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| 1 | Coronary spasm: It's common, but it's still unsolved显示文摘Coronary spasm is caused by a transient coronary nar -rowing due to the constriction of epicardial coronary artery, which leads to myocardial ischemia. More than 50 years have passed since the first recognition of coronary spasm, and many findings on coronary spasm have been reported. Coronary spasm has been considered as having pivotal roles in the cause of not only rest angina but also exertional angina, acute coronary syndrome, and heart failure. In addition, several new findings of the mechanism of coronary spasm have emerged recently. The diagnosis based mainly on coronary angiography and spasm provo-cation test and the mainstream treatment with a focus on a calcium-channel blocker have been established. At a glance, coronary spasm or vasospastic angina(VSA) has become a common disease. On the contrary, there are several uncertain or unsolved problems regarding coronary spasm, including the presence of medically refractory coronary spasm(intractable VSA), or an appropriate use of implantable cardioverter defibrillator in patients with cardiac arrest who have been confirmed as having coronary spasm. This editorial focused on coronary spasm, including recent topics and unsolved problems. | Hiroki Teragawa Chikage Oshita Tomohiro Ueda | 2018 | World Journal of Cardiology2018，10，11： | 7 |
| 2 | Relation between microRNA expression and progression and prognosis of gastric cancer: a microRNA expression analysis显示文摘 | Tetsuya Ueda Stefano Volinia Hiroshi Okumura Masayoshi Shimizu Cristian Taccioli Simona Rossi Hansjuerg Alder Chang-gong Liu Naohide Oue Wataru Yasui Kazuhiro Yoshida Hiroki Sasaki Sachiyo Nomura Yasuyuki Seto Michio Kaminishi George A Calin Carlo M Croce | 2010 | Lancet Oncology2010，，2： | 4 |
| 3 | Mutations in hepatitis B virus core regions correlate with hepatocellular injury in Chinese patients with chronic hepatitis B显示文摘AIM: To elucidate the relationship between the frequency of core mutations and the clinical activity of hepatitis B virus (HBV)-related liver disease and to characterize the amino acid changes in the core region of HBV.METHODS: We studied 17 Chinese patients with chronic hepatitis B according to their clinical courses and patterns of the entire core region of HBV.RESULTS: Amino acid changes often appeared in the HBV core region of the HBV gene in patients with high values of alanine aminotransferase (ALT) or with the seroconversion from HbeAg to anti-HBe. The HBV core region with amino acid changes had high frequency sites that corresponded to HLA Ⅰ/Ⅱ restricted recognition epitopes reported by some investigators.CONCLUSION: The core amino acid changes of this study occur due to influence of host immune system. The presence of mutations in the HBV core region seems to be important for predicting the clinical activity of hepatitis B in Chinese patients. | Hiroto Tanaka Hiroki Ueda Hiroko Hamagami Susumu Yukawa Masakazu Ichinose Motoshige Miyano Keiji Mimura Iwao Nishide Bo-Xin Zhang Su-Wen Wang Shi-Oing Zhou Bei-Hai Li | 2005 | World Journal of Gastroenterology2005，11，30： | 3 |
| 4 | Hepatic encephalopathy with status epileptics: A case report显示文摘有患心脏代偿失调的肝肝硬化的 62 岁的男性与地位 epileptic 由于丙肝病毒开发了严重肝的脑病我们。承认上的血氨水平是多于两次正常铺平。大脑计算了断层摄影术,磁性的回声成像是正常的。另外,脑电图显示出弥漫的锋利的波浪,与肝的脑病一致。地位 epileptic 我们为肝的脑病(分叉的链氨基酸) 在镇癫痫剂治疗(phenytoin ) 和治疗以后被解决。与临床的改进和病人使正常化的血氨水平没有地位 epileptic 的复发我们在镇癫痫剂治疗的结束以后。另外,脑电图显示出正常调查结果。因此,我们与地位 epileptic 作为肝的脑病诊断了病人我们。我们这个病人认为地位 epileptic 是我们到一稀罕、有趣在肝的脑病发现。 | Hiroto Tanaka Hiroki Ueda Yohei Kida Hiroko Hamagami Tomikimi Tsuji Masakazu Ichinose | 2006 | World Journal of Gastroenterology2006，12，11： | 3 |
