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| 1 | MYB Transcription Factors as Regulators of Phenylpropanoid Metabolism in Plants显示文摘导出 Phenylpropanoid 的混合物代表从本氨基丙酸发源的第二等的代谢物的一个多样的家庭。这些混合物对关於生命、不能生活的应力在植物生长和开发,并且在防卫有角色。许多这些混合物对人的健康和福利也有益。V-myb myeloblastosis 病毒的 oncogene 相当或相同的事物(MYB ) 蛋白质属于抄写因素的一个大家庭并且是导出 phenylpropanoid 的混合物的合成的关键管理者。这评论在植物在 phenylpropanoid 新陈代谢的规定总结 MYB 蛋白质和他们的角色的当前的理解。 | Jingying Liu Anne Osbourm Pengda Ma | 2015 | Molecular Plant2015，8，5： | 79 |
| 2 | A Fluorescent Zirconium-Based Metal-Organic Framework for Selective Detection of Nitro Explosives and Metal Ions显示文摘 | YuanzheTang Hongliang Huang Yaguang Peng Qunqun Ruan KekeWang Pengda Yi Dahuan Liu Chongli Zhong | 2017 | Chinese Journal of Chemistry2017，35，7： | 4 |
| 3 | Low-overpotential selective reduction of CO2 to ethanol on electrodeposited CuxAuy nanowire arrays显示文摘Direct electrochemical reduction of CO2 to multicarbon products is highly desirable, yet challenging. Here, we present a potentiostatic pulse-electrodeposition of high-aspect-ratio CuxAuy nanowire arrays (NWAs) as high-performance electrocatalysts for the CO2 reduction reaction (CO2RR). The surface electronic structure related to the Cu:Au ratio in the CuxAuy NWAs could be facilely modulated by controlling the electrodeposition potential and the as-fabricated CuxAuy NWAs could be directly used as the catalytic electrode for the CO2RR. The morphology of the high-aspect-ratio nanowire array significantly lowers the onset potential of the alcohol formation due to the diffusion-induced enhancement of the local pH and CO concentration near the nanowire surface. Besides, the properly adjusted surface electronic structure of the CuxAuy NWA enables the adsorption of CO and facilitates the subsequent CO reduction to ethanol via the C-C coupling pathway. Owing to the synergistic effect of morphology and electronic structure, the optimized CuxAuy NWA selectively reduces CO2 to ethanol at low potentials of -0.5——0.7 V vs. RHE with a highest Faradaic efficiency of 48%. This work demonstrates the feasibility to optimize the activity and selectivity of the Cu-based electrocatalysts toward multicarbon alcohols for the CO2RR via simultaneous adjustment of the electronic structure and morphology of the catalysts. | Weiwei Zhu Kuangmin Zhao Suqin Liu Min Liu Feng Peng Pengda An Binhao Qin Huimin Zhou Hongmei Li Zhen He | 2019 | Journal of Energy Chemistry2019，28，10： | 4 |
| 4 | Cytosolic DNA sensing by cGAS:regulation,function,and human diseases显示文摘Sensing invasive cytosolic DNA is an integral component of innate immunity.cGAS was identified in 2013 as the major cytosolic DNA sensor that binds dsDNA to catalyze the synthesis of a special asymmetric cyclic-dinucleotide,2/3/-cGAMP,as the secondary messenger to bind and activate STING for subsequent production of type I interferons and other immune-modulatory genes.Hyperactivation of cGAS signaling contributes to autoimmune diseases but serves as an adjuvant for anticancer immune therapy.On the other hand,inactivation of cGAS signaling causes deficiency to sense and clear the viral and bacterial infection and creates a tumor-prone immune microenvironment to facilitate tumor evasion of immune surveillance.Thus,cGAS activation is tightly controlled.In this review,we summarize up-to-date multilayers of regulatory mechanisms governing cGAS activation,including cGAS pre-and post-translational regulations,cGAS-binding proteins,and additional cGAS regulators such as ions and small molecules.We will also reveal the pathophysiological function of cGAS and its product cGAMP in human diseases.We hope to provide an up-to-date review for recent research advances of cGAS biology and cGAS-targeted therapies for human diseases. | Le Yu Pengda Liu | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 1 |
