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| 1 | New gene therapy strategies for hepatic fibrosis显示文摘The liver is the largest internal organ of the body, which may suffer acute or chronic injury induced by many factors, leading to cirrhosis and hepatocarcinoma. Cirrhosis is the irreversible end result of fibrous scarring and hepatocellular regeneration, characterized by diffuse disorganization of the normal hepatic structure, regenerative nodules and fibrotic tissue. Cirrhosis is associated with a high co-morbidity and mortality without effective treatment, and much research has been aimed at developing new therapeutic strategies to guarantee recovery. Liver-based gene therapy has been used to downregulate specific genes, to block the expression of deleterious genes, to delivery therapeutic genes, to prevent allograft rejection and to augment liver regeneration. Viral and non-viral vectors have been used, with viral vectors proving to be more efficient. This review provides an overview of the main strategies used in liver-gene therapy represented by non-viral vectors, viral vectors, novel administration methods like hydrodynamic injection, hybrids of two viral vectors and blocking molecules, with the hope of translating findings from the laboratory to the patient′s bed-side. | Adriana M Salazar-Montes Luis D Hernández-Ortega Martha S Lucano-Landeros Juan Armendariz-Borunda | 2015 | World Journal of Gastroenterology2015，21，13： | 12 |
| 2 | 雪上加霜还是枯木逢春—肝硬化并发肝癌显示文摘在肝脏的恶性肿瘤中,原发性肝癌(hepatocellular carcinoma,HCC,下文简称肝癌)约占90%以上,位居全世界恶性肿瘤发病率的第五位,病死率的第三位,每年近100万人死于该病,新增患者也接近100万。其中,约45%的新增病例集中在我国大陆,成为我国恶性肿瘤的第二位致死病因[1]。尽管恶性肿瘤的发病原因尚未阐明,但是。 | 薛冉 孟庆华 | 2015 | 肿瘤代谢与营养电子杂志2015，2，1： | 2 |
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