| 5 | Case of angina pectoris at rest and during effort due to coronary spasm and myocardial bridging显示文摘We present a case of a 71-year-old male who hadchest symptoms at rest and during effort. He had felt chest oppression during effort for 1 year,and his chest symptoms had recently worsened. One month before admission he felt chest squeezing at rest in the early morning. He presented at our institution to evaluate his chest symptoms. Electrocardiography and echocardiography failed to show any specific changes. Because of the possibility that his chest symptoms were due to myocardial ischemia,he was admitted to our institution for coronary angiography(CAG). An initial CAG showed mild atherosclerotic changes in the proximal segment of the left anterior descending coronary artery(LAD) and mid-segment of the left circumflex coronary artery. Subsequent spasm provocation testing using acetylcholine revealed a bilateral coronary vasospasm,which was relieved after the intracoronary infusion of nitroglycerin. Finally,a CAG showed myocardial bridging(MB) of the mid-distal segments of the LAD. Fractional flow reserve using the intravenous administration of adenosine triphosphate was positive at 0.77,which jumped up to 0.90 through the myocardial bridging segments when the pressure wire was pulled back. Thus,coronary vasospasm and MB might have contributed to his chest symptoms at rest and during effort. Interventional cardiologists should consider the presence of MB as a potential cause of myocardial ischemia. | Hiroki Teragawa Yuichi Fujii Tomohiro Ueda Daiki Murata Shuichi Nomura | 2015 | World Journal of Cardiology2015，7，6： | 3 |
| 6 | Decrease in alpha-fetoprotein levels predicts reduced incidence of hepatocellular carcinoma in patients with hepatitis C virus infection receiving interferon therapy: a single center study显示文摘 | Yukio Osaki Yoshihide Ueda Hiroyuki Marusawa Jun Nakajima Toru Kimura Ryuichi Kita Hiroki Nishikawa Sumio Saito Shinichiro Henmi Azusa Sakamoto Yuji Eso Tsutomu Chiba | 2012 | Journal of Gastroenterology2012，，4： | 3 |
| 7 | Occult hepatitis B virus infection and surgical outcomes in non-B, non-C patients with curative resection for hepatocellular carcinoma显示文摘AIM To investigate the prevalence, clinicopathological characteristics and surgical outcomes of occult hepatitis B virus(HBV) infection(OBI) in patients with non-B, non-C(NBNC) hepatocellular carcinoma(HCC).METHODS This study retrospectively examined the cases of 78 NBNC patients with curative resection for HCC for whom DNA could be extracted from formalin-fixed paraffin-embedded tissue. OBI was determined by the HBV-DNA amplification of at least two different sets of primers by TaqM an realtime polymerase chain reaction. Possibly carcinogenetic factors such as alcohol abuse, diabetes mellitus, obesity and non-alcoholic steatohepatitis(NASH) were examined. Surgical outcomes were evaluated according to diseasefree survival(DFS), overall survival(OS) and diseasespecific survival(DSS).RESULTS OBI was found in 27/78 patients(34.6%) with NBNC HCC. The OBI patients were significantly younger than the non-OBI cases at the time of surgery(average age 63.0 vs 68.1, P = 0.0334) and the OBI cases overlapped with other etiologies significantly more frequently compared to the non-OBI cases(P = 0.0057). OBI had no impact on the DFS, OS or DSS. Only tumorrelated factors affected these surgical outcomes.CONCLUSION Our findings indicate that OBI had no impact on surgical outcomes. The surgical outcomes of NBNC HCC depend on early tumor detection; this reconfirms the importance of a periodic medical examination for individuals who have NBNC HCC risk factors. | Hiroki Koga Keita Kai Shinichi Aishima Atsushi Kawaguchi Koutaro Yamaji Takao Ide Junji Ueda Hirokazu Noshiro | 2017 | World Journal of Hepatology2017，9，35： | 2 |