| 5 | Regulation of APC^cdh1 E3 ligase activity by the Fbw7/cyclin E signaling axis contributes to the tumor suppressor function of Fbw7显示文摘Fbw7 和 Cdh1 分别地是 SCF 类型和 APC 类型 E3 ubiquitin ligases 的底层识别子单元。新兴的证据由为破坏指向 oncoproteins 作为肿瘤 suppressors 正在建议那 Fbw7 和 Cdh1 功能。Fbw7 的损失,然而并非 Cdh1,经常在各种各样的人的肿瘤被观察。然而, Fbw7 怎么机械学地作为肿瘤 suppressor 工作并且是否在 Fbw7 和 Cdh1 之间有发信号的串音,仍然保持大部分未知。这里,我们报导那 Fbw7 缺乏的房间不仅显示 SCF Fbw7 底层包括 cyclin E,而且增加了各种各样的 APC Cdh1 底层。我们进一步把 cyclin E 定义为 Fbw7 由管理 APC Cdh1 活动,在 Fbw7 缺乏的房间的 cyclin E 的弄空导致 APC Cdh1 底层到比得上那些的层次在野类型(WT ) 房间。相反地, cyclin E 的宫外的表示概括异常 APC 在 Fbw7 缺乏的房间观察的 Cdh1 底层表示。更重要地,对 Cdk2/cyclin 电子 mediated phosphorylation 抵抗的 4A-Cdh1,然而并非 WT-Cdh1,颠倒了各种各样的 APC 在 Fbw7 缺乏的房间的 Cdh1 底层。4A-Cdh1 的 Overexpression 也导致了延迟的房间生长并且减少抛锚无关的殖民地形成。总的来说,我们识别了 Fbw7 以一种 cyclin 电子依赖者方式由管理 Cdh1 活动的新奇规章的机制。作为结果, Fbw7 的损失能在两 SCF Fbw7 和 APC Cdh1 底层。我们的学习提供 Fbw7 的肿瘤 suppressor 功能的更好的理解,并且建议禁止者能为治疗 Fbw7 缺乏的肿瘤作为有效治疗学的代理人服务的那 Cdk2/cyclin E。 | Alan WLau Hiroyuki Inuzuka Hidefumi Fukushima LixinWan Pengda Liu Daming Gao Yi Sun Wenyi Wei | 2013 | Cell Research2013，23，7： | 1 |
| 6 | 2,3-Dihydroxybiphenyl dioxygenase gene was first discovered in Arthrobacter sp. strain PJ3显示文摘Bacterium strain PJ3,isolated from wastewater and identified as Arthrobacter sp. bacterium based on its 16S rDNA gene,could use carbazole as the sole carbon,nitrogen and energy source. The genomic library of strain PJ3 was constructed and a positive clone JM109(pUCW402) was screened out for the expression of dioxygenase by the ability to form yellow ring-fission product. A 2,3-dihydroxybiphenyl dioxygenase(23DHBD) gene of 933 bp was found in the 3360 bp exogenous fragment of pUCW402 by GenSCAN software and BLAST analysis. The phylogenetic analysis showed that 23DHBD from strain PJ3 formed a deep branch separate from a cluster containing most known 23DHBD in GenBank. Southern hybridization confirmed for the first time that the 23DHBD gene was from the genomic DNA of Arthrobacter sp. PJ3. In order to test the gene function,recombinant bacterium BL21(pETW-8) was constructed to express 23DHBD. The expression level in BL21(pETW-8) was highest compared with the recombinant bacteria JM109(pUCW402) and strain PJ3. We observed that 23DHBD was not absolute specific. The enzyme activity was higher with 2,3-dihydroxybiphenyl as a substrate than with catechol. The substrate specificity assay suggested that 23DHBD was essential for cleavage of bi-cyclic aromatic compounds during the course of aromatic compound biodegradation in Arthrobacter sp. strain PJ3. | YANG MeiYing MA PengDa LI WenMing LIU JinYing LI Liang ZHU XiaoJuan WANG XingZhi | 2007 | Chinese Science Bulletin2007，52，9： | 1 |
| 7 | Application of The Geo-anomaly Unit Concept in Quantitative Delineation and Assessment of Gold Ore Targets In Western Shandong Uplift Terrain, Eastern China显示文摘 | Pengda Zhao Jianguo Chen Jiping Liu | 2001 | Natural Resources Research2001，10，1： | 1 |
| 8 | Hybrid TaON/LaTiO_(2)N photoelectrode for water oxidation显示文摘Efficient and stable photoelectrodes for water oxidation are highly desirable in the field of photoelectrochemical(PEC)water splitting.However,photoelectrodes with low externally applied bias usually exhibit weak photocurrent and vice versa.Herein,novel and efficient CoO_(x)-TaON/LTON composite photoanodes have been successfully prepared by a microwave assisted method followed with a particle transfer procedure.The obtained photoanode generated an anodic photocurrent of∼7.2 mA cm^(−2) at 1.2 V_(RHE) and initiated the anodic photourrent at∼0.5 V_(RHE).The HC-STH of the composite photoelectrode reached 1.0%at 1.2 V_(RHE).Further,stoichiometric oxygen and hydrogen are stably produced on the photoanode and the counter electrode with a Faraday efficiency of unity for 2 h. | Pengda An Baopeng Yang Ning Zhang Hongmei Li Min Liu | 2019 | Transportation Safety and Environment2019，1，3： | 0 |
