 1 | Immunohistochemical expression of intrarenal renin angiotensin system components in response to tempol in rats fed a high salt diet显示文摘AIM To determine the effect of tempol in normal rats fed high salt on arterial pressure and the balance between antagonist components of the renal renin-angiotensin system.METHODS Sprague-Dawley rats were fed with 8% Na Cl highsalt(HS) or 0.4% Na Cl(normal-salt,NS) diet for 3 wk,with or without tempol(T)(1 mmol/L,administered in drinking water). Mean arterial pressure(MAP),glomerularfiltration rate(GFR),and urinary sodium excretion(UVNa) were measured. We evaluated angiotensin Ⅱ(Ang Ⅱ),angiotensin 1-7(Ang 1-7),angiotensin converting enzyme 2(ACE2),mas receptor(Mas R),angiotensin type 1 receptor(AT1R) and angiotensin type 2 receptor(AT2R) in renal tissues by immunohistochemistry.RESULTS The intake of high sodium produced a slight but significant increase in MAP and differentially regulated components of the renal renin-angiotensin system(RAS). This included an increase in Ang Ⅱ and AT1 R,and decrease in ACE-2 staining intensity using immunohistochemistry. Antioxidant supplementation with tempol increased natriuresis and GFR,prevented changes in blood pressure and reversed the imbalance of renal RAS components. This includes a decrease in Ang Ⅱ and AT1 R,as increase in AT2,ACE2,Ang(1-7) and Mas R staining intensity using immunohistochemistry. In addition,the natriuretic effects of tempol were observed in NS-T group,which showed an increased staining intensity of AT2,ACE2,Ang(1-7) and Mas R.CONCLUSION These findings suggest that a high salt diet leads to changes in the homeostasis and balance between opposing components of the renal RAS in hypertension to favour an increase in Ang Ⅱ. Chronic antioxidant supplementation can modulate the balance between the natriuretic and antinatriuretic components of the renal RAS. | Gabriel Cao Silvana Lorena Della Penna Nicolas Martín Kouyoumdzian Marcelo Roberto Choi Susana Gorzalczany Belisario Enrique Fernández Jorge Eduardo Toblli María Inés Roson | 2017 | World Journal of Nephrology2017，6，1： | 4 |
| 2 | The economic impact of restricted water supply: A computable general equilibrium analysis显示文摘 | Maria Berrittella Arjen Y. Hoekstra Katrin Rehdanz Roberto Roson Richard S.J. Tol | 2007 | Water Research2007，，8： | 2 |
| 3 | Causes and lactot's associated with early tailure in hospitalized patients with com- munity-acquired pneumonia 显示文摘 | Roson B Carratala J Fernandez-Sabe N | 2004 | Arch Intern Med2004，164，5： | 1 |
| 4 | general equilibrium analysis of climate change impacts on tourism显示文摘 | Berrittella M Bigano A Roson R A | 2006 | Tourism Management2006，27，5： | 1 |
| 5 | Two-sided Markets: A Tentative Survey 显示文摘 | Roson R | 2005 | Review of Network Economics2005，，4： | 1 |
| 6 | Two-sided market:a tentative survey显示文摘 | Roberto Roson | 2005 | Review of Network Economics2005，，2： | 1 |
| 7 | Effects of ketogenic diet on epileptiform activity in children with therapy resistant epi- lepsy 显示文摘 | Hallbook T Kohler S Roson I | 2007 | Epilepsy Res2007，77，： | 1 |
| 8 | Novel regulators of bone formation:Molecular clones and activities显示文摘 | Wozney J M Roson V Celeste A J | 1988 | Science1988，242，： | 1 |
| 9 | Causes and factors associated with early failure in hospitalized patients with community- acquired pneumonia显示文摘 | Roson B Carratala J Fernandez-Sabe N | 2004 | Arch Intern Med2004，164，： | 1 |
| 10 | Sonographic findings of mesenteric panniculitis:correlation with CT and literaturereview显示文摘 | Nuria Roson MD Victoria Garriga MD | | 0，，4： | 1 |
| 11 | Two --sidedmarkets:ATentativeSurvey显示文摘 | Roson | 2005 | ReviewofNetwork Economics2005，4，2： | 1 |
| 12 | Pigmented Villonodular Synovitis and Giant Cell Tumors of the Tendon Sheath:Radiologic and Pathologic Features显示文摘 | Llauger J Palmer J Roson N | 1999 | AJR1999，172，3： | 1 |
| 13 | Fentanyl and Sufentanyl anesthesia revisivited:how much is enough显示文摘 | Philibin DM Roson CE Schneider RC | 1990 | Anesthesiology1990，73，： | 1 |
| 14 | Leaf emer- gence, tiller growth, and apical development of nitrogen-defi- cient spring wheat显示文摘 | LONGNECKER N KIRBY E J M ROSON A | 1993 | Crop Science1993，33，： | 1 |
| 15 | Combat hypoxia:the importance of airway management and oxygenation of the traumatic brain injury patient显示文摘 | Rosoner G | 2003 | J Emergency Medical Services2003，28，： | 1 |
| 16 | A General Equilibrium Analysis of Climate Change Impacts on Tourism显示文摘 | BERRITTELLA M B A ROSON R | 2006 | Tourism Management2006，27，5： | 1 |
| 17 | Causes and factors associated with early failure in hospitalized patients with community- acquired pneumonia显示文摘 | Roson B Carratala J Fernandez-Sabe N | 2004 | Arch Intern Med2004，164，： | 1 |
| 18 | Platform competition in the two-sided markets:the case of payment networks显示文摘 | Chakravorti S Roson R | 2006 | Review of Network Economics2006，5，1： | 1 |
| 19 | Treatment of alphal-antitrypsin -deficiency panniculitis with minocycline 显示文摘 | GINARTE M ROSON E PETEIRO C | 2001 | Cutis2001，68，2： | 1 |
| 20 | The Description of Road Surface Roughness 显示文摘 | Dodds C J Roson J D | 1973 | Journal of Sound and Vibration1973，31，2： | 1 |
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