| 8 | Combination gene therapy of HGF and truncated type II TGF-β receptor for rat liver cirrhosis after partial hepatectomy显示文摘 | Satoru Ozawa Kazuhisa Uchiyama Mikihito Nakamori Kentaro Ueda Makoto Iwahashi Hikaru Ueno Yasuteru Muragaki Akira Ooshima Hiroki Yamaue | 2006 | Surgery2006，，4： | 2 |
| 9 | Impaired coronary microvascular endothelial function in men with metabolic syndrome显示文摘AIM: To assess coronary endothelial function of conduit and resistance vessels in patients with metabolic syndrome (MS). METHODS: Seventy-eight men (mean age, 57 years) with chest pain and angiographically normal coronary arteries were included in the study. Patients with coronary spastic angina were excluded. Changes in coronary artery diameter and coronary blood flow (CBF) in response to acetylcholine (ACh) were determined using quantitative coronary angiography and Doppler velocity measurements. Coronary flow reserve was calculated as the ratio of coronary blood velocity after adenosine triphosphate infusion relative to baseline values. Patients were divided into two groups based on the presence or absence of MS. RESULTS: There were 24 patients in the MS group (31%). The increase in CBF in response to ACh infusion was impaired in the MS group (P < 0.0001) compared to the non-MS group, whereas changes in coronary artery diameter in response to ACh infusion did not differ between the two groups. Multivariate regression analysis revealed that MS was a significant factor associated with the lesser change in CBF induced by ACh infusion at 30 μg/min (P < 0.0001, r 2 = 0.46). CONCLUSION: Coronary endothelial dysfunction was present at the level of resistance vessels but not conduit vessels in the MS patients included in our study. | Hiroki Teragawa Naoya Mitsuba Kenji Nishioka Kentaro Ueda Shingo Kono Yukihito Higashi Kazuaki Chayama Yasuki Kihara | 2010 | World Journal of Cardiology2010，2，7： | 2 |
| 10 | Relation between microRNA expression and progression and prognosis of gastric cancer: a microRNA expression analysis显示文摘 | Tetsuya Ueda Stefano Volinia Hiroshi Okumura Masayoshi Shimizu Cristian Taccioli Simona Rossi Hansjuerg Alder Chang-gong Liu Naohide Oue Wataru Yasui Kazuhiro Yoshida Hiroki Sasaki Sachiyo Nomura Yasuyuki Seto Michio Kaminishi George A Calin Carlo M Croce | 2010 | Lancet Oncology2010，，2： | 2 |
| 11 | A case of chronic pancreatitis in which endoscopic ultrasonography was effective in the diagnosis of a pseudoaneurysm显示文摘Endoscopic ultrasonography (EUS) was performed on a patient being treated for chronic pancreatitis because a submucosal tumor was observed in the stomach during gastrointestinal endoscopy. As internal pulsa- tile blood flow on Doppler was present, the diagnosis of an aneurysm was made. The pseudoaneurysm of the left gastric artery was embolized with histoacryl and lipiodol and the splenic artery was embolized with coils at the location of the pseudoaneurysm to prevent hemorrhage. Follow up EUS confirmed the cessation of blood flow from the pseudoaneurysm. Clinicians encountering a gastric submucosal tumor-like protrusion in a patient with chronic pancreatitis should use EUS to investigate the possibility of a pseudoaneurysm, which must be treated as quickly as possible once identified. | Kazuhiro Fukatsu Kazuki Ueda Hiroki Maeda Yasunobu Yamashita Masahiro Itonaga Yoshiyuki Mori Kosaku Moribata Naoki Shingaki Hisanobu Deguchi Shotaro Enomoto Izumi Inoue Takao Maekita Mikitaka Iguchi Hideyuki Tamai Jun Kato Masao Ichinose | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，7： | 2 |