| 9 | CVRgram for Demodulation Band Determination in Bearing Fault Diagnosis under Strong Gear Interference显示文摘Fault-related resonance frequency band extraction-based demodulation methods are widely used for bearing diagnostics.However,due to the high peaks of strong gear meshing interference,the classical band selection methods have poor performance and cannot work well for bearing fault type detection.As such,the CVRgram-based bearing fault diagnosis method is proposed in this paper.In the proposed method,inspired by the conditional variance(CV)index and root mean square(RMS),a novel index,named the CV/root mean square(CVR),is first proposed.The CVR index has high robustness for the interference of non-Gaussian or Gaussian noise and has the ability to determine the center frequency of the weak bearing fault-related resonance frequency band under strong interference.Secondly,motived by the Kurtogram,the CVRgram algorithm is developed for adaptively determining the optimal filtering parameters.Finally,the CVRgram-based bearing fault diagnosis method under strong gear meshing interference is proposed.The performance of the CVRgram-based method is verified by both the simulation signal and the experiment signal.The comparison analysis with the Kurtogram,Protrugram,and CVgram-based method shows that the proposed technique has a much better ability for bearing fault detection under strong noise interference. | Pengda Wang Dezun Zhao Dongdong Liu Lingli Cui | 2022 | Journal of Dynamics, Monitoring and Diagnostics2022，1，4： | 0 |
| 10 | Dhx33 promotes B-cell growth and proliferation by controlling activation-induced rRNA upregulation显示文摘Upon recognition of foreign antigens,naïve B cells undergo rapid activation,growth,and proliferation.How B-cell growth and proliferation are coupled with activation remains poorly understood.Combining CRISPR/Cas9-mediated functional analysis and mouse genetics approaches,we found that Dhx33,an activation-induced RNA helicase,plays a critical role in coupling B-cell activation with growth and proliferation.Mutant mice with B-cell-specific deletion of Dhx33 exhibited impaired B-cell development,germinal center reactions,plasma cell differentiation,and antibody production.Dhx33-deficient B cells appeared normal in the steady state and early stage of activation but were retarded in growth and proliferation.Mechanistically,Dhx33 played an indispensable role in activation-induced upregulation of ribosomal DNA(rDNA)transcription.In the absence of Dhx33,activated B cells were compromised in their ability to ramp up 47S ribosomal RNA(rRNA)production and ribosome biogenesis,resulting in nucleolar stress,p53 accumulation,and cellular death.Our findings demonstrate an essential role for Dhx33 in coupling B-cell activation with growth and proliferation and suggest that Dhx33 inhibition is a potential therapy for lymphoma and antibody-mediated autoimmune diseases. | Xiaoyu He Jiayi Zhao Abidan Adilijiang Peicheng Hong Pengda Chen Xinyong Lin Jun Xie Ying Du Yun Liu Lianghua Lin Hyun Yong Jin Yazhen Hong Wen-Hsien Liu Changchun Xiao | 2023 | Cellular & Molecular Immunology2023，20，3： | 0 |
| 11 | Dual phosphorylation of Sin1 at T86 and T398 negatively regulates mTORC2 complex integrity and activity显示文摘 | Pengda Liu Jianping Guo Wenjian Gan Wenyi Wei | 2014 | Protein & Cell2014，5，3： | 0 |
| 12 | Lenalidomide downregulates ACE2 protein abundance to alleviate infection by SARS-CoV-2 spike protein conditioned pseudoviruses显示文摘Dear Editor,The recent health emergency caused by SARS-CoV-2 created a global pandemic.Similar to other CoVs,SARS-CoV-2 utilizes its Spike(S)protein to specifically recognize the human angiotensin converting enzyme 2(ACE2)membrane receptor for infection. | Siyuan Su Jianfeng Chen Ying Wang Lilly M.Wong Zhichuan Zhu Guochun Jiang Pengda Liu | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 0 |
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