| 12 | Autoimmune hepatitis triggered by acute hepatitis A显示文摘The patient was a 57-year-old woman presenting with jaundice as the chief complaint. She began vomiting on July 10, 2003.Jaundice was noted and admitted to our hospital for thorough testing. Tests on admission indicated severe hepatitis, based on: aspartate aminotransferase (AST), 1 076 IU/L; alanine aminotransferase (ALT), 1 400 IU/L; total bilirubin (TB), 20.9 mg/dL; and prothrombin time rate (PT%), 46.9%. Acute hepatitis A (HA) was diagnosed based on negative hepatitis B surface antigen and hepatitis C virus RNA and positive immunoglobulin (Ig) M HA antibody, but elevation of anti-nuclear antigen (×320) and IgG (3 112 mg/dL) led to suspicion of autoimmune hepatitis (AIH). Plasma exchange was performed for 3 d from July 17, and steroid pulse therapy was performed for 3 d starting on July 18, followed by oral steroid therapy. Liver biopsy was performed on August 5, and the results confirmed acute hepatitis and mild chronic inflammation. Levels of AST and ALT normalized,so dose of oral steroid was markedly reduced. Steroid therapy was terminated after 4 mo, as the patient had glaucoma. Starting 3 mo after cessation of steroid therapy,levels of AST and ALT began to increase again. Another liver biopsy was performed and AIH was diagnosed based on serum data and biopsy specimen. Oral steroid therapy was reinitiated. Levels of AST and ALT again normalized.The present case was thus considered to represent AIH triggered by acute HA. | Hiroto Tanaka Hiroto Tujioka Hiroki Ueda Hiroko Hamagami Youhei Kida Masakazu Ichinose | 2005 | World Journal of Gastroenterology2005，11，38： | 2 |
| 13 | Use of collagen sponge incorporating transforming growth factor-β1 to promote bone repair in skull defects in rabbits显示文摘 | Hiroki Ueda Liu Hong Masaya Yamamoto | 2002 | Biomaterials2002，23，： | 1 |
| 14 | Repairing of rabbit skull defect by dehydrothermally crosslinked collagen sponges incorporating transforming growth factor β1显示文摘 | Hiroki Ueda Tatsuo Nakamura Masaya Yamamoto | 2003 | Journal of Controlled Release2003，88，： | 1 |
| 15 | Analysis of the prognostic factors and evaluation of surgical treatment for synchronous liver metastases from gastric cancer显示文摘 | Kentaro Ueda Makoto Iwahashi Mikihito Nakamori Masaki Nakamura Teiji Naka Koichiro Ishida Toshiyasu Ojima Hiroki Yamaue | 2009 | Langenbeck’s Archives of Surgery2009，，4： | 1 |
| 16 | Cell wall treatment of fafiap hodomarch yeast显示文摘 | Kobayashi Hiroki Ueda Yasuyoshi Sawalkuo Imamura Shiro | 1996 | JP Patent08-2148701996，，： | 1 |
| 17 | Surgical Management of Small Gastrointestinal Stromal Tumors of the Stomach显示文摘 | Makoto Iwahashi MD Katsunari Takifuji MD Toshiyasu Ojima MD Masaki Nakamura MD Mikihito Nakamori MD Yoshihiro Nakatani MD Kentaro Ueda MD Koichiro Ishida MD Teiji Naka MD Kazuo Ono MD Hiroki Yamaue MD | 2006 | World Journal of Surgery2006，，1： | 1 |
| 18 | Surgical Management of Small Gastrointestinal Stromal Tumors of the Stomach显示文摘 | Makoto Iwahashi MD Katsunari Takifuji MD Toshiyasu Ojima MD Masaki Nakamura MD Mikihito Nakamori MD Yoshihiro Nakatani MD Kentaro Ueda MD Koichiro Ishida MD Teiji Naka MD Kazuo Ono MD Hiroki Yamaue MD | 2006 | World Journal of Surgery2006，，1： | 1 |
| 19 | Palonosetron exhibits higher total control rate compared to first?generationserotonin antagonists and improves appetite in delayed?phase chemotherapy?inducednausea and vomiting显示文摘 | Hiroki Ueda Chigusa Shimono Tomoyasu Nishimura Megumi Shimamoto Hiroki Yamaue | 2014 | Molecular and Clinical Oncology2014，，： | 1 |
| 20 | Relation between microRNA expression and progression and prognosis of gastric cancer: a microRNA expression analysis显示文摘 | Tetsuya Ueda Stefano Volinia Hiroshi Okumura Masayoshi Shimizu Cristian Taccioli Simona Rossi Hansjuerg Alder Chang-gong Liu Naohide Oue Wataru Yasui Kazuhiro Yoshida Hiroki Sasaki Sachiyo Nomura Yasuyuki Seto Michio Kaminishi George A Calin Carlo M Croce | 2010 | Lancet Oncology2010，，2： | 1 |
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